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    Gene Silencing

    Gene Silencing: describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and RNAi. Methods to silence genes are exploited by researchers to study gene function, and for the development of therapeutics for diseases including cancer, infectious diseases and neurodegenerative disorders.

    Webinars

    • JUN 29, 2023 | 7:55 PM
      RNA Interference - From Single Gene Studies to Whole Genome Screens
      RNA Interference - From Single Gene Studies to Whole Genome Screens
      RNA interference (RNAi) offers a fast and easy system to study gene functions. However, the traditionally used small interfering RNAs (siRNAs) can exhibit pronounced and problematic off-targ...
      Speaker: Julia Krüger, PhD
      Sponsored By: MilliporeSigma
      9
      NOV 03, 2021 | 10:00 AM
      Streamline your path from immunodiagnostic development to commercialization
      Streamline your path from immunodiagnostic development to commercialization
      Date: November 3, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Developing and commercializing immunodiagnostic assays are challenging and time-consuming. Selecting the best combination of tools an...
      Speaker: Anthony Chiulli
      Sponsored By: Thermo Fisher Scientific
      3
      AUG 25, 2021 | 12:00 AM
      The Long Hangover: Adolescent Intermittent Ethanol's Effects on Hippocampal Neuroimmune and Cell Death Markers, Reversal by Donepezil
      The Long Hangover: Adolescent Intermittent Ethanol's Effects on...
      Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
      Speaker: Kati Healey, MA, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      1
      MAR 31, 2021 | 9:00 AM
      Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored targeting
      Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored...
      Date: March 31, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Knockdown studies are prevalent and powerful ways to illustrate gene function. CRISPRi delivers a new mechanism for gene knockdown, PAM...
      Speaker: Steve Smith, PhD, MBA
      Sponsored By: Horizon Discovery
      13 2
      NOV 19, 2020 | 9:00 AM
      Highly specific multiplexed RNA imaging in tissues with split-FISH
      Highly specific multiplexed RNA imaging in tissues with split-FISH
      Date: November 19, 2020 Time: 12:00am (PDT), 9:00am (CET), 4:00pm (SGT) We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to...
      Speaker: Kok Hao Chen , Alan Mullan, PhD
      Sponsored By: Andor
      6 2
      SEP 30, 2020 | 10:30 AM
      Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
      Straightforward CRISPR knockout: Leveraging predesigned synthetic...
      CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
      Speaker: James Goldmeyer, PhD
      Presented at: CRISPR Virtual Event Series 2020
      Sponsored By: Horizon Discovery
      3 1
      SEP 10, 2020 | 9:00 AM
      An Insider's Look: How One Parameter Can Optimize Key Phases of Bioprocessing Workflows
      An Insider's Look: How One Parameter Can Optimize Key Phases of...
      Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
      Speaker: Tara Barreira , Kristeena Wright
      Sponsored By: Advanced Instruments
      7
      SEP 08, 2020 | 9:00 AM
      Keynote Presentation: A Universal Influenza Virus Vaccine
      Keynote Presentation: A Universal Influenza Virus Vaccine
      Seasonal and pandemic influenza virus infections can cause significant disease worldwide. Current vaccines only provide limited, short-lived protection, and antigenic drift/shift in the hema...
      Speaker: Peter Palese, PhD
      Presented at: Microbiology Week Virtual Event Series 2020
      3
      JUL 22, 2020 | 10:00 AM
      Molecular Diagnostic Solutions in a Pandemic: Planning for the 2020/2021 Flu Season with the Implementation of the ePlex® Respiratory Pathogen Panel 2
      Molecular Diagnostic Solutions in a Pandemic: Planning for the...
      DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
      Speaker: Heba Mostafa, MD, PhD, D(ABMM)
      Sponsored By: GenMark Dx
      27 13
      JUN 03, 2020 | 1:00 PM
      Gene manipulation in primary human immune cells: Successful strategies and applications for CRISPRko, RNAi and beyond
      Gene manipulation in primary human immune cells: Successful strategies...
      Gene manipulation studies in primary human immune cells can answer important biological questions within a clinically relevant cellular context. In this webinar we explore the use of several...
      Speaker: Verena Brucklacher-Waldert, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Horizon Discovery
      2
      APR 07, 2020 | 8:00 AM
      Best Practice Criteria for Pluripotent Stem Cell Lines
      Best Practice Criteria for Pluripotent Stem Cell Lines
      DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
      Speaker: Lyn Healy
      Sponsored By: STEMCELL Technologies
      22
      JAN 01, 2020 | 6:00 AM
      Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
      Uncovering the mechanism of stress-resistant DNA replication in...
      Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
      Speaker: Chames Kermi, PhD, PharmD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      SEP 05, 2019 | 7:00 AM
      The bread and butter method of genomics: How to improve your (q)PCR
      The bread and butter method of genomics: How to improve your (q)PCR
      DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
      Speaker: Tim Schommartz, PhD
      Sponsored By: Eppendorf
      17 1
      AUG 29, 2019 | 9:00 AM
      Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
      Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
      DATE: August 29, 2019TIME: 9:00am PT/ 12:00pm ET Monoclonal antibodies (mAbs) are a cornerstone of modern biomedical research and biotherapeutics. Therefore, reproducibly obtai...
      Speaker: Ian Huggins, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      6
      MAY 08, 2019 | 6:00 AM
      C.E. CREDITS
      Novel DNA Methylation in Mammals
      Novel DNA Methylation in Mammals
      Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
      Speaker: Tao Wu, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2019
      2
      NOV 15, 2018 | 10:30 AM
      Management of HPV-Positive Women by QIAsure Methylation Test
      Management of HPV-Positive Women by QIAsure Methylation Test
      Cervical cancer is the 4th most common cancer worldwide with 528,000 new cases and 266,000 deaths every year. It is also the only cancer 100% preventable. It has been extensively proved, that...
      Speaker: Chris Meijer, MD, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      Sponsored By: QIAGEN
      3
      OCT 11, 2018 | 1:30 PM
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
      Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
      Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
      Speaker: Martin Hirst, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
      JUL 19, 2018 | 9:00 AM
      Investigating the role of microRNAs in pancreatic cancer progression
      Investigating the role of microRNAs in pancreatic cancer progression
      DATE:  July 19, 2018TIME:  09:00am PDT Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5 year-survival rate of approximately 6%. Despite recent...
      Speaker: Silvia Ottaviani, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      9 5
      SEP 19, 2017 | 10:30 AM
      WEBINAR: Structure and Function of Epigenetic Regulators in Human Disease
      WEBINAR: Structure and Function of Epigenetic Regulators in Human...
      DATE: September 19, 2017TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CESTPart 1 – Cigall Kadoch, Ph.D. (30 min.)Exome- and genome-wide sequencing studies in human cancer have...
      Speaker: Cigall Kadoch, PhD , Chris Fry, PhD
      Sponsored By: Cell Signaling Technology
      9 1
      JUL 01, 2017 | 12:00 AM
      Comprehensive Characterization of Pluripotent Stem Cells
      Comprehensive Characterization of Pluripotent Stem Cells
      As reprogramming methodologies have become more reliable and efficient, corresponding improvements were needed in the characterization workflow as well; specifically in terms of the speed, ef...
      Speaker: Suman Pradhan
      Presented at: 5th annual 24 Hours of Stem Cellsâ„¢ virtual event
      1
      MAY 31, 2017 | 9:00 AM
      WEBINAR: Disruptive technologies for improving disease resistance in crop plants. So many genomes ...and so little time
      WEBINAR: Disruptive technologies for improving disease resistance...
      DATE: May 31, 2017TIME: 9:00AM PDT, 12:00PM ETAlthough more remains to be learnt, great advances have recently been made in the understanding of the molecular & genetic bases of dis...
      Speaker: Richard Michelmore, PhD Natural Sciences
      Sponsored By: Dovetail Genomics
      6
      APR 19, 2017 | 4:00 AM
      WEBINAR: Patient Derived Micro Tumor systems: Future Trends towards improved testing systems
      WEBINAR: Patient Derived Micro Tumor systems: Future Trends towards...
      DATE: April 20th, 2017TIME: 10:00AM SGT, 11:00AM KST, 12:00PM AEST, 2:00PM NZSTWith increasing breadth and depth of genomics studies across a range of cancers, it is now apparent that t...
      Speaker: Giridharan Periyasamy, PhD
      Sponsored By: Revvity
      8
      MAR 22, 2016 | 11:30 AM
      Tu nuevo mejor amigo: Tu relación con el laboratorio de genética
      Tu nuevo mejor amigo: Tu relación con el laboratorio de genética
      Esta sesión le brindara ejemplos de estudios genéticos que son frecuentemente solicitados y que información pueden brindar al medico y al paciente. Los conferencistas ex...
      Speaker: Carlos Bacino, MD
      Presented at: GENETICS IN YOUR CLINIC: WHAT YOU CAN AND SHOULD DO NOW
      2
      MAY 13, 2015 | 3:00 PM
      Population genomics of sex chromosome evolution
      Population genomics of sex chromosome evolution
      There is tremendous sexual dimorphism in human genetic disease susceptibility, progression, and drug response. It is thus alarming that most genome-wide association studies exclude the most s...
      Speaker: Melissa A Wilson Sayres, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2015
      0
    JUN 29, 2023 | 7:55 PM
    RNA Interference - From Single Gene Studies to Whole Genome Screens
    RNA Interference - From Single Gene Studies to Whole Genome Screens
    RNA interference (RNAi) offers a fast and easy system to study gene functions. However, the traditionally used small interfering RNAs (siRNAs) can exhibit pronounced and problematic off-targ...
    Speaker: Julia Krüger, PhD
    Sponsored By: MilliporeSigma
    9
    NOV 03, 2021 | 10:00 AM
    Streamline your path from immunodiagnostic development to commercialization
    Streamline your path from immunodiagnostic development to commercialization
    Date: November 3, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Developing and commercializing immunodiagnostic assays are challenging and time-consuming. Selecting the best combination of tools an...
    Speaker: Anthony Chiulli
    Sponsored By: Thermo Fisher Scientific
    3
    AUG 25, 2021 | 12:00 AM
    The Long Hangover: Adolescent Intermittent Ethanol's Effects on Hippocampal Neuroimmune and Cell Death Markers, Reversal by Donepezil
    The Long Hangover: Adolescent Intermittent Ethanol's Effects on...
    Adolescence is a critical period for the developing brain, and binge drinking during this neuromaturation can result in enduring abnormal brain function and behavior. Repeated adolescent bin...
    Speaker: Kati Healey, MA, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    1
    MAR 31, 2021 | 9:00 AM
    Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored targeting
    Gene inactivation by CRISPRi: Modulate gene expression with PAM-anchored...
    Date: March 31, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Knockdown studies are prevalent and powerful ways to illustrate gene function. CRISPRi delivers a new mechanism for gene knockdown, PAM...
    Speaker: Steve Smith, PhD, MBA
    Sponsored By: Horizon Discovery
    13 2
    NOV 19, 2020 | 9:00 AM
    Highly specific multiplexed RNA imaging in tissues with split-FISH
    Highly specific multiplexed RNA imaging in tissues with split-FISH
    Date: November 19, 2020 Time: 12:00am (PDT), 9:00am (CET), 4:00pm (SGT) We present split-FISH, a multiplexed fluorescence in situ hybridization method that leverages a split-probe design to...
    Speaker: Kok Hao Chen , Alan Mullan, PhD
    Sponsored By: Andor
    6 2
     
     
  • SEP 30, 2020 | 10:30 AM
    Straightforward CRISPR knockout: Leveraging predesigned synthetic sgRNAs for highly functional and specific gene knockout
    Straightforward CRISPR knockout: Leveraging predesigned synthetic...
    CRISPR-based genome editing has accelerated biological research and holds great potential for studying and treating human diseases. The CRISPR-Cas9 system requires a Cas9 nuclease and a guid...
    Speaker: James Goldmeyer, PhD
    Presented at: CRISPR Virtual Event Series 2020
    Sponsored By: Horizon Discovery
    3 1
    SEP 10, 2020 | 9:00 AM
    An Insider's Look: How One Parameter Can Optimize Key Phases of Bioprocessing Workflows
    An Insider's Look: How One Parameter Can Optimize Key Phases of...
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    Speaker: Tara Barreira , Kristeena Wright
    Sponsored By: Advanced Instruments
    7
    SEP 08, 2020 | 9:00 AM
    Keynote Presentation: A Universal Influenza Virus Vaccine
    Keynote Presentation: A Universal Influenza Virus Vaccine
    Seasonal and pandemic influenza virus infections can cause significant disease worldwide. Current vaccines only provide limited, short-lived protection, and antigenic drift/shift in the hema...
    Speaker: Peter Palese, PhD
    Presented at: Microbiology Week Virtual Event Series 2020
    3
    JUL 22, 2020 | 10:00 AM
    Molecular Diagnostic Solutions in a Pandemic: Planning for the 2020/2021 Flu Season with the Implementation of the ePlex® Respiratory Pathogen Panel 2
    Molecular Diagnostic Solutions in a Pandemic: Planning for the...
    DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
    Speaker: Heba Mostafa, MD, PhD, D(ABMM)
    Sponsored By: GenMark Dx
    27 13
    JUN 03, 2020 | 1:00 PM
    Gene manipulation in primary human immune cells: Successful strategies and applications for CRISPRko, RNAi and beyond
    Gene manipulation in primary human immune cells: Successful strategies...
    Gene manipulation studies in primary human immune cells can answer important biological questions within a clinically relevant cellular context. In this webinar we explore the use of several...
    Speaker: Verena Brucklacher-Waldert, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Horizon Discovery
    2
     
     
  • APR 07, 2020 | 8:00 AM
    Best Practice Criteria for Pluripotent Stem Cell Lines
    Best Practice Criteria for Pluripotent Stem Cell Lines
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    Speaker: Lyn Healy
    Sponsored By: STEMCELL Technologies
    22
    JAN 01, 2020 | 6:00 AM
    Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
    Uncovering the mechanism of stress-resistant DNA replication in...
    Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
    Speaker: Chames Kermi, PhD, PharmD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    SEP 05, 2019 | 7:00 AM
    The bread and butter method of genomics: How to improve your (q)PCR
    The bread and butter method of genomics: How to improve your (q)PCR
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    Speaker: Tim Schommartz, PhD
    Sponsored By: Eppendorf
    17 1
    AUG 29, 2019 | 9:00 AM
    Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
    Enabling Next-Generation Targeted siRNA Therapies with ExpiCHO
    DATE: August 29, 2019TIME: 9:00am PT/ 12:00pm ET Monoclonal antibodies (mAbs) are a cornerstone of modern biomedical research and biotherapeutics. Therefore, reproducibly obtai...
    Speaker: Ian Huggins, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    6
    MAY 08, 2019 | 6:00 AM
    C.E. CREDITS
    Novel DNA Methylation in Mammals
    Novel DNA Methylation in Mammals
    Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. Although the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognize...
    Speaker: Tao Wu, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2019
    2
     
     
  • NOV 15, 2018 | 10:30 AM
    Management of HPV-Positive Women by QIAsure Methylation Test
    Management of HPV-Positive Women by QIAsure Methylation Test
    Cervical cancer is the 4th most common cancer worldwide with 528,000 new cases and 266,000 deaths every year. It is also the only cancer 100% preventable. It has been extensively proved, that...
    Speaker: Chris Meijer, MD, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    Sponsored By: QIAGEN
    3
    OCT 11, 2018 | 1:30 PM
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in Cancer
    Exploiting Cis-Regulatory Enhancers as Therapeutic Targets in...
    Recent work has identified epigenomic features of distal regulatory elements to be dynamic and defining indicators of cellular specification and transformation. Of particular relevance is our...
    Speaker: Martin Hirst, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
    JUL 19, 2018 | 9:00 AM
    Investigating the role of microRNAs in pancreatic cancer progression
    Investigating the role of microRNAs in pancreatic cancer progression
    DATE:  July 19, 2018TIME:  09:00am PDT Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5 year-survival rate of approximately 6%. Despite recent...
    Speaker: Silvia Ottaviani, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    9 5
    SEP 19, 2017 | 10:30 AM
    WEBINAR: Structure and Function of Epigenetic Regulators in Human Disease
    WEBINAR: Structure and Function of Epigenetic Regulators in Human...
    DATE: September 19, 2017TIME: 10:30am PDT/ 1:30pm EDT/ 7:30pm CESTPart 1 – Cigall Kadoch, Ph.D. (30 min.)Exome- and genome-wide sequencing studies in human cancer have...
    Speaker: Cigall Kadoch, PhD , Chris Fry, PhD
    Sponsored By: Cell Signaling Technology
    9 1
    JUL 01, 2017 | 12:00 AM
    Comprehensive Characterization of Pluripotent Stem Cells
    Comprehensive Characterization of Pluripotent Stem Cells
    As reprogramming methodologies have become more reliable and efficient, corresponding improvements were needed in the characterization workflow as well; specifically in terms of the speed, ef...
    Speaker: Suman Pradhan
    Presented at: 5th annual 24 Hours of Stem Cellsâ„¢ virtual event
    1
     
     
  • MAY 31, 2017 | 9:00 AM
    WEBINAR: Disruptive technologies for improving disease resistance in crop plants. So many genomes ...and so little time
    WEBINAR: Disruptive technologies for improving disease resistance...
    DATE: May 31, 2017TIME: 9:00AM PDT, 12:00PM ETAlthough more remains to be learnt, great advances have recently been made in the understanding of the molecular & genetic bases of dis...
    Speaker: Richard Michelmore, PhD Natural Sciences
    Sponsored By: Dovetail Genomics
    6
    APR 19, 2017 | 4:00 AM
    WEBINAR: Patient Derived Micro Tumor systems: Future Trends towards improved testing systems
    WEBINAR: Patient Derived Micro Tumor systems: Future Trends towards...
    DATE: April 20th, 2017TIME: 10:00AM SGT, 11:00AM KST, 12:00PM AEST, 2:00PM NZSTWith increasing breadth and depth of genomics studies across a range of cancers, it is now apparent that t...
    Speaker: Giridharan Periyasamy, PhD
    Sponsored By: Revvity
    8
    MAR 22, 2016 | 11:30 AM
    Tu nuevo mejor amigo: Tu relación con el laboratorio de genética
    Tu nuevo mejor amigo: Tu relación con el laboratorio de genética
    Esta sesión le brindara ejemplos de estudios genéticos que son frecuentemente solicitados y que información pueden brindar al medico y al paciente. Los conferencistas ex...
    Speaker: Carlos Bacino, MD
    Presented at: GENETICS IN YOUR CLINIC: WHAT YOU CAN AND SHOULD DO NOW
    2
    MAY 13, 2015 | 3:00 PM
    Population genomics of sex chromosome evolution
    Population genomics of sex chromosome evolution
    There is tremendous sexual dimorphism in human genetic disease susceptibility, progression, and drug response. It is thus alarming that most genome-wide association studies exclude the most s...
    Speaker: Melissa A Wilson Sayres, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2015
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