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    Molecular Diagnostics

    Molecular Diagnostics: Molecular diagnostic tests detect specific sequences in DNA or RNA that may or may not be associated with disease, including single nucleotide polymorphism (SNP), deletions, rearrangements, insertions and others. By analysing the specifics of the patient and their disease, molecular diagnostics offers the prospect of personalized medicine. These tests are useful in a range of medical specialisms, including infectious disease, oncology, human leucocyte antigen typing, coagulation, and pharmacogenomics-the genetic prediction of which drugs will work best.

    Webinars

    • OCT 06, 2016 | 6:00 AM
      Detection and analysis of circulating tumor cells - challenges and solutions
      Detection and analysis of circulating tumor cells - challenges...
      Circulating Tumor Cells (CTCs) have been extensively explored as circulating biomarkers in various cancers. Due to their rarity, heterogeneity and stem cell-like properties, detecting and pro...
      Speaker: Siegfried Hauch
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      3
      OCT 05, 2016 | 12:00 PM
      Label-free FTIR imaging to distinguish malignant from non-malignant tissues
      Label-free FTIR imaging to distinguish malignant from non-malignant...
      FTIR spectroscopic imaging is an emerging tool for label-free, non-destructive characterization of tissues. The pathological annotation of tissue can be performed in an automated and objectiv...
      Speaker: Klaus Gerwert, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      1
      OCT 05, 2016 | 7:30 AM
      Keynote Speaker: How to meet the challenge of counting and analyzing tumor cells circulating in the peripheral blood
      Keynote Speaker: How to meet the challenge of counting and analyzing...
      The talk will first report on a new patented method of counting CTCs based on the metabolism of tumor cells, that favors acidification of their near environment. In order to maintain the acid...
      Speaker: Giacinto Scoles, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      3
      OCT 04, 2016 | 8:00 AM
      Overcoming the Clinical Sample Bottleneck for Expression Studies
      Overcoming the Clinical Sample Bottleneck for Expression Studies
      DATE:  October 4, 2016 TIME:  8:00am PT, 11:00am ET Extracting robust expression data from clinical samples represents a unique opportunity to find actionable biomarkers. But it...
      Speaker: Mark Manary, MD , Sean Diehl, PhD
      Sponsored By: Affymetrix, Affymetrix
      4
      SEP 08, 2016 | 1:30 PM
      The Paradigm Shift in Clinical Microbiology
      The Paradigm Shift in Clinical Microbiology
      Multi-Drug Resistant Organisms (MDROs) are becoming a bigger and bigger concern throughout the world. Antibiotic resistance forms and spreads faster than pharmaceutical companies have been ab...
      Speaker: Steven Cagas, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      3
      SEP 08, 2016 | 9:00 AM
      Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, A Neuroimmune Disease
      Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic...
      ME/CFS is a debilitating disease with a controversial history and multiple names.  The Institute of Medicine recently recommended renaming the disease “Systemic Exertion Intoleranc...
      Speaker: Maureen Hanson
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      2
      SEP 08, 2016 | 7:30 AM
      The Molecular Pathology Perspective of the CDC's Infectious Diseases Pathology Branch
      The Molecular Pathology Perspective of the CDC's Infectious Diseases...
      The Infectious Diseases Pathology Branch of the Centers for Disease Control and Prevention (CDC) routinely receives autopsy and biopsy tissues for diagnostic evaluation. These tissues are typ...
      Speaker: Amy Denison, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      4
      SEP 07, 2016 | 10:30 AM
      Diagnostic Development and Laboratory Response to Infectious Disease Outbreaks
      Diagnostic Development and Laboratory Response to Infectious Disease...
      The field of infectious disease diagnostics is ever changing with both newly identified infections such as SARS, Ebola, and Zika virus as well as yearly epidemics and potential for pandemic w...
      Speaker: Paula Revell, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      3
      SEP 07, 2016 | 9:00 AM
      Keynote Speaker: You Want Me to Culture What? : Challenging Requests for Culture in the Clinical Microbiology Lab
      Keynote Speaker: You Want Me to Culture What? : Challenging Requests...
      In an era of healthcare reform and evidenced-based medicine, it is important to use the most clinically relevant and cost effective methods in all aspects of microbiology. This session will c...
      Speaker: Amy Leber, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      5
      AUG 11, 2016 | 11:00 AM
      RNA-ISH for Long non-coding RNAs - new game changers in pathology
      RNA-ISH for Long non-coding RNAs - new game changers in pathology
      DATE: August 11, 2016 TIME: 11:00AM PST, 2:00PM ET, 7:00PM GMT The central dogma that forms the backbone of molecular biology is that DNA codes for RNA (transcription) which then c...
      Speaker: Rohit Mehra, M.D.
      Sponsored By: Advanced Cell Diagnostics, Advanced Cell Diagnostics
      12
      AUG 10, 2016 | 11:00 AM
      Emerging Laboratory Diagnostic Options for Sexually-transmitted Infections
      Emerging Laboratory Diagnostic Options for Sexually-transmitted...
      Following attendance of this virtual event, participants should appreciate the changing epidemiology of trichomoniasis and clinician ordering patterns on the basis of improved laboratory...
      Speaker: Erik Munson, Ph.D., D(ABMM)
      Presented at: A Virtual Destination for Laboratory Professionals
      Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
      3
      AUG 10, 2016 | 7:30 AM
      Payer Perspectives: Value in Healthcare
      Payer Perspectives: Value in Healthcare
      Medicare is clearly moving to a pay for value paradigm, and commercial payers continue their own march away from traditional fee-for-service payment. How can you develop and articulate a pers...
      Speaker: Louis Jacques, MD
      Presented at: A Virtual Destination for Laboratory Professionals
      Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
      4 1
      JUL 28, 2016 | 8:00 AM
      Mission Possible: Automating NGS sample prep for challenging samples and niche applications
      Mission Possible: Automating NGS sample prep for challenging samples...
      Accelerating discoveries to improve human and environmental health often require the implementation of niche applications that may involve complex processes and working with challenging sampl...
      Speaker: David Horvath, MS , Zach Smith, MS
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      6 1
      JUL 13, 2016 | 8:00 PM
      Easy Automation Solutions. Better Results.
      Easy Automation Solutions. Better Results.
      This presentation is a rebroadcast of a previous webinar with live Q&A. Please confirm the start time and date in your time zone. We’ve included several examples below for your re...
      Speaker: David Horvath, MS , Zach Smith, MS
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      2 1
      JUL 13, 2016 | 9:00 AM
      Solana GAS Molecular Assay...No Culture Confirmation Required!
      Solana GAS Molecular Assay...No Culture Confirmation Required!
      The Solana GAS Assay is a rapid in vitro diagnostic test for the qualitative detection of Group A β-hemolytic Streptococcus (Streptococcus pyogenes) nucleic acids isolated from throat sw...
      Speaker: PRODUCT DEMO Presented by Sean Redmond
      Presented at: A Virtual Destination for Laboratory Professionals
      Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics, Quidel
      2
      JUL 12, 2016 | 11:00 AM
      SeraCare Life Sciences - Innovation, Quality, Performance, and Confidence
      SeraCare Life Sciences - Innovation, Quality, Performance, and...
      SeraCare partners with IVD researchers and manufacturers as well as clinical laboratories to bridge the gap between today’s diagnostic solutions and tomorrow’s emerging technologi...
      Speaker: PRODUCT DEMO Presenter by David Hall
      Presented at: A Virtual Destination for Laboratory Professionals
      Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
      1
      JUN 30, 2016 | 8:00 AM
      Surveying expression of immune checkpoint markers in the tissue microenvironment
      Surveying expression of immune checkpoint markers in the tissue...
      DATE:  June 30, 2016 TIME:  8:00am Pacific time, 11:00am Eastern time Focusing solely on malignant cancer cells and the genes that they express is modestly just a glimpse of the...
      Speaker: Jeffrey Kim, PhD
      Sponsored By: Advanced Cell Diagnostics, Advanced Cell Diagnostics
      3 1
      JUN 23, 2016 | 8:00 AM
      DNA & RNA Sequencing Sample Prep: Automating Simple to Complex Methods
      DNA & RNA Sequencing Sample Prep: Automating Simple to Complex...
      DNA and RNA sequencing sample preparation can involve many tedious and error prone steps. Liquid handling automation solutions can help standardize your processes and achieve more consistent ...
      Speaker: David Horvath, MS , Zach Smith, MS
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      3
      JUN 22, 2016 | 8:00 AM
      Applications of targeted NGS panels for clinical research of primary immunodeficiency diseases
      Applications of targeted NGS panels for clinical research of primary...
      Primary immunodeficiencies (PIDs) are a group of more than 250 genetic disorders that disrupt the immune system, resulting in susceptibility to life-threatening infections, autoimmune disease...
      Speaker: Janet Chou, MD , Wayne Bainter
      Sponsored By: Thermo Fisher Scientific - Ion Torrent, Thermo Fisher Scientific - Ion Torrent
      4
      JUN 21, 2016 | 8:00 AM
      Combining Aggregate Determination with Light Scattering Detection: More Data, More Easily
      Combining Aggregate Determination with Light Scattering Detection:...
      Size Exclusion Chromatography is the method of choice for quantification of aggregates in Biotherapeutic samples using a UV detector for determining concentration.  However the addition ...
      Speaker: Andy Coffey
      Sponsored By: Agilent Genomics, Agilent Genomics
      4
      JUN 07, 2016 | 9:00 AM
      DC health care update for laboratorians
      DC health care update for laboratorians
      I will be discussing the following subjects in my presentation: Update from 2015 PAMA Proposed (or Final Rule) FDA Regulation of LDTs Change to Physician Payment and impact on diagn...
      Speaker: Michael Beebe
      Presented at: A Virtual Destination for Laboratory Professionals
      Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
      5
      MAY 19, 2016 | 8:00 AM
      WEBINAR: Easy Automation Solutions. Better Results.
      WEBINAR: Easy Automation Solutions. Better Results.
      Generating NGS data you can trust is highly reliant on the quality of the library sample that’s sequenced.  NGS sample prep has become more streamlined, but it’s still a labo...
      Speaker: David Horvath, MS , Zach Smith, MS
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      6
      MAY 12, 2016 | 3:00 PM
      Using big data to interpret genomes for diagnostics, therapeutics, and precision medicine
      Using big data to interpret genomes for diagnostics, therapeutics,...
      Millions of individuals have been sequenced or genotyped and linked with medical records, providing an exciting opportunity for therapeutic target discovery. My lab has been using a resilienc...
      Speaker: Rong Chen, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2016
      2
      MAY 12, 2016 | 7:30 AM
      The molecular analysis on circulating tumor cells to determine prognostic and predictive factors in cancer research
      The molecular analysis on circulating tumor cells to determine...
      Circulating tumor cells (CTCs) is an emerging source used molecular cancer diagnostics. Through expression profiling of CTCs, it allows a deeper understanding about which metabolic pathways e...
      Speaker: Siegfried Hauch
      Presented at: Genetics and Genomics Virtual Event Series 2016
      8
    OCT 06, 2016 | 6:00 AM
    Detection and analysis of circulating tumor cells - challenges and solutions
    Detection and analysis of circulating tumor cells - challenges...
    Circulating Tumor Cells (CTCs) have been extensively explored as circulating biomarkers in various cancers. Due to their rarity, heterogeneity and stem cell-like properties, detecting and pro...
    Speaker: Siegfried Hauch
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    3
    OCT 05, 2016 | 12:00 PM
    Label-free FTIR imaging to distinguish malignant from non-malignant tissues
    Label-free FTIR imaging to distinguish malignant from non-malignant...
    FTIR spectroscopic imaging is an emerging tool for label-free, non-destructive characterization of tissues. The pathological annotation of tissue can be performed in an automated and objectiv...
    Speaker: Klaus Gerwert, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    1
    OCT 05, 2016 | 7:30 AM
    Keynote Speaker: How to meet the challenge of counting and analyzing tumor cells circulating in the peripheral blood
    Keynote Speaker: How to meet the challenge of counting and analyzing...
    The talk will first report on a new patented method of counting CTCs based on the metabolism of tumor cells, that favors acidification of their near environment. In order to maintain the acid...
    Speaker: Giacinto Scoles, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    3
    OCT 04, 2016 | 8:00 AM
    Overcoming the Clinical Sample Bottleneck for Expression Studies
    Overcoming the Clinical Sample Bottleneck for Expression Studies
    DATE:  October 4, 2016 TIME:  8:00am PT, 11:00am ET Extracting robust expression data from clinical samples represents a unique opportunity to find actionable biomarkers. But it...
    Speaker: Mark Manary, MD , Sean Diehl, PhD
    Sponsored By: Affymetrix, Affymetrix
    4
    SEP 08, 2016 | 1:30 PM
    The Paradigm Shift in Clinical Microbiology
    The Paradigm Shift in Clinical Microbiology
    Multi-Drug Resistant Organisms (MDROs) are becoming a bigger and bigger concern throughout the world. Antibiotic resistance forms and spreads faster than pharmaceutical companies have been ab...
    Speaker: Steven Cagas, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    3
     
     
  • SEP 08, 2016 | 9:00 AM
    Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, A Neuroimmune Disease
    Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic...
    ME/CFS is a debilitating disease with a controversial history and multiple names.  The Institute of Medicine recently recommended renaming the disease “Systemic Exertion Intoleranc...
    Speaker: Maureen Hanson
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    2
    SEP 08, 2016 | 7:30 AM
    The Molecular Pathology Perspective of the CDC's Infectious Diseases Pathology Branch
    The Molecular Pathology Perspective of the CDC's Infectious Diseases...
    The Infectious Diseases Pathology Branch of the Centers for Disease Control and Prevention (CDC) routinely receives autopsy and biopsy tissues for diagnostic evaluation. These tissues are typ...
    Speaker: Amy Denison, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    4
    SEP 07, 2016 | 10:30 AM
    Diagnostic Development and Laboratory Response to Infectious Disease Outbreaks
    Diagnostic Development and Laboratory Response to Infectious Disease...
    The field of infectious disease diagnostics is ever changing with both newly identified infections such as SARS, Ebola, and Zika virus as well as yearly epidemics and potential for pandemic w...
    Speaker: Paula Revell, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    3
    SEP 07, 2016 | 9:00 AM
    Keynote Speaker: You Want Me to Culture What? : Challenging Requests for Culture in the Clinical Microbiology Lab
    Keynote Speaker: You Want Me to Culture What? : Challenging Requests...
    In an era of healthcare reform and evidenced-based medicine, it is important to use the most clinically relevant and cost effective methods in all aspects of microbiology. This session will c...
    Speaker: Amy Leber, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    5
    AUG 11, 2016 | 11:00 AM
    RNA-ISH for Long non-coding RNAs - new game changers in pathology
    RNA-ISH for Long non-coding RNAs - new game changers in pathology
    DATE: August 11, 2016 TIME: 11:00AM PST, 2:00PM ET, 7:00PM GMT The central dogma that forms the backbone of molecular biology is that DNA codes for RNA (transcription) which then c...
    Speaker: Rohit Mehra, M.D.
    Sponsored By: Advanced Cell Diagnostics, Advanced Cell Diagnostics
    12
     
     
  • AUG 10, 2016 | 11:00 AM
    Emerging Laboratory Diagnostic Options for Sexually-transmitted Infections
    Emerging Laboratory Diagnostic Options for Sexually-transmitted...
    Following attendance of this virtual event, participants should appreciate the changing epidemiology of trichomoniasis and clinician ordering patterns on the basis of improved laboratory...
    Speaker: Erik Munson, Ph.D., D(ABMM)
    Presented at: A Virtual Destination for Laboratory Professionals
    Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
    3
    AUG 10, 2016 | 7:30 AM
    Payer Perspectives: Value in Healthcare
    Payer Perspectives: Value in Healthcare
    Medicare is clearly moving to a pay for value paradigm, and commercial payers continue their own march away from traditional fee-for-service payment. How can you develop and articulate a pers...
    Speaker: Louis Jacques, MD
    Presented at: A Virtual Destination for Laboratory Professionals
    Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
    4 1
    JUL 28, 2016 | 8:00 AM
    Mission Possible: Automating NGS sample prep for challenging samples and niche applications
    Mission Possible: Automating NGS sample prep for challenging samples...
    Accelerating discoveries to improve human and environmental health often require the implementation of niche applications that may involve complex processes and working with challenging sampl...
    Speaker: David Horvath, MS , Zach Smith, MS
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    6 1
    JUL 13, 2016 | 8:00 PM
    Easy Automation Solutions. Better Results.
    Easy Automation Solutions. Better Results.
    This presentation is a rebroadcast of a previous webinar with live Q&A. Please confirm the start time and date in your time zone. We’ve included several examples below for your re...
    Speaker: David Horvath, MS , Zach Smith, MS
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    2 1
    JUL 13, 2016 | 9:00 AM
    Solana GAS Molecular Assay...No Culture Confirmation Required!
    Solana GAS Molecular Assay...No Culture Confirmation Required!
    The Solana GAS Assay is a rapid in vitro diagnostic test for the qualitative detection of Group A β-hemolytic Streptococcus (Streptococcus pyogenes) nucleic acids isolated from throat sw...
    Speaker: PRODUCT DEMO Presented by Sean Redmond
    Presented at: A Virtual Destination for Laboratory Professionals
    Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics, Quidel
    2
     
     
  • JUL 12, 2016 | 11:00 AM
    SeraCare Life Sciences - Innovation, Quality, Performance, and Confidence
    SeraCare Life Sciences - Innovation, Quality, Performance, and...
    SeraCare partners with IVD researchers and manufacturers as well as clinical laboratories to bridge the gap between today’s diagnostic solutions and tomorrow’s emerging technologi...
    Speaker: PRODUCT DEMO Presenter by David Hall
    Presented at: A Virtual Destination for Laboratory Professionals
    Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
    1
    JUN 30, 2016 | 8:00 AM
    Surveying expression of immune checkpoint markers in the tissue microenvironment
    Surveying expression of immune checkpoint markers in the tissue...
    DATE:  June 30, 2016 TIME:  8:00am Pacific time, 11:00am Eastern time Focusing solely on malignant cancer cells and the genes that they express is modestly just a glimpse of the...
    Speaker: Jeffrey Kim, PhD
    Sponsored By: Advanced Cell Diagnostics, Advanced Cell Diagnostics
    3 1
    JUN 23, 2016 | 8:00 AM
    DNA & RNA Sequencing Sample Prep: Automating Simple to Complex Methods
    DNA & RNA Sequencing Sample Prep: Automating Simple to Complex...
    DNA and RNA sequencing sample preparation can involve many tedious and error prone steps. Liquid handling automation solutions can help standardize your processes and achieve more consistent ...
    Speaker: David Horvath, MS , Zach Smith, MS
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    3
    JUN 22, 2016 | 8:00 AM
    Applications of targeted NGS panels for clinical research of primary immunodeficiency diseases
    Applications of targeted NGS panels for clinical research of primary...
    Primary immunodeficiencies (PIDs) are a group of more than 250 genetic disorders that disrupt the immune system, resulting in susceptibility to life-threatening infections, autoimmune disease...
    Speaker: Janet Chou, MD , Wayne Bainter
    Sponsored By: Thermo Fisher Scientific - Ion Torrent, Thermo Fisher Scientific - Ion Torrent
    4
    JUN 21, 2016 | 8:00 AM
    Combining Aggregate Determination with Light Scattering Detection: More Data, More Easily
    Combining Aggregate Determination with Light Scattering Detection:...
    Size Exclusion Chromatography is the method of choice for quantification of aggregates in Biotherapeutic samples using a UV detector for determining concentration.  However the addition ...
    Speaker: Andy Coffey
    Sponsored By: Agilent Genomics, Agilent Genomics
    4
     
     
  • JUN 07, 2016 | 9:00 AM
    DC health care update for laboratorians
    DC health care update for laboratorians
    I will be discussing the following subjects in my presentation: Update from 2015 PAMA Proposed (or Final Rule) FDA Regulation of LDTs Change to Physician Payment and impact on diagn...
    Speaker: Michael Beebe
    Presented at: A Virtual Destination for Laboratory Professionals
    Sponsored By: Cardinal Healthâ„¢ OptiFreight® Logistics
    5
    MAY 19, 2016 | 8:00 AM
    WEBINAR: Easy Automation Solutions. Better Results.
    WEBINAR: Easy Automation Solutions. Better Results.
    Generating NGS data you can trust is highly reliant on the quality of the library sample that’s sequenced.  NGS sample prep has become more streamlined, but it’s still a labo...
    Speaker: David Horvath, MS , Zach Smith, MS
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
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    MAY 12, 2016 | 3:00 PM
    Using big data to interpret genomes for diagnostics, therapeutics, and precision medicine
    Using big data to interpret genomes for diagnostics, therapeutics,...
    Millions of individuals have been sequenced or genotyped and linked with medical records, providing an exciting opportunity for therapeutic target discovery. My lab has been using a resilienc...
    Speaker: Rong Chen, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2016
    2
    MAY 12, 2016 | 7:30 AM
    The molecular analysis on circulating tumor cells to determine prognostic and predictive factors in cancer research
    The molecular analysis on circulating tumor cells to determine...
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    Speaker: Siegfried Hauch
    Presented at: Genetics and Genomics Virtual Event Series 2016
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