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    Structural Biology

    Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, how they acquire the structures they have, and how alterations in their structures affect their function.

    Webinars

    • MAR 11, 2020 | 12:00 PM
      PANEL: Thought to action: developing brain machine interfaces to assist individuals with paralysis
      PANEL: Thought to action: developing brain machine interfaces...
      Brain machine interfaces (BMIs) aim to help patients with paralysis to use their recorded brain activity to control assistive devices. BMI research requires the collaboration of neuroscienti...
      Speaker: Tyson Aflalo, PhD , Richard Andersen, PhD , Spencer Kellis, PhD , Charles Liu, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      FEB 26, 2020 | 12:00 PM
      Characterizing the role of B cells in Response to Immunotherapy with the NanoString GeoMx Platform
      Characterizing the role of B cells in Response to Immunotherapy...
      Digital spatial profiling (DSP) on the NanoString GeoMx platform enables high plex molecular profiling of clinical tissue samples. This new profiling strategy enables deep insights into the...
      Speaker: Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: NanoString Technologies
      1
      JAN 29, 2020 | 9:00 AM
      A case study of protein sample prep strategies for membrane proteins
      A case study of protein sample prep strategies for membrane proteins
      DATE: January 29, 2019 TIME: 9:00am PST Plasma membrane proteins are a difficult subset of proteins to solubilize, purify, quantify, and detect, largely due to the challenge of extracting th...
      Speaker: Barbara Kaboord, PhD
      Sponsored By: Thermo Fisher Scientific
      6
      JAN 14, 2020 | 8:00 AM
      CiPA initiative and validation of high-throughput methods to characterize compound effects in human iPSC-derived cardiomyocytes
      CiPA initiative and validation of high-throughput methods to characterize...
      DATE: January 14, 2019 TIME: 8:00am PST Drug-induced QT interval prolongation and Torsades de Pointes (TdP) arrhythmias are the leading causes for drug withdrawals from market and compound a...
      Speaker: Muthukrishnan Renganathan, PhD , Panida Lertkiatmongkol, PhD , Oksana Sirenko, PhD , Carole Crittenden
      Sponsored By: Molecular Devices, Eurofins Discovery
      3
      JAN 01, 2020 | 6:00 AM
      Selective D4R Ligands Reveal Structure-Activity Relationships that Engender Agonist Efficacy
      Selective D4R Ligands Reveal Structure-Activity Relationships...
      The dopamine D4 receptor (D4R) is enriched in the prefrontal cortex where it plays important roles in cognition, attention, decision making and executive function. Novel D4R-selective ligand...
      Speaker: Comfort Boateng, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      DEC 10, 2019 | 8:00 AM
      Expi293: New Tools for Structural Biology and Difficult to Express Proteins
      Expi293: New Tools for Structural Biology and Difficult to Express...
      DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
      Speaker: Jon Zmuda, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      7 1
      NOV 19, 2019 | 10:00 AM
      LC3-associated endocytosis: guarding against neuroinflammation & neurodegeneration
      LC3-associated endocytosis: guarding against neuroinflammation...
      DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
      Speaker: Bradlee L. Heckmann, Ph.D.
      Sponsored By: Miltenyi Biotec
      6
      NOV 15, 2019 | 8:00 AM
      Exosomes and super-resolution microscopy
      Exosomes and super-resolution microscopy
      DATE: November 15, 2019TIME: 8:00am PST, 11:00am EST Exosomes are small vesicles, ranging from 30-120 nanometers in diameter, secreted from cells throughout the human body. The...
      Speaker: Ryan McNamara, PhD
      Sponsored By: ONI
      8
      NOV 12, 2019 | 10:00 AM
      Leveraging single cell copy number to resolve tumor clonality
      Leveraging single cell copy number to resolve tumor clonality
      DATE: November 12, 2019TIME: 10:00am PSTDirect measurement of copy number by droplet-based shallow sequencing of genomic DNA has the potential to provide new insights into tumor heterog...
      Speaker: Dr. David Craig
      Sponsored By: 10x Genomics
      9 1
      NOV 06, 2019 | 12:00 PM
      A dose of the flu: influenza's variable virus particles
      A dose of the flu: influenza's variable virus particles
      Influenza viruses are transmitted by membrane-bound virus particles, or virions. Unlike some viruses, which produce near-identical virions from a well-defined set of viral components, influen...
      Speaker: Edward Hutchinson, PhD
      Presented at: Influenza Virtual Event Series 2019
      4 2
      OCT 24, 2019 | 1:30 PM
      Characterization of Biotherapeutics by Chemometric and Machine Learning Analysis of NMR Spectra
      Characterization of Biotherapeutics by Chemometric and Machine...
      With annual sales exceeding $145 billion, growth of biologic therapeutics is outpacing that of small-molecule drugs, and the development, manufacture, and delivery of biologics presents very...
      Speaker: Frank Delaglio, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2019
      4 1
      OCT 10, 2019 | 10:30 AM
      Whole genome imaging for sensitive and accurate analysis of structural variations in cancer
      Whole genome imaging for sensitive and accurate analysis of structural...
      Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
      Speaker: Sven Bocklandt, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: Bionano
      1
      OCT 03, 2019 | 9:00 AM
      Structures of CRISPR-Cas surveillance complexes
      Structures of CRISPR-Cas surveillance complexes
      CRISPR (clustered regularly interspaced short palindromic repeats) RNA and CRISPR-associated genes (Cas) assemble into RNA-guided surveillance complex that targets foreign nucleic acids for d...
      Speaker: David Taylor, PhD
      Presented at: CRISPR Virtual Event Series 2019
      1
      OCT 03, 2019 | 7:30 AM
      Keynote Presentation: CRISPR/Cas9 genome editing in mouse and rat: The PHENOMIN-ICS experience
      Keynote Presentation: CRISPR/Cas9 genome editing in mouse and...
      CRISPR/Cas9 technology has become very popular in the last 5 years and has profoundly changed our way to do genetically engineered animals. I will present the latest development in genome edi...
      Speaker: Marie-Christine Birling, PhD
      Presented at: CRISPR Virtual Event Series 2019
      1
      OCT 01, 2019 | 8:00 AM
      Looking under the Hood and Getting Started with the Optima AUC
      Looking under the Hood and Getting Started with the Optima AUC
      DATE: October 1, 2019TIME: 8:00am PTIn the webinar, Introduction to Characterization of Biomolecules Using Analytical Ultracentrifugation, we discussed the fundamentals of analytical...
      Speaker: Akash Bhattacharya, PhD , Ross VerHeul
      Sponsored By: Beckman Coulter Life Sciences
      4
      SEP 26, 2019 | 12:00 PM
      Understanding the Regulation of Membrane Curvature During Mating in Tetrahymena Thermophila
      Understanding the Regulation of Membrane Curvature During Mating...
      The active shaping of biological membranes is essential for a variety of cellular functions including but not limited to cell migration, cell division, organelle morphology, and cell and memb...
      Speaker: Sabrice Guerrier, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      2
      SEP 26, 2019 | 9:00 AM
      Identification of Novel Biomarker Candidates for Early Detection of Melanoma
      Identification of Novel Biomarker Candidates for Early Detection...
      Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the dete...
      Speaker: Margaret Hoang, PhD , Maija Kiuru, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      1
      SEP 26, 2019 | 7:30 AM
      Keynote Presentation: Phagocytosis, macropinocytosis and the innate immune response; recent advances
      Keynote Presentation: Phagocytosis, macropinocytosis and the innate...
      The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of parti...
      Speaker: Sergio Grinstein, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      2
      SEP 26, 2019 | 6:00 AM
      Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics and the Challenge of Low Input Samples
      Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics...
      Spatial transcriptomics methods permit gene expression from focal areas within a tissue to be profiled while maintaining the morphologic context of the tissue microenvironment. This presentat...
      Speaker: Bruce Seligmann, PhD
      Presented at: Cell Biology Virtual Event Series 2019
      1
      SEP 25, 2019 | 8:00 AM
      Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
      Expression, Purification and Characterization of Difficult to...
      DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
      Speaker: Anass Jawhari, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      4
      SEP 12, 2019 | 1:30 PM
      Gender Parity in Virology Conference Speaker Selections
      Gender Parity in Virology Conference Speaker Selections
      Scientific conferences are most beneficial to participants when they showcase significant new experimental developments, accurately summarize the current state of the field, and provide stron...
      Speaker: Ann Palmenberg, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      1
      SEP 12, 2019 | 6:00 AM
      Using the NASA GeneLab Data System to Study the Metagenomes of Spaceships and Their Occupants
      Using the NASA GeneLab Data System to Study the Metagenomes of...
      With humans pushing to live further off Earth for longer periods of time, it is increasingly important to understand the changes that occur in biological systems during spaceflight whether th...
      Speaker: Jonathan Galazka, PhD , Daniela Bezdan, PhD , Peng Jiang, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      1
      SEP 11, 2019 | 10:30 AM
      Structural analysis to understand the molecular mechanism for CPV species-jump
      Structural analysis to understand the molecular mechanism for...
      Canine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis and cerebellar disease. Cross-species transmission of CPV...
      Speaker: Susan Hafenstein, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      1
      SEP 05, 2019 | 7:00 AM
      The bread and butter method of genomics: How to improve your (q)PCR
      The bread and butter method of genomics: How to improve your (q)PCR
      DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
      Speaker: Tim Schommartz, PhD
      Sponsored By: Eppendorf
      17 1
    MAR 11, 2020 | 12:00 PM
    PANEL: Thought to action: developing brain machine interfaces to assist individuals with paralysis
    PANEL: Thought to action: developing brain machine interfaces...
    Brain machine interfaces (BMIs) aim to help patients with paralysis to use their recorded brain activity to control assistive devices. BMI research requires the collaboration of neuroscienti...
    Speaker: Tyson Aflalo, PhD , Richard Andersen, PhD , Spencer Kellis, PhD , Charles Liu, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
    FEB 26, 2020 | 12:00 PM
    Characterizing the role of B cells in Response to Immunotherapy with the NanoString GeoMx Platform
    Characterizing the role of B cells in Response to Immunotherapy...
    Digital spatial profiling (DSP) on the NanoString GeoMx platform enables high plex molecular profiling of clinical tissue samples. This new profiling strategy enables deep insights into the...
    Speaker: Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: NanoString Technologies
    1
    JAN 29, 2020 | 9:00 AM
    A case study of protein sample prep strategies for membrane proteins
    A case study of protein sample prep strategies for membrane proteins
    DATE: January 29, 2019 TIME: 9:00am PST Plasma membrane proteins are a difficult subset of proteins to solubilize, purify, quantify, and detect, largely due to the challenge of extracting th...
    Speaker: Barbara Kaboord, PhD
    Sponsored By: Thermo Fisher Scientific
    6
    JAN 14, 2020 | 8:00 AM
    CiPA initiative and validation of high-throughput methods to characterize compound effects in human iPSC-derived cardiomyocytes
    CiPA initiative and validation of high-throughput methods to characterize...
    DATE: January 14, 2019 TIME: 8:00am PST Drug-induced QT interval prolongation and Torsades de Pointes (TdP) arrhythmias are the leading causes for drug withdrawals from market and compound a...
    Speaker: Muthukrishnan Renganathan, PhD , Panida Lertkiatmongkol, PhD , Oksana Sirenko, PhD , Carole Crittenden
    Sponsored By: Molecular Devices, Eurofins Discovery
    3
    JAN 01, 2020 | 6:00 AM
    Selective D4R Ligands Reveal Structure-Activity Relationships that Engender Agonist Efficacy
    Selective D4R Ligands Reveal Structure-Activity Relationships...
    The dopamine D4 receptor (D4R) is enriched in the prefrontal cortex where it plays important roles in cognition, attention, decision making and executive function. Novel D4R-selective ligand...
    Speaker: Comfort Boateng, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
     
     
  • DEC 10, 2019 | 8:00 AM
    Expi293: New Tools for Structural Biology and Difficult to Express Proteins
    Expi293: New Tools for Structural Biology and Difficult to Express...
    DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
    Speaker: Jon Zmuda, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    7 1
    NOV 19, 2019 | 10:00 AM
    LC3-associated endocytosis: guarding against neuroinflammation & neurodegeneration
    LC3-associated endocytosis: guarding against neuroinflammation...
    DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
    Speaker: Bradlee L. Heckmann, Ph.D.
    Sponsored By: Miltenyi Biotec
    6
    NOV 15, 2019 | 8:00 AM
    Exosomes and super-resolution microscopy
    Exosomes and super-resolution microscopy
    DATE: November 15, 2019TIME: 8:00am PST, 11:00am EST Exosomes are small vesicles, ranging from 30-120 nanometers in diameter, secreted from cells throughout the human body. The...
    Speaker: Ryan McNamara, PhD
    Sponsored By: ONI
    8
    NOV 12, 2019 | 10:00 AM
    Leveraging single cell copy number to resolve tumor clonality
    Leveraging single cell copy number to resolve tumor clonality
    DATE: November 12, 2019TIME: 10:00am PSTDirect measurement of copy number by droplet-based shallow sequencing of genomic DNA has the potential to provide new insights into tumor heterog...
    Speaker: Dr. David Craig
    Sponsored By: 10x Genomics
    9 1
    NOV 06, 2019 | 12:00 PM
    A dose of the flu: influenza's variable virus particles
    A dose of the flu: influenza's variable virus particles
    Influenza viruses are transmitted by membrane-bound virus particles, or virions. Unlike some viruses, which produce near-identical virions from a well-defined set of viral components, influen...
    Speaker: Edward Hutchinson, PhD
    Presented at: Influenza Virtual Event Series 2019
    4 2
     
     
  • OCT 24, 2019 | 1:30 PM
    Characterization of Biotherapeutics by Chemometric and Machine Learning Analysis of NMR Spectra
    Characterization of Biotherapeutics by Chemometric and Machine...
    With annual sales exceeding $145 billion, growth of biologic therapeutics is outpacing that of small-molecule drugs, and the development, manufacture, and delivery of biologics presents very...
    Speaker: Frank Delaglio, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2019
    4 1
    OCT 10, 2019 | 10:30 AM
    Whole genome imaging for sensitive and accurate analysis of structural variations in cancer
    Whole genome imaging for sensitive and accurate analysis of structural...
    Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
    Speaker: Sven Bocklandt, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: Bionano
    1
    OCT 03, 2019 | 9:00 AM
    Structures of CRISPR-Cas surveillance complexes
    Structures of CRISPR-Cas surveillance complexes
    CRISPR (clustered regularly interspaced short palindromic repeats) RNA and CRISPR-associated genes (Cas) assemble into RNA-guided surveillance complex that targets foreign nucleic acids for d...
    Speaker: David Taylor, PhD
    Presented at: CRISPR Virtual Event Series 2019
    1
    OCT 03, 2019 | 7:30 AM
    Keynote Presentation: CRISPR/Cas9 genome editing in mouse and rat: The PHENOMIN-ICS experience
    Keynote Presentation: CRISPR/Cas9 genome editing in mouse and...
    CRISPR/Cas9 technology has become very popular in the last 5 years and has profoundly changed our way to do genetically engineered animals. I will present the latest development in genome edi...
    Speaker: Marie-Christine Birling, PhD
    Presented at: CRISPR Virtual Event Series 2019
    1
    OCT 01, 2019 | 8:00 AM
    Looking under the Hood and Getting Started with the Optima AUC
    Looking under the Hood and Getting Started with the Optima AUC
    DATE: October 1, 2019TIME: 8:00am PTIn the webinar, Introduction to Characterization of Biomolecules Using Analytical Ultracentrifugation, we discussed the fundamentals of analytical...
    Speaker: Akash Bhattacharya, PhD , Ross VerHeul
    Sponsored By: Beckman Coulter Life Sciences
    4
     
     
  • SEP 26, 2019 | 12:00 PM
    Understanding the Regulation of Membrane Curvature During Mating in Tetrahymena Thermophila
    Understanding the Regulation of Membrane Curvature During Mating...
    The active shaping of biological membranes is essential for a variety of cellular functions including but not limited to cell migration, cell division, organelle morphology, and cell and memb...
    Speaker: Sabrice Guerrier, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    2
    SEP 26, 2019 | 9:00 AM
    Identification of Novel Biomarker Candidates for Early Detection of Melanoma
    Identification of Novel Biomarker Candidates for Early Detection...
    Early detection is critical for improved survival in melanoma. Melanocytic nevi are extremely common benign tumors that mimic melanoma and are therefore commonly biopsied. Currently, the dete...
    Speaker: Margaret Hoang, PhD , Maija Kiuru, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    1
    SEP 26, 2019 | 7:30 AM
    Keynote Presentation: Phagocytosis, macropinocytosis and the innate immune response; recent advances
    Keynote Presentation: Phagocytosis, macropinocytosis and the innate...
    The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of parti...
    Speaker: Sergio Grinstein, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    2
    SEP 26, 2019 | 6:00 AM
    Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics and the Challenge of Low Input Samples
    Profiling Focal Areas of FFPE Tissue: Spatial Transcriptomics...
    Spatial transcriptomics methods permit gene expression from focal areas within a tissue to be profiled while maintaining the morphologic context of the tissue microenvironment. This presentat...
    Speaker: Bruce Seligmann, PhD
    Presented at: Cell Biology Virtual Event Series 2019
    1
    SEP 25, 2019 | 8:00 AM
    Expression, Purification and Characterization of Difficult to Express Membrane Proteins in the Expi293 and ExpiCHO Expression Systems:  Case study of Potassium chloride co-transporter KCC2
    Expression, Purification and Characterization of Difficult to...
    DATE: September 25, 2019TIME: 8:00am PT, 11:00am ET This talk will focus on strategies for optimizing expression levels of membrane proteins using the Gibcoâ„¢ Expi293â„¢ and ExpiCHOâ„¢ Expres...
    Speaker: Anass Jawhari, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    4
     
     
  • SEP 12, 2019 | 1:30 PM
    Gender Parity in Virology Conference Speaker Selections
    Gender Parity in Virology Conference Speaker Selections
    Scientific conferences are most beneficial to participants when they showcase significant new experimental developments, accurately summarize the current state of the field, and provide stron...
    Speaker: Ann Palmenberg, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    1
    SEP 12, 2019 | 6:00 AM
    Using the NASA GeneLab Data System to Study the Metagenomes of Spaceships and Their Occupants
    Using the NASA GeneLab Data System to Study the Metagenomes of...
    With humans pushing to live further off Earth for longer periods of time, it is increasingly important to understand the changes that occur in biological systems during spaceflight whether th...
    Speaker: Jonathan Galazka, PhD , Daniela Bezdan, PhD , Peng Jiang, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    1
    SEP 11, 2019 | 10:30 AM
    Structural analysis to understand the molecular mechanism for CPV species-jump
    Structural analysis to understand the molecular mechanism for...
    Canine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis and cerebellar disease. Cross-species transmission of CPV...
    Speaker: Susan Hafenstein, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    1
    SEP 05, 2019 | 7:00 AM
    The bread and butter method of genomics: How to improve your (q)PCR
    The bread and butter method of genomics: How to improve your (q)PCR
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    Speaker: Tim Schommartz, PhD
    Sponsored By: Eppendorf
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