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    CHO Cells

    Chinese hamster ovary (CHO) cells are an epithelial cell line derived from the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of therapeutic proteins. They have found wide use in studies of genetics, toxicity screening, nutrition and gene expression, particularly to express recombinant proteins. CHO cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics.

    Webinars

    • JUL 01, 2017 | 8:00 AM
      Pluripotent stem cell bioprocessing platforms for cell therapy manufacturing
      Pluripotent stem cell bioprocessing platforms for cell therapy...
      Pluripotent stem cell (PSC) culture at commercial scale requires a shift from the current manual processing methods and costly materials to deliver affordable differentiated cell products in...
      Speaker: Jahid Hasan
      Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
      2
      MAY 10, 2017 | 1:00 PM
      Modification of Glycans in Bioprocessing
      Modification of Glycans in Bioprocessing
      Glycosylation is an important product quality attribute for biotherapeutic proteins expressed in CHO cells. Glycoform variability can significantly affect the safety and efficacy of therapeut...
      Speaker: Ryan Boniface
      Presented at: 2017 Gibco ExpressionWorld
      4
      MAY 10, 2017 | 12:00 PM
      Ask the Expert: Mammalian Transient Expression
      Ask the Expert: Mammalian Transient Expression
      Getting started Equipment Troubleshooting Scale up or scale down your expression runs Tackling difficult-to-express proteins 293 vs. CHO cell expression...
      Speaker: Henry Chiou, PhD , Richard Altman, MS , Jon Zmuda, PhD , Konrad Miatkowski
      Presented at: 2017 Gibco ExpressionWorld
      3
      MAY 10, 2017 | 11:00 AM
      An ongoing evaluation of our transient expression systems; Can we predict the appropriate expression system for any drug modality?
      An ongoing evaluation of our transient expression systems; Can...
      CHO cells are the predominant host for biotherapeutic protein expression with approximately 70% of licensed biologics manufactured in Chinese Hamster Ovary (CHO) cells.  The ability to e...
      Speaker: Richard Altman, MS
      Presented at: 2017 Gibco ExpressionWorld
      4
      MAY 10, 2017 | 8:00 AM
      Optimisation of UCB's Transient Expression Platforms
      Optimisation of UCB's Transient Expression Platforms
      Development of antibody therapeutics, from early stage research to preclinical and clinical development, requires ever-increasing amounts of reagents. To meet the challenge of furnishing a di...
      Speaker: Christina Gordon
      Presented at: 2017 Gibco ExpressionWorld
      4
      MAY 10, 2017 | 7:00 AM
      Basic Concepts in Transient Expression using 293 and CHO cells
      Basic Concepts in Transient Expression using 293 and CHO cells
      HEK293 and CHO cells are the primary cell lines used in rapid, scalable suspension culture systems for transient protein expression. This presentation provides a primer on fundamental concept...
      Speaker: Henry Chiou, PhD
      Presented at: 2017 Gibco ExpressionWorld
      5
      MAY 10, 2017 | 6:00 AM
      Latest Developments in High Titer Transient Protein Expression using the ExpiCHO Transient Expression System
      Latest Developments in High Titer Transient Protein Expression...
      The ExpiCHO™ transient expression system offers a turnkey solution for generating high-titer recombinant proteins for therapeutic drug development, reagent generation, as well as an alt...
      Speaker: Jon Zmuda, PhD
      Presented at: 2017 Gibco ExpressionWorld
      8
      MAY 10, 2017 | 5:00 AM
      Complete workflow solution from gene-to-protein combine highly advanced expression systems with expression optimized genes
      Complete workflow solution from gene-to-protein combine highly...
      Reliable autologous expression of recombinant human proteins - from gene sequence to the expressed and purified protein - in human or CHO cells is essential for many aspects of biomedical res...
      Speaker: Stephan Fath, PhD
      Presented at: 2017 Gibco ExpressionWorld
      4 1
      MAY 09, 2017 | 8:00 PM
      使用293和CHO细胞进行瞬时表达的基本概念
      使用293和CHO细胞进行瞬时表达的基本概念
      HEK293和CHO细胞是快速、规模可调的悬浮培养系统中常用的细胞系,可用于瞬时蛋白表达。此次演讲介绍了瞬时表达的基本概念和使用材料,以及使用293或CHO细胞时需要考虑的主要差异。...
      Speaker: Jian Liu
      Presented at: 2017 Gibco ExpressionWorld
      7
      MAY 09, 2017 | 7:00 PM
      Gibco™ ExpiCHO哺乳动物瞬时蛋白表达系统的最新研发进展
      Gibco™ ExpiCHO哺乳动物瞬时蛋白表达系统的最新研发进展
      Gibco™ ExpiCHO是一款全新优化的瞬时重组蛋白表达系统,可以在瞬转中获得极高的蛋白产量,为临床新药和诊断试剂的研发及快速筛选提供了高效便捷的最佳手段。一些难以在传统HEK293细胞中表达的蛋白亦可在ExpiCHO系统中获得高水平表达。正是基于ExpiCHO系统在CHO细胞重组蛋白瞬时表达方面的突破性进展,该系统作为不可或缺的革命性工具,目前己成为世界上众多生...
      Speaker: Chao Yan Liu
      Presented at: 2017 Gibco ExpressionWorld
      12
      MAY 04, 2016 | 1:00 PM
      Mammalian in vitro translation (cell-free) systems for rapid protein expression and production of therapeutic proteins
      Mammalian in vitro translation (cell-free) systems for rapid protein...
      In vitro translation (IVT) using mammalian cell extracts is a quick and convenient alternative to in vivo mammalian protein expression. Thermo Fisher has developed IVT systems from two mammal...
      Speaker: Penny Jensen, PhD , Govind Rao, PhD
      Presented at: 2016 Gibco ExpressionWorld
      2
      MAY 04, 2016 | 12:00 PM
      Development of a Mammalian Recombinant Protein Production Suite
      Development of a Mammalian Recombinant Protein Production Suite
      Complex recombinant protein biologics, such as monoclonal antibodies and coagulation factors, are key components of today’s biopharmaceutical industry. There are many effective paths fo...
      Speaker: Catherine Owczarek, PhD
      Presented at: 2016 Gibco ExpressionWorld
      2
      MAY 04, 2016 | 10:00 AM
      The ExpiCHO transient expression system: Optimization of monoclonal antibody protein A purification
      The ExpiCHO transient expression system: Optimization of monoclonal...
      The ExpiCHO transient expression system allows for the high titer production of a broad range of recombinant proteins. Due to the high titers observed for many proteins in the ExpiCHO system,...
      Speaker: Lina Mpanda, MSc.
      Presented at: 2016 Gibco ExpressionWorld
      2
      MAY 04, 2016 | 6:00 AM
      Streamlining the Drug Development Process with the ExpiCHO Transient Expression System
      Streamlining the Drug Development Process with the ExpiCHO Transient...
      CHO cells are the predominant host for biotherapeutic protein expression, with roughly 70% of licensed biologics manufactured in CHO.  Multiple attributes make CHO cells desirable for bi...
      Speaker: Jon Zmuda, PhD
      Presented at: 2016 Gibco ExpressionWorld
      2
    JUL 01, 2017 | 8:00 AM
    Pluripotent stem cell bioprocessing platforms for cell therapy manufacturing
    Pluripotent stem cell bioprocessing platforms for cell therapy...
    Pluripotent stem cell (PSC) culture at commercial scale requires a shift from the current manual processing methods and costly materials to deliver affordable differentiated cell products in...
    Speaker: Jahid Hasan
    Presented at: 5th annual 24 Hours of Stem Cells™ virtual event
    2
    MAY 10, 2017 | 1:00 PM
    Modification of Glycans in Bioprocessing
    Modification of Glycans in Bioprocessing
    Glycosylation is an important product quality attribute for biotherapeutic proteins expressed in CHO cells. Glycoform variability can significantly affect the safety and efficacy of therapeut...
    Speaker: Ryan Boniface
    Presented at: 2017 Gibco ExpressionWorld
    4
    MAY 10, 2017 | 12:00 PM
    Ask the Expert: Mammalian Transient Expression
    Ask the Expert: Mammalian Transient Expression
    Getting started Equipment Troubleshooting Scale up or scale down your expression runs Tackling difficult-to-express proteins 293 vs. CHO cell expression...
    Speaker: Henry Chiou, PhD , Richard Altman, MS , Jon Zmuda, PhD , Konrad Miatkowski
    Presented at: 2017 Gibco ExpressionWorld
    3
    MAY 10, 2017 | 11:00 AM
    An ongoing evaluation of our transient expression systems; Can we predict the appropriate expression system for any drug modality?
    An ongoing evaluation of our transient expression systems; Can...
    CHO cells are the predominant host for biotherapeutic protein expression with approximately 70% of licensed biologics manufactured in Chinese Hamster Ovary (CHO) cells.  The ability to e...
    Speaker: Richard Altman, MS
    Presented at: 2017 Gibco ExpressionWorld
    4
    MAY 10, 2017 | 8:00 AM
    Optimisation of UCB's Transient Expression Platforms
    Optimisation of UCB's Transient Expression Platforms
    Development of antibody therapeutics, from early stage research to preclinical and clinical development, requires ever-increasing amounts of reagents. To meet the challenge of furnishing a di...
    Speaker: Christina Gordon
    Presented at: 2017 Gibco ExpressionWorld
    4
     
     
  • MAY 10, 2017 | 7:00 AM
    Basic Concepts in Transient Expression using 293 and CHO cells
    Basic Concepts in Transient Expression using 293 and CHO cells
    HEK293 and CHO cells are the primary cell lines used in rapid, scalable suspension culture systems for transient protein expression. This presentation provides a primer on fundamental concept...
    Speaker: Henry Chiou, PhD
    Presented at: 2017 Gibco ExpressionWorld
    5
    MAY 10, 2017 | 6:00 AM
    Latest Developments in High Titer Transient Protein Expression using the ExpiCHO Transient Expression System
    Latest Developments in High Titer Transient Protein Expression...
    The ExpiCHO™ transient expression system offers a turnkey solution for generating high-titer recombinant proteins for therapeutic drug development, reagent generation, as well as an alt...
    Speaker: Jon Zmuda, PhD
    Presented at: 2017 Gibco ExpressionWorld
    8
    MAY 10, 2017 | 5:00 AM
    Complete workflow solution from gene-to-protein combine highly advanced expression systems with expression optimized genes
    Complete workflow solution from gene-to-protein combine highly...
    Reliable autologous expression of recombinant human proteins - from gene sequence to the expressed and purified protein - in human or CHO cells is essential for many aspects of biomedical res...
    Speaker: Stephan Fath, PhD
    Presented at: 2017 Gibco ExpressionWorld
    4 1
    MAY 09, 2017 | 8:00 PM
    使用293和CHO细胞进行瞬时表达的基本概念
    使用293和CHO细胞进行瞬时表达的基本概念
    HEK293和CHO细胞是快速、规模可调的悬浮培养系统中常用的细胞系,可用于瞬时蛋白表达。此次演讲介绍了瞬时表达的基本概念和使用材料,以及使用293或CHO细胞时需要考虑的主要差异。...
    Speaker: Jian Liu
    Presented at: 2017 Gibco ExpressionWorld
    7
    MAY 09, 2017 | 7:00 PM
    Gibco™ ExpiCHO哺乳动物瞬时蛋白表达系统的最新研发进展
    Gibco™ ExpiCHO哺乳动物瞬时蛋白表达系统的最新研发进展
    Gibco™ ExpiCHO是一款全新优化的瞬时重组蛋白表达系统,可以在瞬转中获得极高的蛋白产量,为临床新药和诊断试剂的研发及快速筛选提供了高效便捷的最佳手段。一些难以在传统HEK293细胞中表达的蛋白亦可在ExpiCHO系统中获得高水平表达。正是基于ExpiCHO系统在CHO细胞重组蛋白瞬时表达方面的突破性进展,该系统作为不可或缺的革命性工具,目前己成为世界上众多生...
    Speaker: Chao Yan Liu
    Presented at: 2017 Gibco ExpressionWorld
    12
     
     
  • MAY 04, 2016 | 1:00 PM
    Mammalian in vitro translation (cell-free) systems for rapid protein expression and production of therapeutic proteins
    Mammalian in vitro translation (cell-free) systems for rapid protein...
    In vitro translation (IVT) using mammalian cell extracts is a quick and convenient alternative to in vivo mammalian protein expression. Thermo Fisher has developed IVT systems from two mammal...
    Speaker: Penny Jensen, PhD , Govind Rao, PhD
    Presented at: 2016 Gibco ExpressionWorld
    2
    MAY 04, 2016 | 12:00 PM
    Development of a Mammalian Recombinant Protein Production Suite
    Development of a Mammalian Recombinant Protein Production Suite
    Complex recombinant protein biologics, such as monoclonal antibodies and coagulation factors, are key components of today’s biopharmaceutical industry. There are many effective paths fo...
    Speaker: Catherine Owczarek, PhD
    Presented at: 2016 Gibco ExpressionWorld
    2
    MAY 04, 2016 | 10:00 AM
    The ExpiCHO transient expression system: Optimization of monoclonal antibody protein A purification
    The ExpiCHO transient expression system: Optimization of monoclonal...
    The ExpiCHO transient expression system allows for the high titer production of a broad range of recombinant proteins. Due to the high titers observed for many proteins in the ExpiCHO system,...
    Speaker: Lina Mpanda, MSc.
    Presented at: 2016 Gibco ExpressionWorld
    2
    MAY 04, 2016 | 6:00 AM
    Streamlining the Drug Development Process with the ExpiCHO Transient Expression System
    Streamlining the Drug Development Process with the ExpiCHO Transient...
    CHO cells are the predominant host for biotherapeutic protein expression, with roughly 70% of licensed biologics manufactured in CHO.  Multiple attributes make CHO cells desirable for bi...
    Speaker: Jon Zmuda, PhD
    Presented at: 2016 Gibco ExpressionWorld
    2
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