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    Functional Assays

    Functional Assays: An assay is an analytical procedure in laboratory medicine, pharmacology, environmental biology and molecular biology for qualitatively examining or quantitatively measuring the presence, amount, or functional activity of a target entity.

    Webinars

    • SEP 10, 2020 | 12:00 AM
      Visualizing viral replication of oncogenic human herpesviruses
      Visualizing viral replication of oncogenic human herpesviruses
      Viruses are the causative agents of approximately 12% of human cancers. The most recently discovered herpesvirus, Kaposi’s sarcoma herpesvirus (KSHV) is known to cause three human canc...
      Speaker: Lindsey M. Costantini, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 08, 2020 | 11:00 PM
      Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
      Deep mutational scanning of SARS-CoV-2 receptor binding domain...
      The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
      Speaker: Tyler Starr, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      4
      AUG 27, 2020 | 7:00 AM
      Atlas of the SARS-CoV-2 Proteome
      Atlas of the SARS-CoV-2 Proteome
      DATE: August 27, 2020 TIME: 7:00am PT Novel anti-viral medications, including biologics and small molecule inhibitors, as well as serologic diagnostic tool sets are in urgent demand to fight...
      Speaker: Yuning Chen, Ph.D.
      Sponsored By: Sino Biological
      32 3
      JUL 29, 2020 | 2:00 PM
      Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells
      Route of 41BB/41BBL costimulation determines effector function...
      B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H...
      Speaker: Christopher DeRenzo, MD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 29, 2020 | 11:00 AM
      STAT3 phosphorylation during phagocytosis is required to activate autophagy and prevent macrophage immuno-senescence
      STAT3 phosphorylation during phagocytosis is required to activate...
      Background: Acute liver injury (ALI) is characterised by hepatocyte death and liver inflammation. Macrophages play a pivotal role in ALI by phagocytosing dead cells and producing pro-regener...
      Speaker: Lara Campana, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      2
      JUL 29, 2020 | 12:00 AM
      Modeling anti-tumor function of human T cells
      Modeling anti-tumor function of human T cells
      Mouse models have been essential for establishing the role of the T cells in anti-tumor responses, but they have limited utility in translational studies for the testing of candidate therape...
      Speaker: Michael Overstreet, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 07, 2020 | 9:00 AM
      Enhancing risk stratification in early colon cancer with TNM-I (Immune) staging: focus on stage II T4N0 patients
      Enhancing risk stratification in early colon cancer with TNM-I...
      DATE: July 07, 2020 TIME: 9:00 am PDT The widely used TNM staging system is poorly predictive of response to adjuvant chemotherapy in Stage II and III colon cancer. As a result, there is ove...
      Speaker: Jérôme Galon, Ph.D , Graham Poage, Ph.D
      Sponsored By: HalioDx
      22 14
      JUL 01, 2020 | 12:45 PM
      Multicentric Evaluation of Oncomine Precision Assay on Ion Torrent Genexus System
      Multicentric Evaluation of Oncomine Precision Assay on Ion Torrent...
      NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
      Speaker: Prof. Dr. Michael Hummel
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      1
      JUN 30, 2020 | 9:00 AM
      Quality Control for the Pharmaceutical Industry; Stage 3, Continued Verification, in the Lifecycle of Analytical Procedures
      Quality Control for the Pharmaceutical Industry; Stage 3, Continued...
      DATE: June 30, 2020 TIME: 9:00am PDT, 12:00pm EDT QC laboratories perform a critical role in demonstrating pharmaceutical products are consistently manufactured, safe, potent, and pure. At t...
      Speaker: Jane Weitzel
      Sponsored By: Sartorius
      17 1
      JUN 17, 2020 | 1:30 PM
      Insights into the Pathogenesis of COVID-19 as Revealed by Spatial Biology
      Insights into the Pathogenesis of COVID-19 as Revealed by Spatial...
      Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
      Speaker: Joseph M. Beechem, PhD , Christopher E. Mason, PhD , Robert Schwartz, PhD
      Presented at: Coronavirus Series
      Sponsored By: NanoString Technologies
      9
      JUN 17, 2020 | 12:00 PM
      High-Throughput Assay for Monitoring COVID19 Antibodies and Their Isotypes
      High-Throughput Assay for Monitoring COVID19 Antibodies and Their...
      The 2020 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to rage. While PCR-based assays are used for viral diagnosis, high through-put, rapid s...
      Speaker: Susan Zolla-Pazner, PhD
      Presented at: Coronavirus Series
      Sponsored By: Luminex - A DiaSorin Company
      1
      JUN 03, 2020 | 1:00 PM
      Gene manipulation in primary human immune cells: Successful strategies and applications for CRISPRko, RNAi and beyond
      Gene manipulation in primary human immune cells: Successful strategies...
      Gene manipulation studies in primary human immune cells can answer important biological questions within a clinically relevant cellular context. In this webinar we explore the use of several...
      Speaker: Verena Brucklacher-Waldert, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Horizon Discovery
      2
      JUN 03, 2020 | 8:00 AM
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
      Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
      Speaker: Alexander David Borowsky, MD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Leica Biosystems
      1
      JUN 03, 2020 | 12:00 AM
      Microenvironment on Demand: A breakthrough technology for personalized cell therapy discoveries
      Microenvironment on Demand: A breakthrough technology for personalized...
      NCI estimates that cancer will be the leading cause of death in 2030, worldwide. Checkpoint inhibitors and adoptive cell therapies (ACTs) cost up to ~$2 million/patient and have shown durabl...
      Speaker: Maithreyan Srinivasan
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      MAY 21, 2020 | 8:00 AM
      Accelerating gene editing research using the power of flow cytometry
      Accelerating gene editing research using the power of flow cytometry
      DATE: May 21, 2020 TIME: 8:00am PDT, 11:00am EDT The advent of CRISPR has radically changed the face and pace of biological research and has unlocked unprecedented potential in the study of...
      Speaker: Natasha Jacobsen
      Sponsored By: Thermo Fisher Scientific
      22 2
      MAY 20, 2020 | 7:30 AM
      Keynote Presentation: Bridging Multiscale Physiological Systems via Microfluidics- from single cell to tissue-scale to organ-scale
      Keynote Presentation: Bridging Multiscale Physiological Systems...
      Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered. In addition to identifying the molecular and ce...
      Speaker: Abraham Lee
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      1
      MAY 20, 2020 | 12:00 AM
      Next-gen protein assays enabling precision medicine and data-driven biology
      Next-gen protein assays enabling precision medicine and data-driven...
      Proteins are the functional blocks of any biological entity from 50 nm sized viruses to the 100 ft long mammals (blue whale). They perform intra cellular, tissue, organ, system, or organism...
      Speaker: Kursad Araz, PhD
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      1
      MAY 20, 2020 | 12:00 AM
      Single-cell Genomics Tools for better understanding and treatment of Human Disease
      Single-cell Genomics Tools for better understanding and treatment...
      The basic units of biological structure and function are cells, which exhibit wide variation in regard to both type and state. We assess such variation by simultaneously profiling the transc...
      Speaker: Anindita Basu, PhD
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      2
      MAY 20, 2020 | 12:00 AM
      Lab on a Particle: Democratizing Single-Cell Secretion Assays
      Lab on a Particle: Democratizing Single-Cell Secretion Assays
      Techniques to analyze and sort single cells based on secreted products have the potential to transform our understanding of cellular biology as well as accelerate the development of next gen...
      Speaker: Joseph de Rutte
      Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
      1
      MAY 19, 2020 | 11:15 AM
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
      We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
      Speaker: Alex Swarbrick, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      4
      MAY 14, 2020 | 3:30 PM
      Genexus - A Major Step Forward in Diagnostic NGS
      Genexus - A Major Step Forward in Diagnostic NGS
      NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
      Speaker: Prof. Dr. Michael Hummel
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      MAY 14, 2020 | 3:30 PM
      Genexus - A Major Step Forward in Diagnostic NGS
      Genexus - A Major Step Forward in Diagnostic NGS
      NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
      Speaker: Prof. Dr. Michael Hummel
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      10
      MAY 14, 2020 | 2:15 PM
      First Experience from New World of Easy NGS - Ion Torrent Genexus Workflow
      First Experience from New World of Easy NGS - Ion Torrent Genexus...
      In the past years, next-generation sequencing has revolutionized the way testing is done in the field of clinical oncology research. Parallel testing of genomic markers in tissue biopsies as...
      Speaker: Philip Jermann, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      2
      MAY 14, 2020 | 2:15 PM
      First Experience from New World of Easy NGS - Ion Torrent Genexus Workflow
      First Experience from New World of Easy NGS - Ion Torrent Genexus...
      In the past years, next-generation sequencing has revolutionized the way testing is done in the field of clinical oncology research. Parallel testing of genomic markers in tissue biopsies as...
      Speaker: Philip Jermann, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      8
    SEP 10, 2020 | 12:00 AM
    Visualizing viral replication of oncogenic human herpesviruses
    Visualizing viral replication of oncogenic human herpesviruses
    Viruses are the causative agents of approximately 12% of human cancers. The most recently discovered herpesvirus, Kaposi’s sarcoma herpesvirus (KSHV) is known to cause three human canc...
    Speaker: Lindsey M. Costantini, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    SEP 08, 2020 | 11:00 PM
    Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
    Deep mutational scanning of SARS-CoV-2 receptor binding domain...
    The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor, and is a major determinant of host range and a dominant target of neutraliz...
    Speaker: Tyler Starr, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    4
    AUG 27, 2020 | 7:00 AM
    Atlas of the SARS-CoV-2 Proteome
    Atlas of the SARS-CoV-2 Proteome
    DATE: August 27, 2020 TIME: 7:00am PT Novel anti-viral medications, including biologics and small molecule inhibitors, as well as serologic diagnostic tool sets are in urgent demand to fight...
    Speaker: Yuning Chen, Ph.D.
    Sponsored By: Sino Biological
    32 3
    JUL 29, 2020 | 2:00 PM
    Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells
    Route of 41BB/41BBL costimulation determines effector function...
    B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H...
    Speaker: Christopher DeRenzo, MD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 29, 2020 | 11:00 AM
    STAT3 phosphorylation during phagocytosis is required to activate autophagy and prevent macrophage immuno-senescence
    STAT3 phosphorylation during phagocytosis is required to activate...
    Background: Acute liver injury (ALI) is characterised by hepatocyte death and liver inflammation. Macrophages play a pivotal role in ALI by phagocytosing dead cells and producing pro-regener...
    Speaker: Lara Campana, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    2
     
     
  • JUL 29, 2020 | 12:00 AM
    Modeling anti-tumor function of human T cells
    Modeling anti-tumor function of human T cells
    Mouse models have been essential for establishing the role of the T cells in anti-tumor responses, but they have limited utility in translational studies for the testing of candidate therape...
    Speaker: Michael Overstreet, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 07, 2020 | 9:00 AM
    Enhancing risk stratification in early colon cancer with TNM-I (Immune) staging: focus on stage II T4N0 patients
    Enhancing risk stratification in early colon cancer with TNM-I...
    DATE: July 07, 2020 TIME: 9:00 am PDT The widely used TNM staging system is poorly predictive of response to adjuvant chemotherapy in Stage II and III colon cancer. As a result, there is ove...
    Speaker: Jérôme Galon, Ph.D , Graham Poage, Ph.D
    Sponsored By: HalioDx
    22 14
    JUL 01, 2020 | 12:45 PM
    Multicentric Evaluation of Oncomine Precision Assay on Ion Torrent Genexus System
    Multicentric Evaluation of Oncomine Precision Assay on Ion Torrent...
    NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
    Speaker: Prof. Dr. Michael Hummel
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    1
    JUN 30, 2020 | 9:00 AM
    Quality Control for the Pharmaceutical Industry; Stage 3, Continued Verification, in the Lifecycle of Analytical Procedures
    Quality Control for the Pharmaceutical Industry; Stage 3, Continued...
    DATE: June 30, 2020 TIME: 9:00am PDT, 12:00pm EDT QC laboratories perform a critical role in demonstrating pharmaceutical products are consistently manufactured, safe, potent, and pure. At t...
    Speaker: Jane Weitzel
    Sponsored By: Sartorius
    17 1
    JUN 17, 2020 | 1:30 PM
    Insights into the Pathogenesis of COVID-19 as Revealed by Spatial Biology
    Insights into the Pathogenesis of COVID-19 as Revealed by Spatial...
    Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
    Speaker: Joseph M. Beechem, PhD , Christopher E. Mason, PhD , Robert Schwartz, PhD
    Presented at: Coronavirus Series
    Sponsored By: NanoString Technologies
    9
     
     
  • JUN 17, 2020 | 12:00 PM
    High-Throughput Assay for Monitoring COVID19 Antibodies and Their Isotypes
    High-Throughput Assay for Monitoring COVID19 Antibodies and Their...
    The 2020 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to rage. While PCR-based assays are used for viral diagnosis, high through-put, rapid s...
    Speaker: Susan Zolla-Pazner, PhD
    Presented at: Coronavirus Series
    Sponsored By: Luminex - A DiaSorin Company
    1
    JUN 03, 2020 | 1:00 PM
    Gene manipulation in primary human immune cells: Successful strategies and applications for CRISPRko, RNAi and beyond
    Gene manipulation in primary human immune cells: Successful strategies...
    Gene manipulation studies in primary human immune cells can answer important biological questions within a clinically relevant cellular context. In this webinar we explore the use of several...
    Speaker: Verena Brucklacher-Waldert, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Horizon Discovery
    2
    JUN 03, 2020 | 8:00 AM
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
    Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
    Speaker: Alexander David Borowsky, MD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Leica Biosystems
    1
    JUN 03, 2020 | 12:00 AM
    Microenvironment on Demand: A breakthrough technology for personalized cell therapy discoveries
    Microenvironment on Demand: A breakthrough technology for personalized...
    NCI estimates that cancer will be the leading cause of death in 2030, worldwide. Checkpoint inhibitors and adoptive cell therapies (ACTs) cost up to ~$2 million/patient and have shown durabl...
    Speaker: Maithreyan Srinivasan
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
    MAY 21, 2020 | 8:00 AM
    Accelerating gene editing research using the power of flow cytometry
    Accelerating gene editing research using the power of flow cytometry
    DATE: May 21, 2020 TIME: 8:00am PDT, 11:00am EDT The advent of CRISPR has radically changed the face and pace of biological research and has unlocked unprecedented potential in the study of...
    Speaker: Natasha Jacobsen
    Sponsored By: Thermo Fisher Scientific
    22 2
     
     
  • MAY 20, 2020 | 7:30 AM
    Keynote Presentation: Bridging Multiscale Physiological Systems via Microfluidics- from single cell to tissue-scale to organ-scale
    Keynote Presentation: Bridging Multiscale Physiological Systems...
    Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered. In addition to identifying the molecular and ce...
    Speaker: Abraham Lee
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    1
    MAY 20, 2020 | 12:00 AM
    Next-gen protein assays enabling precision medicine and data-driven biology
    Next-gen protein assays enabling precision medicine and data-driven...
    Proteins are the functional blocks of any biological entity from 50 nm sized viruses to the 100 ft long mammals (blue whale). They perform intra cellular, tissue, organ, system, or organism...
    Speaker: Kursad Araz, PhD
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    1
    MAY 20, 2020 | 12:00 AM
    Single-cell Genomics Tools for better understanding and treatment of Human Disease
    Single-cell Genomics Tools for better understanding and treatment...
    The basic units of biological structure and function are cells, which exhibit wide variation in regard to both type and state. We assess such variation by simultaneously profiling the transc...
    Speaker: Anindita Basu, PhD
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    2
    MAY 20, 2020 | 12:00 AM
    Lab on a Particle: Democratizing Single-Cell Secretion Assays
    Lab on a Particle: Democratizing Single-Cell Secretion Assays
    Techniques to analyze and sort single cells based on secreted products have the potential to transform our understanding of cellular biology as well as accelerate the development of next gen...
    Speaker: Joseph de Rutte
    Presented at: Laboratory Automation & Informatics Virtual Event Series 2020
    1
    MAY 19, 2020 | 11:15 AM
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
    We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
    Speaker: Alex Swarbrick, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    4
     
     
  • MAY 14, 2020 | 3:30 PM
    Genexus - A Major Step Forward in Diagnostic NGS
    Genexus - A Major Step Forward in Diagnostic NGS
    NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
    Speaker: Prof. Dr. Michael Hummel
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    MAY 14, 2020 | 3:30 PM
    Genexus - A Major Step Forward in Diagnostic NGS
    Genexus - A Major Step Forward in Diagnostic NGS
    NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
    Speaker: Prof. Dr. Michael Hummel
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    10
    MAY 14, 2020 | 2:15 PM
    First Experience from New World of Easy NGS - Ion Torrent Genexus Workflow
    First Experience from New World of Easy NGS - Ion Torrent Genexus...
    In the past years, next-generation sequencing has revolutionized the way testing is done in the field of clinical oncology research. Parallel testing of genomic markers in tissue biopsies as...
    Speaker: Philip Jermann, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    2
    MAY 14, 2020 | 2:15 PM
    First Experience from New World of Easy NGS - Ion Torrent Genexus Workflow
    First Experience from New World of Easy NGS - Ion Torrent Genexus...
    In the past years, next-generation sequencing has revolutionized the way testing is done in the field of clinical oncology research. Parallel testing of genomic markers in tissue biopsies as...
    Speaker: Philip Jermann, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    8
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