Therapeutics: In medicine, the branch that deals specifically with the treatment of disease and the art and science of healing. Exercise, diet, and mental factors are therefore integral to the prevention, as well as the management, of disease processes. More specific measures that are employed to treat specific symptoms include the use of drugs to relieve pain or treat infection, surgery to remove diseased tissue or replace poorly functioning or nonfunctioning organs with fully operating ones, and counseling or psychotherapy to relieve emotional distress.
The detection of circulating molecular biomarkers is useful for monitoring pathogenic processes and response to therapeutic intervention1,2. In cancer, genomic and proteomic biomarkers are us...
Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
The detection of CTCs has been used as useful biomarkers in prognosis and monitoring therapeutic response of patients with metastatic cancer. However, during the course of cancer therapy, CTC...
The role played by inflammatory hypoxia in biology and treatment of solid tumors will be reviewed. The opportunity to enhance all forms of current anti-tumor therapies through tumor re-...
The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
DATE: October 10, 2017TIME: 9:00AM PDTPatient-derived xenografts (PDX) are increasingly being used in biomedical research for therapeutic analysis in mice. Unlike traditional cell line...
DATE: October 4th, 2017TIME: 8:00AM PT, 11:00AM ET, 5:00PM (GMT+2)New HCV drugs are now approved which, when used in combination, yield very high rates of cure of HC...
How are your RNA yields? Some sample types present special challenges in RNA purification and analysis. In this webinar, we will discuss and provide tips for the following topics: &b...
Stem cells can self-renew and differentiate into multiple different cell types. Engineering of stem cells has enabled new methods to study development and organogenesis in humans as well as d...
DATE: September 28, 2017TIME: 10:00am PDT, 1:00pm EDT The use of gene therapy is well studied due to its potential to treat cancer, the second leading cause of death worldwide....
To study cell metabolism, our laboratory has found it exceedingly informative to integrate Agilent Seahorse XF Analyzers with mass spectrometry-based measurements of metabolomics and stable i...
DATE: September 19, 2017TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CESTPart 1 – Cigall Kadoch, Ph.D. (30 min.)Exome- and genome-wide sequencing studies in human cancer have...
The human large intestine houses trillions of microorganisms which collectively form the highly diverse microbial community known as the gut microbiota. The gut microbiota performs many funct...
INTRODUCTION: The recent coincidental emergence of the human microbiota and the Hologneomic Theory of Co-evolution unmasked the “Dual Citizenship” of symbiotic microbes and...
Increasing prevalence and severity of multi-drug-resistant (MDR) bacterial infections has necessitated novel antibacterial strategies. Ideally, new approaches would target bacterial pat...
DATE: September 7, 2017TIME: 9:00AM PT, 12:00PM ETThe success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on can...
DATE: September 6, 2017TIME: 9:00AM PST, 12:00PM ET The era of using extracellular vesicles (EVs) and exosomes for regenerative medicine applications in the clinic is here. We...
Creating inducible Pluripotent Stem Cell (iPSC) collections of rare patients scattered world-wide can lower the barrier of biological discovery of rare disease, provide a platform for potenti...
DATE: July 13, 2017TIME: 9:00am PT, 12:00pm ETAlmost 1.5 million Americans are diagnosed with diabetes every year. In 2012 alone, close to 10% of the population has diab...
The continuous generation of blood cells throughout life relies on the existence of hematopoietic stem cells (HSC) generated during embryogenesis. Given the importance of HSC transplantation...
Therapeutic application of pluripotent stem (PS) cell-derived products represents the ultimate goal of stem cell research. In order to apply this technology to patients, it is fundamental to ...
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (iPSCs) as well as engineered heart muscles offer great potential for regenerative applications by CM transplantation, f...
The detection of circulating molecular biomarkers is useful for monitoring pathogenic processes and response to therapeutic intervention1,2. In cancer, genomic and proteomic biomarkers are us...
Acral lentiginous melanoma (ALM) is a rare sun-shielded melanoma subtype associated with worse survival than cutaneous melanoma (CM), a more common form of skin cancer linked to exposure to u...
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
The detection of CTCs has been used as useful biomarkers in prognosis and monitoring therapeutic response of patients with metastatic cancer. However, during the course of cancer therapy, CTC...
The role played by inflammatory hypoxia in biology and treatment of solid tumors will be reviewed. The opportunity to enhance all forms of current anti-tumor therapies through tumor re-...
The first small molecule inhibitor of the molecular chaperone Heat Shock Protein 90 (HSP90) was identified more than 20 years ago. Upon determination of the drug binding site and clarificatio...
DATE: October 10, 2017TIME: 9:00AM PDTPatient-derived xenografts (PDX) are increasingly being used in biomedical research for therapeutic analysis in mice. Unlike traditional cell line...
DATE: October 4th, 2017TIME: 8:00AM PT, 11:00AM ET, 5:00PM (GMT+2)New HCV drugs are now approved which, when used in combination, yield very high rates of cure of HC...
How are your RNA yields? Some sample types present special challenges in RNA purification and analysis. In this webinar, we will discuss and provide tips for the following topics: &b...
Stem cells can self-renew and differentiate into multiple different cell types. Engineering of stem cells has enabled new methods to study development and organogenesis in humans as well as d...
DATE: September 28, 2017TIME: 10:00am PDT, 1:00pm EDT The use of gene therapy is well studied due to its potential to treat cancer, the second leading cause of death worldwide....
To study cell metabolism, our laboratory has found it exceedingly informative to integrate Agilent Seahorse XF Analyzers with mass spectrometry-based measurements of metabolomics and stable i...
DATE: September 19, 2017TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CESTPart 1 – Cigall Kadoch, Ph.D. (30 min.)Exome- and genome-wide sequencing studies in human cancer have...
The human large intestine houses trillions of microorganisms which collectively form the highly diverse microbial community known as the gut microbiota. The gut microbiota performs many funct...
INTRODUCTION: The recent coincidental emergence of the human microbiota and the Hologneomic Theory of Co-evolution unmasked the “Dual Citizenship” of symbiotic microbes and...
Increasing prevalence and severity of multi-drug-resistant (MDR) bacterial infections has necessitated novel antibacterial strategies. Ideally, new approaches would target bacterial pat...
DATE: September 7, 2017TIME: 9:00AM PT, 12:00PM ETThe success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite efforts made on can...
DATE: September 6, 2017TIME: 9:00AM PST, 12:00PM ET The era of using extracellular vesicles (EVs) and exosomes for regenerative medicine applications in the clinic is here. We...
Creating inducible Pluripotent Stem Cell (iPSC) collections of rare patients scattered world-wide can lower the barrier of biological discovery of rare disease, provide a platform for potenti...
DATE: July 13, 2017TIME: 9:00am PT, 12:00pm ETAlmost 1.5 million Americans are diagnosed with diabetes every year. In 2012 alone, close to 10% of the population has diab...
The continuous generation of blood cells throughout life relies on the existence of hematopoietic stem cells (HSC) generated during embryogenesis. Given the importance of HSC transplantation...
Therapeutic application of pluripotent stem (PS) cell-derived products represents the ultimate goal of stem cell research. In order to apply this technology to patients, it is fundamental to ...
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (iPSCs) as well as engineered heart muscles offer great potential for regenerative applications by CM transplantation, f...
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