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    Gene Silencing

    Gene Silencing: describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and RNAi. Methods to silence genes are exploited by researchers to study gene function, and for the development of therapeutics for diseases including cancer, infectious diseases and neurodegenerative disorders.

    Trending News

    • JAN 25, 2017
      Cell & Molecular Biology
      Partnering MicroRNAs & Targets in a Molecular Dance
      Partnering MicroRNAs & Targets in a Molecular Dance
      In every cell, the right genes have to be turned on or off and carefully controlled in order to carry out cellular funct ...
      Written By: Carmen Leitch
      2
      JAN 17, 2017
      Genetics & Genomics
      Epigenetics Initiate Pancreatic Cancer Metastasis
      Epigenetics Initiate Pancreatic Cancer Metastasis
      epigenetics initiates pancreatic cancer metastasis
      Written By: Jennifer Ellis
      2 1
      JAN 07, 2017
      Cancer
      How a Native Indian Pepper Suppresses Cancer
      How a Native Indian Pepper Suppresses Cancer
      Peppers are in the spotlight again this week as scientists reveal the biological mechanism behind the anticancer effects ...
      Written By: Xuan Pham
      4 1
      DEC 20, 2016
      Immunology
      T Cells Pushed Into Hyperdrive to Fight Viruses
      T Cells Pushed Into Hyperdrive to Fight Viruses
      As part of the immune response, T cells react differently to an acute infection versus a chronic infection, and this dif ...
      Written By: Kara Marker
      4
      DEC 19, 2016
      Cell & Molecular Biology
      "Junk" RNA has a Functional Role in Cell Stress Response
      "Junk" RNA has a Functional Role in Cell Stress Response
      There are vast swaths of genomic regions that don't code for protein, once nicknamed and thought of as junk DNA and RNA. ...
      Written By: Carmen Leitch
      1
      DEC 17, 2016
      Cell & Molecular Biology
      New Insight Into X Chromosome Inactivation in Humans
      New Insight Into X Chromosome Inactivation in Humans
      Females carry two X chromosomes, and the genes of one of those chromosomes cannot be expressed during development or myr ...
      Written By: Carmen Leitch
      2
      NOV 08, 2016
      Cell & Molecular Biology
      Algorithm Created to Engineer Cellular Behavior
      Algorithm Created to Engineer Cellular Behavior
      Engineers and scientists have long been trying to use cells to manufacture molecules that humans need, like biofuel or m ...
      Written By: Carmen Leitch
      2
      NOV 03, 2016
      Cardiology
      Nuclear Dysfunction at the Center of Heart Disease and Leukemia
      Nuclear Dysfunction at the Center of Heart Disease and Leukemia
      Risk factors leading to cardiovascular disease are often thought to be obesity, a sedentary lifestyle, and environmental ...
      Written By: Kara Marker
      3
      NOV 01, 2016
      Cardiology
      New Drug Targets for Atherosclerosis Limit Macrophage Activation
      New Drug Targets for Atherosclerosis Limit Macrophage Activation
      Two interactive proteins were discovered in connection to atherosclerosis-related macrophage activation, according to a ...
      Written By: Kara Marker
      4
      OCT 21, 2016
      Cell & Molecular Biology
      Direct Inheritance of Gene-silencing dsRNA Observed in C. elegans
      Direct Inheritance of Gene-silencing dsRNA Observed in C. elegans
      Epigenetics - the study of how genetic modifications, instead of the genetic code itself, affects the expression of gene ...
      Written By: Carmen Leitch
      2 2
      OCT 18, 2016
      Immunology
      Transcriptional Repressor Responsible for B Lymphocyte Identity
      Transcriptional Repressor Responsible for B Lymphocyte Identity
      Since the 1960s, scientists have studied the antibody production and cell-mediated immune response duties of B lymphocyt ...
      Written By: Kara Marker
      3
      OCT 03, 2016
      Cell & Molecular Biology
      Genomic Imprinting Does not Stay Stable Over Time
      Genomic Imprinting Does not Stay Stable Over Time
      To put it simply, organisms inherit a copy of each gene from each parent. For a small group of genes, roughly one hundre ...
      Written By: Carmen Leitch
      2
      SEP 30, 2016
      Cancer
      Gene Therapy with MicroRNAs Can Suppress Cancer Metastasis
      Gene Therapy with MicroRNAs Can Suppress Cancer Metastasis
      Tiny non-coding RNA molecules are now being marshaled against breast cancer. In a recent report, scientists at the Massa ...
      Written By: Xuan Pham
      3 1
      SEP 12, 2016
      Genetics & Genomics
      Crossing the ‘Valley of Death': Gene Therapy is on Its Way to Curing Sickle Cell Disease
      Crossing the ‘Valley of Death': Gene Therapy is on Its Way to Curing Sickle Cell Disease
      Dana Farber/Boston Children's has been able to selectively silence a gene, BCL11A, found in 2008 to be an integral part ...
      Written By: Jennifer Ellis
      4
      SEP 08, 2016
      Cell & Molecular Biology
      High Levels of Estrogen in utero may Cause Tamoxifen Resistance
      High Levels of Estrogen in utero may Cause Tamoxifen Resistance
      Stuff in our world is made up of matter, composed of atoms, which means that everything is basically a chemical. But som ...
      Written By: Carmen Leitch
      3
      AUG 22, 2016
      Cell & Molecular Biology
      Dormant Ovules Awakened by Molecular Clock
      Dormant Ovules Awakened by Molecular Clock
      Egg cells, or ovules in animals, remain dormant for many years after the start of reproductive age, and that is one reas ...
      Written By: Carmen Leitch
      2
      JUL 27, 2016
      Health & Medicine
      Is Asthma More Of A Genetic Disease Than An Inflammatory Disease?
      Is Asthma More Of A Genetic Disease Than An Inflammatory Disease?
      Is ADAM to blame for the prevalence of asthma? Maybe, but it’s the gene and not the man. In a new study from the U ...
      Written By: Kara Marker
      4
      JUL 27, 2016
      Cancer
      Scientists Create Triple-Lethal Patch to Annihilate Cancer
      Scientists Create Triple-Lethal Patch to Annihilate Cancer
      Recent research estimate that tumors receive less than 1 percent of the nanomedicine that’s delivered systemically ...
      Written By: Xuan Pham
      4
      JUL 22, 2016
      Genetics & Genomics
      Sporadic Bursts of Gene Activity Are Vital for Regulation
      Sporadic Bursts of Gene Activity Are Vital for Regulation
      Geneticists are constantly discovering new ways the genes are expressed, silenced, and altered in other ways. A new stud ...
      Written By: Kara Marker
      5
      JUL 19, 2016
      Cell & Molecular Biology
      Researchers Reveal Functions of an Inactive Chromosome
      Researchers Reveal Functions of an Inactive Chromosome
      In a report published in the Proceedings of the National Academy of Sciences, researchers working at Florida State Unive ...
      Written By: Carmen Leitch
      5
      JUL 14, 2016
      Genetics & Genomics
      DNA Collision Report: Mutagenesis in the Promoter
      DNA Collision Report: Mutagenesis in the Promoter
      Replication, transcription, and translation, the pedestals of genetics, occur in synchrony. The unique machinery of each ...
      Written By: Kara Marker
      4
      JUN 03, 2016
      Genetics & Genomics
      For the First Time: CRISPR for RNA
      For the First Time: CRISPR for RNA
      For the first time since 2007 when scientists were just beginning to understand the DNA manipulation capabilities of CRI ...
      Written By: Kara Marker
      4 3
      MAY 13, 2016
      Cancer
      Mobile DNA Linked to Colon Cancer
      Mobile DNA Linked to Colon Cancer
      It may come as a surprise to some people to know that some genes are capable of moving around in our genome. Scientists ...
      Written By: Xuan Pham
      4 2
      MAR 27, 2016
      Clinical & Molecular DX
      MicroRNA Point to New Targets For Diabetes Treatment
      MicroRNA Point to New Targets For Diabetes Treatment
      Since their discovery in the early 1990s and 2000s, micro-RNAs (miRNAs) have been implicated in a variety of human condi ...
      Written By: Xuan Pham
      3
    JAN 25, 2017
    Cell & Molecular Biology
    Partnering MicroRNAs & Targets in a Molecular Dance
    Partnering MicroRNAs & Targets in a Molecular Dance
    In every cell, the right genes have to be turned on or off and carefully controlled in order to carry out cellular funct ...
    Written By: Carmen Leitch
    2
    JAN 17, 2017
    Genetics & Genomics
    Epigenetics Initiate Pancreatic Cancer Metastasis
    Epigenetics Initiate Pancreatic Cancer Metastasis
    epigenetics initiates pancreatic cancer metastasis
    Written By: Jennifer Ellis
    2 1
    JAN 07, 2017
    Cancer
    How a Native Indian Pepper Suppresses Cancer
    How a Native Indian Pepper Suppresses Cancer
    Peppers are in the spotlight again this week as scientists reveal the biological mechanism behind the anticancer effects ...
    Written By: Xuan Pham
    4 1
    DEC 20, 2016
    Immunology
    T Cells Pushed Into Hyperdrive to Fight Viruses
    T Cells Pushed Into Hyperdrive to Fight Viruses
    As part of the immune response, T cells react differently to an acute infection versus a chronic infection, and this dif ...
    Written By: Kara Marker
    4
    DEC 19, 2016
    Cell & Molecular Biology
    "Junk" RNA has a Functional Role in Cell Stress Response
    "Junk" RNA has a Functional Role in Cell Stress Response
    There are vast swaths of genomic regions that don't code for protein, once nicknamed and thought of as junk DNA and RNA. ...
    Written By: Carmen Leitch
    1
     
     
  • DEC 17, 2016
    Cell & Molecular Biology
    New Insight Into X Chromosome Inactivation in Humans
    New Insight Into X Chromosome Inactivation in Humans
    Females carry two X chromosomes, and the genes of one of those chromosomes cannot be expressed during development or myr ...
    Written By: Carmen Leitch
    2
    NOV 08, 2016
    Cell & Molecular Biology
    Algorithm Created to Engineer Cellular Behavior
    Algorithm Created to Engineer Cellular Behavior
    Engineers and scientists have long been trying to use cells to manufacture molecules that humans need, like biofuel or m ...
    Written By: Carmen Leitch
    2
    NOV 03, 2016
    Cardiology
    Nuclear Dysfunction at the Center of Heart Disease and Leukemia
    Nuclear Dysfunction at the Center of Heart Disease and Leukemia
    Risk factors leading to cardiovascular disease are often thought to be obesity, a sedentary lifestyle, and environmental ...
    Written By: Kara Marker
    3
    NOV 01, 2016
    Cardiology
    New Drug Targets for Atherosclerosis Limit Macrophage Activation
    New Drug Targets for Atherosclerosis Limit Macrophage Activation
    Two interactive proteins were discovered in connection to atherosclerosis-related macrophage activation, according to a ...
    Written By: Kara Marker
    4
    OCT 21, 2016
    Cell & Molecular Biology
    Direct Inheritance of Gene-silencing dsRNA Observed in C. elegans
    Direct Inheritance of Gene-silencing dsRNA Observed in C. elegans
    Epigenetics - the study of how genetic modifications, instead of the genetic code itself, affects the expression of gene ...
    Written By: Carmen Leitch
    2 2
     
     
  • OCT 18, 2016
    Immunology
    Transcriptional Repressor Responsible for B Lymphocyte Identity
    Transcriptional Repressor Responsible for B Lymphocyte Identity
    Since the 1960s, scientists have studied the antibody production and cell-mediated immune response duties of B lymphocyt ...
    Written By: Kara Marker
    3
    OCT 03, 2016
    Cell & Molecular Biology
    Genomic Imprinting Does not Stay Stable Over Time
    Genomic Imprinting Does not Stay Stable Over Time
    To put it simply, organisms inherit a copy of each gene from each parent. For a small group of genes, roughly one hundre ...
    Written By: Carmen Leitch
    2
    SEP 30, 2016
    Cancer
    Gene Therapy with MicroRNAs Can Suppress Cancer Metastasis
    Gene Therapy with MicroRNAs Can Suppress Cancer Metastasis
    Tiny non-coding RNA molecules are now being marshaled against breast cancer. In a recent report, scientists at the Massa ...
    Written By: Xuan Pham
    3 1
    SEP 12, 2016
    Genetics & Genomics
    Crossing the ‘Valley of Death': Gene Therapy is on Its Way to Curing Sickle Cell Disease
    Crossing the ‘Valley of Death': Gene Therapy is on Its Way to Curing Sickle Cell Disease
    Dana Farber/Boston Children's has been able to selectively silence a gene, BCL11A, found in 2008 to be an integral part ...
    Written By: Jennifer Ellis
    4
    SEP 08, 2016
    Cell & Molecular Biology
    High Levels of Estrogen in utero may Cause Tamoxifen Resistance
    High Levels of Estrogen in utero may Cause Tamoxifen Resistance
    Stuff in our world is made up of matter, composed of atoms, which means that everything is basically a chemical. But som ...
    Written By: Carmen Leitch
    3
     
     
  • AUG 22, 2016
    Cell & Molecular Biology
    Dormant Ovules Awakened by Molecular Clock
    Dormant Ovules Awakened by Molecular Clock
    Egg cells, or ovules in animals, remain dormant for many years after the start of reproductive age, and that is one reas ...
    Written By: Carmen Leitch
    2
    JUL 27, 2016
    Health & Medicine
    Is Asthma More Of A Genetic Disease Than An Inflammatory Disease?
    Is Asthma More Of A Genetic Disease Than An Inflammatory Disease?
    Is ADAM to blame for the prevalence of asthma? Maybe, but it’s the gene and not the man. In a new study from the U ...
    Written By: Kara Marker
    4
    JUL 27, 2016
    Cancer
    Scientists Create Triple-Lethal Patch to Annihilate Cancer
    Scientists Create Triple-Lethal Patch to Annihilate Cancer
    Recent research estimate that tumors receive less than 1 percent of the nanomedicine that’s delivered systemically ...
    Written By: Xuan Pham
    4
    JUL 22, 2016
    Genetics & Genomics
    Sporadic Bursts of Gene Activity Are Vital for Regulation
    Sporadic Bursts of Gene Activity Are Vital for Regulation
    Geneticists are constantly discovering new ways the genes are expressed, silenced, and altered in other ways. A new stud ...
    Written By: Kara Marker
    5
    JUL 19, 2016
    Cell & Molecular Biology
    Researchers Reveal Functions of an Inactive Chromosome
    Researchers Reveal Functions of an Inactive Chromosome
    In a report published in the Proceedings of the National Academy of Sciences, researchers working at Florida State Unive ...
    Written By: Carmen Leitch
    5
     
     
  • JUL 14, 2016
    Genetics & Genomics
    DNA Collision Report: Mutagenesis in the Promoter
    DNA Collision Report: Mutagenesis in the Promoter
    Replication, transcription, and translation, the pedestals of genetics, occur in synchrony. The unique machinery of each ...
    Written By: Kara Marker
    4
    JUN 03, 2016
    Genetics & Genomics
    For the First Time: CRISPR for RNA
    For the First Time: CRISPR for RNA
    For the first time since 2007 when scientists were just beginning to understand the DNA manipulation capabilities of CRI ...
    Written By: Kara Marker
    4 3
    MAY 13, 2016
    Cancer
    Mobile DNA Linked to Colon Cancer
    Mobile DNA Linked to Colon Cancer
    It may come as a surprise to some people to know that some genes are capable of moving around in our genome. Scientists ...
    Written By: Xuan Pham
    4 2
    MAR 27, 2016
    Clinical & Molecular DX
    MicroRNA Point to New Targets For Diabetes Treatment
    MicroRNA Point to New Targets For Diabetes Treatment
    Since their discovery in the early 1990s and 2000s, micro-RNAs (miRNAs) have been implicated in a variety of human condi ...
    Written By: Xuan Pham
    3
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