Biotechnology: is the use of living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use" (UN Convention on Biological Diversity, Art. 2). Depending on the tools and applications, it often overlaps with the (related) fields of bioengineering, biomedical engineering, biomanufacturing, molecular engineering, etc. 
            
            
            
         
     
    
        
                    
                                    
                
         
                
                    
                                        
                        
                    
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        Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
    
    
            
     
                                     
 
                                    
                                                                    
                                    
                                        
    
    
    
        Osteosarcoma (OS) is the most common bone tumor in pediatric and adolescent/young adult patients. Over the past three decades, significant improvements in the survival rates or therapeutic ap...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their preva...
    
    
            
     
                                     
                                    
                                                                    
                                    
                                        
    
    
    
        The introduction of robot-assisted surgical technology into urological practice, has introduced new horizons for reducing the morbidity and enhancing the efficacy of surgery. Open radical cys...