Gene Expression: the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA. The process of gene expression is used by all known life-eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses-to generate the macromolecular machinery for life.
Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered. In addition to identifying the molecular and ce...
While many technologies focus on either exploring the spatial context of a handful of targets, or expression patterns of hundreds or thousands of targets in bulk samples or dissociated singl...
Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive disease associated with poor outcome. It is expected to be the leading cause of cancer-related death in 2030. The unique microe...
B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
DATE: May 14, 2020 TIME: 10:00am PT, 1:00pm ET Massively parallel genome engineering enables rapid and simultaneous evaluation of genotype-phenotype relationships at a genomic scale....
NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
DATE: May 14, 2020 TIME: 10:00am CEST Massively parallel genome engineering enables rapid and simultaneous evaluation of genotype-phenotype relationships at a genomic scale. With the Inscrip...
DATE: May 7, 2020 TIME: 8:00AM PDT, 11:00AM EDT With the recent explosion of cell therapy, we know more about conditions affecting cell growth than ever before. Your CO2 incubator should not...
The forensic investigation of crime involves answering four basic questions: who, what, where, and when. Tools exist to answer questions of who, what and where, but the question when is ofte...
Crime scene investigation is more than just processing or documentation of crime scenes, nor is it just the collection or packaging of physical evidence. It is the first step and the most cr...
The toxicology of particulate matter is complicated by characteristics not normally encountered when addressing poisonings associated with chemical substances. Particle shape, surface reacti...
The potential for cognitive bias in forensic evidence interpretation and crime scene investigation continues to receive attention and debate within forensic and academic communities. Startin...
The current standard methodology in forensic DNA typing relies on amplification of short tandem repeat (STR) markers by the polymerase chain reaction (PCR) and allele sizes (i.e., length-bas...
Hydroxychloroquine and chloroquine are long-standing antimalarial drugs recently brought into the spotlight as potential treatments for the pandemic-causing coronavirus (SARS-CoV-2). Notable...
Learning Objectives: 1. Molecular basis of microhaplotypes 2. Informativeness and power of discrimination of microhaplotypes 3. Mixture deconvolution via microhaplotypes...
The ever-increasing number of deaths along the U.S.-México border and the diversification in the demographic characteristics of the Latin American migrants, who perish in this region,...
Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
Precision medicine is the paradigm to develop treatments for patients based on molecular-targets that are effective in vivo when administered. In addition to identifying the molecular and ce...
While many technologies focus on either exploring the spatial context of a handful of targets, or expression patterns of hundreds or thousands of targets in bulk samples or dissociated singl...
Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
The RNAscope in situ hybridization technology allows high sensitivity, specificity and spatial resolution providing pivotal single-cell gene expression information to gain better insights in...
Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive disease associated with poor outcome. It is expected to be the leading cause of cancer-related death in 2030. The unique microe...
B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
DATE: May 14, 2020 TIME: 10:00am PT, 1:00pm ET Massively parallel genome engineering enables rapid and simultaneous evaluation of genotype-phenotype relationships at a genomic scale....
NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
NGS is still perceived as a complex, hard to implement and validate method that requires highly experienced people. Outsourcing next-generation sequencing (NGS) testing could be an option to...
DATE: May 14, 2020 TIME: 10:00am CEST Massively parallel genome engineering enables rapid and simultaneous evaluation of genotype-phenotype relationships at a genomic scale. With the Inscrip...
DATE: May 7, 2020 TIME: 8:00AM PDT, 11:00AM EDT With the recent explosion of cell therapy, we know more about conditions affecting cell growth than ever before. Your CO2 incubator should not...
The forensic investigation of crime involves answering four basic questions: who, what, where, and when. Tools exist to answer questions of who, what and where, but the question when is ofte...
Crime scene investigation is more than just processing or documentation of crime scenes, nor is it just the collection or packaging of physical evidence. It is the first step and the most cr...
The toxicology of particulate matter is complicated by characteristics not normally encountered when addressing poisonings associated with chemical substances. Particle shape, surface reacti...
The potential for cognitive bias in forensic evidence interpretation and crime scene investigation continues to receive attention and debate within forensic and academic communities. Startin...
The current standard methodology in forensic DNA typing relies on amplification of short tandem repeat (STR) markers by the polymerase chain reaction (PCR) and allele sizes (i.e., length-bas...
Hydroxychloroquine and chloroquine are long-standing antimalarial drugs recently brought into the spotlight as potential treatments for the pandemic-causing coronavirus (SARS-CoV-2). Notable...
Learning Objectives: 1. Molecular basis of microhaplotypes 2. Informativeness and power of discrimination of microhaplotypes 3. Mixture deconvolution via microhaplotypes...
The ever-increasing number of deaths along the U.S.-México border and the diversification in the demographic characteristics of the Latin American migrants, who perish in this region,...
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