Gene Expression: the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA. The process of gene expression is used by all known life-eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses-to generate the macromolecular machinery for life.
Training in your own institution or corporation can be challenging in trying to meet the goals of the program and the needs of the researchers. If you are challenged with training visiting in...
All personnel involved in an animal care and use program are expected to have an appropriate level of education, training and/or qualifications to perform their duties as defined through laws...
Rabbits are commonly used in biomedical research for many years due to its ease of use and phylogenetical similarities with humans. They are commonly used in cardiovascular research (atherosc...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scien...
Nonhuman primates are commonly used in biomedical research due to its anatomical, behavioral, and genetic similarities with humans. Macaques, especially the Rhesus macaque (Macaca mulatta) ar...
GOAL:"A simple and reliable method for mouse intubation" is designed as an instructional tutorial with learning objectives that are twofold. First is becoming familiar with the procedure an...
In the laboratory setting, rats are commonly housed in clear caging in brightly lit rooms. As their natural history suggests a preference for low-light conditions, this practice is likely str...
Environmental enrichment can be defined as altering the living environment of captive animals in order to provide opportunities to express more of their natural behavioral repertoire. The cha...
Public concerns over animal experimentation are becoming felt on both sides of the Atlantic, and a dangerous chasm is appearing between those who conduct such experiments and those who are o...
The city of Valdivia is located in Chile, South America, 841 km south of its capital city Santiago. I moved to Valdivia early in 2004 to participate in the development of a new animal facilit...
The primary goal of all gnotobiotic facilities is to maintain a germ-free colony until such time as protocols require associations with other organisms. As such, a well-trained and knowledgea...
Contract Research Organizations present unique challenges in the field of environmental enrichment for laboratory animals. CRO's are service oriented and budget conscious, with large animal p...
The 8th Edition of the Guide for the Care and Use of Laboratory Animals (Guide NRC, 2011) has been in use since 2011. What changes has it brought? What are the impacts of those changes? The g...
Simplifying Rodent Surgery... Tips for improving technique without incurring unreasonable costs Good science is greatly dependent on minimization of study variables. Surgery has the potential...
This presentation will discuss the properties of beddings on the market today and why the use of bedding alone does not promote thermoregulation. Topics included will be the importance of bed...
The NCI's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) is a comprehensive genomic characterization initiative to determine the molecular changes that drive th...
Prostate cancer epithelial cells depend on androgens for their survival. Because of this dependence, androgen deprivation therapy is the major treatment of advanced prostate cancer. Such ther...
DNASTAR offers an integrated suite of software for assembling and analyzing data from all major next-generation sequencing platforms. The software supports a variety of reference guided and d...
RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
The remarkable diversity we see between different cell types in the human body is governed by the specificity attained through transcriptional and epigenetic regulatory programs. Cancer is a...
While androgen deprivation therapy (ADT) remains the primary treatment modality for patients with metastatic prostate cancer (PCa), treatment is uniformly marked by progression to castration-...
Cancer cells have historically been classified by microscopic analysis of blood smears and tissue sections. Current technologies use molecular techniques to categorize and classify tumor cell...
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
Training in your own institution or corporation can be challenging in trying to meet the goals of the program and the needs of the researchers. If you are challenged with training visiting in...
All personnel involved in an animal care and use program are expected to have an appropriate level of education, training and/or qualifications to perform their duties as defined through laws...
Rabbits are commonly used in biomedical research for many years due to its ease of use and phylogenetical similarities with humans. They are commonly used in cardiovascular research (atherosc...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scien...
Nonhuman primates are commonly used in biomedical research due to its anatomical, behavioral, and genetic similarities with humans. Macaques, especially the Rhesus macaque (Macaca mulatta) ar...
GOAL:"A simple and reliable method for mouse intubation" is designed as an instructional tutorial with learning objectives that are twofold. First is becoming familiar with the procedure an...
In the laboratory setting, rats are commonly housed in clear caging in brightly lit rooms. As their natural history suggests a preference for low-light conditions, this practice is likely str...
Environmental enrichment can be defined as altering the living environment of captive animals in order to provide opportunities to express more of their natural behavioral repertoire. The cha...
Public concerns over animal experimentation are becoming felt on both sides of the Atlantic, and a dangerous chasm is appearing between those who conduct such experiments and those who are o...
The city of Valdivia is located in Chile, South America, 841 km south of its capital city Santiago. I moved to Valdivia early in 2004 to participate in the development of a new animal facilit...
The primary goal of all gnotobiotic facilities is to maintain a germ-free colony until such time as protocols require associations with other organisms. As such, a well-trained and knowledgea...
Contract Research Organizations present unique challenges in the field of environmental enrichment for laboratory animals. CRO's are service oriented and budget conscious, with large animal p...
The 8th Edition of the Guide for the Care and Use of Laboratory Animals (Guide NRC, 2011) has been in use since 2011. What changes has it brought? What are the impacts of those changes? The g...
Simplifying Rodent Surgery... Tips for improving technique without incurring unreasonable costs Good science is greatly dependent on minimization of study variables. Surgery has the potential...
This presentation will discuss the properties of beddings on the market today and why the use of bedding alone does not promote thermoregulation. Topics included will be the importance of bed...
The NCI's Therapeutically Applicable Research to Generate Effective Treatments (TARGET) is a comprehensive genomic characterization initiative to determine the molecular changes that drive th...
Prostate cancer epithelial cells depend on androgens for their survival. Because of this dependence, androgen deprivation therapy is the major treatment of advanced prostate cancer. Such ther...
DNASTAR offers an integrated suite of software for assembling and analyzing data from all major next-generation sequencing platforms. The software supports a variety of reference guided and d...
RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
The remarkable diversity we see between different cell types in the human body is governed by the specificity attained through transcriptional and epigenetic regulatory programs. Cancer is a...
While androgen deprivation therapy (ADT) remains the primary treatment modality for patients with metastatic prostate cancer (PCa), treatment is uniformly marked by progression to castration-...
Cancer cells have historically been classified by microscopic analysis of blood smears and tissue sections. Current technologies use molecular techniques to categorize and classify tumor cell...
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
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