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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
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SEP 08, 2016Health & Medicine
LA JOLLA, CA – September 8, 2016 – A series of new studies led by scientists at The Scripps Research Institu ...Written By: The Scripps Research Institute (TSRI)AUG 29, 2016Immunology
An enzyme thought to only be active in human metabolism found to play a dual role in the immune response. Thanks to this ...Written By: Kara MarkerAUG 28, 2016Cell & Molecular Biology
Glucocorticoids are steroidal hormones that signal through the glucorticoid receptor in complex ways throughout the body ...Written By: Carmen LeitchAUG 24, 2016Cell & Molecular Biology
When cells in our bodies are on the move, they often must fit into tight places and squeeze through tiny spaces before r ...Written By: Carmen LeitchAUG 16, 2016Microbiology
In a new study published in Nature, scientists describe a new protein family that are an integral part of the cell walls ...Written By: Carmen LeitchAUG 15, 2016Genetics & Genomics
LA JOLLA, CA—August 15, 2015—Scientists at The Scripps Research Institute (TSRI) have taken a big step towar ...Written By: The Scripps Research Institute (TSRI)AUG 14, 2016Microbiology
Fusobacteria are a type of bacteria that may worsen colon cancer. A new study from the Harvard T.H. Chan School of Publi ...Written By: Kerry EvansAUG 14, 2016Cell & Molecular Biology
Heat shock proteins (Hsps) are a kind of protein that are important in normal metabolic processes, and also the cellular ...Written By: Carmen LeitchAUG 08, 2016Cell & Molecular Biology
In the study of cell signaling, one well established paradigm is that receptors on the surface of cells receive input fr ...Written By: Carmen LeitchAUG 08, 2016Health & Medicine
LA JOLLA, CA – August 8, 2016 – Scientists at The Scripps Research Institute (TSRI) now have a high-resoluti ...Written By: The Scripps Research Institute (TSRI)AUG 07, 2016Microbiology
Eukaryotic cells are nicely organized - all the important bits are housed in the nucleus or associated with other organe ...Written By: Kerry EvansAUG 04, 2016Genetics & Genomics
DNA and RNA have nearly identical building blocks yet DNA seems “chosen” to be the holder of genetic informa ...Written By: Kara MarkerJUL 29, 2016Health & Medicine
A compelling new study from the Australian National University has uncovered hundreds of proteins scientists never knew ...Written By: Kara MarkerJUL 28, 2016Clinical & Molecular DX
It’s rare that a drug can be FDA-approved to treat a condition without a known mechanism behind the drug’s a ...JUL 25, 2016Genetics & Genomics
The immune cells of the brain are to thank for clearing Alzheimer’s disease-related plaques. Mutations in a certai ...Written By: Kara MarkerJUN 21, 2016Cardiology
For unknown reasons, a new study has uncovered the ability of a protein called hepatoma derived growth factor (HDGF) to ...Written By: Kara MarkerJUN 12, 2016Neuroscience
Parkinson’s disease is the second most common neurodegenerative disease, currently affecting ~ 1 million people in ...Written By: Cassidy ReichMAY 17, 2016Genetics & Genomics
Although the genetic code is famous for its double helix and not its quadruple helix, it is known to occur in other form ...Written By: Kara MarkerMAY 11, 2016Genetics & Genomics
Scientists from Michigan State University are developing a system to read the genome like normal people read a book. Lik ...Written By: Kara MarkerMAY 03, 2016Cancer
Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the mole ...Written By: The Scripps Research Institute (TSRI)APR 29, 2016Neuroscience
Binge drinking is a huge problem in the United States, with one in six adults binge drinking four times a month. Costs d ...Written By: Cassidy ReichAPR 14, 2016Neuroscience
Glutamate is the main excitatory neurotransmitter and is essential for many important processes in the brain. In accorda ...Written By: Cassidy ReichAPR 11, 2016Health & Medicine
Celiac disease is an autoimmune disorder that is directly related to a misdirected immune response to gluten, a protein ...Written By: Kara MarkerMAR 24, 2016Cancer
About 90% of cancer-related deaths are attributed to metastasis, events where cancer migrates from its original source o ...
SEP 08, 2016
Health & Medicine
LA JOLLA, CA – September 8, 2016 – A series of new studies led by scientists at The Scripps Research Institu
...
Written By:
The Scripps Research Institute (TSRI)
AUG 29, 2016
Immunology
An enzyme thought to only be active in human metabolism found to play a dual role in the immune response. Thanks to this
...
Written By:
Kara Marker
AUG 28, 2016
Cell & Molecular Biology
Glucocorticoids are steroidal hormones that signal through the glucorticoid receptor in complex ways throughout the body
...
Written By:
Carmen Leitch
AUG 24, 2016
Cell & Molecular Biology
When cells in our bodies are on the move, they often must fit into tight places and squeeze through tiny spaces before r
...
Written By:
Carmen Leitch
AUG 16, 2016
Microbiology
In a new study published in Nature, scientists describe a new protein family that are an integral part of the cell walls
...
Written By:
Carmen Leitch
AUG 15, 2016
Genetics & Genomics
LA JOLLA, CA—August 15, 2015—Scientists at The Scripps Research Institute (TSRI) have taken a big step towar
...
Written By:
The Scripps Research Institute (TSRI)
AUG 14, 2016
Microbiology
Fusobacteria are a type of bacteria that may worsen colon cancer. A new study from the Harvard T.H. Chan School of Publi
...
Written By:
Kerry Evans
AUG 14, 2016
Cell & Molecular Biology
Heat shock proteins (Hsps) are a kind of protein that are important in normal metabolic processes, and also the cellular
...
Written By:
Carmen Leitch
AUG 08, 2016
Cell & Molecular Biology
In the study of cell signaling, one well established paradigm is that receptors on the surface of cells receive input fr
...
Written By:
Carmen Leitch
AUG 08, 2016
Health & Medicine
LA JOLLA, CA – August 8, 2016 – Scientists at The Scripps Research Institute (TSRI) now have a high-resoluti
...
Written By:
The Scripps Research Institute (TSRI)
AUG 07, 2016
Microbiology
Eukaryotic cells are nicely organized - all the important bits are housed in the nucleus or associated with other organe
...
Written By:
Kerry Evans
AUG 04, 2016
Genetics & Genomics
DNA and RNA have nearly identical building blocks yet DNA seems “chosen” to be the holder of genetic informa
...
Written By:
Kara Marker
JUL 29, 2016
Health & Medicine
A compelling new study from the Australian National University has uncovered hundreds of proteins scientists never knew
...
Written By:
Kara Marker
JUL 28, 2016
Clinical & Molecular DX
It’s rare that a drug can be FDA-approved to treat a condition without a known mechanism behind the drug’s a
...
JUL 25, 2016
Genetics & Genomics
The immune cells of the brain are to thank for clearing Alzheimer’s disease-related plaques. Mutations in a certai
...
Written By:
Kara Marker
JUN 21, 2016
Cardiology
For unknown reasons, a new study has uncovered the ability of a protein called hepatoma derived growth factor (HDGF) to
...
Written By:
Kara Marker
JUN 12, 2016
Neuroscience
Parkinson’s disease is the second most common neurodegenerative disease, currently affecting ~ 1 million people in
...
Written By:
Cassidy Reich
MAY 17, 2016
Genetics & Genomics
Although the genetic code is famous for its double helix and not its quadruple helix, it is known to occur in other form
...
Written By:
Kara Marker
MAY 11, 2016
Genetics & Genomics
Scientists from Michigan State University are developing a system to read the genome like normal people read a book. Lik
...
Written By:
Kara Marker
MAY 03, 2016
Cancer
Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the mole
...
Written By:
The Scripps Research Institute (TSRI)
APR 29, 2016
Neuroscience
Binge drinking is a huge problem in the United States, with one in six adults binge drinking four times a month. Costs d
...
Written By:
Cassidy Reich
APR 14, 2016
Neuroscience
Glutamate is the main excitatory neurotransmitter and is essential for many important processes in the brain. In accorda
...
Written By:
Cassidy Reich
APR 11, 2016
Health & Medicine
Celiac disease is an autoimmune disorder that is directly related to a misdirected immune response to gluten, a protein
...
Written By:
Kara Marker
MAR 24, 2016
Cancer
About 90% of cancer-related deaths are attributed to metastasis, events where cancer migrates from its original source o
...