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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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MAR 16, 2016
Neuroscience
Chemogenetics and especially optogenetics have been game-changers in neuroscience research. By providing precise control
...
Written By:
Cassidy Reich
FEB 19, 2016
Neuroscience
Approximately one million people in the U.S. have Parkinson’s Disease (PD), a progressive neurodegenerative disord
...
Written By:
Cassidy Reich
FEB 11, 2016
Cardiology
Rare but deadly, thrombotic thrombocytopenic purpura (TTP) is a disease where blood clots block the smallest blood vesse
...
Written By:
Kara Marker
FEB 06, 2016
Immunology
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...
Written By:
Kara Marker
FEB 05, 2016
Cancer
Overall brain cancer is rare, but it’s actually the most common form of solid tumors in children under 15 years ol
...
Written By:
Kara Marker
FEB 04, 2016
Health & Medicine
Besides having on average larger feet than short people, a new study shows tall people are also more at risk for getting
...
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Kara Marker
JAN 31, 2016
Genetics & Genomics
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...
Written By:
Cassidy Reich
JAN 26, 2016
Chemistry & Physics
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...
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Futurity (futurity.org)
JAN 26, 2016
Cancer
TSRI and UC Berkeley Team Solves Structure of 'Flipping' Cellular Machine, Pointing to Possible Alzheimer’
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The Scripps Research Institute (TSRI)
JAN 05, 2016
Cardiology
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...
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JAN 03, 2016
Health & Medicine
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...
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Julianne Chiaet
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Health & Medicine
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DEC 26, 2015
Cardiology
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...
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Immunology
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...
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The Scripps Research Institute (TSRI)
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Immunology
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...
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Kara Marker
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Cardiology
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...
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NOV 22, 2015
Videos
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...
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...
Written By:
Sarah Hertrich
NOV 16, 2015
Cell & Molecular Biology
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...
Written By:
Sarah Hertrich
SEP 30, 2015
Cell & Molecular Biology
The liquid-liquid phase separation, observed when a crystallization reagent is added to a protein resulting in liquid dr
...
Written By:
Sarah Hertrich
SEP 22, 2015
Genetics & Genomics
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...
Written By:
Ilene Schneider
SEP 11, 2015
Cancer
A protein domain may be critical to helping patients fighting acute myeloid leukemia (AML) avoid a relapse. Researchers
...
Written By:
Ilene Schneider
AUG 11, 2015
Microbiology
Bacteria spend a lot of time and energy avoiding detection by the immune system (no self-respecting pathogen gives up wi
...
Written By:
Kerry Evans
AUG 06, 2015
Cancer
How do tumors grow, and how can they be stopped? A collaborative study between Sanford Burnham Prebys Medical Discovery
...
Written By:
Ilene Schneider