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    Drug Design

    Drug Design: often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.

    Webinars

    • MAR 28, 2018 | 1:30 PM
      Interplay Between Federal Law and State Law Regarding Marijuana Laws
      Interplay Between Federal Law and State Law Regarding Marijuana...
      More than half of the states around the country have legalized marijuana laws that permit individuals to use marijuana for medical or recreational purposes.  However, the possession and...
      Speaker: Jeffrey Matura
      Presented at: Cannabis Sciences Virtual Event Series 2018
      2
      MAR 28, 2018 | 12:00 PM
      Economies of Scale in Cannabis: Moving from lab-scale CO2 Extraction (SFE) to production-scale
      Economies of Scale in Cannabis: Moving from lab-scale CO2 Extraction...
      As with all new unique recreational or nutritional natural products, the cannabis supply chain will change from state-to-state and become more uniform and efficient over time.  From deca...
      Speaker: Lalit Chordia, PhD
      Presented at: Cannabis Sciences Virtual Event Series 2018
      3
      MAR 28, 2018 | 10:30 AM
      Factors That Influence Label Accuracy - Who's to Blame?
      Factors That Influence Label Accuracy - Who's to Blame?
      DATE: March 28, 2018TIME: 10:30AM PDTAs consumers in modern society, we have become accustomed to the purchase of foods and drugs that are safe and accurately labeled. This is a result...
      Speaker: Catharine Layton
      Presented at: Cannabis Sciences Virtual Event Series 2018
      4
      MAR 27, 2018 | 9:00 AM
      How to use CRISPR-Cas9 for knockout, knock-in and gene activation
      How to use CRISPR-Cas9 for knockout, knock-in and gene activation
      DATE: March 27, 2018TIME: 09:00am PDT, 12:00pm EDTThe rapid adoption and ease of use of CRISPR-Cas9 has driven the development of applications for gene knockout, precise gene editing, a...
      Speaker: Amanda Haas
      Sponsored By: Horizon Discovery
      23 15
      MAR 15, 2018 | 10:30 AM
      An Emerging Role of DNA Damage-Repair in Huntington's Disease
      An Emerging Role of DNA Damage-Repair in Huntington's Disease
      Machine learning approaches to pattern discovery in protein-protein interaction networks of Huntington’s disease brain and model organisms are revealing novel connections of the disease...
      Speaker: Animesh Ray, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      2
      FEB 28, 2018 | 12:00 AM
      Improved Neuronal Performance with the Gibco B-27 Plus Culture System
      Improved Neuronal Performance with the Gibco B-27 Plus Culture...
      TBD...
      Speaker: David Kuninger, PhD
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      2
      FEB 22, 2018 | 12:00 PM
      New Structure Based Drug Design Opportunities for GPCRs and Related Transporters
      New Structure Based Drug Design Opportunities for GPCRs and Related...
      Structure based drug design is now well established as a highly efficient approach in pharmaceutical research.  The approach uses atomic level detail structures of target proteins, most...
      Speaker: Sid Topiol, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      2
      FEB 22, 2018 | 10:30 AM
      Protective Effect of a Novel Noncompetitive IL-1 Receptor-Biased Ligand in an Infection - and Inflammation-Induced Preterm Birth as Well as in Fetal Injury and Developmental Outcomes
      Protective Effect of a Novel Noncompetitive IL-1 Receptor-Biased...
      Preterm birth (PTB) is the leading cause of infant mortality and morbidity worldwide. Both preterm labor and neonatal injuries have been linked to inflammation. Of all mediators of inflammati...
      Speaker: Sylvain Chemtob, MD, PhD, FRCPC, FAAP, FCAHS
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 21, 2018 | 1:30 PM
      Liposomes for Drug Delivery and Targeting: Examples of Their Potential from Our Laboratories Research
      Liposomes for Drug Delivery and Targeting: Examples of Their Potential...
      In the last years a number of advanced nanotechnologies have been proposed developed for the  administration of drugs (nanomedicines for drug delivery), in order to provide possibilities...
      Speaker: Sophia Antimisiaris, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 21, 2018 | 1:30 PM
      Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative Binding Affinities Based on Pre-computed Ensembles
      Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative...
      Rapid, accurate estimation of relative ligand affinities offers the potential to allow computational methods to direct drug design and development.  Towards this goal we have developed t...
      Speaker: Alexander MacKerell, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      FEB 21, 2018 | 7:30 AM
      Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular Pathological Epidemiology) and Immuno-MPE for Precision Medicine
      Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular...
      This lecture introduces the evolving paradigm of Molecular Pathological Epidemiology (MPE) as simply as possible.  Any given human disease represents fundamentally heterogeneous process,...
      Speaker: Shuji Ogino, MD, PhD, MS
      Presented at: Drug Discovery Virtual Event Series 2018
      1 1
      FEB 08, 2018 | 12:00 PM
      Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks
      Data Collection as Environmental Enrichment: Automated Behavioral...
      The translation gap in biomedical research can be attributed in part to differences in how outcomes are assessed in preclinical research and in the clinic. Reasons for these mismatches includ...
      Speaker: Jamie Ahloy Dallaire, MSc, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2018
      5
      FEB 07, 2018 | 7:30 AM
      Keynote Presentation: Male management - Recent Literature on How to Reduce Aggression in Male Mice
      Keynote Presentation: Male management - Recent Literature on How...
      Conspecific aggression is a common problem amongst laboratory housed male mice. While C57BL/6  are not the most aggressive strain we house, they are exceedingly common, and dealing with...
      Speaker: Brianna Gaskill, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2018
      4 1
      DEC 12, 2017 | 10:00 AM
      WEBINAR: Gold Standards and innovative processes for DC research in immuno-oncology
      WEBINAR: Gold Standards and innovative processes for DC research...
      DATE: December 12, 2017TIME: 10:00AM PTSince their discovery, dendritic cells (DCs) have demonstrated a central role in the development of effective immune responses. Their unique abili...
      Speaker: Andrzej Dzionek, PhD
      Sponsored By: Miltenyi Biotec
      7
      NOV 14, 2017 | 10:00 AM
      WEBINAR:  Cancer Cells Send Signals Boosting Survival and Drug Resistance in Other Cancer Cells
      WEBINAR: Cancer Cells Send Signals Boosting Survival and Drug...
      DATE: November 14, 2017TIME: 10:00am PST, 1:00pm ESTSuccessful tumor outgrowth requires the coordination of a variety of cell intrinsic and cell extrinsic signaling events. These events...
      Speaker: Jeffrey Rodvold, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco, Thermo Fisher Scientific/Gibco
      5 5
      NOV 08, 2017 | 12:00 PM
      The Opioid Crisis and other Novel Psychoactive Substances (NPS):  Forensic Toxicological Perspectives
      The Opioid Crisis and other Novel Psychoactive Substances (NPS):...
      Novel psychoactive substances (NPS) emerged in the United States around 2000.  Initially, synthetic cannabinoids and stimulants prevailed.  Now, designer opioids, benzodiazepines an...
      Speaker: Robert Middleberg, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
      1
      NOV 08, 2017 | 9:00 AM
      Tough Targets. Simple Genotyping. Complete Solutions for Mitochondrial Disease, CRISPR, Pharmacogenetics, and Neuroscience Research
      Tough Targets. Simple Genotyping. Complete Solutions for Mitochondrial...
      Do you have targets that are difficult to genotype? Are you starting new projects and looking for a fast, convenient genotyping solution?Whether detecting mitochondrial disease targets, s...
      Speaker: Dana Sullivan
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
      Sponsored By: Canon BioMedical
      1
      OCT 24, 2017 | 9:00 AM
      WEBINAR:  Genome Editing for Functional Genomics and Drug Discovery
      WEBINAR: Genome Editing for Functional Genomics and Drug Discovery
      DATE: October 24, 2017TIME: 09:00am PDT, 12:00pm EDTDoes your work involve disease models? Do you have a need to introduce specific genomic changes in the cells of your choice? Do you w...
      Speaker: Chetana Revankar , Sanjay Kumar
      Sponsored By: Thermo Fisher Scientific
      4 2
      OCT 17, 2017 | 8:00 AM
      WEBINAR: Transcriptomics to decipher the pathobiology of drug resistance and enable targeted therapeutics
      WEBINAR: Transcriptomics to decipher the pathobiology of drug...
      DATE: October 17, 2017TIME: 08:00am PDT, 11:00am EDTResearching and understanding the mechanisms of drug resistance are essential to determine therapies that are more effective on an in...
      Speaker: Yesim Gökmen-Polar, PhD
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      8 1
      OCT 12, 2017 | 10:30 AM
      Hypersecretion of fibroblast-derived exosomes during chemotherapy promotes pancreatic cancer chemoresistance
      Hypersecretion of fibroblast-derived exosomes during chemotherapy...
      Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
      Speaker: Reginald Hill, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      1
      SEP 27, 2017 | 12:00 PM
      CRISPR-Cas9 genome engineering: Experimental Design and Applications
      CRISPR-Cas9 genome engineering: Experimental Design and Applications
      The manipulation of the genome to study disease, evaluate drug targets and to stratify patient populations is now a widely accepted concept in the field. At Horizon Discovery, genome engineer...
      Speaker: Danielle Folkard
      Presented at: Cell Biology Virtual Event Series 2017
      Sponsored By: Horizon Discovery
      2
      SEP 14, 2017 | 7:30 AM
      Keynote Presentation: A Mechanistic Approach to Overcoming Antibacterial Drug Resistance
      Keynote Presentation: A Mechanistic Approach to Overcoming Antibacterial...
      Quinolones are one the most commonly prescribed classes of antibacterials in the world and are used to treat a broad variety of Gram-negative and Gram-positive bacterial infections in humans....
      Speaker: Neil Osheroff, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      1
      JUL 25, 2017 | 9:00 AM
      WEBINAR: Functional Genomics and Drug Metabolism
      WEBINAR: Functional Genomics and Drug Metabolism
      EVENT DETAILS:DATE: July 25, 2017TIME: 9:00am PT, Noon ETThermo Fisher Scientific is proud to present the SyncD3 webinar series.  As a thought-leader in science...
      Speaker: David Piper, PhD
      Sponsored By: Thermo Fisher Scientific
      7 1
      JUL 20, 2017 | 10:00 AM
      WEBINAR: Innovative quantitative imaging techniques and their utility in advancing neurobiology research
      WEBINAR: Innovative quantitative imaging techniques and their...
      DATE: July 20, 2017TIME: 10:00am PT, 1:00pm ETPart 1 - Daniel Beacham: Case study showing how CyQUANT Direct Cell Proliferation and Fluo-4 calcium imaging assays were us...
      Speaker: Dan Beacham, Ph.D. , Nicholas Radio Ph.D. , Michael Derr, M.S.
      Sponsored By: Thermo Fisher Scientific/Gibco
      3
    MAR 28, 2018 | 1:30 PM
    Interplay Between Federal Law and State Law Regarding Marijuana Laws
    Interplay Between Federal Law and State Law Regarding Marijuana...
    More than half of the states around the country have legalized marijuana laws that permit individuals to use marijuana for medical or recreational purposes.  However, the possession and...
    Speaker: Jeffrey Matura
    Presented at: Cannabis Sciences Virtual Event Series 2018
    2
    MAR 28, 2018 | 12:00 PM
    Economies of Scale in Cannabis: Moving from lab-scale CO2 Extraction (SFE) to production-scale
    Economies of Scale in Cannabis: Moving from lab-scale CO2 Extraction...
    As with all new unique recreational or nutritional natural products, the cannabis supply chain will change from state-to-state and become more uniform and efficient over time.  From deca...
    Speaker: Lalit Chordia, PhD
    Presented at: Cannabis Sciences Virtual Event Series 2018
    3
    MAR 28, 2018 | 10:30 AM
    Factors That Influence Label Accuracy - Who's to Blame?
    Factors That Influence Label Accuracy - Who's to Blame?
    DATE: March 28, 2018TIME: 10:30AM PDTAs consumers in modern society, we have become accustomed to the purchase of foods and drugs that are safe and accurately labeled. This is a result...
    Speaker: Catharine Layton
    Presented at: Cannabis Sciences Virtual Event Series 2018
    4
    MAR 27, 2018 | 9:00 AM
    How to use CRISPR-Cas9 for knockout, knock-in and gene activation
    How to use CRISPR-Cas9 for knockout, knock-in and gene activation
    DATE: March 27, 2018TIME: 09:00am PDT, 12:00pm EDTThe rapid adoption and ease of use of CRISPR-Cas9 has driven the development of applications for gene knockout, precise gene editing, a...
    Speaker: Amanda Haas
    Sponsored By: Horizon Discovery
    23 15
    MAR 15, 2018 | 10:30 AM
    An Emerging Role of DNA Damage-Repair in Huntington's Disease
    An Emerging Role of DNA Damage-Repair in Huntington's Disease
    Machine learning approaches to pattern discovery in protein-protein interaction networks of Huntington’s disease brain and model organisms are revealing novel connections of the disease...
    Speaker: Animesh Ray, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    2
     
     
  • FEB 28, 2018 | 12:00 AM
    Improved Neuronal Performance with the Gibco B-27 Plus Culture System
    Improved Neuronal Performance with the Gibco B-27 Plus Culture...
    TBD...
    Speaker: David Kuninger, PhD
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    2
    FEB 22, 2018 | 12:00 PM
    New Structure Based Drug Design Opportunities for GPCRs and Related Transporters
    New Structure Based Drug Design Opportunities for GPCRs and Related...
    Structure based drug design is now well established as a highly efficient approach in pharmaceutical research.  The approach uses atomic level detail structures of target proteins, most...
    Speaker: Sid Topiol, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    2
    FEB 22, 2018 | 10:30 AM
    Protective Effect of a Novel Noncompetitive IL-1 Receptor-Biased Ligand in an Infection - and Inflammation-Induced Preterm Birth as Well as in Fetal Injury and Developmental Outcomes
    Protective Effect of a Novel Noncompetitive IL-1 Receptor-Biased...
    Preterm birth (PTB) is the leading cause of infant mortality and morbidity worldwide. Both preterm labor and neonatal injuries have been linked to inflammation. Of all mediators of inflammati...
    Speaker: Sylvain Chemtob, MD, PhD, FRCPC, FAAP, FCAHS
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    FEB 21, 2018 | 1:30 PM
    Liposomes for Drug Delivery and Targeting: Examples of Their Potential from Our Laboratories Research
    Liposomes for Drug Delivery and Targeting: Examples of Their Potential...
    In the last years a number of advanced nanotechnologies have been proposed developed for the  administration of drugs (nanomedicines for drug delivery), in order to provide possibilities...
    Speaker: Sophia Antimisiaris, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    FEB 21, 2018 | 1:30 PM
    Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative Binding Affinities Based on Pre-computed Ensembles
    Can CADD Drive GPCR Drug Design? Rapid Estimation of Relative...
    Rapid, accurate estimation of relative ligand affinities offers the potential to allow computational methods to direct drug design and development.  Towards this goal we have developed t...
    Speaker: Alexander MacKerell, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
     
     
  • FEB 21, 2018 | 7:30 AM
    Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular Pathological Epidemiology) and Immuno-MPE for Precision Medicine
    Keynote Presentation: Evolving Paradigms of Pharmaco-MPE (Molecular...
    This lecture introduces the evolving paradigm of Molecular Pathological Epidemiology (MPE) as simply as possible.  Any given human disease represents fundamentally heterogeneous process,...
    Speaker: Shuji Ogino, MD, PhD, MS
    Presented at: Drug Discovery Virtual Event Series 2018
    1 1
    FEB 08, 2018 | 12:00 PM
    Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks
    Data Collection as Environmental Enrichment: Automated Behavioral...
    The translation gap in biomedical research can be attributed in part to differences in how outcomes are assessed in preclinical research and in the clinic. Reasons for these mismatches includ...
    Speaker: Jamie Ahloy Dallaire, MSc, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2018
    5
    FEB 07, 2018 | 7:30 AM
    Keynote Presentation: Male management - Recent Literature on How to Reduce Aggression in Male Mice
    Keynote Presentation: Male management - Recent Literature on How...
    Conspecific aggression is a common problem amongst laboratory housed male mice. While C57BL/6  are not the most aggressive strain we house, they are exceedingly common, and dealing with...
    Speaker: Brianna Gaskill, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2018
    4 1
    DEC 12, 2017 | 10:00 AM
    WEBINAR: Gold Standards and innovative processes for DC research in immuno-oncology
    WEBINAR: Gold Standards and innovative processes for DC research...
    DATE: December 12, 2017TIME: 10:00AM PTSince their discovery, dendritic cells (DCs) have demonstrated a central role in the development of effective immune responses. Their unique abili...
    Speaker: Andrzej Dzionek, PhD
    Sponsored By: Miltenyi Biotec
    7
    NOV 14, 2017 | 10:00 AM
    WEBINAR:  Cancer Cells Send Signals Boosting Survival and Drug Resistance in Other Cancer Cells
    WEBINAR: Cancer Cells Send Signals Boosting Survival and Drug...
    DATE: November 14, 2017TIME: 10:00am PST, 1:00pm ESTSuccessful tumor outgrowth requires the coordination of a variety of cell intrinsic and cell extrinsic signaling events. These events...
    Speaker: Jeffrey Rodvold, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco, Thermo Fisher Scientific/Gibco
    5 5
     
     
  • NOV 08, 2017 | 12:00 PM
    The Opioid Crisis and other Novel Psychoactive Substances (NPS):  Forensic Toxicological Perspectives
    The Opioid Crisis and other Novel Psychoactive Substances (NPS):...
    Novel psychoactive substances (NPS) emerged in the United States around 2000.  Initially, synthetic cannabinoids and stimulants prevailed.  Now, designer opioids, benzodiazepines an...
    Speaker: Robert Middleberg, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
    1
    NOV 08, 2017 | 9:00 AM
    Tough Targets. Simple Genotyping. Complete Solutions for Mitochondrial Disease, CRISPR, Pharmacogenetics, and Neuroscience Research
    Tough Targets. Simple Genotyping. Complete Solutions for Mitochondrial...
    Do you have targets that are difficult to genotype? Are you starting new projects and looking for a fast, convenient genotyping solution?Whether detecting mitochondrial disease targets, s...
    Speaker: Dana Sullivan
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2017
    Sponsored By: Canon BioMedical
    1
    OCT 24, 2017 | 9:00 AM
    WEBINAR:  Genome Editing for Functional Genomics and Drug Discovery
    WEBINAR: Genome Editing for Functional Genomics and Drug Discovery
    DATE: October 24, 2017TIME: 09:00am PDT, 12:00pm EDTDoes your work involve disease models? Do you have a need to introduce specific genomic changes in the cells of your choice? Do you w...
    Speaker: Chetana Revankar , Sanjay Kumar
    Sponsored By: Thermo Fisher Scientific
    4 2
    OCT 17, 2017 | 8:00 AM
    WEBINAR: Transcriptomics to decipher the pathobiology of drug resistance and enable targeted therapeutics
    WEBINAR: Transcriptomics to decipher the pathobiology of drug...
    DATE: October 17, 2017TIME: 08:00am PDT, 11:00am EDTResearching and understanding the mechanisms of drug resistance are essential to determine therapies that are more effective on an in...
    Speaker: Yesim Gökmen-Polar, PhD
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    8 1
    OCT 12, 2017 | 10:30 AM
    Hypersecretion of fibroblast-derived exosomes during chemotherapy promotes pancreatic cancer chemoresistance
    Hypersecretion of fibroblast-derived exosomes during chemotherapy...
    Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of only 9%. Acquired drug resistance is a major factor that limits the effectiveness of chemotherapy. Exosomes, secreted...
    Speaker: Reginald Hill, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    1
     
     
  • SEP 27, 2017 | 12:00 PM
    CRISPR-Cas9 genome engineering: Experimental Design and Applications
    CRISPR-Cas9 genome engineering: Experimental Design and Applications
    The manipulation of the genome to study disease, evaluate drug targets and to stratify patient populations is now a widely accepted concept in the field. At Horizon Discovery, genome engineer...
    Speaker: Danielle Folkard
    Presented at: Cell Biology Virtual Event Series 2017
    Sponsored By: Horizon Discovery
    2
    SEP 14, 2017 | 7:30 AM
    Keynote Presentation: A Mechanistic Approach to Overcoming Antibacterial Drug Resistance
    Keynote Presentation: A Mechanistic Approach to Overcoming Antibacterial...
    Quinolones are one the most commonly prescribed classes of antibacterials in the world and are used to treat a broad variety of Gram-negative and Gram-positive bacterial infections in humans....
    Speaker: Neil Osheroff, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    1
    JUL 25, 2017 | 9:00 AM
    WEBINAR: Functional Genomics and Drug Metabolism
    WEBINAR: Functional Genomics and Drug Metabolism
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    Sponsored By: Thermo Fisher Scientific
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    Sponsored By: Thermo Fisher Scientific/Gibco
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