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CRISPR
CRISPR is an abbreviation of Clustered Regularly Interspaced Short Palindromic Repeats. The name was minted at a time when the origin and use of the interspacing subsequences were not known. At that time the CRISPRs were described as segments of prokaryotic DNA containing short, repetitive base sequences. In a palindromic repeat, the sequence of nucleotides is the same in both directions. Each repetition is followed by short segments of spacer DNA from previous exposures to foreign DNA (e.g., a virus or plasmid). Small clusters of cas (CRISPR-associated) genes are located next to CRISPR sequences.
MAY 08, 2019 | 7:30 AM
C.E. CREDITS
To interpret genome sequence from telomere to telomere, it is helpful end-to-end haplotypes with single-molecule epigenetics overlays, via in situ omics at sub-cellular (20 nm) resolution an...
MAY 08, 2019 | 6:00 AM
In this webinar, we will discuss our most recent additions to our CRISPR protein portfolio, the GFP-SpCas9 and GFP-eCas9 fusion proteins. The two GFP-Cas9 fusion proteins offer great visualiz...
MAY 08, 2019 | 6:00 AM
C.E. CREDITS
Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
APR 17, 2019 | 9:00 AM
DATE: April 17, 2019TIME: 9:00am PDT...
APR 09, 2019 | 9:00 AM
DATE: April 9, 2019TIME: 9:00 AM PDTWe will provide a general introduction to the Single-Cell Western Technology (SCW) and then present data from 2 ongoing projects from the Col...
APR 03, 2019 | 9:00 AM
DATE: April 3, 2019TIME: 9:00am PDT...
MAR 20, 2019 | 9:00 AM
DATE: March 20, 2019TIME: 9:00am PDT...
FEB 20, 2019 | 9:00 AM
DATE: February 20, 2019TIME: 9:00am PST ...
JAN 31, 2019 | 6:00 AM
Ambrx’s mammalian expression platform (EuCODE™) enables non-native amino acids (nnAAs) through an expanded genetic code to both generate novel bio-therapeutics and to optimize the...
DEC 13, 2018 | 9:00 AM
DATE: December 13 15,2018TIME: 09:00am PST, 12:00pm EST Breast cancers are classified into three main subtypes according to their receptor status: estrogen receptor-positive...
NOV 15, 2018 | 1:00 PM
The Neon transfection system enables robust transfection efficiencies in hiPSC for DNA, mRNA and Cas9/gRNA RNP complexes. For hiPSC these improved transfection as well as post-electroporation...
NOV 15, 2018 | 11:00 AM
Generation of robust iPSC-derived neural stem cell cultures and neurons with shorter maturation times provide opportunities for quick and reliable generation of neuronal in vitro models. This...
NOV 15, 2018 | 8:00 AM
CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
NOV 15, 2018 | 7:00 AM
The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
NOV 15, 2018 | 4:00 AM
Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...
OCT 25, 2018 | 8:00 AM
DATE: October 25, 2018TIME: 08:00am PDT, 11:00am EDT While the significance of the microbiome is unprecedented, a thorough study to dissect the role of individual popul...
OCT 23, 2018 | 9:00 AM
DATE: October 23, 2018TIME: 9:00AM PDTIxodes scapularis is the principal vector of the Lyme disease spirochete, Borrelia burgdorferi. I. scapularis genome was the first and only...
OCT 11, 2018 | 10:30 AM
Two projects looking at novel approaches to targeting inflammatory breast cancer will be presented. Inflammatory breast cancer (IBC) is a unique, understudied, and most lethal subtype account...
OCT 11, 2018 | 9:00 AM
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
OCT 11, 2018 | 7:30 AM
In the past two decades a small number of infrequently dividing cells have been proposed as the source of multi-drug resistance during cancer treatment. These cells identified by their expres...
