Methodology: is a system of methods used in an area of study. The methodology used in an experiment is crucial to its success. When a piece of research is published in a scientific journal, the researchers always carefully describe their methodology.
Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individu...
Until recently most of the phenotypic information on congenital endocrine disorders have relied on biochemical testing of steroids, biogenic amines and peptides but is now...
Recent evidence demonstrating the importance of structural complexity in advancing compounds to the clinic points to the need for enhancing small molecule screening collections with sp3-rich ...
The antibiotic pipeline is broken, with a dearth of new antibiotics, a collapse in pharmaceutical company research1, and the exhaustion of chemical diversity contained in pharma libraries. "T...
Biofilm is an ancient and preferred mode of growth for microbes with 99% of all microbes residing in a biofilm. Biofilm is characterized by a community of microbes (usually polymicrobial ofte...
Discussion of the guaiac based test introduced in 1971 and its' shortcomings versus Fecal Immunochemical Testing (FIT) and how it relates to acute and non-acute facilities.
Why is FIT...
Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autor...
Soiled-bedding sentinels are not always efficient in detecting pathogens in rodent colonies. In this context, PCR-based testing can be more sensitive and is being advocated as adjunct to trad...
Sedimentation velocity (SV) experiments on dispersed nanoparticles are a powerful method for determining otherwise hard to evaluate properties of the nanoparticle such as the...
Mass spectrometry (MS)-based profiling of clinical specimens has been increasingly used in cancer research to characterize changes in protein expression between tumor and healthy tissue or be...
The era of omics has ushered in the hope for personalized medicine. Proteomic and genomic strategies that allow unbiased identification of genes and proteins and their post-transcriptional a...
Proteomics technology has improved dramatically over the last decade. The technology developments have largely been directed around instrument hardware, where instruments have been developed...
This presentation will focus on NuMediis general approach towards the discovery of new therapeutic uses for existing drugs. While the business models for repurposing marketed drugs versus rep...
Late-stage drug attrition rates in oncology remain higher than in other therapeutic areas. To reduce attrition, it is critical to identify appropriate drug targets and pre-clinical models. Th...
While the "Jolie effect" has refocused attention on the central role of BRCA gene analyses in the diagnosis and prevention of hereditary breast and ovarian cancer, there is a global disparity...
With a rising prevalence recently exceeding 1%, autism spectrum disorder (ASD) has become a pressing public health issue. Crucial hurdles on the way to targeted treatments are (i) the relianc...
Laboratory rats and mice are the most used animal species in scientific research, but still having a lot of information available about them, there are many places in Latin America where ther...
Informatics and internet are widely accepted tools in education and research. In the past decades new teaching and learning strategies have been developed and implemented. E-learning was def...
Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an ex...
Training in your own institution or corporation can be challenging in trying to meet the goals of the program and the needs of the researchers. If you are challenged with training visiting in...
As the scientific evidence base for pharmacogenetics continues to expand, the use of such information in clinical management and drug development will be in demand.
The FDA advises that the...
It is widely accepted that approximately 85% of known disease-causing DNA variants affect the exons and splice junctions, which is about 1% of the whole genome. As a result, Clinical Exome Se...
RNASeq has become the primary method for studying changes in gene expression in modern genomics research. By directly sequencing the various types of RNA molecules, including mRNA, ncRNA, an...
Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individu...
Until recently most of the phenotypic information on congenital endocrine disorders have relied on biochemical testing of steroids, biogenic amines and peptides but is now...
Recent evidence demonstrating the importance of structural complexity in advancing compounds to the clinic points to the need for enhancing small molecule screening collections with sp3-rich ...
The antibiotic pipeline is broken, with a dearth of new antibiotics, a collapse in pharmaceutical company research1, and the exhaustion of chemical diversity contained in pharma libraries. "T...
Biofilm is an ancient and preferred mode of growth for microbes with 99% of all microbes residing in a biofilm. Biofilm is characterized by a community of microbes (usually polymicrobial ofte...
Discussion of the guaiac based test introduced in 1971 and its' shortcomings versus Fecal Immunochemical Testing (FIT) and how it relates to acute and non-acute facilities.
Why is FIT...
Since the discovery and maturing of in vitro techniques that characterized neurotransmitter receptor systems in animal and human brain and subsequent development of in vitro and in vivo autor...
Soiled-bedding sentinels are not always efficient in detecting pathogens in rodent colonies. In this context, PCR-based testing can be more sensitive and is being advocated as adjunct to trad...
Sedimentation velocity (SV) experiments on dispersed nanoparticles are a powerful method for determining otherwise hard to evaluate properties of the nanoparticle such as the...
Mass spectrometry (MS)-based profiling of clinical specimens has been increasingly used in cancer research to characterize changes in protein expression between tumor and healthy tissue or be...
The era of omics has ushered in the hope for personalized medicine. Proteomic and genomic strategies that allow unbiased identification of genes and proteins and their post-transcriptional a...
Proteomics technology has improved dramatically over the last decade. The technology developments have largely been directed around instrument hardware, where instruments have been developed...
This presentation will focus on NuMediis general approach towards the discovery of new therapeutic uses for existing drugs. While the business models for repurposing marketed drugs versus rep...
Late-stage drug attrition rates in oncology remain higher than in other therapeutic areas. To reduce attrition, it is critical to identify appropriate drug targets and pre-clinical models. Th...
While the "Jolie effect" has refocused attention on the central role of BRCA gene analyses in the diagnosis and prevention of hereditary breast and ovarian cancer, there is a global disparity...
With a rising prevalence recently exceeding 1%, autism spectrum disorder (ASD) has become a pressing public health issue. Crucial hurdles on the way to targeted treatments are (i) the relianc...
Laboratory rats and mice are the most used animal species in scientific research, but still having a lot of information available about them, there are many places in Latin America where ther...
Informatics and internet are widely accepted tools in education and research. In the past decades new teaching and learning strategies have been developed and implemented. E-learning was def...
Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an ex...
Training in your own institution or corporation can be challenging in trying to meet the goals of the program and the needs of the researchers. If you are challenged with training visiting in...
As the scientific evidence base for pharmacogenetics continues to expand, the use of such information in clinical management and drug development will be in demand.
The FDA advises that the...
It is widely accepted that approximately 85% of known disease-causing DNA variants affect the exons and splice junctions, which is about 1% of the whole genome. As a result, Clinical Exome Se...
RNASeq has become the primary method for studying changes in gene expression in modern genomics research. By directly sequencing the various types of RNA molecules, including mRNA, ncRNA, an...
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