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    Ion Channels

    Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all excitable cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins).

    Webinars

    • JAN 14, 2020 | 8:00 AM
      CiPA initiative and validation of high-throughput methods to characterize compound effects in human iPSC-derived cardiomyocytes
      CiPA initiative and validation of high-throughput methods to characterize...
      DATE: January 14, 2019 TIME: 8:00am PST Drug-induced QT interval prolongation and Torsades de Pointes (TdP) arrhythmias are the leading causes for drug withdrawals from market and compound a...
      Speaker: Muthukrishnan Renganathan, PhD , Panida Lertkiatmongkol, PhD , Oksana Sirenko, PhD , Carole Crittenden
      Sponsored By: Molecular Devices, Eurofins Discovery
      3
      DEC 10, 2019 | 8:00 AM
      Expi293: New Tools for Structural Biology and Difficult to Express Proteins
      Expi293: New Tools for Structural Biology and Difficult to Express...
      DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
      Speaker: Jon Zmuda, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      7 1
      DEC 04, 2019 | 7:00 AM
      Improve your reproducibility - Liquid Handling is a crucial factor Exemplarily shown for NGS, ELISA and qPCR
      Improve your reproducibility - Liquid Handling is a crucial factor...
      DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
      Speaker: Katja Baesler, PhD , Ulrike Gast, PhD , Alisa Gruschka
      Sponsored By: Eppendorf
      12
      NOV 18, 2019 | 7:00 AM
      Protect your cells with proper pipetting - How liquid handling influences your cell culture work
      Protect your cells with proper pipetting - How liquid handling...
      DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
      Speaker: Nadine Mellies, PhD , Katja Baesler, PhD
      Sponsored By: Eppendorf
      22 2
      NOV 07, 2019 | 9:00 AM
      Factor V Expression in ExpiCHO Cells
      Factor V Expression in ExpiCHO Cells
      DATE: November 7, 2019 TIME: 9:00am PST, 12:00pm EST In collaboration with Hematherix and Thermo Fisher, Dr. Laurent Mosnier is investigating a new treatment for acute traumatic bl...
      Speaker: Laurent Mosnier, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      5 2
      OCT 01, 2019 | 8:00 AM
      Looking under the Hood and Getting Started with the Optima AUC
      Looking under the Hood and Getting Started with the Optima AUC
      DATE: October 1, 2019TIME: 8:00am PTIn the webinar, Introduction to Characterization of Biomolecules Using Analytical Ultracentrifugation, we discussed the fundamentals of analytical...
      Speaker: Akash Bhattacharya, PhD , Ross VerHeul
      Sponsored By: Beckman Coulter Life Sciences
      4
      SEP 26, 2019 | 7:30 AM
      Keynote Presentation: Phagocytosis, macropinocytosis and the innate immune response; recent advances
      Keynote Presentation: Phagocytosis, macropinocytosis and the innate...
      The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of parti...
      Speaker: Sergio Grinstein, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      2
      SEP 25, 2019 | 8:00 AM
      Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
      Expression, Purification and Characterization of Difficult to...
      DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
      Speaker: Anass Jawhari, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      4
      JUN 05, 2019 | 5:00 PM
      Everyday culture practice - Improving reproducibility in cell culture
      Everyday culture practice - Improving reproducibility in cell...
      DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
      Speaker: Jessica Wagener, PhD
      Sponsored By: Eppendorf
      23 2
      MAY 16, 2019 | 4:00 PM
      Towards Standardized Workflows - A focus on microbiome insights
      Towards Standardized Workflows - A focus on microbiome insights
      DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
      Speaker: Rita Colwell, PhD , Christiane Honisch, PhD
      Sponsored By: Eppendorf
      10 2
      MAR 28, 2019 | 12:00 PM
      The Intersection of Nutrition, Microbiome and Medical Cannabis
      The Intersection of Nutrition, Microbiome and Medical Cannabis
      Whole food plant-based diets and medical cannabis have shared and continues to share similar levels of scrutiny, doubt, and stigma by the traditional medical community. One reason for the med...
      Speaker: Debra Kimless, MD
      Presented at: Cannabis Sciences Virtual Event Series 2019
      6
      FEB 27, 2019 | 1:30 PM
      Advances in Three-Dimensional Cell Culture in Drug Research and Discovery
      Advances in Three-Dimensional Cell Culture in Drug Research and...
      Cellular research is optimal when using physiologically-relevant cell phenotypes and genotypes of human origin. This assertion has accelerated the adoption of primary cells, stem cells, and i...
      Speaker: Richard Eglen, PhD
      Presented at: Drug Discovery Virtual Event Series 2019
      2
      JAN 31, 2019 | 10:30 AM
      Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries to Improve Process Efficiencies
      Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries...
      Multi-mode chromatography has come to prominence in recent years due to the general utility of multi-mode ligands for product capture and polishing. In particular, their application in flow-t...
      Speaker: Buzz Lobbezoo
      Presented at: BioProcessing Virtual Event Series 2019
      Sponsored By: Astrea Bioseparations
      1
      NOV 01, 2018 | 12:00 AM
      Real-time analysis of cellular phagocytosis
      Real-time analysis of cellular phagocytosis
      Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell t...
      Speaker: Tim Dale
      Presented at: Dimension of Time: From Culture to Assay
      1
      SEP 20, 2018 | 9:00 AM
      Defects in potassium channels contribute to reduced immune surveillance in cancers
      Defects in potassium channels contribute to reduced immune surveillance...
       DATE: September 20 2018TIME: 09:00am PDT, 12:00pm EDT Harnessing the immune system has emerged as a powerful therapeutic strategy in oncology. However, the limited...
      Speaker: Ameet Chimote, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      6
      SEP 11, 2018 | 7:00 AM
      Answering the Challenges of Cell Viability and Reporter Gene Assays Screening Cost and Quality
      Answering the Challenges of Cell Viability and Reporter Gene Assays...
      DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
      Speaker: Vincent Dupriez, PhD , Jeanine Hinterneder, PhD , Maria Kuzikov, MSc
      Sponsored By: Revvity
      5
      MAR 14, 2018 | 6:00 AM
      Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics and Functional Magnetic Resonance Imaging
      Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics...
      Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
      Speaker: Paul Mathews, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      4 1
      NOV 09, 2017 | 4:00 AM
      Human pluripotent stem cells in understanding genetic cardiovascular disease and effects of drugs
      Human pluripotent stem cells in understanding genetic cardiovascular...
      Derivation of many different cell types from human pluripotent stem cells (embryonic stem cells or HESCs and induced pluripotent stem cells or hiPS cells) is an area of growing interest both ...
      Speaker: Christine Mummery
      Presented at: 5th annual 24 Hours of Stem Cellsâ„¢ virtual event
      4 1
      SEP 01, 2017 | 12:00 AM
      A gut feeling about stem cell therapy for enteric neuropathies
      A gut feeling about stem cell therapy for enteric neuropathies
      The enteric nervous system (ENS) plays an essential role in gut motility. Diseases of the ENS result in bowel motility disorders that are some of the most challenging clinical conditions to m...
      Speaker: Lincon Stamp
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      1
      JUL 25, 2017 | 9:00 AM
      WEBINAR: Functional Genomics and Drug Metabolism
      WEBINAR: Functional Genomics and Drug Metabolism
      EVENT DETAILS:DATE: July 25, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science...
      Speaker: David Piper, PhD
      Sponsored By: Thermo Fisher Scientific
      7 1
      JUL 20, 2017 | 10:00 AM
      WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
      WEBINAR: Innovative quantitative imaging techniques and their...
      DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
      Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
      Sponsored By: Thermo Fisher Scientific/Gibco
      3
      MAY 16, 2017 | 9:00 AM
      WEBINAR: Disease Models
      WEBINAR: Disease Models
      EVENT DETAILS:DATE: May 16, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science our first commit...
      Speaker: David Piper, PhD , Mark Kennedy, Ph.D.
      Sponsored By: Thermo Fisher Scientific
      5 3
      MAY 10, 2017 | 4:00 AM
      Stabilization of native & functional membrane proteins for drug discovery
      Stabilization of native & functional membrane proteins for drug...
      CALIXAR has developed an innovative detergent/surfactant based approach consisting on native isolation and stabilization of therapeutic membrane protein targets such as GPCRs, ion channels, t...
      Speaker: Anass Jawhari, PhD
      Presented at: 2017 Gibco ExpressionWorld
      10 1
      MAY 09, 2017 | 7:00 AM
      WEBINAR: Advanced assays for high-throughput assessment of ion channel inhibition and cardiac toxicity
      WEBINAR: Advanced assays for high-throughput assessment of ion...
      DATE: May 9th, 2017TIME: 7:00AM PDT, 10:00AM ET, 2:00PM GMT Early detection and elimination of new chemical entities with cardiac or hERG liability could substantially improve...
      Speaker: Beiyan Zou, PhD , Oksana Sirenko, PhD
      Sponsored By: Molecular Devices
      6
    JAN 14, 2020 | 8:00 AM
    CiPA initiative and validation of high-throughput methods to characterize compound effects in human iPSC-derived cardiomyocytes
    CiPA initiative and validation of high-throughput methods to characterize...
    DATE: January 14, 2019 TIME: 8:00am PST Drug-induced QT interval prolongation and Torsades de Pointes (TdP) arrhythmias are the leading causes for drug withdrawals from market and compound a...
    Speaker: Muthukrishnan Renganathan, PhD , Panida Lertkiatmongkol, PhD , Oksana Sirenko, PhD , Carole Crittenden
    Sponsored By: Molecular Devices, Eurofins Discovery
    3
    DEC 10, 2019 | 8:00 AM
    Expi293: New Tools for Structural Biology and Difficult to Express Proteins
    Expi293: New Tools for Structural Biology and Difficult to Express...
    DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
    Speaker: Jon Zmuda, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    7 1
    DEC 04, 2019 | 7:00 AM
    Improve your reproducibility - Liquid Handling is a crucial factor Exemplarily shown for NGS, ELISA and qPCR
    Improve your reproducibility - Liquid Handling is a crucial factor...
    DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
    Speaker: Katja Baesler, PhD , Ulrike Gast, PhD , Alisa Gruschka
    Sponsored By: Eppendorf
    12
    NOV 18, 2019 | 7:00 AM
    Protect your cells with proper pipetting - How liquid handling influences your cell culture work
    Protect your cells with proper pipetting - How liquid handling...
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    Speaker: Nadine Mellies, PhD , Katja Baesler, PhD
    Sponsored By: Eppendorf
    22 2
    NOV 07, 2019 | 9:00 AM
    Factor V Expression in ExpiCHO Cells
    Factor V Expression in ExpiCHO Cells
    DATE: November 7, 2019 TIME: 9:00am PST, 12:00pm EST In collaboration with Hematherix and Thermo Fisher, Dr. Laurent Mosnier is investigating a new treatment for acute traumatic bl...
    Speaker: Laurent Mosnier, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    5 2
     
     
  • OCT 01, 2019 | 8:00 AM
    Looking under the Hood and Getting Started with the Optima AUC
    Looking under the Hood and Getting Started with the Optima AUC
    DATE: October 1, 2019TIME: 8:00am PTIn the webinar, Introduction to Characterization of Biomolecules Using Analytical Ultracentrifugation, we discussed the fundamentals of analytical...
    Speaker: Akash Bhattacharya, PhD , Ross VerHeul
    Sponsored By: Beckman Coulter Life Sciences
    4
    SEP 26, 2019 | 7:30 AM
    Keynote Presentation: Phagocytosis, macropinocytosis and the innate immune response; recent advances
    Keynote Presentation: Phagocytosis, macropinocytosis and the innate...
    The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of parti...
    Speaker: Sergio Grinstein, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    2
    SEP 25, 2019 | 8:00 AM
    Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
    Expression, Purification and Characterization of Difficult to...
    DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
    Speaker: Anass Jawhari, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    4
    JUN 05, 2019 | 5:00 PM
    Everyday culture practice - Improving reproducibility in cell culture
    Everyday culture practice - Improving reproducibility in cell...
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    Speaker: Jessica Wagener, PhD
    Sponsored By: Eppendorf
    23 2
    MAY 16, 2019 | 4:00 PM
    Towards Standardized Workflows - A focus on microbiome insights
    Towards Standardized Workflows - A focus on microbiome insights
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    Speaker: Rita Colwell, PhD , Christiane Honisch, PhD
    Sponsored By: Eppendorf
    10 2
     
     
  • MAR 28, 2019 | 12:00 PM
    The Intersection of Nutrition, Microbiome and Medical Cannabis
    The Intersection of Nutrition, Microbiome and Medical Cannabis
    Whole food plant-based diets and medical cannabis have shared and continues to share similar levels of scrutiny, doubt, and stigma by the traditional medical community. One reason for the med...
    Speaker: Debra Kimless, MD
    Presented at: Cannabis Sciences Virtual Event Series 2019
    6
    FEB 27, 2019 | 1:30 PM
    Advances in Three-Dimensional Cell Culture in Drug Research and Discovery
    Advances in Three-Dimensional Cell Culture in Drug Research and...
    Cellular research is optimal when using physiologically-relevant cell phenotypes and genotypes of human origin. This assertion has accelerated the adoption of primary cells, stem cells, and i...
    Speaker: Richard Eglen, PhD
    Presented at: Drug Discovery Virtual Event Series 2019
    2
    JAN 31, 2019 | 10:30 AM
    Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries to Improve Process Efficiencies
    Flow-Through Polishing and The Use of Multi-Mode Ligand Libraries...
    Multi-mode chromatography has come to prominence in recent years due to the general utility of multi-mode ligands for product capture and polishing. In particular, their application in flow-t...
    Speaker: Buzz Lobbezoo
    Presented at: BioProcessing Virtual Event Series 2019
    Sponsored By: Astrea Bioseparations
    1
    NOV 01, 2018 | 12:00 AM
    Real-time analysis of cellular phagocytosis
    Real-time analysis of cellular phagocytosis
    Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell t...
    Speaker: Tim Dale
    Presented at: Dimension of Time: From Culture to Assay
    1
    SEP 20, 2018 | 9:00 AM
    Defects in potassium channels contribute to reduced immune surveillance in cancers
    Defects in potassium channels contribute to reduced immune surveillance...
     DATE: September 20 2018TIME: 09:00am PDT, 12:00pm EDT Harnessing the immune system has emerged as a powerful therapeutic strategy in oncology. However, the limited...
    Speaker: Ameet Chimote, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    6
     
     
  • SEP 11, 2018 | 7:00 AM
    Answering the Challenges of Cell Viability and Reporter Gene Assays Screening Cost and Quality
    Answering the Challenges of Cell Viability and Reporter Gene Assays...
    DATE: September 11, 2018TIME: 07:00AM PDTWith increasing safety requirements, and time and financial pressure, the development of new drugs, and the execution of basic research p...
    Speaker: Vincent Dupriez, PhD , Jeanine Hinterneder, PhD , Maria Kuzikov, MSc
    Sponsored By: Revvity
    5
    MAR 14, 2018 | 6:00 AM
    Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics and Functional Magnetic Resonance Imaging
    Mapping Cerebellum-to-Forebrain Connectivity Using Optogenetics...
    Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
    Speaker: Paul Mathews, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    4 1
    NOV 09, 2017 | 4:00 AM
    Human pluripotent stem cells in understanding genetic cardiovascular disease and effects of drugs
    Human pluripotent stem cells in understanding genetic cardiovascular...
    Derivation of many different cell types from human pluripotent stem cells (embryonic stem cells or HESCs and induced pluripotent stem cells or hiPS cells) is an area of growing interest both ...
    Speaker: Christine Mummery
    Presented at: 5th annual 24 Hours of Stem Cellsâ„¢ virtual event
    4 1
    SEP 01, 2017 | 12:00 AM
    A gut feeling about stem cell therapy for enteric neuropathies
    A gut feeling about stem cell therapy for enteric neuropathies
    The enteric nervous system (ENS) plays an essential role in gut motility. Diseases of the ENS result in bowel motility disorders that are some of the most challenging clinical conditions to m...
    Speaker: Lincon Stamp
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    1
    JUL 25, 2017 | 9:00 AM
    WEBINAR: Functional Genomics and Drug Metabolism
    WEBINAR: Functional Genomics and Drug Metabolism
    EVENT DETAILS:DATE: July 25, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science...
    Speaker: David Piper, PhD
    Sponsored By: Thermo Fisher Scientific
    7 1
     
     
  • JUL 20, 2017 | 10:00 AM
    WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
    WEBINAR: Innovative quantitative imaging techniques and their...
    DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
    Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
    Sponsored By: Thermo Fisher Scientific/Gibco
    3
    MAY 16, 2017 | 9:00 AM
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