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    Cellular Mechanism

    Cellular Mechanism: is an abstraction of an electrophysiological mechanism present on a cell. The three main types are Channel Mechanism, Synaptic Mechanism and Ion Concentration.

    Webinars

    • JUL 19, 2022 | 8:00 AM
      Getting started in Cryo-EM
      Getting started in Cryo-EM
      Date: July 19, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping thes...
      Speaker: Melissa Chambers , Natalia de Val
      Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
      Sponsored By: Thermo Fisher Scientific
      9
      JUN 29, 2022 | 7:00 AM
      Insights into Structure, Dynamics, and Function of Endocytic Vesicles on the STELLARIS Confocal Platform
      Insights into Structure, Dynamics, and Function of Endocytic Vesicles...
      Date: June 29, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Imaging live cells is key to reveal their inner workings, dynamics, and function. Current technological advances in confo...
      Speaker: Julia Roberti, Ph.D.
      Sponsored By: Leica Microsystems
      5
      JUN 09, 2022 | 8:00 AM
      Revealing the role of Mononuclear phagocytes in human pregnancy via automated high purity isolation
      Revealing the role of Mononuclear phagocytes in human pregnancy...
      Date: June 09, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) It is known that immune responses of pregnant women undergo recognized changes that ensure the mother does not reject the...
      Speaker: Prof. Cathy Thornton, PhD , Salvador Vento Asturias, PhD
      Sponsored By: Miltenyi Biotec
      9
      JUN 02, 2022 | 8:00 AM
      From pathogen identification to disease prevention and cure: understanding how Sanger sequencing and fragment analysis is powering infectious disease research today
      From pathogen identification to disease prevention and cure: understanding...
      Infectious diseases present a great challenge to global health and its economy. The 2020 SARS- CoV-2 pandemic highlighted the importance of rapid identification, characterization and surveil...
      Speaker: Dr. Archana Gupta
      Sponsored By: Thermo Fisher Scientific
      16
      JUN 01, 2022 | 10:00 AM
      AI Microscopy Symposium, 7th edition
      AI Microscopy Symposium, 7th edition
      Date: June 1, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) The AI Microscopy Symposium, offers an unique forum for presenting and discussing the latest AI-based technologies and too...
      Speaker: Yicong Wu , Vijay Rajagopal , Afshin Khadangi , Parmida Ghahremani
      Sponsored By: Leica Microsystems
      15
      APR 26, 2022 | 7:00 AM
      Modelling of cellular interactions in mixed murine organoids
      Modelling of cellular interactions in mixed murine organoids
      Date: April 26, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CET) Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We...
      Speaker: Saskia J.E Suijkerbuijk
      Sponsored By: Andor
      8
      APR 05, 2022 | 8:00 AM
      Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing
      Investigating antimicrobial mechanisms-of-action using automated...
      Date: April 05, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEDT) Members of the cinnamic acid and stilbenoid chemical families are common intermediates in the production of important bi...
      Speaker: Ali Clark-ElSayed
      Sponsored By: Inscripta
      8
      MAR 09, 2022 | 10:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      5
      DEC 08, 2021 | 11:00 AM
      Human Breast Organoid Models for Cancer Research
      Human Breast Organoid Models for Cancer Research
      Date: December 8, 2021 Time: 11:00am (PST), 2:00pam (EST) Breast cancer is the most common type of cancer and the leading cause of cancer deaths for women. Despite considerable ongoing resea...
      Speaker: Xiaojiang Cui, PhD
      Sponsored By: Akoya Biosciences
      12
      DEC 07, 2021 | 9:00 AM
      Enhanced ACE2 humanized rodent models to make COVID-19 research more translatable
      Enhanced ACE2 humanized rodent models to make COVID-19 research...
      Date: December 7, 2021 Time: 9:00am (PST), 12:00pm (EST) The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than...
      Speaker: Justin Zhao, PhD
      Sponsored By: Envigo
      4 1
      SEP 29, 2021 | 9:00 AM
      Panel Presentation: Harnessing Novel CRISPR Systems for Transcriptome Engineering
      Panel Presentation: Harnessing Novel CRISPR Systems for Transcriptome...
      RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. We demonstrate that RNA-targeting CRISPR effector Cas13 and novel RNA targeti...
      Speaker: Omar Abudayyeh, PhD , Jonathan Gootenberg, PhD
      Presented at: CRISPR Virtual Event Series 2021
      1
      SEP 07, 2021 | 12:00 AM
      CMPK2 Restricts the Replication of Multiple Flaviviruses
      CMPK2 Restricts the Replication of Multiple Flaviviruses
      Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
      Speaker: Maudry Laurent-Rolle, MD/PhD
      Presented at: Microbiology Week Virtual Event Series 2021
      2
      AUG 25, 2021 | 8:00 AM
      Improving heterologous protein production in yeast with massively parallel CRISPR genome editing
      Improving heterologous protein production in yeast with massively...
      Date: August 25, 2021 Time: 8:00am (PDT), 11:00am (EDT) Heterologous protein production is an indispensable tool in biotechnology and biopharma for manufacturing enzymes, protein therapeutic...
      Speaker: Eric Abbate
      Sponsored By: Inscripta
      5 2
      AUG 25, 2021 | 12:00 AM
      The Long Hangover: Adolescent Intermittent Ethanol's Effects on Hippocampal Neuroimmune and Cell Death Markers, Reversal by Donepezil
      The Long Hangover: Adolescent Intermittent Ethanol's Effects on...
      Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
      Speaker: Kati Healey, MA, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      1
      AUG 25, 2021 | 12:00 AM
      Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant and How can we Model it?
      Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant...
      Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
      Speaker: Andrii Domanskyi, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      5
      JUN 10, 2021 | 10:00 AM
      GABA-receptive microglia selectively sculpt developing inhibitory circuits
      GABA-receptive microglia selectively sculpt developing inhibitory...
      Date: June 10, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Microglia, the primary brain macrophages, regulate a plethora of processes that impact the organization of neural circuits, including sy...
      Speaker: Loic Binan, Ph.D , Emilia Favuzzi, Ph.D
      Sponsored By: Vizgen
      13 3
      JUN 09, 2021 | 7:00 AM
      Preventing cell misidentification in your daily lab routine
      Preventing cell misidentification in your daily lab routine
      Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
      Speaker: Gabriela Saldanha , Jessica Wagener, PhD
      Sponsored By: Eppendorf
      40 3
      JUN 08, 2021 | 8:00 AM
      Antigen-specific CD4 T cell responses in humans: SARS-CoV-2 and beyond
      Antigen-specific CD4 T cell responses in humans: SARS-CoV-2 and...
      Date: June 08, 2021 Time: 08:00am (PDT) COVID-19 displays high clinical variability, but what determines its severity is unclear. Analysis of antigen-specific T cell responses has contribu...
      Speaker: Prof. Dr. Alexander Scheffold , Felix Eppler, PhD
      Sponsored By: Miltenyi Biotec
      15
      MAY 26, 2021 | 9:00 AM
      Advanced Phenotyping of the Tumor Immune Microenvironment
      Advanced Phenotyping of the Tumor Immune Microenvironment
      Date: May 26, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors but is challenged in that only a minority of patie...
      Speaker: Angela Vasaturo, Ph.D. , Fabian Schneider, Ph.D.
      Sponsored By: Ultivue
      6 1
      MAY 05, 2021 | 12:00 AM
      Identification and Interpretation of Fly Pattern Evidence at Crime Scenes
      Identification and Interpretation of Fly Pattern Evidence at Crime...
      When violent crimes are committed, the crime scene is usually covered with blood. Blood may be shed when the person is standing, sitting, or on the ground. The weapon that caused blood to be...
      Speaker: David Rivers, PhD
      Presented at: Forensic Sciences Virtual Event Series 2021
      2
      APR 22, 2021 | 5:00 PM
      Researchers share their Spatial Discoveries in Neurology Research
      Researchers share their Spatial Discoveries in Neurology Research
      Date: April 22, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) System transcriptomics of the schizophrenia brain - Phillip Khaitovich Schizophrenia tops the psychiatric disorder l...
      Speaker: Philipp Khaitovich , Joan Liu
      Sponsored By: NanoString Technologies, Illumina
      5
      APR 21, 2021 | 5:00 PM
      Immunology Researchers share their Spatial Discoveries in SARS-CoV-2 host response and in multiple sclerosis
      Immunology Researchers share their Spatial Discoveries in SARS-CoV-2...
      Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
      Speaker: Doug Brown, PhD , Susanne Krasemann, MD, PhD , Michelle Naughton, PhD
      Sponsored By: NanoString Technologies, Illumina
      5
      APR 20, 2021 | 9:00 AM
      Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation and Contextualizes Alzheimer's Associated Polymorphisms
      Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation...
      Chromatin Immunoprecipitation, coupled with sequencing, has shaped our understanding of how transcriptional machinery interacts with genomes to facilitate gene regulation. These protein-DNA...
      Speaker: Cory Padilla, PhD
      Presented at: Genetics Week Virtual Event Series 2021
      Sponsored By: Dovetail Genomics
      1
      MAR 31, 2021 | 9:00 AM
      Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored targeting
      Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored...
      Date: March 31, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Knockdown studies are prevalent and powerful ways to illustrate gene function. CRISPRi delivers a new mechanism for gene knockdown, PAM...
      Speaker: Steve Smith, PhD, MBA
      Sponsored By: Horizon Discovery
      13 2
    JUL 19, 2022 | 8:00 AM
    Getting started in Cryo-EM
    Getting started in Cryo-EM
    Date: July 19, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping thes...
    Speaker: Melissa Chambers , Natalia de Val
    Presented at: Thermo Fisher Scientific - Electron Microscopy Webinars
    Sponsored By: Thermo Fisher Scientific
    9
    JUN 29, 2022 | 7:00 AM
    Insights into Structure, Dynamics, and Function of Endocytic Vesicles on the STELLARIS Confocal Platform
    Insights into Structure, Dynamics, and Function of Endocytic Vesicles...
    Date: June 29, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Imaging live cells is key to reveal their inner workings, dynamics, and function. Current technological advances in confo...
    Speaker: Julia Roberti, Ph.D.
    Sponsored By: Leica Microsystems
    5
    JUN 09, 2022 | 8:00 AM
    Revealing the role of Mononuclear phagocytes in human pregnancy via automated high purity isolation
    Revealing the role of Mononuclear phagocytes in human pregnancy...
    Date: June 09, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) It is known that immune responses of pregnant women undergo recognized changes that ensure the mother does not reject the...
    Speaker: Prof. Cathy Thornton, PhD , Salvador Vento Asturias, PhD
    Sponsored By: Miltenyi Biotec
    9
    JUN 02, 2022 | 8:00 AM
    From pathogen identification to disease prevention and cure: understanding how Sanger sequencing and fragment analysis is powering infectious disease research today
    From pathogen identification to disease prevention and cure: understanding...
    Infectious diseases present a great challenge to global health and its economy. The 2020 SARS- CoV-2 pandemic highlighted the importance of rapid identification, characterization and surveil...
    Speaker: Dr. Archana Gupta
    Sponsored By: Thermo Fisher Scientific
    16
    JUN 01, 2022 | 10:00 AM
    AI Microscopy Symposium, 7th edition
    AI Microscopy Symposium, 7th edition
    Date: June 1, 2022 Time: 10:00am (PDT), 1:00pm (EDT), 7:00pm (CEST) The AI Microscopy Symposium, offers an unique forum for presenting and discussing the latest AI-based technologies and too...
    Speaker: Yicong Wu , Vijay Rajagopal , Afshin Khadangi , Parmida Ghahremani
    Sponsored By: Leica Microsystems
    15
     
     
  • APR 26, 2022 | 7:00 AM
    Modelling of cellular interactions in mixed murine organoids
    Modelling of cellular interactions in mixed murine organoids
    Date: April 26, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CET) Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We...
    Speaker: Saskia J.E Suijkerbuijk
    Sponsored By: Andor
    8
    APR 05, 2022 | 8:00 AM
    Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing
    Investigating antimicrobial mechanisms-of-action using automated...
    Date: April 05, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEDT) Members of the cinnamic acid and stilbenoid chemical families are common intermediates in the production of important bi...
    Speaker: Ali Clark-ElSayed
    Sponsored By: Inscripta
    8
    MAR 09, 2022 | 10:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    5
    DEC 08, 2021 | 11:00 AM
    Human Breast Organoid Models for Cancer Research
    Human Breast Organoid Models for Cancer Research
    Date: December 8, 2021 Time: 11:00am (PST), 2:00pam (EST) Breast cancer is the most common type of cancer and the leading cause of cancer deaths for women. Despite considerable ongoing resea...
    Speaker: Xiaojiang Cui, PhD
    Sponsored By: Akoya Biosciences
    12
    DEC 07, 2021 | 9:00 AM
    Enhanced ACE2 humanized rodent models to make COVID-19 research more translatable
    Enhanced ACE2 humanized rodent models to make COVID-19 research...
    Date: December 7, 2021 Time: 9:00am (PST), 12:00pm (EST) The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than...
    Speaker: Justin Zhao, PhD
    Sponsored By: Envigo
    4 1
     
     
  • SEP 29, 2021 | 9:00 AM
    Panel Presentation: Harnessing Novel CRISPR Systems for Transcriptome Engineering
    Panel Presentation: Harnessing Novel CRISPR Systems for Transcriptome...
    RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. We demonstrate that RNA-targeting CRISPR effector Cas13 and novel RNA targeti...
    Speaker: Omar Abudayyeh, PhD , Jonathan Gootenberg, PhD
    Presented at: CRISPR Virtual Event Series 2021
    1
    SEP 07, 2021 | 12:00 AM
    CMPK2 Restricts the Replication of Multiple Flaviviruses
    CMPK2 Restricts the Replication of Multiple Flaviviruses
    Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
    Speaker: Maudry Laurent-Rolle, MD/PhD
    Presented at: Microbiology Week Virtual Event Series 2021
    2
    AUG 25, 2021 | 8:00 AM
    Improving heterologous protein production in yeast with massively parallel CRISPR genome editing
    Improving heterologous protein production in yeast with massively...
    Date: August 25, 2021 Time: 8:00am (PDT), 11:00am (EDT) Heterologous protein production is an indispensable tool in biotechnology and biopharma for manufacturing enzymes, protein therapeutic...
    Speaker: Eric Abbate
    Sponsored By: Inscripta
    5 2
    AUG 25, 2021 | 12:00 AM
    The Long Hangover: Adolescent Intermittent Ethanol's Effects on Hippocampal Neuroimmune and Cell Death Markers, Reversal by Donepezil
    The Long Hangover: Adolescent Intermittent Ethanol's Effects on...
    Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
    Speaker: Kati Healey, MA, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    1
    AUG 25, 2021 | 12:00 AM
    Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant and How can we Model it?
    Alpha-synuclein Aggregation in Parkinson's Disease - Is it Relevant...
    Parkinson’s disease (PD) is the second most common neurodegenerative disorder with multiple motor and non-motor symptoms. PD is characterized by the presence on proteinaceous neuronal...
    Speaker: Andrii Domanskyi, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    5
     
     
  • JUN 10, 2021 | 10:00 AM
    GABA-receptive microglia selectively sculpt developing inhibitory circuits
    GABA-receptive microglia selectively sculpt developing inhibitory...
    Date: June 10, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Microglia, the primary brain macrophages, regulate a plethora of processes that impact the organization of neural circuits, including sy...
    Speaker: Loic Binan, Ph.D , Emilia Favuzzi, Ph.D
    Sponsored By: Vizgen
    13 3
    JUN 09, 2021 | 7:00 AM
    Preventing cell misidentification in your daily lab routine
    Preventing cell misidentification in your daily lab routine
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    Speaker: Gabriela Saldanha , Jessica Wagener, PhD
    Sponsored By: Eppendorf
    40 3
    JUN 08, 2021 | 8:00 AM
    Antigen-specific CD4 T cell responses in humans: SARS-CoV-2 and beyond
    Antigen-specific CD4 T cell responses in humans: SARS-CoV-2 and...
    Date: June 08, 2021 Time: 08:00am (PDT) COVID-19 displays high clinical variability, but what determines its severity is unclear. Analysis of antigen-specific T cell responses has contribu...
    Speaker: Prof. Dr. Alexander Scheffold , Felix Eppler, PhD
    Sponsored By: Miltenyi Biotec
    15
    MAY 26, 2021 | 9:00 AM
    Advanced Phenotyping of the Tumor Immune Microenvironment
    Advanced Phenotyping of the Tumor Immune Microenvironment
    Date: May 26, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors but is challenged in that only a minority of patie...
    Speaker: Angela Vasaturo, Ph.D. , Fabian Schneider, Ph.D.
    Sponsored By: Ultivue
    6 1
    MAY 05, 2021 | 12:00 AM
    Identification and Interpretation of Fly Pattern Evidence at Crime Scenes
    Identification and Interpretation of Fly Pattern Evidence at Crime...
    When violent crimes are committed, the crime scene is usually covered with blood. Blood may be shed when the person is standing, sitting, or on the ground. The weapon that caused blood to be...
    Speaker: David Rivers, PhD
    Presented at: Forensic Sciences Virtual Event Series 2021
    2
     
     
  • APR 22, 2021 | 5:00 PM
    Researchers share their Spatial Discoveries in Neurology Research
    Researchers share their Spatial Discoveries in Neurology Research
    Date: April 22, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) System transcriptomics of the schizophrenia brain - Phillip Khaitovich Schizophrenia tops the psychiatric disorder l...
    Speaker: Philipp Khaitovich , Joan Liu
    Sponsored By: NanoString Technologies, Illumina
    5
    APR 21, 2021 | 5:00 PM
    Immunology Researchers share their Spatial Discoveries in SARS-CoV-2 host response and in multiple sclerosis
    Immunology Researchers share their Spatial Discoveries in SARS-CoV-2...
    Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
    Speaker: Doug Brown, PhD , Susanne Krasemann, MD, PhD , Michelle Naughton, PhD
    Sponsored By: NanoString Technologies, Illumina
    5
    APR 20, 2021 | 9:00 AM
    Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation and Contextualizes Alzheimer's Associated Polymorphisms
    Enhancer-Promoter Interactome Drives Neuronal Cell Differentiation...
    Chromatin Immunoprecipitation, coupled with sequencing, has shaped our understanding of how transcriptional machinery interacts with genomes to facilitate gene regulation. These protein-DNA...
    Speaker: Cory Padilla, PhD
    Presented at: Genetics Week Virtual Event Series 2021
    Sponsored By: Dovetail Genomics
    1
    MAR 31, 2021 | 9:00 AM
    Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored targeting
    Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored...
    Date: March 31, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Knockdown studies are prevalent and powerful ways to illustrate gene function. CRISPRi delivers a new mechanism for gene knockdown, PAM...
    Speaker: Steve Smith, PhD, MBA
    Sponsored By: Horizon Discovery
    13 2
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