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    Follow

    Gene Silencing

    Gene Silencing: describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and RNAi. Methods to silence genes are exploited by researchers to study gene function, and for the development of therapeutics for diseases including cancer, infectious diseases and neurodegenerative disorders.

    Trending News

    • MAR 24, 2016
      Cancer
      The Molecular 'Switch' that Suppresses Cancer Metastasis
      The Molecular 'Switch' that Suppresses Cancer Metastasis
      About 90% of cancer-related deaths are attributed to metastasis, events where cancer migrates from its original source o ...
      Written By: Xuan Pham
      4
      MAR 23, 2016
      Cancer
      New Drug Duo Effective Against Childhood Brain Cancer
      New Drug Duo Effective Against Childhood Brain Cancer
      In a large drug screening trial, scientists identified a unique drug combination that is effective against the most aggr ...
      Written By: Xuan Pham
      4
      MAR 14, 2016
      Immunology
      Defining the Role of Tumor Necrosis Factor During Chronic Viral Infections
      Defining the Role of Tumor Necrosis Factor During Chronic Viral Infections
      New research from a collaboration between the University of Bonn, University of Cologne, and the Technical University of ...
      Written By: Kara Marker
      5
      MAR 11, 2016
      Genetics & Genomics
      Improved CRISPR System Reads Induced Pluripotent Stem Cell Genome For the First Time
      Improved CRISPR System Reads Induced Pluripotent Stem Cell Genome For the First Time
      With an enhanced form of the CRISPR-Cas9 system, scientists were able to read the genome of induced pluripotent stem cel ...
      Written By: Kara Marker
      5
      FEB 08, 2016
      Clinical & Molecular DX
      New DNA Hypermethylation Signature Found in 5 Types of Cancers
      New DNA Hypermethylation Signature Found in 5 Types of Cancers
      According to researchers from the National Institute of Health (NIH), a simple blood test may soon be able to detect fiv ...
      Written By: Xuan Pham
      4
      JAN 17, 2016
      Microbiology
      Host microRNAs Shape the Microbiome
      Host microRNAs Shape the Microbiome
      Researchers at Brigham and Women’s Hospital and Harvard Medical School identified a new mechanism that mammals use ...
      Written By: Kerry Evans
      4
      DEC 11, 2015
      Clinical & Molecular DX
      Triple microRNA Helix Shrinks Aggressive Tumors
      Triple microRNA Helix Shrinks Aggressive Tumors
      Since their discovery in the early 1990s and 2000s, micro RNAs (miRNAs) have been implicated in a variety of human condi ...
      Written By: Xuan Pham
      2
      NOV 22, 2015
      Cell & Molecular Biology
      Advanced Molecular Diagnostics for Microvillus Inclusion Disease
      Advanced Molecular Diagnostics for Microvillus Inclusion Disease
      Microvillus inclusion disease (MVID) is a cause of chronic watery diarrhea that is attributed to a lack of nutrient abso ...
      Written By: Sarah Hertrich
      1
      NOV 21, 2015
      Clinical & Molecular DX
      CRISPR/Cas9 Gene Editing in Pigs to Solve Organ Shortage?
      CRISPR/Cas9 Gene Editing in Pigs to Solve Organ Shortage?
      The United Network for Organ Sharing (UNOS) tabulated that 122,563 people currently are in need of a lifesaving organ tr ...
      Written By: Xuan Pham
      1
      NOV 16, 2015
      Cell & Molecular Biology
      The Influence of Micro-RNAs on Physical Characteristics of Animals
      The Influence of Micro-RNAs on Physical Characteristics of Animals
      The genomes of humans and animals are much more complex than scientists originally thought. In addition to DNA and RNA, ...
      Written By: Sarah Hertrich
      3 1
      OCT 26, 2015
      Microbiology
      Potential Dengue Vaccine Target
      Potential Dengue Vaccine Target
      Researchers at the University of South Carolina School of Medicine and the Central Michigan University College of Medici ...
      Written By: Kerry Evans
      1
      OCT 16, 2015
      Microbiology
      A Cure for Ebola?
      A Cure for Ebola?
      This isn’t the first time I’ve written about Ebola (and it probably won’t be the last).  Recently ...
      Written By: Kerry Evans
      1
      SEP 30, 2015
      Cell & Molecular Biology
      Plant Parasites Mimic Plant Hormones to Cause Disease
      Plant Parasites Mimic Plant Hormones to Cause Disease
      Plant parasitic nematodes, such as the well-known root-knot nematode and the cyst nematode, invade plant roots near the ...
      Written By: Sarah Hertrich
      2
      SEP 28, 2015
      Genetics & Genomics
      Cancer Drugs Lead Gene Therapy Pipeline
      Cancer Drugs Lead Gene Therapy Pipeline
      In spite of the fact that few products have reached the market and captured strong revenues thus far, the gene therapy p ...
      Written By: Ilene Schneider
      2
      SEP 25, 2015
      Genetics & Genomics
      Immunity by Manipulating Genes
      Immunity by Manipulating Genes
      To protect people from infectious disease, clinicians can target pathogens and parasites with medicines such as antibiot ...
      Written By: Ilene Schneider
      2
      AUG 08, 2015
      Neuroscience
      Bench to Bedside
      Bench to Bedside
      Researchers Amber Southwell, Michael Hayden and Blair Leavitt at the University of British Columbia Centre for Molecular ...
      Written By: Ilene Schneider
      2
      JUL 08, 2015
      Genetics & Genomics
      Gene Therapy and the Restoration of Hearing
      Gene Therapy and the Restoration of Hearing
      A group of scientists at Harvard University have recently seen success in restoring hearing in deaf mice. The key: repla ...
      Written By: Kara Marker
      5 1
      MAY 14, 2015
      Genetics & Genomics
      Long Non-Coding RNAs Steer Bodily Functions
      Long Non-Coding RNAs Steer Bodily Functions
      Understanding the function of certain groups of non-coding RNAs will lead to a greater understanding of how certain illn ...
      Written By: Ilene Schneider
      8 3
      APR 27, 2015
      Cell & Molecular Biology
      Observe How an RNA Gene Silences an Entire Chromosome
      Observe How an RNA Gene Silences an Entire Chromosome
      Caltech researchers have found how an abundant class of RNA genes-called long non-coding RNAs (lncRNAs, pronounced link ...
      Written By: Judy O'Rourke
      3
      APR 22, 2015
      Genetics & Genomics
      Steering the epigenome to turn on specific genes
      Steering the epigenome to turn on specific genes
      Could the epigenome provide a new avenue for gene therapies and guiding stem cell differentiation?

      Written By: Robert Woodard
      5
      APR 14, 2015
      Cancer
      Central Signaling Pathway in Lymphoma Blocked Successfully
      Central Signaling Pathway in Lymphoma Blocked Successfully
      Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant ...
      Written By: Ilene Schneider
      4
      APR 06, 2015
      Cancer
      Cancer Genes Turned Off in Deadly Brain Cancer
      Cancer Genes Turned Off in Deadly Brain Cancer
      Northwestern Medicine scientists have identified a small RNA molecule called miR-182 that can suppress cancer-causing ge ...
      Written By: Ilene Schneider
      7 1
      MAR 20, 2015
      Cancer
      World-First Cancer Drugs Could Work in Larger Group of Patients
      World-First Cancer Drugs Could Work in Larger Group of Patients
      A pioneering class of drugs that target cancers with mutations in the BRCA breast cancer genes could also work against t ...
      Written By: Ilene Schneider
      7
      MAR 11, 2015
      Cell & Molecular Biology
      Roadblock in Mapping the Human Connectome
      Roadblock in Mapping the Human Connectome
      The human connectome can be described as a map of the millions of connections between all of the neurons in the brain. M ...
      Written By: Brenda Kelley Kim
      7
    MAR 24, 2016
    Cancer
    The Molecular 'Switch' that Suppresses Cancer Metastasis
    The Molecular 'Switch' that Suppresses Cancer Metastasis
    About 90% of cancer-related deaths are attributed to metastasis, events where cancer migrates from its original source o ...
    Written By: Xuan Pham
    4
    MAR 23, 2016
    Cancer
    New Drug Duo Effective Against Childhood Brain Cancer
    New Drug Duo Effective Against Childhood Brain Cancer
    In a large drug screening trial, scientists identified a unique drug combination that is effective against the most aggr ...
    Written By: Xuan Pham
    4
    MAR 14, 2016
    Immunology
    Defining the Role of Tumor Necrosis Factor During Chronic Viral Infections
    Defining the Role of Tumor Necrosis Factor During Chronic Viral Infections
    New research from a collaboration between the University of Bonn, University of Cologne, and the Technical University of ...
    Written By: Kara Marker
    5
    MAR 11, 2016
    Genetics & Genomics
    Improved CRISPR System Reads Induced Pluripotent Stem Cell Genome For the First Time
    Improved CRISPR System Reads Induced Pluripotent Stem Cell Genome For the First Time
    With an enhanced form of the CRISPR-Cas9 system, scientists were able to read the genome of induced pluripotent stem cel ...
    Written By: Kara Marker
    5
    FEB 08, 2016
    Clinical & Molecular DX
    New DNA Hypermethylation Signature Found in 5 Types of Cancers
    New DNA Hypermethylation Signature Found in 5 Types of Cancers
    According to researchers from the National Institute of Health (NIH), a simple blood test may soon be able to detect fiv ...
    Written By: Xuan Pham
    4
     
     
  • JAN 17, 2016
    Microbiology
    Host microRNAs Shape the Microbiome
    Host microRNAs Shape the Microbiome
    Researchers at Brigham and Women’s Hospital and Harvard Medical School identified a new mechanism that mammals use ...
    Written By: Kerry Evans
    4
    DEC 11, 2015
    Clinical & Molecular DX
    Triple microRNA Helix Shrinks Aggressive Tumors
    Triple microRNA Helix Shrinks Aggressive Tumors
    Since their discovery in the early 1990s and 2000s, micro RNAs (miRNAs) have been implicated in a variety of human condi ...
    Written By: Xuan Pham
    2
    NOV 22, 2015
    Cell & Molecular Biology
    Advanced Molecular Diagnostics for Microvillus Inclusion Disease
    Advanced Molecular Diagnostics for Microvillus Inclusion Disease
    Microvillus inclusion disease (MVID) is a cause of chronic watery diarrhea that is attributed to a lack of nutrient abso ...
    Written By: Sarah Hertrich
    1
    NOV 21, 2015
    Clinical & Molecular DX
    CRISPR/Cas9 Gene Editing in Pigs to Solve Organ Shortage?
    CRISPR/Cas9 Gene Editing in Pigs to Solve Organ Shortage?
    The United Network for Organ Sharing (UNOS) tabulated that 122,563 people currently are in need of a lifesaving organ tr ...
    Written By: Xuan Pham
    1
    NOV 16, 2015
    Cell & Molecular Biology
    The Influence of Micro-RNAs on Physical Characteristics of Animals
    The Influence of Micro-RNAs on Physical Characteristics of Animals
    The genomes of humans and animals are much more complex than scientists originally thought. In addition to DNA and RNA, ...
    Written By: Sarah Hertrich
    3 1
     
     
  • OCT 26, 2015
    Microbiology
    Potential Dengue Vaccine Target
    Potential Dengue Vaccine Target
    Researchers at the University of South Carolina School of Medicine and the Central Michigan University College of Medici ...
    Written By: Kerry Evans
    1
    OCT 16, 2015
    Microbiology
    A Cure for Ebola?
    A Cure for Ebola?
    This isn’t the first time I’ve written about Ebola (and it probably won’t be the last).  Recently ...
    Written By: Kerry Evans
    1
    SEP 30, 2015
    Cell & Molecular Biology
    Plant Parasites Mimic Plant Hormones to Cause Disease
    Plant Parasites Mimic Plant Hormones to Cause Disease
    Plant parasitic nematodes, such as the well-known root-knot nematode and the cyst nematode, invade plant roots near the ...
    Written By: Sarah Hertrich
    2
    SEP 28, 2015
    Genetics & Genomics
    Cancer Drugs Lead Gene Therapy Pipeline
    Cancer Drugs Lead Gene Therapy Pipeline
    In spite of the fact that few products have reached the market and captured strong revenues thus far, the gene therapy p ...
    Written By: Ilene Schneider
    2
    SEP 25, 2015
    Genetics & Genomics
    Immunity by Manipulating Genes
    Immunity by Manipulating Genes
    To protect people from infectious disease, clinicians can target pathogens and parasites with medicines such as antibiot ...
    Written By: Ilene Schneider
    2
     
     
  • AUG 08, 2015
    Neuroscience
    Bench to Bedside
    Bench to Bedside
    Researchers Amber Southwell, Michael Hayden and Blair Leavitt at the University of British Columbia Centre for Molecular ...
    Written By: Ilene Schneider
    2
    JUL 08, 2015
    Genetics & Genomics
    Gene Therapy and the Restoration of Hearing
    Gene Therapy and the Restoration of Hearing
    A group of scientists at Harvard University have recently seen success in restoring hearing in deaf mice. The key: repla ...
    Written By: Kara Marker
    5 1
    MAY 14, 2015
    Genetics & Genomics
    Long Non-Coding RNAs Steer Bodily Functions
    Long Non-Coding RNAs Steer Bodily Functions
    Understanding the function of certain groups of non-coding RNAs will lead to a greater understanding of how certain illn ...
    Written By: Ilene Schneider
    8 3
    APR 27, 2015
    Cell & Molecular Biology
    Observe How an RNA Gene Silences an Entire Chromosome
    Observe How an RNA Gene Silences an Entire Chromosome
    Caltech researchers have found how an abundant class of RNA genes-called long non-coding RNAs (lncRNAs, pronounced link ...
    Written By: Judy O'Rourke
    3
    APR 22, 2015
    Genetics & Genomics
    Steering the epigenome to turn on specific genes
    Steering the epigenome to turn on specific genes
    Could the epigenome provide a new avenue for gene therapies and guiding stem cell differentiation?

    Written By: Robert Woodard
    5
     
     
  • APR 14, 2015
    Cancer
    Central Signaling Pathway in Lymphoma Blocked Successfully
    Central Signaling Pathway in Lymphoma Blocked Successfully
    Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant ...
    Written By: Ilene Schneider
    4
    APR 06, 2015
    Cancer
    Cancer Genes Turned Off in Deadly Brain Cancer
    Cancer Genes Turned Off in Deadly Brain Cancer
    Northwestern Medicine scientists have identified a small RNA molecule called miR-182 that can suppress cancer-causing ge ...
    Written By: Ilene Schneider
    7 1
    MAR 20, 2015
    Cancer
    World-First Cancer Drugs Could Work in Larger Group of Patients
    World-First Cancer Drugs Could Work in Larger Group of Patients
    A pioneering class of drugs that target cancers with mutations in the BRCA breast cancer genes could also work against t ...
    Written By: Ilene Schneider
    7
    MAR 11, 2015
    Cell & Molecular Biology
    Roadblock in Mapping the Human Connectome
    Roadblock in Mapping the Human Connectome
    The human connectome can be described as a map of the millions of connections between all of the neurons in the brain. M ...
    Written By: Brenda Kelley Kim
    7
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