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    Synapses

    Synapses: a bridge between two nerve cells, consisting of a small gap across which impulses pass by in the form of a neurotransmitter.

    Webinars

    • AUG 23, 2023 | 10:00 AM
      Emerging role of neuroinflammation in C9orf72-ALS
      Emerging role of neuroinflammation in C9orf72-ALS
      C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially...
      Speaker: Deepti Lall, PhD
      Sponsored By: Miltenyi Biotec
      16
      JUL 26, 2023 | 2:30 PM
      Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
      Serine-129 phosphorylation of α-synuclein is an activity-dependent...
      Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
      Speaker: Dr. Leonardo Parra-Rivas
      Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
      4
      JUN 06, 2023 | 9:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      8
      MAR 09, 2022 | 10:00 AM
      Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
      Time-resolved electron microscopy: synaptic ultrastructure millisecond...
      Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
      Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
      Sponsored By: Leica Microsystems
      5
      JUN 10, 2021 | 10:00 AM
      GABA-receptive microglia selectively sculpt developing inhibitory circuits
      GABA-receptive microglia selectively sculpt developing inhibitory...
      Date: June 10, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Microglia, the primary brain macrophages, regulate a plethora of processes that impact the organization of neural circuits, including sy...
      Speaker: Loic Binan, Ph.D , Emilia Favuzzi, Ph.D
      Sponsored By: Vizgen
      13 3
      JUN 17, 2020 | 10:30 AM
      Applications of Flow Cytometry and Imaging Flow Cytometry to COVID-19 Research
      Applications of Flow Cytometry and Imaging Flow Cytometry to COVID-19...
      COVID 19 has resulted in diverse research needs ranging from mechanism and impact of the disease, to solutions to identify, combat or treat the disease. Cellular technologies such as flow an...
      Speaker: Haley R. Pugsley, PhD , Kamala Tyagarajan, PhD
      Presented at: Coronavirus Series
      Sponsored By: Luminex - A DiaSorin Company
      1
      JUN 03, 2020 | 8:00 AM
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
      Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
      Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
      Speaker: Alexander David Borowsky, MD
      Presented at: Immuno-Oncology Virtual Event Series 2020
      Sponsored By: Leica Biosystems
      1
      JUN 02, 2020 | 11:30 AM
      Symposium 5 - Toward Petascale and Exascale Connectomics?
      Symposium 5 - Toward Petascale and Exascale Connectomics?
      With technology advances and collaboration between engineers and neuroscientists, single-synapse network maps of the brain are possible at increasing scales. In this symposium, our speakers...
      Speaker: Organizer(s): William Gray-Roncal, Brock Wester
      Presented at: 2020 6th annual BRAIN Initiative Investigators Virtual Meeting
      1
      MAR 11, 2020 | 10:30 AM
      PANEL: The Berghia Brain Project: A Team Approach to Understanding Whole-Brain Control of State-Dependent, Motivated Behaviors
      PANEL: The Berghia Brain Project: A Team Approach to Understanding...
      The neural basis of simple rhythmic and reflexive behaviors such as swimming and gill withdrawal have been successfully studied in nudibranchs and other gastropod molluscs because the brains...
      Speaker: Paul Katz, PhD , Jeff Lichtman, MD, PhD , William Frost, PhD , Deidre Lyons, PhD , Vince Lyzinski, PhD, B.Sc, M.Sc, M.Sc.E.
      Presented at: Neuroscience Virtual Event Series 2020
      1
      JAN 01, 2020 | 6:00 AM
      Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling Using Genetically Encoded Fluorescent Sensors
      Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling...
      Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
      Speaker: Shana Augustin, PhD
      Presented at: Neuroscience Virtual Event Series 2020
      1
      SEP 05, 2019 | 12:00 PM
      Advancing astrocyte research with novel tools for characterization, isolation, and cultivation
      Advancing astrocyte research with novel tools for characterization,...
      DATE: September 5, 2019TIME: 12:00pm PDTAstrocytes are a major cell type in the mammalian CNS. They are involved in a number of essential processes such as synapse formation and functio...
      Speaker: Melanie Jungblut, Ph.D
      Sponsored By: Miltenyi Biotec
      4
      MAR 14, 2018 | 12:00 PM
      Decoding How Clathrin is Transported to Distal Synapses Along Axons
      Decoding How Clathrin is Transported to Distal Synapses Along...
      Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
      Speaker: Archan Ganguly, PhD
      Presented at: Neuroscience Virtual Event Series 2018
      2
      FEB 21, 2018 | 12:00 PM
      Allosteric Modulation of Metabotropic Glutamate Receptors for the Treatment of Neurodevelopmental Disorders
      Allosteric Modulation of Metabotropic Glutamate Receptors for...
      Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG Binding Protein 2 (MECP2) gene. In mouse models of RTT, deficits in long-term potentiation (LTP) at...
      Speaker: Colleen Niswender, PhD
      Presented at: Drug Discovery Virtual Event Series 2018
      1
      OCT 11, 2017 | 9:00 AM
      New insights into the role of actin cytoskeleton and autophagy at the immune synapse
      New insights into the role of actin cytoskeleton and autophagy...
      Natural killer cells (NKs) are lymphocytes of the innate immune system that target and kill cancer cells through the secretion of lytic granules containing granzyme B and perforin. This proce...
      Speaker: Antoun Al Absi
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
      Sponsored By: MilliporeSigma
      1
      MAR 15, 2017 | 1:30 PM
      New generation open source miniaturized microscopes for network dynamic imaging in freely moving mice
      New generation open source miniaturized microscopes for network...
      Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
      Speaker: Peyman Golshani, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2017
      2
      JAN 17, 2017 | 8:00 AM
      An Introduction to In-Cell ELISA
      An Introduction to In-Cell ELISA
      In-Cell ELISA, is a well-accepted assay approach to perform quantitative immunocytochemistry of cultured cells using either a colormetric or fluorometric readout.  Join our In-Cell ELISA...
      Speaker: John Constable, PhD
      Presented at: Abcam virtual exhibition: support and products to advance your research
      4
      APR 30, 2015 | 8:00 AM
      Swimming in Transcriptomics: Using Next-Gen sequencing to study the evolution of neural circuitry and swimming behavior of sea slugs
      Swimming in Transcriptomics: Using Next-Gen sequencing to study...
      Sea slugs (Mollusca, Gastropoda, Nudipleura) provide unique opportunities for studying the evolution of behavior at the levels of single neurons, neural circuits, and their synaptic connectio...
      Speaker: Adriano Senatore, PhD, MSc, BSc
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Genomics, Beckman Coulter Genomics
      9
      MAR 18, 2015 | 9:00 AM
      Special Lecturer - DREADD2.0: an Enhanced Chemogenetic Toolkit
      Special Lecturer - DREADD2.0: an Enhanced Chemogenetic Toolkit
      The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has the ambitious goal of elucidating how neuronal ensembles interactively encode higher brain processes....
      Speaker: Bryan L. Roth, MD, PhD
      Presented at: Neuroscience Virtual Event Series 2015
      14
      MAR 20, 2014 | 6:00 AM
      Connectomics - Defining Neural Circuits to Understand Brain Function
      Connectomics - Defining Neural Circuits to Understand Brain Function
      Connectomics is a new field of research that aims to map the synapses of the nervous system in order to construct a wiring diagram of all the neural circuits. It is necessary to use the elect...
      Speaker: Scott W. Emmons, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      54
      MAR 19, 2014 | 12:00 PM
      Abeta oligomer receptor antagonists as disease-modifying Alzheimers therapeutics
      Abeta oligomer receptor antagonists as disease-modifying Alzheimers...
      Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
      Speaker: Susan Catalano, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      46
      MAR 19, 2014 | 10:00 AM
      NMDA receptor regulation in health and disease
      NMDA receptor regulation in health and disease
      Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
      Speaker: Michael Salter, MD, PhD, FRSC
      Presented at: Neuroscience Virtual Event Series 2014
      54
      MAR 19, 2014 | 9:00 AM
      Age-Dependent Responses of Dendrite Structure to Hippocampal Synaptic Plasticity
      Age-Dependent Responses of Dendrite Structure to Hippocampal Synaptic...
      Dendritic spine shape enables sequestering of subcellular components needed for synaptic plasticity, including polyribosomes for local protein synthesis, smooth endoplasmic reticulum (SER) to...
      Speaker: Kristen Harris, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      24
      MAR 19, 2014 | 8:00 AM
      BRAIN Initiative Panel Discussion - science overview
      BRAIN Initiative Panel Discussion - science overview
      The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By...
      Speaker: Emery N. Brown, MD, PhD, William Newsome, PhD, Justin Sanchez, PhD, Terrence J Sejnowski, PhD
      Presented at: Neuroscience Virtual Event Series 2014
      59
    AUG 23, 2023 | 10:00 AM
    Emerging role of neuroinflammation in C9orf72-ALS
    Emerging role of neuroinflammation in C9orf72-ALS
    C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially...
    Speaker: Deepti Lall, PhD
    Sponsored By: Miltenyi Biotec
    16
    JUL 26, 2023 | 2:30 PM
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
    Serine-129 phosphorylation of α-synuclein is an activity-dependent...
    Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
    Speaker: Dr. Leonardo Parra-Rivas
    Presented at: GenScript 3rd Annual Gene and Cell Engineering Summit
    4
    JUN 06, 2023 | 9:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    8
    MAR 09, 2022 | 10:00 AM
    Time-resolved electron microscopy: synaptic ultrastructure millisecond by millisecond with high-pressure freezing
    Time-resolved electron microscopy: synaptic ultrastructure millisecond...
    Date: March 09, 2022 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CEST) Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severe...
    Speaker: Shigeki Watanabe, Ph.D , Grant Kusick
    Sponsored By: Leica Microsystems
    5
    JUN 10, 2021 | 10:00 AM
    GABA-receptive microglia selectively sculpt developing inhibitory circuits
    GABA-receptive microglia selectively sculpt developing inhibitory...
    Date: June 10, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Microglia, the primary brain macrophages, regulate a plethora of processes that impact the organization of neural circuits, including sy...
    Speaker: Loic Binan, Ph.D , Emilia Favuzzi, Ph.D
    Sponsored By: Vizgen
    13 3
     
     
  • JUN 17, 2020 | 10:30 AM
    Applications of Flow Cytometry and Imaging Flow Cytometry to COVID-19 Research
    Applications of Flow Cytometry and Imaging Flow Cytometry to COVID-19...
    COVID 19 has resulted in diverse research needs ranging from mechanism and impact of the disease, to solutions to identify, combat or treat the disease. Cellular technologies such as flow an...
    Speaker: Haley R. Pugsley, PhD , Kamala Tyagarajan, PhD
    Presented at: Coronavirus Series
    Sponsored By: Luminex - A DiaSorin Company
    1
    JUN 03, 2020 | 8:00 AM
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment) in Experimental and Diagnostic Pathology
    Keynote Presentation: It is Time for TIME (Tumor Immune Microenvironment)...
    Cancer initiation and virulence depends on mechanisms to evade host immunosurveillance and suppression of early invasion and growth. Distinct phenotypes of the immune infiltrates in and arou...
    Speaker: Alexander David Borowsky, MD
    Presented at: Immuno-Oncology Virtual Event Series 2020
    Sponsored By: Leica Biosystems
    1
    JUN 02, 2020 | 11:30 AM
    Symposium 5 - Toward Petascale and Exascale Connectomics?
    Symposium 5 - Toward Petascale and Exascale Connectomics?
    With technology advances and collaboration between engineers and neuroscientists, single-synapse network maps of the brain are possible at increasing scales. In this symposium, our speakers...
    Speaker: Organizer(s): William Gray-Roncal, Brock Wester
    Presented at: 2020 6th annual BRAIN Initiative Investigators Virtual Meeting
    1
    MAR 11, 2020 | 10:30 AM
    PANEL: The Berghia Brain Project: A Team Approach to Understanding Whole-Brain Control of State-Dependent, Motivated Behaviors
    PANEL: The Berghia Brain Project: A Team Approach to Understanding...
    The neural basis of simple rhythmic and reflexive behaviors such as swimming and gill withdrawal have been successfully studied in nudibranchs and other gastropod molluscs because the brains...
    Speaker: Paul Katz, PhD , Jeff Lichtman, MD, PhD , William Frost, PhD , Deidre Lyons, PhD , Vince Lyzinski, PhD, B.Sc, M.Sc, M.Sc.E.
    Presented at: Neuroscience Virtual Event Series 2020
    1
    JAN 01, 2020 | 6:00 AM
    Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling Using Genetically Encoded Fluorescent Sensors
    Real-Time Monitoring of Striatal GPCR Mediated cAMP Signaling...
    Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
    Speaker: Shana Augustin, PhD
    Presented at: Neuroscience Virtual Event Series 2020
    1
     
     
  • SEP 05, 2019 | 12:00 PM
    Advancing astrocyte research with novel tools for characterization, isolation, and cultivation
    Advancing astrocyte research with novel tools for characterization,...
    DATE: September 5, 2019TIME: 12:00pm PDTAstrocytes are a major cell type in the mammalian CNS. They are involved in a number of essential processes such as synapse formation and functio...
    Speaker: Melanie Jungblut, Ph.D
    Sponsored By: Miltenyi Biotec
    4
    MAR 14, 2018 | 12:00 PM
    Decoding How Clathrin is Transported to Distal Synapses Along Axons
    Decoding How Clathrin is Transported to Distal Synapses Along...
    Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
    Speaker: Archan Ganguly, PhD
    Presented at: Neuroscience Virtual Event Series 2018
    2
    FEB 21, 2018 | 12:00 PM
    Allosteric Modulation of Metabotropic Glutamate Receptors for the Treatment of Neurodevelopmental Disorders
    Allosteric Modulation of Metabotropic Glutamate Receptors for...
    Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG Binding Protein 2 (MECP2) gene. In mouse models of RTT, deficits in long-term potentiation (LTP) at...
    Speaker: Colleen Niswender, PhD
    Presented at: Drug Discovery Virtual Event Series 2018
    1
    OCT 11, 2017 | 9:00 AM
    New insights into the role of actin cytoskeleton and autophagy at the immune synapse
    New insights into the role of actin cytoskeleton and autophagy...
    Natural killer cells (NKs) are lymphocytes of the innate immune system that target and kill cancer cells through the secretion of lytic granules containing granzyme B and perforin. This proce...
    Speaker: Antoun Al Absi
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2017
    Sponsored By: MilliporeSigma
    1
    MAR 15, 2017 | 1:30 PM
    New generation open source miniaturized microscopes for network dynamic imaging in freely moving mice
    New generation open source miniaturized microscopes for network...
    Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
    Speaker: Peyman Golshani, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2017
    2
     
     
  • JAN 17, 2017 | 8:00 AM
    An Introduction to In-Cell ELISA
    An Introduction to In-Cell ELISA
    In-Cell ELISA, is a well-accepted assay approach to perform quantitative immunocytochemistry of cultured cells using either a colormetric or fluorometric readout.  Join our In-Cell ELISA...
    Speaker: John Constable, PhD
    Presented at: Abcam virtual exhibition: support and products to advance your research
    4
    APR 30, 2015 | 8:00 AM
    Swimming in Transcriptomics: Using Next-Gen sequencing to study the evolution of neural circuitry and swimming behavior of sea slugs
    Swimming in Transcriptomics: Using Next-Gen sequencing to study...
    Sea slugs (Mollusca, Gastropoda, Nudipleura) provide unique opportunities for studying the evolution of behavior at the levels of single neurons, neural circuits, and their synaptic connectio...
    Speaker: Adriano Senatore, PhD, MSc, BSc
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Genomics, Beckman Coulter Genomics
    9
    MAR 18, 2015 | 9:00 AM
    Special Lecturer - DREADD2.0: an Enhanced Chemogenetic Toolkit
    Special Lecturer - DREADD2.0: an Enhanced Chemogenetic Toolkit
    The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has the ambitious goal of elucidating how neuronal ensembles interactively encode higher brain processes....
    Speaker: Bryan L. Roth, MD, PhD
    Presented at: Neuroscience Virtual Event Series 2015
    14
    MAR 20, 2014 | 6:00 AM
    Connectomics - Defining Neural Circuits to Understand Brain Function
    Connectomics - Defining Neural Circuits to Understand Brain Function
    Connectomics is a new field of research that aims to map the synapses of the nervous system in order to construct a wiring diagram of all the neural circuits. It is necessary to use the elect...
    Speaker: Scott W. Emmons, PhD
    Presented at: Neuroscience Virtual Event Series 2014
    54
    MAR 19, 2014 | 12:00 PM
    Abeta oligomer receptor antagonists as disease-modifying Alzheimers therapeutics
    Abeta oligomer receptor antagonists as disease-modifying Alzheimers...
    Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic Amyloid beta (Abeta)1-42 oligomers is proposed to underlie cognitive decline in Alzheimers disease (AD). Syn...
    Speaker: Susan Catalano, PhD
    Presented at: Neuroscience Virtual Event Series 2014
    46
     
     
  • MAR 19, 2014 | 10:00 AM
    NMDA receptor regulation in health and disease
    NMDA receptor regulation in health and disease
    Neuron-glial interactions are increasingly recognized as being key for physiological and pathological processes in the central nervous system. Microglia have been found to play a causal role...
    Speaker: Michael Salter, MD, PhD, FRSC
    Presented at: Neuroscience Virtual Event Series 2014
    54
    MAR 19, 2014 | 9:00 AM
    Age-Dependent Responses of Dendrite Structure to Hippocampal Synaptic Plasticity
    Age-Dependent Responses of Dendrite Structure to Hippocampal Synaptic...
    Dendritic spine shape enables sequestering of subcellular components needed for synaptic plasticity, including polyribosomes for local protein synthesis, smooth endoplasmic reticulum (SER) to...
    Speaker: Kristen Harris, PhD
    Presented at: Neuroscience Virtual Event Series 2014
    24
    MAR 19, 2014 | 8:00 AM
    BRAIN Initiative Panel Discussion - science overview
    BRAIN Initiative Panel Discussion - science overview
    The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By...
    Speaker: Emery N. Brown, MD, PhD, William Newsome, PhD, Justin Sanchez, PhD, Terrence J Sejnowski, PhD
    Presented at: Neuroscience Virtual Event Series 2014
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