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    Host Cell Protein

    Host Cell Proteins: these are process-related impurities, expressed by the host cell used for production of biopharmaceutical proteins. Host cells express many of their own proteins that can easily contaminate the recombinant protein drug.

    Webinars

    • OCT 03, 2018 | 12:00 PM
      Mechanisms of CRISPR-Cas Systems: From Adaptive Immunity to Biotechnology
      Mechanisms of CRISPR-Cas Systems: From Adaptive Immunity to Biotechnology
      All forms of life require immune systems to stave off infection from viruses and other pathogens. In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) a...
      Speaker: Dipali Sashital, PhD
      Presented at: CRISPR Virtual Event Series 2018
      3
      SEP 18, 2018 | 8:00 AM
      High-throughput CRISPR-Cas9 Genome Engineering in Primary T Cells
      High-throughput CRISPR-Cas9 Genome Engineering in Primary T Cells
      DATE: September 18,2018TIME: 08:00am PDT, 11:00am EDT CRISPR-Cas9 gene editing strategies have revolutionized our ability to engineer the genomes of diverse cell types and sp...
      Speaker: Judd Hultquist, PhD
      Sponsored By: Horizon Discovery
      7
      SEP 13, 2018 | 1:30 PM
      Mechanisms of Antimicrobial Bioconversion by Environmental and Host-Associated Bacteria
      Mechanisms of Antimicrobial Bioconversion by Environmental and...
      The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them. Resistance genes are widely distributed in the soil and may act as a reservoir for pathogen antibioti...
      Speaker: Terence Crofts, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      3
      SEP 13, 2018 | 10:30 AM
      Studying Environmental Sensing and Response in a Bacterial Plant Pathogen - Inside Out
      Studying Environmental Sensing and Response in a Bacterial Plant...
      The bacterium Pantoea stewartii subsp. stewartii causes Stewart’s wilt disease in corn and serves as a model for other xylem-dwelling phytopathogens. P. stewartii is transmitted to plan...
      Speaker: Ann Stevens, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      3
      SEP 12, 2018 | 9:00 AM
      The Persistence of Pertussis and the Prognostic Value of Bordetella Detection
      The Persistence of Pertussis and the Prognostic Value of Bordetella...
      Whooping cough caused by Bordetella infection has resurged in recent years.  Dr. Karissa Culbreath will discuss the clinical presentation of Bordetella infection and its public health im...
      Speaker: Karissa Culbreath, Ph.D., D(ABMM)
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      Sponsored By: Diasorin
      1
      SEP 12, 2018 | 6:00 AM
      Accelerating Tuberculosis Elimination with Genomics
      Accelerating Tuberculosis Elimination with Genomics
      The WHO has set ambitious targets for eliminating TB in low-incidence countries such as the US and Canada. While it’s true that the majority of TB cases in these settings arise from rea...
      Speaker: Jennifer Gardy, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2018
      3
      JUN 20, 2018 | 7:30 AM
      Keynote Presentation: Supporting Precision Medicine and Clinical Research at Scale - Challenges and Opportunities
      Keynote Presentation: Supporting Precision Medicine and Clinical...
      Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
      Speaker: Niall Lennon, PhD
      Presented at: Precision Medicine Virtual Event Series 2018
      1
      MAY 17, 2018 | 9:00 AM
      Efficient purification of recombinant Strep-tag® fusion proteins from Expi supernatants using Strep-Tactin®XT
      Efficient purification of recombinant Strep-tag® fusion proteins...
      Mammalian transient expression has become an effective method to provide recombinant proteins in a short time. Therefore, mammalian transient expression systems are applied to a great extend...
      Speaker: Dennis Niermeier, MS
      Presented at: Gibco ExpressionWorld 2018
      5
      MAY 09, 2018 | 9:00 AM
      Gene Expression Analysis - Critical Factors for Overcoming Challenges Using qPCR
      Gene Expression Analysis - Critical Factors for Overcoming Challenges...
      Gene expression studies give a snapshot of the different types of RNAs being expressed at a given time point in cells or tissues in vivo. Different RNA types have different roles, for example...
      Speaker: Ina Scheuerpflug, PhD , Verena Schramm, PhD
      Presented at: Genetics and Genomics Virtual Event Series 2018
      Sponsored By: QIAGEN
      1
      MAR 15, 2018 | 10:30 AM
      Overcoming Hurdles in the Study of Rare Diseases: Innovative Strategies for Novel Therapy Development
      Overcoming Hurdles in the Study of Rare Diseases: Innovative Strategies...
      The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
      Speaker: Jill Weimer, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      1
      FEB 21, 2018 | 6:00 AM
      Using HDAC Inhibitors to Improve Cancer Immunotherapy
      Using HDAC Inhibitors to Improve Cancer Immunotherapy
      We recently reported that HDAC6 is involved in the regulation of a number of immunosuppressive checkpoint proteins, including the Program Death Receptor Ligand 1 (PD-L1). This protein is one...
      Speaker: Alejandro Villagra, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      NOV 14, 2017 | 10:00 AM
      WEBINAR:  Cancer Cells Send Signals Boosting Survival and Drug Resistance in Other Cancer Cells
      WEBINAR: Cancer Cells Send Signals Boosting Survival and Drug...
      DATE: November 14, 2017TIME: 10:00am PST, 1:00pm ESTSuccessful tumor outgrowth requires the coordination of a variety of cell intrinsic and cell extrinsic signaling events. These events...
      Speaker: Jeffrey Rodvold, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco, Thermo Fisher Scientific/Gibco
      5 5
      SEP 14, 2017 | 1:30 PM
      Dissecting the ecological and molecular mechanisms underlying the interaction between plant viruses and their insect vectors
      Dissecting the ecological and molecular mechanisms underlying...
      Plant viruses cause significant damage in terms of reduction in quality and quantity of yield in a wide range of crop plants worldwide. The majority of plant viruses are transmitted from one...
      Speaker: Punya Nachappa, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      2
      SEP 14, 2017 | 10:30 AM
      Clinical and Laboratory Studies of Zika Virus Infection
      Clinical and Laboratory Studies of Zika Virus Infection
      An unbiased metagenomic next-generation approach (mNGS) been shown to be useful in the broad identification of pathogens in clinical samples for infectious disease diagnosis, including viruse...
      Speaker: Charles Chiu, MD, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      2
      SEP 14, 2017 | 9:00 AM
      Development of tools enabling tunable, in situ delivery of therapeutics using probiotics
      Development of tools enabling tunable, in situ delivery of therapeutics...
      The human large intestine houses trillions of microorganisms which collectively form the highly diverse microbial community known as the gut microbiota. The gut microbiota performs many funct...
      Speaker: Nathan Crook, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      2
      SEP 14, 2017 | 6:00 AM
      A neo-virus lifestyle exhibited by a (+)ssRNA virus hosted in an unrelated dsRNA virus: taxonomic and evolutionary considerations
      A neo-virus lifestyle exhibited by a (+)ssRNA virus hosted in...
      A rapidly growing number of viruses of lower eukaryotes have been reported in the past few decades. These have enhanced our understanding of virus evolution and diversity. Simultaneously, som...
      Speaker: Nobuhiro Suzuki, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      3
      SEP 13, 2017 | 9:00 AM
      Insights into virus replication: the role of co-opted host proteins and lipids
      Insights into virus replication: the role of co-opted host proteins...
      Virus – host interactions are currently among the most intensively studied research areas due to the promising new antiviral approaches emerging from these studies. Indeed, RNA viruses,...
      Speaker: Peter L. Nagy, MD., PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      3
      SEP 13, 2017 | 9:00 AM
      How Biomarker Testing Shapes Immunotherapy
      How Biomarker Testing Shapes Immunotherapy
      The immune system is complex and dynamic, focused on defending the body from a host of pathogens ranging from viruses to cancer. A number of different mechanisms have evolved that help the bo...
      Speaker: Condie Carmack, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2017
      Sponsored By: Vela Diagnostics
      1
      JUN 08, 2017 | 10:00 AM
      WEBINAR: Analysis of the transcriptome of carriers of pathological variants in PSEN1, PSEN2 and APP that cause Alzheimer's Disease
      WEBINAR: Analysis of the transcriptome of carriers of pathological...
      DATE: June 8, 2017TIME: 10:00AM PDT, 1:00PM EDT, 7:00PM CESTAlzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in m...
      Speaker: Oscar Harari, PhD
      Sponsored By: Lexogen
      6
      MAY 30, 2017 | 9:00 AM
      Protein and Cell Analysis Education Series featuring the Antibody Validation Forum
      Protein and Cell Analysis Education Series featuring the Antibody...
      Addressing the antibody reproducibility crisis: A panel discussion with key scientific leaders  Reproducibility and antibody validation standards are two significant challenges f...
      Speaker: Aled Edwards, PhD , Matt Baker , Anita Bandrowski, PhD , Paul Wallace, PhD , John Rogers, PhD , Christoph Hergersberg, PhD
      Presented at: Protein and Cell Analysis Education Series
      15
      MAY 10, 2017 | 11:00 AM
      An ongoing evaluation of our transient expression systems; Can we predict the appropriate expression system for any drug modality?
      An ongoing evaluation of our transient expression systems; Can...
      CHO cells are the predominant host for biotherapeutic protein expression with approximately 70% of licensed biologics manufactured in Chinese Hamster Ovary (CHO) cells.  The ability to e...
      Speaker: Richard Altman, MS
      Presented at: 2017 Gibco ExpressionWorld
      4
      MAY 10, 2017 | 8:00 AM
      Optimisation of UCB's Transient Expression Platforms
      Optimisation of UCB's Transient Expression Platforms
      Development of antibody therapeutics, from early stage research to preclinical and clinical development, requires ever-increasing amounts of reagents. To meet the challenge of furnishing a di...
      Speaker: Christina Gordon
      Presented at: 2017 Gibco ExpressionWorld
      4
      MAY 10, 2017 | 5:00 AM
      Complete workflow solution from gene-to-protein combine highly advanced expression systems with expression optimized genes
      Complete workflow solution from gene-to-protein combine highly...
      Reliable autologous expression of recombinant human proteins - from gene sequence to the expressed and purified protein - in human or CHO cells is essential for many aspects of biomedical res...
      Speaker: Stephan Fath, PhD
      Presented at: 2017 Gibco ExpressionWorld
      4 1
      MAY 09, 2017 | 10:00 PM
      Cost effective protein production for R&D and animal trials
      Cost effective protein production for R&D and animal trials
      The CSIRO Tissue Culture Facility (CTCF) employs a range of in-house optimized platform technologies to identify optimum vector-host cell combinations for both transient and stable protein pr...
      Speaker: George Lovrecz, PhD
      Presented at: 2017 Gibco ExpressionWorld
      9 1
    OCT 03, 2018 | 12:00 PM
    Mechanisms of CRISPR-Cas Systems: From Adaptive Immunity to Biotechnology
    Mechanisms of CRISPR-Cas Systems: From Adaptive Immunity to Biotechnology
    All forms of life require immune systems to stave off infection from viruses and other pathogens. In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) a...
    Speaker: Dipali Sashital, PhD
    Presented at: CRISPR Virtual Event Series 2018
    3
    SEP 18, 2018 | 8:00 AM
    High-throughput CRISPR-Cas9 Genome Engineering in Primary T Cells
    High-throughput CRISPR-Cas9 Genome Engineering in Primary T Cells
    DATE: September 18,2018TIME: 08:00am PDT, 11:00am EDT CRISPR-Cas9 gene editing strategies have revolutionized our ability to engineer the genomes of diverse cell types and sp...
    Speaker: Judd Hultquist, PhD
    Sponsored By: Horizon Discovery
    7
    SEP 13, 2018 | 1:30 PM
    Mechanisms of Antimicrobial Bioconversion by Environmental and Host-Associated Bacteria
    Mechanisms of Antimicrobial Bioconversion by Environmental and...
    The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them. Resistance genes are widely distributed in the soil and may act as a reservoir for pathogen antibioti...
    Speaker: Terence Crofts, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    3
    SEP 13, 2018 | 10:30 AM
    Studying Environmental Sensing and Response in a Bacterial Plant Pathogen - Inside Out
    Studying Environmental Sensing and Response in a Bacterial Plant...
    The bacterium Pantoea stewartii subsp. stewartii causes Stewart’s wilt disease in corn and serves as a model for other xylem-dwelling phytopathogens. P. stewartii is transmitted to plan...
    Speaker: Ann Stevens, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    3
    SEP 12, 2018 | 9:00 AM
    The Persistence of Pertussis and the Prognostic Value of Bordetella Detection
    The Persistence of Pertussis and the Prognostic Value of Bordetella...
    Whooping cough caused by Bordetella infection has resurged in recent years.  Dr. Karissa Culbreath will discuss the clinical presentation of Bordetella infection and its public health im...
    Speaker: Karissa Culbreath, Ph.D., D(ABMM)
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    Sponsored By: Diasorin
    1
     
     
  • SEP 12, 2018 | 6:00 AM
    Accelerating Tuberculosis Elimination with Genomics
    Accelerating Tuberculosis Elimination with Genomics
    The WHO has set ambitious targets for eliminating TB in low-incidence countries such as the US and Canada. While it’s true that the majority of TB cases in these settings arise from rea...
    Speaker: Jennifer Gardy, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2018
    3
    JUN 20, 2018 | 7:30 AM
    Keynote Presentation: Supporting Precision Medicine and Clinical Research at Scale - Challenges and Opportunities
    Keynote Presentation: Supporting Precision Medicine and Clinical...
    Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
    Speaker: Niall Lennon, PhD
    Presented at: Precision Medicine Virtual Event Series 2018
    1
    MAY 17, 2018 | 9:00 AM
    Efficient purification of recombinant Strep-tag® fusion proteins from Expi supernatants using Strep-Tactin®XT
    Efficient purification of recombinant Strep-tag® fusion proteins...
    Mammalian transient expression has become an effective method to provide recombinant proteins in a short time. Therefore, mammalian transient expression systems are applied to a great extend...
    Speaker: Dennis Niermeier, MS
    Presented at: Gibco ExpressionWorld 2018
    5
    MAY 09, 2018 | 9:00 AM
    Gene Expression Analysis - Critical Factors for Overcoming Challenges Using qPCR
    Gene Expression Analysis - Critical Factors for Overcoming Challenges...
    Gene expression studies give a snapshot of the different types of RNAs being expressed at a given time point in cells or tissues in vivo. Different RNA types have different roles, for example...
    Speaker: Ina Scheuerpflug, PhD , Verena Schramm, PhD
    Presented at: Genetics and Genomics Virtual Event Series 2018
    Sponsored By: QIAGEN
    1
    MAR 15, 2018 | 10:30 AM
    Overcoming Hurdles in the Study of Rare Diseases: Innovative Strategies for Novel Therapy Development
    Overcoming Hurdles in the Study of Rare Diseases: Innovative Strategies...
    The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
    Speaker: Jill Weimer, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    1
     
     
  • FEB 21, 2018 | 6:00 AM
    Using HDAC Inhibitors to Improve Cancer Immunotherapy
    Using HDAC Inhibitors to Improve Cancer Immunotherapy
    We recently reported that HDAC6 is involved in the regulation of a number of immunosuppressive checkpoint proteins, including the Program Death Receptor Ligand 1 (PD-L1). This protein is one...
    Speaker: Alejandro Villagra, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    NOV 14, 2017 | 10:00 AM
    WEBINAR:  Cancer Cells Send Signals Boosting Survival and Drug Resistance in Other Cancer Cells
    WEBINAR: Cancer Cells Send Signals Boosting Survival and Drug...
    DATE: November 14, 2017TIME: 10:00am PST, 1:00pm ESTSuccessful tumor outgrowth requires the coordination of a variety of cell intrinsic and cell extrinsic signaling events. These events...
    Speaker: Jeffrey Rodvold, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco, Thermo Fisher Scientific/Gibco
    5 5
    SEP 14, 2017 | 1:30 PM
    Dissecting the ecological and molecular mechanisms underlying the interaction between plant viruses and their insect vectors
    Dissecting the ecological and molecular mechanisms underlying...
    Plant viruses cause significant damage in terms of reduction in quality and quantity of yield in a wide range of crop plants worldwide. The majority of plant viruses are transmitted from one...
    Speaker: Punya Nachappa, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    2
    SEP 14, 2017 | 10:30 AM
    Clinical and Laboratory Studies of Zika Virus Infection
    Clinical and Laboratory Studies of Zika Virus Infection
    An unbiased metagenomic next-generation approach (mNGS) been shown to be useful in the broad identification of pathogens in clinical samples for infectious disease diagnosis, including viruse...
    Speaker: Charles Chiu, MD, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    2
    SEP 14, 2017 | 9:00 AM
    Development of tools enabling tunable, in situ delivery of therapeutics using probiotics
    Development of tools enabling tunable, in situ delivery of therapeutics...
    The human large intestine houses trillions of microorganisms which collectively form the highly diverse microbial community known as the gut microbiota. The gut microbiota performs many funct...
    Speaker: Nathan Crook, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    2
     
     
  • SEP 14, 2017 | 6:00 AM
    A neo-virus lifestyle exhibited by a (+)ssRNA virus hosted in an unrelated dsRNA virus: taxonomic and evolutionary considerations
    A neo-virus lifestyle exhibited by a (+)ssRNA virus hosted in...
    A rapidly growing number of viruses of lower eukaryotes have been reported in the past few decades. These have enhanced our understanding of virus evolution and diversity. Simultaneously, som...
    Speaker: Nobuhiro Suzuki, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    3
    SEP 13, 2017 | 9:00 AM
    Insights into virus replication: the role of co-opted host proteins and lipids
    Insights into virus replication: the role of co-opted host proteins...
    Virus – host interactions are currently among the most intensively studied research areas due to the promising new antiviral approaches emerging from these studies. Indeed, RNA viruses,...
    Speaker: Peter L. Nagy, MD., PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    3
    SEP 13, 2017 | 9:00 AM
    How Biomarker Testing Shapes Immunotherapy
    How Biomarker Testing Shapes Immunotherapy
    The immune system is complex and dynamic, focused on defending the body from a host of pathogens ranging from viruses to cancer. A number of different mechanisms have evolved that help the bo...
    Speaker: Condie Carmack, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2017
    Sponsored By: Vela Diagnostics
    1
    JUN 08, 2017 | 10:00 AM
    WEBINAR: Analysis of the transcriptome of carriers of pathological variants in PSEN1, PSEN2 and APP that cause Alzheimer's Disease
    WEBINAR: Analysis of the transcriptome of carriers of pathological...
    DATE: June 8, 2017TIME: 10:00AM PDT, 1:00PM EDT, 7:00PM CESTAlzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in m...
    Speaker: Oscar Harari, PhD
    Sponsored By: Lexogen
    6
    MAY 30, 2017 | 9:00 AM
    Protein and Cell Analysis Education Series featuring the Antibody Validation Forum
    Protein and Cell Analysis Education Series featuring the Antibody...
    Addressing the antibody reproducibility crisis: A panel discussion with key scientific leaders  Reproducibility and antibody validation standards are two significant challenges f...
    Speaker: Aled Edwards, PhD , Matt Baker , Anita Bandrowski, PhD , Paul Wallace, PhD , John Rogers, PhD , Christoph Hergersberg, PhD
    Presented at: Protein and Cell Analysis Education Series
    15
     
     
  • MAY 10, 2017 | 11:00 AM
    An ongoing evaluation of our transient expression systems; Can we predict the appropriate expression system for any drug modality?
    An ongoing evaluation of our transient expression systems; Can...
    CHO cells are the predominant host for biotherapeutic protein expression with approximately 70% of licensed biologics manufactured in Chinese Hamster Ovary (CHO) cells.  The ability to e...
    Speaker: Richard Altman, MS
    Presented at: 2017 Gibco ExpressionWorld
    4
    MAY 10, 2017 | 8:00 AM
    Optimisation of UCB's Transient Expression Platforms
    Optimisation of UCB's Transient Expression Platforms
    Development of antibody therapeutics, from early stage research to preclinical and clinical development, requires ever-increasing amounts of reagents. To meet the challenge of furnishing a di...
    Speaker: Christina Gordon
    Presented at: 2017 Gibco ExpressionWorld
    4
    MAY 10, 2017 | 5:00 AM
    Complete workflow solution from gene-to-protein combine highly advanced expression systems with expression optimized genes
    Complete workflow solution from gene-to-protein combine highly...
    Reliable autologous expression of recombinant human proteins - from gene sequence to the expressed and purified protein - in human or CHO cells is essential for many aspects of biomedical res...
    Speaker: Stephan Fath, PhD
    Presented at: 2017 Gibco ExpressionWorld
    4 1
    MAY 09, 2017 | 10:00 PM
    Cost effective protein production for R&D and animal trials
    Cost effective protein production for R&D and animal trials
    The CSIRO Tissue Culture Facility (CTCF) employs a range of in-house optimized platform technologies to identify optimum vector-host cell combinations for both transient and stable protein pr...
    Speaker: George Lovrecz, PhD
    Presented at: 2017 Gibco ExpressionWorld
    9 1
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