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    T-cell Receptor

    T-Cell Receptor: or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex molecules.

    Webinars

    • SEP 23, 2020 | 6:00 AM
      Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate the biology of the Tumor Microenvironment
      Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate...
      MicroRNAs (miRs) are small non-coding RNAs whose expression is altered in several types of human cancers. Recent evidence supports their inter-cellular transfer through extracellular vesicle...
      Speaker: Muller Fabbri, MD, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 23, 2020 | 12:00 AM
      Extracellular Matrix in Renal Development and Cancer
      Extracellular Matrix in Renal Development and Cancer
      The extracellular matrix (ECM) is a three-dimensional structure that provides physical support for tissues/organs and biochemical/biomechanical cues for tissue morphogenesis, differentiation...
      Speaker: Astgik Petrosyan, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      4
      SEP 17, 2020 | 4:30 PM
      COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell Repertoires
      COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell...
      T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of...
      Speaker: Sean Nolan , Patrick Raber, PhD , Thomas Snyder, PhD
      Presented at: Coronavirus Series
      Sponsored By: Adaptive Biotechnologies
      6
      JUL 29, 2020 | 2:00 PM
      Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells
      Route of 41BB/41BBL costimulation determines effector function...
      B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H...
      Speaker: Christopher DeRenzo, MD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 29, 2020 | 12:00 AM
      Modeling anti-tumor function of human T cells
      Modeling anti-tumor function of human T cells
      Mouse models have been essential for establishing the role of the T cells in anti-tumor responses, but they have limited utility in translational studies for the testing of candidate therape...
      Speaker: Michael Overstreet, PhD
      Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
      1
      JUL 02, 2020 | 12:15 PM
      Authenticating human cells: Knowing exactly what is in your test tube
      Authenticating human cells: Knowing exactly what is in your test...
      The study of human development and diseases relies on analysis of samples obtained and manipulated ex vivo. It is critical in such studies to know the provenance and confirm that the identit...
      Speaker: Steve Jackson, PhD
      Presented at: APJ Virtual Genetic Solutions Tour 2020
      1
      JUN 30, 2020 | 9:00 AM
      Quality Control for the Pharmaceutical Industry; Stage 3, Continued Verification, in the Lifecycle of Analytical Procedures
      Quality Control for the Pharmaceutical Industry; Stage 3, Continued...
      DATE: June 30, 2020 TIME: 9:00am PDT, 12:00pm EDT QC laboratories perform a critical role in demonstrating pharmaceutical products are consistently manufactured, safe, potent, and pure. At t...
      Speaker: Jane Weitzel
      Sponsored By: Sartorius
      17 1
      JUN 03, 2020 | 12:00 PM
      Single cell multiomic analysis of T-cell exhaustion
      Single cell multiomic analysis of T-cell exhaustion
      A key step in the clinical production of CAR T cells is the expansion of engineered T cells. To generate enough cells for viable adoptive cell therapy, cells must be robustly stimulated, whi...
      Speaker: Pratip K. Chattopadhyay
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: BD
      2
      JUN 03, 2020 | 12:00 AM
      Deciphering the function of B cells in human cancer
      Deciphering the function of B cells in human cancer
      B cells have recently come into vogue as important contributors to the anti-tumor immune response in cancer patients. Specifically, B cells and the immune structures in which they reside (te...
      Speaker: Tullia C. Bruno, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      3
      JUN 03, 2020 | 12:00 AM
      Microenvironment on Demand: A breakthrough technology for personalized cell therapy discoveries
      Microenvironment on Demand: A breakthrough technology for personalized...
      NCI estimates that cancer will be the leading cause of death in 2030, worldwide. Checkpoint inhibitors and adoptive cell therapies (ACTs) cost up to ~$2 million/patient and have shown durabl...
      Speaker: Maithreyan Srinivasan
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      JUN 03, 2020 | 12:00 AM
      Overcoming cell therapy barriers in the suppressive tumor microenvironment with engineered proteins
      Overcoming cell therapy barriers in the suppressive tumor microenvironment...
      1. Identify 3 barriers to immune cell response to cancer 2. List 3 approaches to overcome immunosuppressive barriers to bolster the immune response to cancer 3. Explain how fusion proteins c...
      Speaker: Shannon K. Oda, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      1
      MAY 20, 2020 | 1:15 PM
      Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells & CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment...
      Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart®...
      Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
      Speaker: Jan Davidson, MD, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 20, 2020 | 11:15 AM
      Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant Ribociclib Plus Letrozole Versus Chemotherapy in PAM50 Luminal B Early Breast Cancer
      Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant...
      Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
      Speaker: Aleix Prat, MD, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      1
      MAY 19, 2020 | 11:15 AM
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
      A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
      We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
      Speaker: Alex Swarbrick, PhD
      Presented at: Advancing Science - A Virtual Oncology Conference
      4
      MAY 14, 2020 | 7:05 PM
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
      Speaker: Timothy Looney, PhD
      Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
      8
      MAY 14, 2020 | 7:05 PM
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
      B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
      Speaker: Timothy Looney, PhD
      Presented at: OncomineWorld Autumn: A virtual NGS education meeting
      1
      MAY 12, 2020 | 9:00 AM
      Analytical Quality Control for the Pharmaceutical Industry
      Analytical Quality Control for the Pharmaceutical Industry
      NEW DATE: Date: May 12, 2020 Time: 9:00am PDT, 12:00pm EDT...
      Speaker: Joy McElroy
      Sponsored By: Sartorius
      29 9
      MAR 11, 2020 | 10:30 AM
      Innate immunity in chronic neurodegeneration
      Innate immunity in chronic neurodegeneration
      The accumulation of neurotoxic amyloid beta peptides and/or neurofibrillary tangle formation are key pathological hallmarks of neurodegenerative diseases including but not limited to Alzheim...
      Speaker: Michael Heneka, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      Sponsored By: NanoString Technologies
      1
      FEB 26, 2020 | 7:30 AM
      Keynote Presentation: Emerging Drug Combinations: Evolution From Pre-Clinical Discovery to Clinical Development
      Keynote Presentation: Emerging Drug Combinations: Evolution From...
      Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
      Speaker: Khyati Shah, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      OCT 10, 2019 | 9:00 AM
      Next Generation Targets for Immuno-Oncology
      Next Generation Targets for Immuno-Oncology
      Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
      Speaker: Anthony Persen, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: ACD - A Bio-Techne Brand
      1
      SEP 10, 2019 | 8:00 AM
      Next Generation Sequencing of the Immune System: From Single Cell to Bulk RNA
      Next Generation Sequencing of the Immune System: From Single Cell...
      DATE: September 10, 2019TIME: 8:00am PTNext generation sequencing of the immune repertoire allows detailed, sequence-specific insight into the immune system’s adaptive response...
      Speaker: Miranda Byrne-Steele, Ph.D.
      Sponsored By: Beckman Coulter Life Sciences
      8 1
      MAY 21, 2019 | 7:00 AM
      Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
      Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key...
      DATE: May 21, 2019TIMEL 7:00am PT, 10:00am ET Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioriti...
      Speaker: Eric Shifrut, PhD
      Sponsored By: Thermo Fisher Scientific
      10 1
      OCT 10, 2018 | 6:00 AM
      Precise Detection of T-Cell Receptors Using RNAseq With Unique Molecular Indexing
      Precise Detection of T-Cell Receptors Using RNAseq With Unique...
      Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
      Speaker: Samuel Rulli, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      Sponsored By: QIAGEN
      1
      OCT 10, 2018 | 6:00 AM
      The Role of Vaccination for the Treatment and Prevention of Breast and Ovarian Cancers
      The Role of Vaccination for the Treatment and Prevention of Breast...
      With over 265,000 new cases per year and over 50,000 deaths, breast and ovarian cancers represent a significant health burden in the USA.  Prior work has demonstrated that CD4 helper T c...
      Speaker: Keith Knutson, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      6
    SEP 23, 2020 | 6:00 AM
    Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate the biology of the Tumor Microenvironment
    Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate...
    MicroRNAs (miRs) are small non-coding RNAs whose expression is altered in several types of human cancers. Recent evidence supports their inter-cellular transfer through extracellular vesicle...
    Speaker: Muller Fabbri, MD, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 23, 2020 | 12:00 AM
    Extracellular Matrix in Renal Development and Cancer
    Extracellular Matrix in Renal Development and Cancer
    The extracellular matrix (ECM) is a three-dimensional structure that provides physical support for tissues/organs and biochemical/biomechanical cues for tissue morphogenesis, differentiation...
    Speaker: Astgik Petrosyan, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    4
    SEP 17, 2020 | 4:30 PM
    COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell Repertoires
    COVID-19 T-Cell Data: Mapping Out SARS-CoV-2 Antigen & T-Cell...
    T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, and also support the development of...
    Speaker: Sean Nolan , Patrick Raber, PhD , Thomas Snyder, PhD
    Presented at: Coronavirus Series
    Sponsored By: Adaptive Biotechnologies
    6
    JUL 29, 2020 | 2:00 PM
    Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells
    Route of 41BB/41BBL costimulation determines effector function...
    B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs). B7-H...
    Speaker: Christopher DeRenzo, MD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
    JUL 29, 2020 | 12:00 AM
    Modeling anti-tumor function of human T cells
    Modeling anti-tumor function of human T cells
    Mouse models have been essential for establishing the role of the T cells in anti-tumor responses, but they have limited utility in translational studies for the testing of candidate therape...
    Speaker: Michael Overstreet, PhD
    Presented at: Immuno-Oncology & Cancer Biology Virtual Conference
    1
     
     
  • JUL 02, 2020 | 12:15 PM
    Authenticating human cells: Knowing exactly what is in your test tube
    Authenticating human cells: Knowing exactly what is in your test...
    The study of human development and diseases relies on analysis of samples obtained and manipulated ex vivo. It is critical in such studies to know the provenance and confirm that the identit...
    Speaker: Steve Jackson, PhD
    Presented at: APJ Virtual Genetic Solutions Tour 2020
    1
    JUN 30, 2020 | 9:00 AM
    Quality Control for the Pharmaceutical Industry; Stage 3, Continued Verification, in the Lifecycle of Analytical Procedures
    Quality Control for the Pharmaceutical Industry; Stage 3, Continued...
    DATE: June 30, 2020 TIME: 9:00am PDT, 12:00pm EDT QC laboratories perform a critical role in demonstrating pharmaceutical products are consistently manufactured, safe, potent, and pure. At t...
    Speaker: Jane Weitzel
    Sponsored By: Sartorius
    17 1
    JUN 03, 2020 | 12:00 PM
    Single cell multiomic analysis of T-cell exhaustion
    Single cell multiomic analysis of T-cell exhaustion
    A key step in the clinical production of CAR T cells is the expansion of engineered T cells. To generate enough cells for viable adoptive cell therapy, cells must be robustly stimulated, whi...
    Speaker: Pratip K. Chattopadhyay
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: BD
    2
    JUN 03, 2020 | 12:00 AM
    Deciphering the function of B cells in human cancer
    Deciphering the function of B cells in human cancer
    B cells have recently come into vogue as important contributors to the anti-tumor immune response in cancer patients. Specifically, B cells and the immune structures in which they reside (te...
    Speaker: Tullia C. Bruno, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    3
    JUN 03, 2020 | 12:00 AM
    Microenvironment on Demand: A breakthrough technology for personalized cell therapy discoveries
    Microenvironment on Demand: A breakthrough technology for personalized...
    NCI estimates that cancer will be the leading cause of death in 2030, worldwide. Checkpoint inhibitors and adoptive cell therapies (ACTs) cost up to ~$2 million/patient and have shown durabl...
    Speaker: Maithreyan Srinivasan
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
     
     
  • JUN 03, 2020 | 12:00 AM
    Overcoming cell therapy barriers in the suppressive tumor microenvironment with engineered proteins
    Overcoming cell therapy barriers in the suppressive tumor microenvironment...
    1. Identify 3 barriers to immune cell response to cancer 2. List 3 approaches to overcome immunosuppressive barriers to bolster the immune response to cancer 3. Explain how fusion proteins c...
    Speaker: Shannon K. Oda, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    1
    MAY 20, 2020 | 1:15 PM
    Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart® Protein-Induced Clustering of CD3+ T Cells & CD123+ AML Cells in Bone Marrow Biopsies Is Associated with Response to Treatment...
    Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart®...
    Background: Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Despite recent advancements in the treatment of AML, approximately 50% of pat...
    Speaker: Jan Davidson, MD, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 20, 2020 | 11:15 AM
    Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant Ribociclib Plus Letrozole Versus Chemotherapy in PAM50 Luminal B Early Breast Cancer
    Primary Results of SOLTI-1402/CORALLEEN Phase 2 Trial of Neoadjuvant...
    Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
    Speaker: Aleix Prat, MD, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    1
    MAY 19, 2020 | 11:15 AM
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals Stromal Suppression of Anti-Cancer Immunity
    A Multi-omic Single Cell and Spatial Atlas of Breast Cancer Reveals...
    We applied CITE-Seq to measure >150 cell surface immune markers and checkpoint proteins simultaneous to RNA-Sequencing. We resolve the tumour-immune milieu with high precision and reveal...
    Speaker: Alex Swarbrick, PhD
    Presented at: Advancing Science - A Virtual Oncology Conference
    4
    MAY 14, 2020 | 7:05 PM
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
    Speaker: Timothy Looney, PhD
    Presented at: OncomineWorld 2022: A Virtual NGS Education Meeting
    8
     
     
  • MAY 14, 2020 | 7:05 PM
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    Haemato-Oncology Applications of BCR Immune Repertoire Sequencing
    B-cell lymphomas and leukemias originate from the malignant transformation and proliferation of one or a small number of B cells. Since each B-cell expresses distinct B-cell receptors (BCRs)...
    Speaker: Timothy Looney, PhD
    Presented at: OncomineWorld Autumn: A virtual NGS education meeting
    1
    MAY 12, 2020 | 9:00 AM
    Analytical Quality Control for the Pharmaceutical Industry
    Analytical Quality Control for the Pharmaceutical Industry
    NEW DATE: Date: May 12, 2020 Time: 9:00am PDT, 12:00pm EDT...
    Speaker: Joy McElroy
    Sponsored By: Sartorius
    29 9
    MAR 11, 2020 | 10:30 AM
    Innate immunity in chronic neurodegeneration
    Innate immunity in chronic neurodegeneration
    The accumulation of neurotoxic amyloid beta peptides and/or neurofibrillary tangle formation are key pathological hallmarks of neurodegenerative diseases including but not limited to Alzheim...
    Speaker: Michael Heneka, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    Sponsored By: NanoString Technologies
    1
    FEB 26, 2020 | 7:30 AM
    Keynote Presentation: Emerging Drug Combinations: Evolution From Pre-Clinical Discovery to Clinical Development
    Keynote Presentation: Emerging Drug Combinations: Evolution From...
    Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
    Speaker: Khyati Shah, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    OCT 10, 2019 | 9:00 AM
    Next Generation Targets for Immuno-Oncology
    Next Generation Targets for Immuno-Oncology
    Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
    Speaker: Anthony Persen, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: ACD - A Bio-Techne Brand
    1
     
     
  • SEP 10, 2019 | 8:00 AM
    Next Generation Sequencing of the Immune System: From Single Cell to Bulk RNA
    Next Generation Sequencing of the Immune System: From Single Cell...
    DATE: September 10, 2019TIME: 8:00am PTNext generation sequencing of the immune repertoire allows detailed, sequence-specific insight into the immune system’s adaptive response...
    Speaker: Miranda Byrne-Steele, Ph.D.
    Sponsored By: Beckman Coulter Life Sciences
    8 1
    MAY 21, 2019 | 7:00 AM
    Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
    Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key...
    DATE: May 21, 2019TIMEL 7:00am PT, 10:00am ET Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based functional studies in T cells could prioriti...
    Speaker: Eric Shifrut, PhD
    Sponsored By: Thermo Fisher Scientific
    10 1
    OCT 10, 2018 | 6:00 AM
    Precise Detection of T-Cell Receptors Using RNAseq With Unique Molecular Indexing
    Precise Detection of T-Cell Receptors Using RNAseq With Unique...
    Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
    Speaker: Samuel Rulli, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    Sponsored By: QIAGEN
    1
    OCT 10, 2018 | 6:00 AM
    The Role of Vaccination for the Treatment and Prevention of Breast and Ovarian Cancers
    The Role of Vaccination for the Treatment and Prevention of Breast...
    With over 265,000 new cases per year and over 50,000 deaths, breast and ovarian cancers represent a significant health burden in the USA.  Prior work has demonstrated that CD4 helper T c...
    Speaker: Keith Knutson, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    6
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