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    Cellular Mechanism

    Cellular Mechanism: is an abstraction of an electrophysiological mechanism present on a cell. The three main types are Channel Mechanism, Synaptic Mechanism and Ion Concentration.

    Webinars

    • MAR 23, 2021 | 9:00 AM
      Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
      Targeted degradation of the enhancer lysine acetyltransferases...
      Date: March 23, 2021 Time: 9:00am (PST), 12:00pm (EST) The chromatin regulators CBP and p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional reg...
      Speaker: Christopher Ott, PhD , Tim Geiger, PhD
      Sponsored By: ACD - A Bio-Techne Brand
      8
      FEB 24, 2021 | 12:00 PM
      Speed up your drug discovery with ready-to-use stable cell lines
      Speed up your drug discovery with ready-to-use stable cell lines
      Stable cell lines are critical tools of cellular assays in drug discovery and development. Over-expressing cell lines are needed to screen for hits, while functional cell lines are needed fo...
      Speaker: Vevian Zhang, M.S.
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      Sponsored By: GenScript
      2
      FEB 24, 2021 | 12:00 PM
      Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
      Deep Mechanistic profiling of immune oncology drug combinations...
      With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
      Speaker: Jason Frazier , Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2021
      Sponsored By: NanoString Technologies
      2
      FEB 09, 2021 | 8:00 AM
      Endpoint assays for the characterization of rare and therapy-resistant cells in cancer
      Endpoint assays for the characterization of rare and therapy-resistant...
      DATE: February 09, 2021 TIME: 08:00am PST Flow cytometry immunophenotyping has become one of the mainstream applications for the diagnosis and classification of several hematologic neoplasms...
      Speaker: Jordi Petriz
      Sponsored By: Thermo Fisher Scientific
      8
      DEC 16, 2020 | 8:00 AM
      Adding Dimensions to Multiplex Molecular Imaging
      Adding Dimensions to Multiplex Molecular Imaging
      Date: December 16, 2020 Time: 8:00am (PST), 11:00am (EST) Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better under...
      Speaker: Scott Fraser, PhD
      Sponsored By: Leica Microsystems
      8
      DEC 09, 2020 | 8:00 AM
      Nanoscopy Meets Lifetime - Introducing the new STELLARIS 8 Ï„-STED
      Nanoscopy Meets Lifetime - Introducing the new STELLARIS 8 Ï„-STED
      Date: December 89 2020 Time: 8:00am (PST), 11:00am (EST) This talk introduces the Leica STELLARIS 8 τ-STED system where STED Nanoscopy meets Leica’s Fast Lifetime Contrast (FALCON)...
      Speaker: Julia Roberti, Ph.D.
      Sponsored By: Leica Microsystems
      1
      NOV 19, 2020 | 9:00 AM
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
      DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
      Speaker: Amal Hassan Ali
      Sponsored By: Thermo Fisher Scientific
      16 1
      NOV 18, 2020 | 8:00 AM
      Whole-organ mapping using AI and light sheet microscopy
      Whole-organ mapping using AI and light sheet microscopy
      DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
      Speaker: Ali Ertürk
      Sponsored By: Miltenyi Biotec
      14
      NOV 18, 2020 | 7:00 AM
      Troubleshooting Cell-based Assays - Ask the Experts to Avoid Common Pitfalls from Cell Seeding to Analysis
      Troubleshooting Cell-based Assays - Ask the Experts to Avoid Common...
      DATE: November 18, 2020 TIME: 7:00am PST, 10:00am PST, 4:00pm CEST The assessment of cell health and cellular responses after experimental manipulation continue to be a very important......
      Speaker: Jessica Wagener, PhD , Erik Bonke, PhD
      Sponsored By: Eppendorf, Promega
      17
      NOV 12, 2020 | 10:00 AM
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
      Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
      Speaker: Tilman Schlothauer, Ph.D
      Sponsored By: Roche CustomBiotech
      3
      OCT 13, 2020 | 2:30 PM
      Panel Discussion: Cancer Care in different regions and what are the current standard of care in Lung cancer
      Panel Discussion: Cancer Care in different regions and what are...
      ...
      Speaker: Arjun Khanna , David Chi Leung Lam, MD, PhD , Chein-Feng Li, MD , Darren Wan Teck Lim
      Presented at: 10 Million Reasons to Defeat Cancer - 2020 Abbott World Summit
      1
      SEP 30, 2020 | 1:30 PM
      Harnessing novel CRISPR systems for genome engineering
      Harnessing novel CRISPR systems for genome engineering
      RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. We demonstrate that RNA-targeting CRISPR effector Cas13 can be engineered for...
      Speaker: Omar Abudayyeh, PhD , Jonathan Gootenberg, PhD
      Presented at: CRISPR Virtual Event Series 2020
      4
      SEP 30, 2020 | 12:00 PM
      Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA
      Efficient Generation of Gene-edited Mouse Models and Cell Lines...
      The CRISPR/Cas genome editing system has revolutionized nearly every aspect of the life science industry. Until recently, the most used formats for this technology have been plasmids, mRNA,...
      Speaker: Gurpreet Balrey, PhD , Peter Romanienko, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      4
      SEP 30, 2020 | 12:00 AM
      Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
      Elucidation of remdesivir cytotoxicity pathways through genome-wide...
      The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
      Speaker: Minja Velimirovic, MSc, PhD Candidate
      Presented at: CRISPR Virtual Event Series 2020
      1
      SEP 23, 2020 | 8:00 AM
      CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic and Lab in Parallel
      CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic...
      Date: Time: Over the last couple of years, it has become apparent that affinity-tuned CAR T cells display enhanced expansion and prolonged persistence in patients and that this strategy can...
      Speaker: John Maher, PhD , Rogier Reijmers, PhD
      LUMICKS
      9 1
      SEP 23, 2020 | 6:30 AM
      Mass Cytometry in Translational Research: Session I
      Mass Cytometry in Translational Research: Session I
      Single-cell mass cytometry identifies mechanisms of resistance to immunotherapy in AML 6:30–7:00 am PDT Presented By: Shelley Herbrich, PhD Understanding CD19 negative relapse followin...
      Speaker: Shelley Herbrich, PhD , Kara L. Davis, DO , Bernd Bodenmiller, PhD
      Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
      2
      SEP 23, 2020 | 12:00 AM
      The role of Nox-derived Reactive Oxygen Species in Axonal Growth and Guidance
      The role of Nox-derived Reactive Oxygen Species in Axonal Growth...
      Reactive oxygen species (ROS) are well-known for their detrimental effects leading to oxidative stress, cell death, aging, and degenerative disorders. However, there is increasing evidence t...
      Speaker: Daniel M. Suter, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      2
      SEP 10, 2020 | 7:30 AM
      Keynote Presentation: Discovery of a gene-microbiome interaction in lung cancer: lessons learned and future directions
      Keynote Presentation: Discovery of a gene-microbiome interaction...
      The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
      Speaker: K. Leigh Greathouse, PhD, MPH, MS, RD
      Presented at: Microbiology Week Virtual Event Series 2020
      3
      SEP 10, 2020 | 12:00 AM
      Host responses to SARS-CoV-2
      Host responses to SARS-CoV-2
      The host response to infection is a critical determinant of virus pathogenicity. Emerging viruses require the host cellular machinery to replicate and successfully infect new hosts, and must...
      Speaker: Angela L. Rasmussen, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      2
      SEP 09, 2020 | 9:00 AM
      Keynote Presentation: Human Monoclonal Antibodies for Emerging Agents
      Keynote Presentation: Human Monoclonal Antibodies for Emerging...
      Epidemics are occurring at an increasing pace and scale. Our laboratory group has developed platform technologies for discovery of broad and potent neutralizing antibodies for many emerging...
      Speaker: James Crowe, MD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 09, 2020 | 12:00 AM
      Environmental stress shapes the evolution of a plant viruses towards a mutualistic relationship with its host
      Environmental stress shapes the evolution of a plant viruses towards...
      Traditionally, virology has been focused in studying the pathogenic effect of viruses. In the recent years, however, this perception is changing and viruses are being studied as mutualistic...
      Speaker: Santiago F. Elena
      Presented at: Microbiology Week Virtual Event Series 2020
      1
      SEP 09, 2020 | 12:00 AM
      How Plant Virology Informs Emergence of Zoonotic Viruses Such as SARS-COV-2
      How Plant Virology Informs Emergence of Zoonotic Viruses Such...
      The statement by Dimitri Ivanovsky in 1882 that "the sap of leaves infected with tobacco mosaic disease retains its infectious properties even after filtration through Chamberland filte...
      Speaker: Michael Goodin, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      3
      SEP 09, 2020 | 12:00 AM
      Understanding the role of virus-host interactions in tissue tropism of plant viruses
      Understanding the role of virus-host interactions in tissue tropism...
      To establish productive infection, plant viruses need to be able to efficiently invade and spread within a plant. Most viruses are introduced into a plant via the epidermal or mesophyll cell...
      Speaker: Svetlana Y. Folimonova
      Presented at: Microbiology Week Virtual Event Series 2020
      2
      SEP 09, 2020 | 12:00 AM
      Fc gamma receptor activation during viral infections: a double-edged sword
      Fc gamma receptor activation during viral infections: a double-edged...
      Over the last several decades, antibodies (Abs) have become a valuable weapon in the fight against viral infections, with several studies demonstrating the importance of both neutralizing an...
      Speaker: Raymond A. Alvarez, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      1
    MAR 23, 2021 | 9:00 AM
    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
    Targeted degradation of the enhancer lysine acetyltransferases...
    Date: March 23, 2021 Time: 9:00am (PST), 12:00pm (EST) The chromatin regulators CBP and p300 maintain gene expression programs through lysine acetylation of chromatin and transcriptional reg...
    Speaker: Christopher Ott, PhD , Tim Geiger, PhD
    Sponsored By: ACD - A Bio-Techne Brand
    8
    FEB 24, 2021 | 12:00 PM
    Speed up your drug discovery with ready-to-use stable cell lines
    Speed up your drug discovery with ready-to-use stable cell lines
    Stable cell lines are critical tools of cellular assays in drug discovery and development. Over-expressing cell lines are needed to screen for hits, while functional cell lines are needed fo...
    Speaker: Vevian Zhang, M.S.
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    Sponsored By: GenScript
    2
    FEB 24, 2021 | 12:00 PM
    Deep Mechanistic profiling of immune oncology drug combinations in cancer patients with CIVO intratumoral micro-dosing and NanoString's GeoMx® Digital Spatial Profiler
    Deep Mechanistic profiling of immune oncology drug combinations...
    With an introduction by Sarah Warren, the Senior Director of Translational Science, this webinar will open by providing a brief technology overview of NanoString Technologies. Dr. Warren wil...
    Speaker: Jason Frazier , Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2021
    Sponsored By: NanoString Technologies
    2
    FEB 09, 2021 | 8:00 AM
    Endpoint assays for the characterization of rare and therapy-resistant cells in cancer
    Endpoint assays for the characterization of rare and therapy-resistant...
    DATE: February 09, 2021 TIME: 08:00am PST Flow cytometry immunophenotyping has become one of the mainstream applications for the diagnosis and classification of several hematologic neoplasms...
    Speaker: Jordi Petriz
    Sponsored By: Thermo Fisher Scientific
    8
    DEC 16, 2020 | 8:00 AM
    Adding Dimensions to Multiplex Molecular Imaging
    Adding Dimensions to Multiplex Molecular Imaging
    Date: December 16, 2020 Time: 8:00am (PST), 11:00am (EST) Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better under...
    Speaker: Scott Fraser, PhD
    Sponsored By: Leica Microsystems
    8
     
     
  • DEC 09, 2020 | 8:00 AM
    Nanoscopy Meets Lifetime - Introducing the new STELLARIS 8 Ï„-STED
    Nanoscopy Meets Lifetime - Introducing the new STELLARIS 8 Ï„-STED
    Date: December 89 2020 Time: 8:00am (PST), 11:00am (EST) This talk introduces the Leica STELLARIS 8 τ-STED system where STED Nanoscopy meets Leica’s Fast Lifetime Contrast (FALCON)...
    Speaker: Julia Roberti, Ph.D.
    Sponsored By: Leica Microsystems
    1
    NOV 19, 2020 | 9:00 AM
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    From Protein Structures to Drug Discovery: Novel therapeutic opportunities.
    DATE: November 19, 2020 TIME: 9:00am PT, 12am ET Knowledge of the three-dimensional structure of therapeutically relevant targets has become an essential step in the pipeline of drug discove...
    Speaker: Amal Hassan Ali
    Sponsored By: Thermo Fisher Scientific
    16 1
    NOV 18, 2020 | 8:00 AM
    Whole-organ mapping using AI and light sheet microscopy
    Whole-organ mapping using AI and light sheet microscopy
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    Speaker: Ali Ertürk
    Sponsored By: Miltenyi Biotec
    14
    NOV 18, 2020 | 7:00 AM
    Troubleshooting Cell-based Assays - Ask the Experts to Avoid Common Pitfalls from Cell Seeding to Analysis
    Troubleshooting Cell-based Assays - Ask the Experts to Avoid Common...
    DATE: November 18, 2020 TIME: 7:00am PST, 10:00am PST, 4:00pm CEST The assessment of cell health and cellular responses after experimental manipulation continue to be a very important......
    Speaker: Jessica Wagener, PhD , Erik Bonke, PhD
    Sponsored By: Eppendorf, Promega
    17
    NOV 12, 2020 | 10:00 AM
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    FcRn Affinity Column Chromatography for Therapeutic mAb Characterization
    Date: November 12, 2020 Time: 10:00am (PST), 1:00pm (EST) Fc receptor based affinity chromatography is a new emerging field of Fc functionality analytics. FcRn affinity columns separate anti...
    Speaker: Tilman Schlothauer, Ph.D
    Sponsored By: Roche CustomBiotech
    3
     
     
  • OCT 13, 2020 | 2:30 PM
    Panel Discussion: Cancer Care in different regions and what are the current standard of care in Lung cancer
    Panel Discussion: Cancer Care in different regions and what are...
    ...
    Speaker: Arjun Khanna , David Chi Leung Lam, MD, PhD , Chein-Feng Li, MD , Darren Wan Teck Lim
    Presented at: 10 Million Reasons to Defeat Cancer - 2020 Abbott World Summit
    1
    SEP 30, 2020 | 1:30 PM
    Harnessing novel CRISPR systems for genome engineering
    Harnessing novel CRISPR systems for genome engineering
    RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. We demonstrate that RNA-targeting CRISPR effector Cas13 can be engineered for...
    Speaker: Omar Abudayyeh, PhD , Jonathan Gootenberg, PhD
    Presented at: CRISPR Virtual Event Series 2020
    4
    SEP 30, 2020 | 12:00 PM
    Efficient Generation of Gene-edited Mouse Models and Cell Lines Using Synthetic sgRNA
    Efficient Generation of Gene-edited Mouse Models and Cell Lines...
    The CRISPR/Cas genome editing system has revolutionized nearly every aspect of the life science industry. Until recently, the most used formats for this technology have been plasmids, mRNA,...
    Speaker: Gurpreet Balrey, PhD , Peter Romanienko, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    4
    SEP 30, 2020 | 12:00 AM
    Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
    Elucidation of remdesivir cytotoxicity pathways through genome-wide...
    The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
    Speaker: Minja Velimirovic, MSc, PhD Candidate
    Presented at: CRISPR Virtual Event Series 2020
    1
    SEP 23, 2020 | 8:00 AM
    CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic and Lab in Parallel
    CAR T-Cell Immunotherapy of Solid Tumors - Learning from the Clinic...
    Date: Time: Over the last couple of years, it has become apparent that affinity-tuned CAR T cells display enhanced expansion and prolonged persistence in patients and that this strategy can...
    Speaker: John Maher, PhD , Rogier Reijmers, PhD
    LUMICKS
    9 1
     
     
  • SEP 23, 2020 | 6:30 AM
    Mass Cytometry in Translational Research: Session I
    Mass Cytometry in Translational Research: Session I
    Single-cell mass cytometry identifies mechanisms of resistance to immunotherapy in AML 6:30–7:00 am PDT Presented By: Shelley Herbrich, PhD Understanding CD19 negative relapse followin...
    Speaker: Shelley Herbrich, PhD , Kara L. Davis, DO , Bernd Bodenmiller, PhD
    Presented at: 9th Annual Fluidigm Mass Cytometry Virtual Summit
    2
    SEP 23, 2020 | 12:00 AM
    The role of Nox-derived Reactive Oxygen Species in Axonal Growth and Guidance
    The role of Nox-derived Reactive Oxygen Species in Axonal Growth...
    Reactive oxygen species (ROS) are well-known for their detrimental effects leading to oxidative stress, cell death, aging, and degenerative disorders. However, there is increasing evidence t...
    Speaker: Daniel M. Suter, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    2
    SEP 10, 2020 | 7:30 AM
    Keynote Presentation: Discovery of a gene-microbiome interaction in lung cancer: lessons learned and future directions
    Keynote Presentation: Discovery of a gene-microbiome interaction...
    The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
    Speaker: K. Leigh Greathouse, PhD, MPH, MS, RD
    Presented at: Microbiology Week Virtual Event Series 2020
    3
    SEP 10, 2020 | 12:00 AM
    Host responses to SARS-CoV-2
    Host responses to SARS-CoV-2
    The host response to infection is a critical determinant of virus pathogenicity. Emerging viruses require the host cellular machinery to replicate and successfully infect new hosts, and must...
    Speaker: Angela L. Rasmussen, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    2
    SEP 09, 2020 | 9:00 AM
    Keynote Presentation: Human Monoclonal Antibodies for Emerging Agents
    Keynote Presentation: Human Monoclonal Antibodies for Emerging...
    Epidemics are occurring at an increasing pace and scale. Our laboratory group has developed platform technologies for discovery of broad and potent neutralizing antibodies for many emerging...
    Speaker: James Crowe, MD
    Presented at: Microbiology Week Virtual Event Series 2020
    1
     
     
  • SEP 09, 2020 | 12:00 AM
    Environmental stress shapes the evolution of a plant viruses towards a mutualistic relationship with its host
    Environmental stress shapes the evolution of a plant viruses towards...
    Traditionally, virology has been focused in studying the pathogenic effect of viruses. In the recent years, however, this perception is changing and viruses are being studied as mutualistic...
    Speaker: Santiago F. Elena
    Presented at: Microbiology Week Virtual Event Series 2020
    1
    SEP 09, 2020 | 12:00 AM
    How Plant Virology Informs Emergence of Zoonotic Viruses Such as SARS-COV-2
    How Plant Virology Informs Emergence of Zoonotic Viruses Such...
    The statement by Dimitri Ivanovsky in 1882 that "the sap of leaves infected with tobacco mosaic disease retains its infectious properties even after filtration through Chamberland filte...
    Speaker: Michael Goodin, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    3
    SEP 09, 2020 | 12:00 AM
    Understanding the role of virus-host interactions in tissue tropism of plant viruses
    Understanding the role of virus-host interactions in tissue tropism...
    To establish productive infection, plant viruses need to be able to efficiently invade and spread within a plant. Most viruses are introduced into a plant via the epidermal or mesophyll cell...
    Speaker: Svetlana Y. Folimonova
    Presented at: Microbiology Week Virtual Event Series 2020
    2
    SEP 09, 2020 | 12:00 AM
    Fc gamma receptor activation during viral infections: a double-edged sword
    Fc gamma receptor activation during viral infections: a double-edged...
    Over the last several decades, antibodies (Abs) have become a valuable weapon in the fight against viral infections, with several studies demonstrating the importance of both neutralizing an...
    Speaker: Raymond A. Alvarez, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
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