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    Single-Molecule

    Single-Molecule methods provide access to details of a population's characteristics that are obscured by ensemble averaging. It is a powerful method used to examine a multitude of phenomena using advanced techniques such as total internal reflection (TIRF) and superresolution imaging.

    Webinars

    • JUN 10, 2021 | 7:00 AM
      Simplify complex genetic diseases by quantifying structural and copy number variants
      Simplify complex genetic diseases by quantifying structural and...
      Date: June 10, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Discover how to categorize small-to-large genetic modifications using molecular combing. Our Proprietary Genome Morse Cod...
      Speaker: Mario Avarello, MSc
      Sponsored By: Genomic Vision
      8 1
      JUN 03, 2021 | 8:00 AM
      How molecular combing technology is transforming genomic research through visualizing DNA at the single-molecule level
      How molecular combing technology is transforming genomic research...
      Date: June 3, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Molecular combing provides unbiased quantification and characterization of DNA structure and dynamics by imaging single DN...
      Speaker: Mark Lynch
      Sponsored By: Genomic Vision
      11 1
      JUN 02, 2021 | 12:00 AM
      Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic Modulators
      Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic...
      Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
      Speaker: Dayana Rivadeneira, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      2
      SEP 23, 2020 | 10:30 AM
      Practical Mass Cytometry
      Practical Mass Cytometry
      On measuring photons and ions: Impact on panel design, signal detection and data quality 10:30–11:00 am PDT Presented By: Tim Bushnell, PhD, MBA Monitoring immunotherapy with a mass cy...
      Speaker: Tim Bushnell, PhD, MBA , Gerd Haga Bringeland, MD, PhD , Greg Hopkins, BS
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      2
      AUG 06, 2020 | 12:00 AM
      Probing (intracellular) physicochemical environments at the nanometer scale, one molecule at a time
      Probing (intracellular) physicochemical environments at the nanometer...
      Recent advances in super-resolution fluorescence microscopy based on single-molecule imaging have led to ~10 nm spatial resolution and exciting science. We are developing new approaches to a...
      Speaker: Ke Xu, PhD
      Presented at: 2020 Beckman Symposium
      1
      AUG 06, 2020 | 12:00 AM
      Heterogeneous ultrafast relaxation in photosynthetic light-harvesting proteins
      Heterogeneous ultrafast relaxation in photosynthetic light-harvesting...
      In photosynthesis, solar energy capture to conversion occurs with a remarkable near-unity quantum efficiency through energy transport across a network of chromophore-containing proteins. The...
      Speaker: Gabriela Schlau-Cohen, PhD
      Presented at: 2020 Beckman Symposium
      1
      JUL 07, 2020 | 11:00 AM
      Comprehensive landscape of the tumor microenvironment analyzed with CyTOF® technology
      Comprehensive landscape of the tumor microenvironment analyzed...
      Immune escape mechanisms such as the induction/recruitment of immunosuppressive cells and the increased expression of various immunosuppressive molecules including PD-1/PD-1 ligands are esse...
      Speaker: Hiroyoshi Nishikawa, MD, PhD
      Presented at: Fluidigm Infectious Disease and Oncology Virtual Summit
      2
      JUL 02, 2020 | 12:45 PM
      Strategies to normalize miRNA expression in serum and plasma
      Strategies to normalize miRNA expression in serum and plasma
      MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post transcriptional level. They are known to play a critical role in multiple biologi...
      Speaker: Emily Zeringer , Harita Veereshlingam, PhD
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      2
      JUN 02, 2020 | 4:30 PM
      Plenary Address
      Plenary Address
      ...
      Speaker: Plenary Keynote: Xiaowei Zhuang, PhD
      Presented at: 2020 6th annual BRAIN Initiative Investigators Virtual Meeting
      1
      MAY 19, 2020 | 11:15 AM
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
      We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
      Speaker: Alex Swarbrick, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      4
      APR 29, 2020 | 6:00 AM
      Development of xMAP based assays for food and environmental safety
      Development of xMAP based assays for food and environmental safety
      In order to emit less contaminants into the environment, and at the same time produce healthier foods that are free of those contaminants, all production systems should be investigated, i.e....
      Speaker: Jeroen Peters, MSc
      Presented at: xMAP® Connect Virtual Conference (On-Demand)
      4
      JAN 01, 2020 | 6:00 AM
      Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
      Uncovering the mechanism of stress-resistant DNA replication in...
      Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
      Speaker: Chames Kermi, PhD, PharmD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling Using Genetically Encoded Fluorescent Sensors
      Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling...
      Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
      Speaker: Shana Augustin, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      DEC 05, 2019 | 9:00 AM
      Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
      Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
      DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
      Speaker: Mathias Holpert, PhD , Traci DeGeer, BS, HT (ASCP) HTL, QIHC
      Sponsored By: Leica Biosystems, NanoString Technologies
      8
      NOV 15, 2019 | 8:00 AM
      Exosomes and super-resolution microscopy
      Exosomes and super-resolution microscopy
      DATE: November 15, 2019TIME: 8:00am PST, 11:00am EST Exosomes are small vesicles, ranging from 30-120 nanometers in diameter, secreted from cells throughout the human body. The...
      Speaker: Ryan McNamara, PhD
      Sponsored By: ONI
      8
      OCT 30, 2019 | 7:00 AM
      A Novel Approach for Single-cell Multi-omic Analysis to Identify Regulatory Signatures in Cancer
      A Novel Approach for Single-cell Multi-omic Analysis to Identify...
      DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
      Speaker: William J. Greenleaf, Ph.D
      Sponsored By: 10x Genomics
      18 1
      OCT 15, 2019 | 10:00 AM
      The 'Three Peak Challenge' for long-read, ultra-deep stool metagenomics on the PromethION
      The 'Three Peak Challenge' for long-read, ultra-deep stool metagenomics...
      DATE: October 15, 2019TIME: 10:00am PDTAdvances in Next-Generation Sequencing technologies as well as bioinformatic tools have advanced our ability to research and explore both human...
      Speaker: Josh Quick , Janina A. Krumbeck, PhD.
      Sponsored By: Zymo Research
      12
      OCT 10, 2019 | 9:00 AM
      Dynamic evolution of unstable genomes: insights from in vitro experiments and cancer genome analysis
      Dynamic evolution of unstable genomes: insights from in vitro...
      Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their preva...
      Speaker: Cheng-Zhong Zhang, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      1
      SEP 26, 2019 | 6:00 AM
      Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics and the Challenge of Low Input Samples
      Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics...
      Spatial transcriptomics methods permit gene expression from focal areas within a tissue to be profiled while maintaining the morphologic context of the tissue microenvironment. This presentat...
      Speaker: Bruce Seligmann, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      1
      SEP 24, 2019 | 9:00 AM
      Validating single-cell RNA-seq data using Single-Cell Western blotting and RNAscope® technology
      Validating single-cell RNA-seq data using Single-Cell Western...
      DATE: September 24, 2019TIME: 9:00am PDTThis webinar will cover the basics of the Milo Single-Cell Western blot (SCW) and RNAScope single-molecule fluorescence RNA In situ hybridizati...
      Speaker: Brian P. Hermann, PhD
      Sponsored By: Advanced Cell Diagnostics
      5
      SEP 11, 2019 | 1:30 PM
      Development of Machine Learning Algorithms to Data Mine Meta-Omic Characterizations of Complex Microbiota
      Development of Machine Learning Algorithms to Data Mine Meta-Omic...
      Background: The vast majority of all genes are contained within the genomes of the prokaryotes, including the eubacteria and the archaea. These largely single-cellular domains of life thus...
      Speaker: Garth Ehrlich, PhD, FAAAS
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      Sponsored By: PacBio
      4
      AUG 13, 2019 | 9:00 AM
      Nanometer-accuracy distance measurements between fluorophores at the single-molecule level
      Nanometer-accuracy distance measurements between fluorophores...
      DATE: August 13, 2019TIME: 9:00am PT, 12:00pm ET, 5:00pm BST Molecular complexes are major constituents of cells, hence unraveling their mechanisms is key to fuller comprehension of c...
      Speaker: Nico Stuurman, PhD , Marcin Barszczewski, PhD
      Sponsored By: Andor
      3
      JUL 23, 2019 | 10:00 AM
      Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
      Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
      DATE: July 23, 2019TIME: 10:00am PDTThe tumor microenvironment is a complex network of different cell types and states that imparts distinct properties to the tumor and plays a signif...
      Speaker: Doug Hinerfeld, PhD , Chris Merritt, PhD , Anushka Dikshit, PhD
      Sponsored By: Advanced Cell Diagnostics
      5
      JUN 20, 2019 | 10:30 AM
      The Massively Parallel Sequencing (MPS) Revolution
      The Massively Parallel Sequencing (MPS) Revolution
      The development of automated DNA sequencers utilizing Sanger sequencing and capillary electrophoresis made it possible to develop the first draft sequences of the human genome. The cost of do...
      Speaker: David Smith, PhD
      Presented at: Precision Medicine Virtual Event Series 2019
      1
    JUN 10, 2021 | 7:00 AM
    Simplify complex genetic diseases by quantifying structural and copy number variants
    Simplify complex genetic diseases by quantifying structural and...
    Date: June 10, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Discover how to categorize small-to-large genetic modifications using molecular combing. Our Proprietary Genome Morse Cod...
    Speaker: Mario Avarello, MSc
    Sponsored By: Genomic Vision
    8 1
    JUN 03, 2021 | 8:00 AM
    How molecular combing technology is transforming genomic research through visualizing DNA at the single-molecule level
    How molecular combing technology is transforming genomic research...
    Date: June 3, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Molecular combing provides unbiased quantification and characterization of DNA structure and dynamics by imaging single DN...
    Speaker: Mark Lynch
    Sponsored By: Genomic Vision
    11 1
    JUN 02, 2021 | 12:00 AM
    Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic Modulators
    Fueling Antitumor Immunity Using Oncolytic Viruses Encoding Metabolic...
    Despite the promising results with current approved immunotherapies, all patients do not have the same level of response, and recent efforts have focused on understanding and avoiding immuno...
    Speaker: Dayana Rivadeneira, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    2
    SEP 23, 2020 | 10:30 AM
    Practical Mass Cytometry
    Practical Mass Cytometry
    On measuring photons and ions: Impact on panel design, signal detection and data quality 10:30–11:00 am PDT Presented By: Tim Bushnell, PhD, MBA Monitoring immunotherapy with a mass cy...
    Speaker: Tim Bushnell, PhD, MBA , Gerd Haga Bringeland, MD, PhD , Greg Hopkins, BS
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    2
    AUG 06, 2020 | 12:00 AM
    Probing (intracellular) physicochemical environments at the nanometer scale, one molecule at a time
    Probing (intracellular) physicochemical environments at the nanometer...
    Recent advances in super-resolution fluorescence microscopy based on single-molecule imaging have led to ~10 nm spatial resolution and exciting science. We are developing new approaches to a...
    Speaker: Ke Xu, PhD
    Presented at: 2020 Beckman Symposium
    1
     
     
  • AUG 06, 2020 | 12:00 AM
    Heterogeneous ultrafast relaxation in photosynthetic light-harvesting proteins
    Heterogeneous ultrafast relaxation in photosynthetic light-harvesting...
    In photosynthesis, solar energy capture to conversion occurs with a remarkable near-unity quantum efficiency through energy transport across a network of chromophore-containing proteins. The...
    Speaker: Gabriela Schlau-Cohen, PhD
    Presented at: 2020 Beckman Symposium
    1
    JUL 07, 2020 | 11:00 AM
    Comprehensive landscape of the tumor microenvironment analyzed with CyTOF® technology
    Comprehensive landscape of the tumor microenvironment analyzed...
    Immune escape mechanisms such as the induction/recruitment of immunosuppressive cells and the increased expression of various immunosuppressive molecules including PD-1/PD-1 ligands are esse...
    Speaker: Hiroyoshi Nishikawa, MD, PhD
    Presented at: Fluidigm Infectious Disease and Oncology Virtual Summit
    2
    JUL 02, 2020 | 12:45 PM
    Strategies to normalize miRNA expression in serum and plasma
    Strategies to normalize miRNA expression in serum and plasma
    MicroRNA(miRNA) are short non-coding single stranded RNA molecules that regulate gene expression at the post transcriptional level. They are known to play a critical role in multiple biologi...
    Speaker: Emily Zeringer , Harita Veereshlingam, PhD
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    2
    JUN 02, 2020 | 4:30 PM
    Plenary Address
    Plenary Address
    ...
    Speaker: Plenary Keynote: Xiaowei Zhuang, PhD
    Presented at: 2020 6th annual BRAIN Initiative Investigators Virtual Meeting
    1
    MAY 19, 2020 | 11:15 AM
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
    We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
    Speaker: Alex Swarbrick, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    4
     
     
  • APR 29, 2020 | 6:00 AM
    Development of xMAP based assays for food and environmental safety
    Development of xMAP based assays for food and environmental safety
    In order to emit less contaminants into the environment, and at the same time produce healthier foods that are free of those contaminants, all production systems should be investigated, i.e....
    Speaker: Jeroen Peters, MSc
    Presented at: xMAP® Connect Virtual Conference (On-Demand)
    4
    JAN 01, 2020 | 6:00 AM
    Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
    Uncovering the mechanism of stress-resistant DNA replication in...
    Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
    Speaker: Chames Kermi, PhD, PharmD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling Using Genetically Encoded Fluorescent Sensors
    Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling...
    Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
    Speaker: Shana Augustin, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
    DEC 05, 2019 | 9:00 AM
    Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
    Morphology Driven High-Plex Spatial Analysis of Tissue Microenvironments
    DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
    Speaker: Mathias Holpert, PhD , Traci DeGeer, BS, HT (ASCP) HTL, QIHC
    Sponsored By: Leica Biosystems, NanoString Technologies
    8
    NOV 15, 2019 | 8:00 AM
    Exosomes and super-resolution microscopy
    Exosomes and super-resolution microscopy
    DATE: November 15, 2019TIME: 8:00am PST, 11:00am EST Exosomes are small vesicles, ranging from 30-120 nanometers in diameter, secreted from cells throughout the human body. The...
    Speaker: Ryan McNamara, PhD
    Sponsored By: ONI
    8
     
     
  • OCT 30, 2019 | 7:00 AM
    A Novel Approach for Single-cell Multi-omic Analysis to Identify Regulatory Signatures in Cancer
    A Novel Approach for Single-cell Multi-omic Analysis to Identify...
    DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
    Speaker: William J. Greenleaf, Ph.D
    Sponsored By: 10x Genomics
    18 1
    OCT 15, 2019 | 10:00 AM
    The 'Three Peak Challenge' for long-read, ultra-deep stool metagenomics on the PromethION
    The 'Three Peak Challenge' for long-read, ultra-deep stool metagenomics...
    DATE: October 15, 2019TIME: 10:00am PDTAdvances in Next-Generation Sequencing technologies as well as bioinformatic tools have advanced our ability to research and explore both human...
    Speaker: Josh Quick , Janina A. Krumbeck, PhD.
    Sponsored By: Zymo Research
    12
    OCT 10, 2019 | 9:00 AM
    Dynamic evolution of unstable genomes: insights from in vitro experiments and cancer genome analysis
    Dynamic evolution of unstable genomes: insights from in vitro...
    Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their preva...
    Speaker: Cheng-Zhong Zhang, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    1
    SEP 26, 2019 | 6:00 AM
    Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics and the Challenge of Low Input Samples
    Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics...
    Spatial transcriptomics methods permit gene expression from focal areas within a tissue to be profiled while maintaining the morphologic context of the tissue microenvironment. This presentat...
    Speaker: Bruce Seligmann, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    1
    SEP 24, 2019 | 9:00 AM
    Validating single-cell RNA-seq data using Single-Cell Western blotting and RNAscope® technology
    Validating single-cell RNA-seq data using Single-Cell Western...
    DATE: September 24, 2019TIME: 9:00am PDTThis webinar will cover the basics of the Milo Single-Cell Western blot (SCW) and RNAScope single-molecule fluorescence RNA In situ hybridizati...
    Speaker: Brian P. Hermann, PhD
    Sponsored By: Advanced Cell Diagnostics
    5
     
     
  • SEP 11, 2019 | 1:30 PM
    Development of Machine Learning Algorithms to Data Mine Meta-Omic Characterizations of Complex Microbiota
    Development of Machine Learning Algorithms to Data Mine Meta-Omic...
    Background: The vast majority of all genes are contained within the genomes of the prokaryotes, including the eubacteria and the archaea. These largely single-cellular domains of life thus...
    Speaker: Garth Ehrlich, PhD, FAAAS
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    Sponsored By: PacBio
    4
    AUG 13, 2019 | 9:00 AM
    Nanometer-accuracy distance measurements between fluorophores at the single-molecule level
    Nanometer-accuracy distance measurements between fluorophores...
    DATE: August 13, 2019TIME: 9:00am PT, 12:00pm ET, 5:00pm BST Molecular complexes are major constituents of cells, hence unraveling their mechanisms is key to fuller comprehension of c...
    Speaker: Nico Stuurman, PhD , Marcin Barszczewski, PhD
    Sponsored By: Andor
    3
    JUL 23, 2019 | 10:00 AM
    Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
    Molecularly Guided High Plex Spatial Profiling in the Tumor Microenvironment
    DATE: July 23, 2019TIME: 10:00am PDTThe tumor microenvironment is a complex network of different cell types and states that imparts distinct properties to the tumor and plays a signif...
    Speaker: Doug Hinerfeld, PhD , Chris Merritt, PhD , Anushka Dikshit, PhD
    Sponsored By: Advanced Cell Diagnostics
    5
    JUN 20, 2019 | 10:30 AM
    The Massively Parallel Sequencing (MPS) Revolution
    The Massively Parallel Sequencing (MPS) Revolution
    The development of automated DNA sequencers utilizing Sanger sequencing and capillary electrophoresis made it possible to develop the first draft sequences of the human genome. The cost of do...
    Speaker: David Smith, PhD
    Presented at: Precision Medicine Virtual Event Series 2019
    1
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