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    Long-Read Sequencing

    Long-Read Sequencing, also known as third-generation sequencing, is a class of DNA sequencing methods which are currently under active development. In contrast to other existing methods of DNA sequencing the process of long-read sequencing does not require breaking long strands of DNA, but simply reading the nucleotide sequences at a molecule level.

    Webinars

    • JUN 20, 2019 | 9:00 AM
      Precision Medicine & Health in Action: Practicing an N-of-1 Approach in the Clinic
      Precision Medicine & Health in Action: Practicing an N-of-1 Approach...
      The NIH put Precision Medicine on the map as a revolutionary way to manage disease, delivering the right treatment, to the right patient, at the right time. But what does Precision Medicine r...
      Speaker: Florence Comite, MD
      Presented at: Precision Medicine Virtual Event Series 2019
      1
      MAY 09, 2019 | 9:00 AM
      Completing the Human Genome: The Progress and Challenge of Satellite DNA Assembly
      Completing the Human Genome: The Progress and Challenge of Satellite...
      Release of the first human genome assembly was a landmark achievement, and after nearly two decades of improvements, the current human reference genome (GRCh38) is the most accurate and compl...
      Speaker: Karen Miga, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      1
      MAY 08, 2019 | 1:30 PM
      Highly Accurate Long Sequence Reads for Comprehensive Genomic Analysis
      Highly Accurate Long Sequence Reads for Comprehensive Genomic...
      Recent improvements in sequencing chemistry and instrument performance combine to create a new PacBio data type of highly accurate (HiFi), long insert reads. Increased read length and improve...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      Sponsored By: PacBio
      2
      APR 25, 2019 | 12:00 PM
      Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges and Threats Posed by Infectious Diseases
      Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges...
      Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
      Speaker: Faramarz Valafar, PhD
      Presented at: Infectious Disease Virtual Event Series 2019
      2
      APR 25, 2019 | 6:00 AM
      Long-Read Sequencing and Infectious Disease: New Insights Into Longstanding Challenges
      Long-Read Sequencing and Infectious Disease: New Insights Into...
      To reduce the global burden diseases causes by infectious disease, including parasites and bacteria, scientists need better information about mechanisms of virulence, immune evasion, and drug...
      Speaker: Meredith Ashby, PhD
      Presented at: Infectious Disease Virtual Event Series 2019
      Sponsored By: PacBio
      2
      OCT 11, 2018 | 6:00 AM
      Revealing the Hidden Landscape of Structural Variants in Cancer Genomes
      Revealing the Hidden Landscape of Structural Variants in Cancer...
      PacBio Sequencing simultaneously provides long sequence reads, high consensus accuracy, minimal sequence bias, and methylation detection. I will highlight new advances and updates on applying...
      Speaker: Jonas Korlach, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      SEP 13, 2018 | 1:30 PM
      New PacBio Solutions for High-Resolution Microbiology & Immunology Analysis
      New PacBio Solutions for High-Resolution Microbiology & Immunology...
      PacBio Sequencing has been recognized as the gold standard in microbial sequencing due to simultaneously providing long sequence reads (genome contiguity), high consensus accuracy (genome acc...
      Speaker: Jonas Korlach, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      Sponsored By: PacBio
      1
      SEP 12, 2018 | 1:30 PM
      The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic Bacteria
      The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic...
      Reducing the impact of infectious diseases is becoming increasingly vital as the prevalence of antimicrobial resistance (AMR) continues to rise, threatening the effective prevention and treat...
      Speaker: Julie Russell, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      1
      SEP 12, 2018 | 8:00 AM
      Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
      Advancing precision immunotherapy through next generation sequencing...
      DATE:  September 12, 2018 TIME:  08:00am PDT, 11:00am EDT In the last presentation of this webinar series, we will continue our discussions on recent advancements i...
      Speaker: Timothy Looney, PhD
      Sponsored By: Thermo Fisher Scientific - Ion Torrent
      9
      MAY 10, 2018 | 10:30 AM
      C.E. CREDITS
      Excavating the Deep Genome: Deciphering Structural Variation in Complex and Repetitive Regions
      Excavating the Deep Genome: Deciphering Structural Variation in...
      Structural variants (SVs), defined as rearrangements of genomic sequences, are both a major source of genetic diversity in human populations and are also directly responsible for the pathogen...
      Speaker: Ryan E Mills, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      1
      MAY 10, 2018 | 9:00 AM
      C.E. CREDITS
      Application of Long-Read PacBio Sequencing for High-Resolution Metagenomics
      Application of Long-Read PacBio Sequencing for High-Resolution...
      Short-read sequencing has found wide-spread use in metagenomics but the short read lengths and bias with regard to sequence composition have translated to limitations of the study of complex...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      1
      MAY 09, 2018 | 9:00 AM
      C.E. CREDITS
      Size Matters: Accurate Detection and Phasing of Structural Variations
      Size Matters: Accurate Detection and Phasing of Structural Variations
      In this presentation I will describe our latest work to obtain comprehensive genomes leveraging long and linked reads. The vast majority of NGS whole-genome data covers hundreds of thousands...
      Speaker: Fritz Sedlazeck, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      1
      MAY 09, 2018 | 6:00 AM
      Genome in a Bottle: Developing Benchmark Sets for Structural Variants
      Genome in a Bottle: Developing Benchmark Sets for Structural Variants
      The Genome in a Bottle Consortium (GIAB) has characterized an Ashkenazi trio from the Personal Genome Project (NIST Reference Material 8392) with 12 short, long, and linked read sequencing an...
      Speaker: Justin Zook, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      1
      JAN 30, 2018 | 9:00 AM
      WEBINAR: Metagenomics and base modifications from long, short, and linked-reads
      WEBINAR: Metagenomics and base modifications from long, short,...
      DATE: January 30, 2018TIME: 9:00AM PST, 12:00PM ESTInfectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatica...
      Speaker: Christopher Mason, PhD , Shuiquan Tang, PhD
      Sponsored By: Zymo Research
      6 1
      OCT 25, 2017 | 6:00 AM
      WEBINAR #3:  Enabling neurological disease research via DNA fragment analysis on the new SeqStudio genetic analyzer
      WEBINAR #3: Enabling neurological disease research via DNA fragment...
      DATE: October 25, 2017TIME: 06:00am PDT, 09:00am EDTThis is the third topic in the webinar series on ‘Sanger Sequencing & Fragment Analysis made easy’.Repetitive DNA...
      Speaker: Gary Latham, PhD
      Sponsored By: Thermo Fisher Scientific
      3
      OCT 11, 2017 | 12:00 PM
      Examining Cancer with the minION: Methylation and Structural Variation
      Examining Cancer with the minION: Methylation and Structural Variation
      Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
      Speaker: Winston Timp, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      Sponsored By: Oxford Nanopore Technologies
      1
      SEP 14, 2017 | 12:00 PM
      How to deploy a portable lab for the surveillance of emerging infectious diseases
      How to deploy a portable lab for the surveillance of emerging...
      Genome sequencing can be used to discover new pathogens but it can also be used to monitor known ones. This is known as genomic surveillance and it becoming an increasingly important tool in...
      Speaker: Josh Quick
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      Sponsored By: Oxford Nanopore Technologies
      1
      MAY 10, 2017 | 1:30 PM
      Addressing "NGS Dead Zones" with Third-Generation PacBio Sequencing
      Addressing "NGS Dead Zones" with Third-Generation PacBio Sequencing
      SMRT Sequencing is a DNA sequencing technology characterized by long read lengths and high consensus accuracy, regardless of the sequence complexity or GC content of the DNA sample. These cha...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2017
      Sponsored By: PacBio
      2
      MAY 11, 2016 | 10:30 AM
      Whole Genome? The Future of High-Quality Genomes & Transcriptomes
      Whole Genome? The Future of High-Quality Genomes & Transcriptomes
      New approaches to generate high-quality representations of human genomes and transcriptomes are now becoming available. In contrast to short-read “Whole-Genome” re-sequencing meth...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2016
      2
      MAY 11, 2016 | 6:00 AM
      Expanding the molecular toolbox for Nanopore sequencing
      Expanding the molecular toolbox for Nanopore sequencing
      Library preparation for Nanopore sequencing is a very flexible process. There are many ways in which a sequencing template, or other analyte, can be presented to a nanopore for analysis. PCR...
      Speaker: David Stoddart, MBioch, DPhil
      Presented at: Genetics and Genomics Virtual Event Series 2016
      5
      MAR 29, 2016 | 8:00 AM
      WEBINAR: Applications of Targeted Gene Panels in Inherited Disease Research
      WEBINAR: Applications of Targeted Gene Panels in Inherited Disease...
      Recent advances in next-generation sequencing (NGS) have helped to accelerate the pace of discovery in the field of genetic disease research and testing. The ability to analyze multiple genes...
      Speaker: Brian Meyer, PhD , Robert Sebra, PhD
      Sponsored By: Thermo Fisher Scientific - Ion Torrent, Thermo Fisher Scientific - Ion Torrent
      11 3
      FEB 24, 2016 | 2:00 PM
      Why we should clinically classify genotypes, not variants
      Why we should clinically classify genotypes, not variants
      A century and a half after we first probed heritability, we risk forgetting one of Mendel's own basic findings, in rushing to broaden clinical genomics to lifelong care for all. Embracing...
      Speaker: Nathaniel Pearson, PhD
      Presented at: Precision Medicine Virtual Event Series 2016
      2
      SEP 02, 2015 | 12:00 PM
      DNASTAR Software for Assembly and Analysis of Microbial Genomes
      DNASTAR Software for Assembly and Analysis of Microbial Genomes
      DNASTAR offers an integrated suite of software for accurate assembly and analysis of sequence data for key NGS workflows, including microbial genome assembly. The DNASTAR assembly software is...
      Speaker: Matthew Keyser, MS
      Presented at: Microbiology Virtual Event Series 2015
      3
      AUG 20, 2014 | 11:30 AM
      More Comprehensive Views of Human Genetic Variation
      More Comprehensive Views of Human Genetic Variation
      High-throughput short-read DNA sequencing has revolutionized our ability to measure genetic variation in the form of single-nucleotide polymorphisms (SNPs) in human genomes. However, ~75% of...
      Speaker: Jonas Korlach, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2014
      8
    JUN 20, 2019 | 9:00 AM
    Precision Medicine & Health in Action: Practicing an N-of-1 Approach in the Clinic
    Precision Medicine & Health in Action: Practicing an N-of-1 Approach...
    The NIH put Precision Medicine on the map as a revolutionary way to manage disease, delivering the right treatment, to the right patient, at the right time. But what does Precision Medicine r...
    Speaker: Florence Comite, MD
    Presented at: Precision Medicine Virtual Event Series 2019
    1
    MAY 09, 2019 | 9:00 AM
    Completing the Human Genome: The Progress and Challenge of Satellite DNA Assembly
    Completing the Human Genome: The Progress and Challenge of Satellite...
    Release of the first human genome assembly was a landmark achievement, and after nearly two decades of improvements, the current human reference genome (GRCh38) is the most accurate and compl...
    Speaker: Karen Miga, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    1
    MAY 08, 2019 | 1:30 PM
    Highly Accurate Long Sequence Reads for Comprehensive Genomic Analysis
    Highly Accurate Long Sequence Reads for Comprehensive Genomic...
    Recent improvements in sequencing chemistry and instrument performance combine to create a new PacBio data type of highly accurate (HiFi), long insert reads. Increased read length and improve...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    Sponsored By: PacBio
    2
    APR 25, 2019 | 12:00 PM
    Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges and Threats Posed by Infectious Diseases
    Diagnosis and Treatment of Tuberculosis, a Case Study in Challenges...
    Tuberculosis has killed more than one billion people in the last 200 years. It is the oldest and the deadliest human pathogen, recently surpassing HIV. Its adaptation to host and drug pressur...
    Speaker: Faramarz Valafar, PhD
    Presented at: Infectious Disease Virtual Event Series 2019
    2
    APR 25, 2019 | 6:00 AM
    Long-Read Sequencing and Infectious Disease: New Insights Into Longstanding Challenges
    Long-Read Sequencing and Infectious Disease: New Insights Into...
    To reduce the global burden diseases causes by infectious disease, including parasites and bacteria, scientists need better information about mechanisms of virulence, immune evasion, and drug...
    Speaker: Meredith Ashby, PhD
    Presented at: Infectious Disease Virtual Event Series 2019
    Sponsored By: PacBio
    2
     
     
  • OCT 11, 2018 | 6:00 AM
    Revealing the Hidden Landscape of Structural Variants in Cancer Genomes
    Revealing the Hidden Landscape of Structural Variants in Cancer...
    PacBio Sequencing simultaneously provides long sequence reads, high consensus accuracy, minimal sequence bias, and methylation detection. I will highlight new advances and updates on applying...
    Speaker: Jonas Korlach, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    SEP 13, 2018 | 1:30 PM
    New PacBio Solutions for High-Resolution Microbiology & Immunology Analysis
    New PacBio Solutions for High-Resolution Microbiology & Immunology...
    PacBio Sequencing has been recognized as the gold standard in microbial sequencing due to simultaneously providing long sequence reads (genome contiguity), high consensus accuracy (genome acc...
    Speaker: Jonas Korlach, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    Sponsored By: PacBio
    1
    SEP 12, 2018 | 1:30 PM
    The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic Bacteria
    The NCTC 3000 Project: Mapping the Genetic Codes of 3000 Pathogenic...
    Reducing the impact of infectious diseases is becoming increasingly vital as the prevalence of antimicrobial resistance (AMR) continues to rise, threatening the effective prevention and treat...
    Speaker: Julie Russell, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    1
    SEP 12, 2018 | 8:00 AM
    Advancing precision immunotherapy through next generation sequencing of T-cell receptors: Part II
    Advancing precision immunotherapy through next generation sequencing...
    DATE:  September 12, 2018 TIME:  08:00am PDT, 11:00am EDT In the last presentation of this webinar series, we will continue our discussions on recent advancements i...
    Speaker: Timothy Looney, PhD
    Sponsored By: Thermo Fisher Scientific - Ion Torrent
    9
    MAY 10, 2018 | 10:30 AM
    C.E. CREDITS
    Excavating the Deep Genome: Deciphering Structural Variation in Complex and Repetitive Regions
    Excavating the Deep Genome: Deciphering Structural Variation in...
    Structural variants (SVs), defined as rearrangements of genomic sequences, are both a major source of genetic diversity in human populations and are also directly responsible for the pathogen...
    Speaker: Ryan E Mills, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    1
     
     
  • MAY 10, 2018 | 9:00 AM
    C.E. CREDITS
    Application of Long-Read PacBio Sequencing for High-Resolution Metagenomics
    Application of Long-Read PacBio Sequencing for High-Resolution...
    Short-read sequencing has found wide-spread use in metagenomics but the short read lengths and bias with regard to sequence composition have translated to limitations of the study of complex...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    1
    MAY 09, 2018 | 9:00 AM
    C.E. CREDITS
    Size Matters: Accurate Detection and Phasing of Structural Variations
    Size Matters: Accurate Detection and Phasing of Structural Variations
    In this presentation I will describe our latest work to obtain comprehensive genomes leveraging long and linked reads. The vast majority of NGS whole-genome data covers hundreds of thousands...
    Speaker: Fritz Sedlazeck, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    1
    MAY 09, 2018 | 6:00 AM
    Genome in a Bottle: Developing Benchmark Sets for Structural Variants
    Genome in a Bottle: Developing Benchmark Sets for Structural Variants
    The Genome in a Bottle Consortium (GIAB) has characterized an Ashkenazi trio from the Personal Genome Project (NIST Reference Material 8392) with 12 short, long, and linked read sequencing an...
    Speaker: Justin Zook, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    1
    JAN 30, 2018 | 9:00 AM
    WEBINAR: Metagenomics and base modifications from long, short, and linked-reads
    WEBINAR: Metagenomics and base modifications from long, short,...
    DATE: January 30, 2018TIME: 9:00AM PST, 12:00PM ESTInfectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatica...
    Speaker: Christopher Mason, PhD , Shuiquan Tang, PhD
    Sponsored By: Zymo Research
    6 1
    OCT 25, 2017 | 6:00 AM
    WEBINAR #3:  Enabling neurological disease research via DNA fragment analysis on the new SeqStudio genetic analyzer
    WEBINAR #3: Enabling neurological disease research via DNA fragment...
    DATE: October 25, 2017TIME: 06:00am PDT, 09:00am EDTThis is the third topic in the webinar series on ‘Sanger Sequencing & Fragment Analysis made easy’.Repetitive DNA...
    Speaker: Gary Latham, PhD
    Sponsored By: Thermo Fisher Scientific
    3
     
     
  • OCT 11, 2017 | 12:00 PM
    Examining Cancer with the minION: Methylation and Structural Variation
    Examining Cancer with the minION: Methylation and Structural Variation
    Nanopore sequencing has enormous potential for application to cancer, but specifically offers advantages into two main arenas, epigenetics and structural variation. Methylation is well-known...
    Speaker: Winston Timp, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    Sponsored By: Oxford Nanopore Technologies
    1
    SEP 14, 2017 | 12:00 PM
    How to deploy a portable lab for the surveillance of emerging infectious diseases
    How to deploy a portable lab for the surveillance of emerging...
    Genome sequencing can be used to discover new pathogens but it can also be used to monitor known ones. This is known as genomic surveillance and it becoming an increasingly important tool in...
    Speaker: Josh Quick
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    Sponsored By: Oxford Nanopore Technologies
    1
    MAY 10, 2017 | 1:30 PM
    Addressing "NGS Dead Zones" with Third-Generation PacBio Sequencing
    Addressing "NGS Dead Zones" with Third-Generation PacBio Sequencing
    SMRT Sequencing is a DNA sequencing technology characterized by long read lengths and high consensus accuracy, regardless of the sequence complexity or GC content of the DNA sample. These cha...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2017
    Sponsored By: PacBio
    2
    MAY 11, 2016 | 10:30 AM
    Whole Genome? The Future of High-Quality Genomes & Transcriptomes
    Whole Genome? The Future of High-Quality Genomes & Transcriptomes
    New approaches to generate high-quality representations of human genomes and transcriptomes are now becoming available. In contrast to short-read “Whole-Genome” re-sequencing meth...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2016
    2
    MAY 11, 2016 | 6:00 AM
    Expanding the molecular toolbox for Nanopore sequencing
    Expanding the molecular toolbox for Nanopore sequencing
    Library preparation for Nanopore sequencing is a very flexible process. There are many ways in which a sequencing template, or other analyte, can be presented to a nanopore for analysis. PCR...
    Speaker: David Stoddart, MBioch, DPhil
    Presented at: Genetics and Genomics Virtual Event Series 2016
    5
     
     
  • MAR 29, 2016 | 8:00 AM
    WEBINAR: Applications of Targeted Gene Panels in Inherited Disease Research
    WEBINAR: Applications of Targeted Gene Panels in Inherited Disease...
    Recent advances in next-generation sequencing (NGS) have helped to accelerate the pace of discovery in the field of genetic disease research and testing. The ability to analyze multiple genes...
    Speaker: Brian Meyer, PhD , Robert Sebra, PhD
    Sponsored By: Thermo Fisher Scientific - Ion Torrent, Thermo Fisher Scientific - Ion Torrent
    11 3
    FEB 24, 2016 | 2:00 PM
    Why we should clinically classify genotypes, not variants
    Why we should clinically classify genotypes, not variants
    A century and a half after we first probed heritability, we risk forgetting one of Mendel's own basic findings, in rushing to broaden clinical genomics to lifelong care for all. Embracing...
    Speaker: Nathaniel Pearson, PhD
    Presented at: Precision Medicine Virtual Event Series 2016
    2
    SEP 02, 2015 | 12:00 PM
    DNASTAR Software for Assembly and Analysis of Microbial Genomes
    DNASTAR Software for Assembly and Analysis of Microbial Genomes
    DNASTAR offers an integrated suite of software for accurate assembly and analysis of sequence data for key NGS workflows, including microbial genome assembly. The DNASTAR assembly software is...
    Speaker: Matthew Keyser, MS
    Presented at: Microbiology Virtual Event Series 2015
    3
    AUG 20, 2014 | 11:30 AM
    More Comprehensive Views of Human Genetic Variation
    More Comprehensive Views of Human Genetic Variation
    High-throughput short-read DNA sequencing has revolutionized our ability to measure genetic variation in the form of single-nucleotide polymorphisms (SNPs) in human genomes. However, ~75% of...
    Speaker: Jonas Korlach, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2014
    8
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