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    Host Cell Protein

    Host Cell Proteins: these are process-related impurities, expressed by the host cell used for production of biopharmaceutical proteins. Host cells express many of their own proteins that can easily contaminate the recombinant protein drug.

    Webinars

    • APR 21, 2020 | 12:00 AM
      Single Cell Multi-omics: Solving the Jigsaw
      Single Cell Multi-omics: Solving the Jigsaw
      Since the introduction of single cell sequencing techniques to the genomics community, interest in its use has grown exponentially and the number of single cell publications has exploded. Th...
      Speaker: Ivan Lukić, MD, PhD
      Presented at: Genetics Week Virtual Event Series 2020
      1
      APR 21, 2020 | 12:00 AM
      Single cell gene expression: new insights through the lens of full length mRNA isoform resolution
      Single cell gene expression: new insights through the lens of...
      Single cell RNA sequencing (scRNA-seq) emerged to characterize gene expression differences between individual cells, allowing a higher resolution look at mRNA abundance than bulk RNA- seq. H...
      Speaker: Jason Underwood, PhD
      Presented at: Genetics Week Virtual Event Series 2020
      1
      APR 08, 2020 | 12:00 AM
      Macroscopic Modeling of Bioreactors for Recombinant Protein Producing Pichia pastoris in Defined Medium
      Macroscopic Modeling of Bioreactors for Recombinant Protein Producing...
      Bioreactor modeling can inform understanding of cellular metabolism—including aspects of growth kinetics, productivity, media consumption, and metabolite secretion—and can be use...
      Speaker: Moo Sun Hong, MS
      Presented at: BioProcessing Virtual Event Series 2020
      2
      FEB 26, 2020 | 1:30 PM
      Automated cell separation for drug discovery assays
      Automated cell separation for drug discovery assays
      Whether you are performing killing assays, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery of new therapeutics. Conc...
      Speaker: Josh Mahlios, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: Miltenyi Biotec
      1
      FEB 26, 2020 | 12:00 PM
      Characterizing the role of B cells in Response to Immunotherapy with the NanoString GeoMx Platform
      Characterizing the role of B cells in Response to Immunotherapy...
      Digital spatial profiling (DSP) on the NanoString GeoMx platform enables high plex molecular profiling of clinical tissue samples. This new profiling strategy enables deep insights into the...
      Speaker: Sarah Warren, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: NanoString Technologies
      1
      FEB 26, 2020 | 10:30 AM
      QIAGEN CLC Genomics Workbench 20 - scalable software for NGS data analysis
      QIAGEN CLC Genomics Workbench 20 - scalable software for NGS data...
      QIAGEN CLC Genomics Workbench is a powerful solution to analyze and visualize next generation sequencing (NGS) data. Powered by cutting-edge technology and accelerated algorithms, it support...
      Speaker: Leif Schauser, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: QIAGEN
      1
      FEB 26, 2020 | 9:00 AM
      CRISPR Based Screening: Advantages of Transcriptional Activators and Inhibitors
      CRISPR Based Screening: Advantages of Transcriptional Activators...
      CRISPR revolutionized gene editing, but multi-target screening remains a complex goal. In addition, the fast pace of CRISPR technology development has brought sophisticated options for libra...
      Speaker: Andrew Ravanelli, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      Sponsored By: MilliporeSigma
      2 1
      FEB 26, 2020 | 7:30 AM
      Keynote Presentation: Emerging Drug Combinations: Evolution From Pre-Clinical Discovery to Clinical Development
      Keynote Presentation: Emerging Drug Combinations: Evolution From...
      Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
      Speaker: Khyati Shah, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      CK18 as a Biomarker in NASH Clinical Trials
      CK18 as a Biomarker in NASH Clinical Trials
      Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries, and it affects over 25% of the population worldwide. Within the next five y...
      Speaker: Jessica Tuohy, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      2
      JAN 01, 2020 | 6:00 AM
      Vancomycin:  How might Urinary Biomarkers and Precision Dosing create Precision Medicine for the most frequently utilized antibiotic in the hospital?
      Vancomycin: How might Urinary Biomarkers and Precision Dosing...
      Learning Objectives: 1. Describe the exposure response relationships with vancomycin and acute kidney injury 2. Define biomarkers that may be useful to improve Precision Dosing...
      Speaker: Marc Scheetz, PharmD, MSc, FCCP, FCP
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Microphysiological Systems for Human Focused Drug Discovery
      Microphysiological Systems for Human Focused Drug Discovery
      Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
      Speaker: Tomasz Kostrzewski, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      3
      JAN 01, 2020 | 6:00 AM
      3D-Micro Tissues in Translational Toxicology and Disease Modelling
      3D-Micro Tissues in Translational Toxicology and Disease Modelling
      The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
      Speaker: Armin Wolf, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Human Tissue models for better therapies
      Human Tissue models for better therapies
      The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
      Speaker: Sebastiaan Trietsch, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Generation of expanded primary liver cells
      Generation of expanded primary liver cells
      The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes)...
      Speaker: Astrid Nörenberg, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
      Uncovering the mechanism of stress-resistant DNA replication in...
      Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
      Speaker: Chames Kermi, PhD, PharmD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Measuring What Matters:  Proliferation and Cell Death Biomarkers for Oncology Research
      Measuring What Matters: Proliferation and Cell Death Biomarkers...
      Biomarkers are critical tools for all stages of cancer research, from drug development through clinical applications. Cancer is fundamentally a disease of unregulated cell growth and circumv...
      Speaker: Olivia Stricker, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Organoids: A Revolutionary New Tool for Drug Screening
      Organoids: A Revolutionary New Tool for Drug Screening
      “The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
      Speaker: Rekha Pal, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Microfabricated Human Liver Tissues for Drug Development
      Microfabricated Human Liver Tissues for Drug Development
      The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
      Speaker: Salman Khetani, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Using 3D cell culture models and high content confocal imaging to evaluate efficacy and expose toxic liabilities in the drug development pipeline
      Using 3D cell culture models and high content confocal imaging...
      With an increasing push to improve safety, efficacy, and efficiency throughout the drug development pipeline, researchers are evermore looking to improve the predictive capacity of their in...
      Speaker: Erin Edwards, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      SEP 11, 2019 | 12:00 PM
      Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
      Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
      immunocompromised populations where the virus can cause systemic and even fatal infections. Indeed, we have shown that astrovirus infections are more prevalent than norovirus in our pediatric...
      Speaker: Stacey Schultz-Cherry, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      5
      MAY 16, 2019 | 4:00 PM
      Towards Standardized Workflows - A focus on microbiome insights
      Towards Standardized Workflows - A focus on microbiome insights
      DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
      Speaker: Rita Colwell, PhD , Christiane Honisch, PhD
      Sponsored By: Eppendorf
      10 2
      JAN 29, 2019 | 9:00 AM
      Targeting prostate cancer stem cells with T cell immunotherapy
      Targeting prostate cancer stem cells with T cell immunotherapy
      DATE:    January 29. 2019TIME:    09:00am PST, 12:00pm EST In healthy tissue, a reservoir of stem cells gives rise to non-stem cells while simul...
      Speaker: Amy Codd
      Sponsored By: Thermo Fisher Scientific/Gibco
      10 2
      NOV 15, 2018 | 10:30 AM
      Management of HPV-Positive Women by QIAsure Methylation Test
      Management of HPV-Positive Women by QIAsure Methylation Test
      Cervical cancer is the 4th most common cancer worldwide with 528,000 new cases and 266,000 deaths every year. It is also the only cancer 100% preventable. It has been extensively proved, that...
      Speaker: Chris Meijer, MD, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      Sponsored By: QIAGEN
      3
      OCT 10, 2018 | 12:00 PM
      Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
      Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
      To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
      Speaker: Jerome Galon, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
      1
    APR 21, 2020 | 12:00 AM
    Single Cell Multi-omics: Solving the Jigsaw
    Single Cell Multi-omics: Solving the Jigsaw
    Since the introduction of single cell sequencing techniques to the genomics community, interest in its use has grown exponentially and the number of single cell publications has exploded. Th...
    Speaker: Ivan Lukić, MD, PhD
    Presented at: Genetics Week Virtual Event Series 2020
    1
    APR 21, 2020 | 12:00 AM
    Single cell gene expression: new insights through the lens of full length mRNA isoform resolution
    Single cell gene expression: new insights through the lens of...
    Single cell RNA sequencing (scRNA-seq) emerged to characterize gene expression differences between individual cells, allowing a higher resolution look at mRNA abundance than bulk RNA- seq. H...
    Speaker: Jason Underwood, PhD
    Presented at: Genetics Week Virtual Event Series 2020
    1
    APR 08, 2020 | 12:00 AM
    Macroscopic Modeling of Bioreactors for Recombinant Protein Producing Pichia pastoris in Defined Medium
    Macroscopic Modeling of Bioreactors for Recombinant Protein Producing...
    Bioreactor modeling can inform understanding of cellular metabolism—including aspects of growth kinetics, productivity, media consumption, and metabolite secretion—and can be use...
    Speaker: Moo Sun Hong, MS
    Presented at: BioProcessing Virtual Event Series 2020
    2
    FEB 26, 2020 | 1:30 PM
    Automated cell separation for drug discovery assays
    Automated cell separation for drug discovery assays
    Whether you are performing killing assays, characterizing the tumor microenvironment, or investigating immunogenicity, primary cells are essential for the discovery of new therapeutics. Conc...
    Speaker: Josh Mahlios, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: Miltenyi Biotec
    1
    FEB 26, 2020 | 12:00 PM
    Characterizing the role of B cells in Response to Immunotherapy with the NanoString GeoMx Platform
    Characterizing the role of B cells in Response to Immunotherapy...
    Digital spatial profiling (DSP) on the NanoString GeoMx platform enables high plex molecular profiling of clinical tissue samples. This new profiling strategy enables deep insights into the...
    Speaker: Sarah Warren, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: NanoString Technologies
    1
     
     
  • FEB 26, 2020 | 10:30 AM
    QIAGEN CLC Genomics Workbench 20 - scalable software for NGS data analysis
    QIAGEN CLC Genomics Workbench 20 - scalable software for NGS data...
    QIAGEN CLC Genomics Workbench is a powerful solution to analyze and visualize next generation sequencing (NGS) data. Powered by cutting-edge technology and accelerated algorithms, it support...
    Speaker: Leif Schauser, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: QIAGEN
    1
    FEB 26, 2020 | 9:00 AM
    CRISPR Based Screening: Advantages of Transcriptional Activators and Inhibitors
    CRISPR Based Screening: Advantages of Transcriptional Activators...
    CRISPR revolutionized gene editing, but multi-target screening remains a complex goal. In addition, the fast pace of CRISPR technology development has brought sophisticated options for libra...
    Speaker: Andrew Ravanelli, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    Sponsored By: MilliporeSigma
    2 1
    FEB 26, 2020 | 7:30 AM
    Keynote Presentation: Emerging Drug Combinations: Evolution From Pre-Clinical Discovery to Clinical Development
    Keynote Presentation: Emerging Drug Combinations: Evolution From...
    Recent advances in DNA sequencing and omics-based capabilities are revealing incredible therapeutic opportunities and quickly transforming drug discovery. Molecularly targeted drugs aim to e...
    Speaker: Khyati Shah, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    CK18 as a Biomarker in NASH Clinical Trials
    CK18 as a Biomarker in NASH Clinical Trials
    Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries, and it affects over 25% of the population worldwide. Within the next five y...
    Speaker: Jessica Tuohy, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    2
    JAN 01, 2020 | 6:00 AM
    Vancomycin:  How might Urinary Biomarkers and Precision Dosing create Precision Medicine for the most frequently utilized antibiotic in the hospital?
    Vancomycin: How might Urinary Biomarkers and Precision Dosing...
    Learning Objectives: 1. Describe the exposure response relationships with vancomycin and acute kidney injury 2. Define biomarkers that may be useful to improve Precision Dosing...
    Speaker: Marc Scheetz, PharmD, MSc, FCCP, FCP
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
     
     
  • JAN 01, 2020 | 6:00 AM
    Microphysiological Systems for Human Focused Drug Discovery
    Microphysiological Systems for Human Focused Drug Discovery
    Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
    Speaker: Tomasz Kostrzewski, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    3
    JAN 01, 2020 | 6:00 AM
    3D-Micro Tissues in Translational Toxicology and Disease Modelling
    3D-Micro Tissues in Translational Toxicology and Disease Modelling
    The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
    Speaker: Armin Wolf, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Human Tissue models for better therapies
    Human Tissue models for better therapies
    The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
    Speaker: Sebastiaan Trietsch, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Generation of expanded primary liver cells
    Generation of expanded primary liver cells
    The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes)...
    Speaker: Astrid Nörenberg, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Uncovering the mechanism of stress-resistant DNA replication in cancer cells using a modern single-molecule technique
    Uncovering the mechanism of stress-resistant DNA replication in...
    Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
    Speaker: Chames Kermi, PhD, PharmD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
     
     
  • JAN 01, 2020 | 6:00 AM
    Measuring What Matters:  Proliferation and Cell Death Biomarkers for Oncology Research
    Measuring What Matters: Proliferation and Cell Death Biomarkers...
    Biomarkers are critical tools for all stages of cancer research, from drug development through clinical applications. Cancer is fundamentally a disease of unregulated cell growth and circumv...
    Speaker: Olivia Stricker, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Organoids: A Revolutionary New Tool for Drug Screening
    Organoids: A Revolutionary New Tool for Drug Screening
    “The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
    Speaker: Rekha Pal, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Microfabricated Human Liver Tissues for Drug Development
    Microfabricated Human Liver Tissues for Drug Development
    The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
    Speaker: Salman Khetani, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Using 3D cell culture models and high content confocal imaging to evaluate efficacy and expose toxic liabilities in the drug development pipeline
    Using 3D cell culture models and high content confocal imaging...
    With an increasing push to improve safety, efficacy, and efficiency throughout the drug development pipeline, researchers are evermore looking to improve the predictive capacity of their in...
    Speaker: Erin Edwards, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    SEP 11, 2019 | 12:00 PM
    Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
    Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
    immunocompromised populations where the virus can cause systemic and even fatal infections. Indeed, we have shown that astrovirus infections are more prevalent than norovirus in our pediatric...
    Speaker: Stacey Schultz-Cherry, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    5
     
     
  • MAY 16, 2019 | 4:00 PM
    Towards Standardized Workflows - A focus on microbiome insights
    Towards Standardized Workflows - A focus on microbiome insights
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    Speaker: Rita Colwell, PhD , Christiane Honisch, PhD
    Sponsored By: Eppendorf
    10 2
    JAN 29, 2019 | 9:00 AM
    Targeting prostate cancer stem cells with T cell immunotherapy
    Targeting prostate cancer stem cells with T cell immunotherapy
    DATE:    January 29. 2019TIME:    09:00am PST, 12:00pm EST In healthy tissue, a reservoir of stem cells gives rise to non-stem cells while simul...
    Speaker: Amy Codd
    Sponsored By: Thermo Fisher Scientific/Gibco
    10 2
    NOV 15, 2018 | 10:30 AM
    Management of HPV-Positive Women by QIAsure Methylation Test
    Management of HPV-Positive Women by QIAsure Methylation Test
    Cervical cancer is the 4th most common cancer worldwide with 528,000 new cases and 266,000 deaths every year. It is also the only cancer 100% preventable. It has been extensively proved, that...
    Speaker: Chris Meijer, MD, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    Sponsored By: QIAGEN
    3
    OCT 10, 2018 | 12:00 PM
    Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
    Integrative Cancer Immunology and Novel Concepts of Cancer Evolution
    To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
    Speaker: Jerome Galon, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2018
    1
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