Follow
Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
-
AUG 05, 2015Genetics & Genomics
According to the National Institutes of Health (NIH) autism spectrum disorders (ASD) are a range of complex neurodevelop ...Written By: Sarah HertrichJUL 27, 2015Cancer
While most scientists have viewed genetic aberrations as the primary cause of almost all cancer, a new study of ovarian ...Written By: Ilene SchneiderJUN 14, 2015Cancer
Oligodendroglioma, which can be an especially aggressive form of brain cancer, may be caused by a genetic mutation. Scie ...Written By: Ilene SchneiderAPR 27, 2015Cell & Molecular Biology
Caltech researchers have found how an abundant class of RNA genes-called long non-coding RNAs (lncRNAs, pronounced link ...Written By: Judy O'RourkeAPR 23, 2015Cardiology
Scientific dogma has the respiration process involving only two elements-oxygen and carbon dioxide. Specifically, the de ...Written By: Judy O'RourkeAPR 22, 2015Genetics & Genomics
Could the epigenome provide a new avenue for gene therapies and guiding stem cell differentiation?
Written By: Robert WoodardAPR 20, 2015Cell & Molecular Biology
Fastening protein-based medical treatments to nanoparticles isn't easy.
With arduous chemistry, scientists ca ...Written By: Will HectorAPR 15, 2015Cancer
The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to el ...Written By: Ilene SchneiderAPR 14, 2015Cancer
Scientists have found six molecules that block HuR, an "oncoprotein" linked to cancer that was thought to be "undruggabl ...Written By: Will HectorAPR 13, 2015Cardiology
When a heart attack strikes, heart muscle cells die and scar tissue forms, paving the way for heart failure.
Written By: Judy O'RourkeAPR 09, 2015Genetics & Genomics
Lung cancer is the second most common type of cancer and the number one cause of cancer-related mortality. It is estimat ...Written By: Ilene SchneiderAPR 06, 2015Cancer
Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery by University of Califor ...Written By: Robert WoodardMAR 25, 2015Cancer
Colon cancer is one of the leading causes of cancer-related deaths worldwide. In spite of research into the genetic muta ...Written By: Ilene SchneiderMAR 17, 2015Chemistry & Physics
To pack two meters of DNA into a microscopic cell, the string of genetic information must be wound extremely carefully i ...Written By: Judy O'RourkeMAR 12, 2015Genetics & Genomics
A new study reveals an important connection between dozens of genes that may contribute to autism, a major step toward u ...Written By: Ilene SchneiderFEB 26, 2015Cancer
A study published in Science Translational Medicine showed that immune cells engineered to seek out and attack a type of ...Written By: Ilene SchneiderFEB 23, 2015Cardiology
The average heart beats 35 million times a year - 2.5 billion times over a lifetime. Those beats must be precisely calib ...Written By: Judy O'RourkeFEB 03, 2015Cancer
According to the American Cancer Society, more than 221,000 Americans will be diagnosed with lung cancer in 2015. Positi ...Written By: Ilene SchneiderJAN 12, 2015Health & Medicine
While long touted for it's health benefits as well as it's ability to enhance any dinner party, red wine has been studie ...Written By: Brenda Kelley KimJUL 18, 2014Microbiology
UC Irvine School of Medicine researchers have learned how bacterial toxins that cause food-borne botulism are absorbed t ...Written By: Ilene SchneiderFEB 07, 2014Genetics & Genomics
Did you know you have a form of shape shifting, cancer-fighting, transforming, DNA-repairing machines already hard at wo ...DEC 12, 2013Microbiology
The phrase "blood clot" rarely has a positive spin-most people associate blood clots with traumatic and potentially fata ...AUG 05, 2015Genetics & Genomics
According to the National Institutes of Health (NIH) autism spectrum disorders (ASD) are a range of complex neurodevelop ...Written By: Sarah HertrichJUL 27, 2015Cancer
While most scientists have viewed genetic aberrations as the primary cause of almost all cancer, a new study of ovarian ...Written By: Ilene SchneiderJUN 14, 2015Cancer
Oligodendroglioma, which can be an especially aggressive form of brain cancer, may be caused by a genetic mutation. Scie ...Written By: Ilene SchneiderAPR 27, 2015Cell & Molecular Biology
Caltech researchers have found how an abundant class of RNA genes-called long non-coding RNAs (lncRNAs, pronounced link ...Written By: Judy O'RourkeAPR 23, 2015Cardiology
Scientific dogma has the respiration process involving only two elements-oxygen and carbon dioxide. Specifically, the de ...Written By: Judy O'RourkeAPR 22, 2015Genetics & Genomics
Could the epigenome provide a new avenue for gene therapies and guiding stem cell differentiation?
Written By: Robert WoodardAPR 20, 2015Cell & Molecular Biology
Fastening protein-based medical treatments to nanoparticles isn't easy.
With arduous chemistry, scientists ca ...Written By: Will HectorAPR 15, 2015Cancer
The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to el ...Written By: Ilene SchneiderAPR 14, 2015Cancer
Scientists have found six molecules that block HuR, an "oncoprotein" linked to cancer that was thought to be "undruggabl ...Written By: Will HectorAPR 13, 2015Cardiology
When a heart attack strikes, heart muscle cells die and scar tissue forms, paving the way for heart failure.
Written By: Judy O'RourkeAPR 09, 2015Genetics & Genomics
Lung cancer is the second most common type of cancer and the number one cause of cancer-related mortality. It is estimat ...Written By: Ilene SchneiderAPR 06, 2015Cancer
Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery by University of Califor ...Written By: Robert WoodardMAR 25, 2015Cancer
Colon cancer is one of the leading causes of cancer-related deaths worldwide. In spite of research into the genetic muta ...Written By: Ilene SchneiderMAR 17, 2015Chemistry & Physics
To pack two meters of DNA into a microscopic cell, the string of genetic information must be wound extremely carefully i ...Written By: Judy O'RourkeMAR 12, 2015Genetics & Genomics
A new study reveals an important connection between dozens of genes that may contribute to autism, a major step toward u ...Written By: Ilene SchneiderFEB 26, 2015Cancer
A study published in Science Translational Medicine showed that immune cells engineered to seek out and attack a type of ...Written By: Ilene SchneiderFEB 23, 2015Cardiology
The average heart beats 35 million times a year - 2.5 billion times over a lifetime. Those beats must be precisely calib ...Written By: Judy O'RourkeFEB 03, 2015Cancer
According to the American Cancer Society, more than 221,000 Americans will be diagnosed with lung cancer in 2015. Positi ...Written By: Ilene SchneiderJAN 12, 2015Health & Medicine
While long touted for it's health benefits as well as it's ability to enhance any dinner party, red wine has been studie ...Written By: Brenda Kelley KimJUL 18, 2014Microbiology
UC Irvine School of Medicine researchers have learned how bacterial toxins that cause food-borne botulism are absorbed t ...Written By: Ilene SchneiderFEB 07, 2014Genetics & Genomics
Did you know you have a form of shape shifting, cancer-fighting, transforming, DNA-repairing machines already hard at wo ...DEC 12, 2013Microbiology
The phrase "blood clot" rarely has a positive spin-most people associate blood clots with traumatic and potentially fata ...
Opens in a new window
Opens an external site
Opens an external site in a new window
Modal title