Biologics: Biological products include a wide range of products such as vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living entities such as cells and tissues. Biologics are isolated from a variety of natural sources - human, animal, or microorganism - and may be produced by biotechnology methods and other cutting-edge technologies. Gene-based and cellular biologics, for example, often are at the forefront of biomedical research, and may be used to treat a variety of medical conditions for which no other treatments are available.
Whole genome sequencing of bacterial isolates via next-generation sequencing is becoming a standard approach for clinical microbiology and bio-surveillance labs seeking to conduct outbreak in...
Some bacteria can use an electrode as an electron donor for respiration, generating an electrical current in the process. We are trying to understand a bacterial community that uses electrici...
The ongoing research and scientific debate on pathophysiology, classification, nomenclature and diagnosis of antiphospholipid syndrome illustrates the complexity of cellular membranes, their...
Whooping cough caused by Bordetella infection has resurged in recent years. Dr. Karissa Culbreath will discuss the clinical presentation of Bordetella infection and its public health im...
Antibiotic resistance is a national and global public health crisis. Each year in the United States (US), at least 2 million people become infected with antibiotic-resistant bacteria an...
There are new generations of comprehensive multiplex molecular panels available for infectious diseases syndromic diagnostics. They are able to rapidly detect and identify the most common pat...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
The WHO has set ambitious targets for eliminating TB in low-incidence countries such as the US and Canada. While it’s true that the majority of TB cases in these settings arise from rea...
With the advent of cost effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
DATE: August 7, 2018TIME: 08:00AM PDT, 11:00AM EDTWe are currently at an exciting precipice in clinical oncology management, where an increased rate of biomarker identification is drivi...
DATE: June 29, 2018TIME: 8:00AM PDTMeasurement of these metabolites represents the digital readout of health. A key aspect of metabolomics is the utilization of high resolu...
DATE: June 28, 2018TIME: 9:00AM PDTStep up your biologics stability screening with HunkyMany methods for studying protein stability and aggregation are qualitative, which can c...
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
Many research laboratories use the ExpiCHO Expression System to transiently produce candidate biomolecules for biologics development. However, after the lead candidate is found, a stable cell...
Complex disease phenotypes - obesity, type II diabetes, and cancer challenge simple models in both evolution and biology. Examination of molecular networks and their dynamic behavior o...
DATE: April 17, 2018TIME: 8:00AM PST, 11:00AM ESTRecently, much research has focused on obtaining 3D brain organoids in an attempt to better recapitulate brain development and function...
98% of small molecules and 100% of large molecules do not cross the blood-brain barrier (BBB). Biologics, including therapeutic antibodies (e.g. anti-amyloid antibodies), have been at the for...
GPCRs constitute the largest receptor family in the human genome. Over the years they have proven themselves to be druggable targets accounting for about 1/3 of all drugs on the market today....
This lecture introduces the evolving paradigm of Molecular Pathological Epidemiology (MPE) as simply as possible. Any given human disease represents fundamentally heterogeneous process,...
QuantiFERON TB (QFT) was the first interferon gamma release assay (IGRA) utilizing whole blood stimulation as a test for TB infection, gaining FDA approval in 2001. Subsequently there have be...
In 2012, Consumers Reports and the American Board of Internal Medicine Foundation launched the Choosing Wisely campaign. This initiative, which attracts media attention, assists physicians, n...
DATE: October 24, 2017TIME: 09:00am PDT, 12:00pm EDTDoes your work involve disease models? Do you have a need to introduce specific genomic changes in the cells of your choice? Do you w...
The “R2G2” (B6;129-Rag2tm1FwaIL2rgtm1Rsky/DwlHsd) knockout mouse is the latest advancement to provide an alternative option in the highly immunodeficient mouse model category for...
Whole genome sequencing of bacterial isolates via next-generation sequencing is becoming a standard approach for clinical microbiology and bio-surveillance labs seeking to conduct outbreak in...
Some bacteria can use an electrode as an electron donor for respiration, generating an electrical current in the process. We are trying to understand a bacterial community that uses electrici...
The ongoing research and scientific debate on pathophysiology, classification, nomenclature and diagnosis of antiphospholipid syndrome illustrates the complexity of cellular membranes, their...
Whooping cough caused by Bordetella infection has resurged in recent years. Dr. Karissa Culbreath will discuss the clinical presentation of Bordetella infection and its public health im...
Antibiotic resistance is a national and global public health crisis. Each year in the United States (US), at least 2 million people become infected with antibiotic-resistant bacteria an...
There are new generations of comprehensive multiplex molecular panels available for infectious diseases syndromic diagnostics. They are able to rapidly detect and identify the most common pat...
Next-generation DNA sequencing has opened new possibilities for microbial water quality monitoring, particularly for addressing emerging concerns like antibiotic resistance and opportunistic...
The WHO has set ambitious targets for eliminating TB in low-incidence countries such as the US and Canada. While it’s true that the majority of TB cases in these settings arise from rea...
With the advent of cost effective culturing approaches, 3D cell culture models (3D-CCMs) have been rapidly adopted for drug discovery since they provide a more physiologically relevant micro-...
DATE: August 7, 2018TIME: 08:00AM PDT, 11:00AM EDTWe are currently at an exciting precipice in clinical oncology management, where an increased rate of biomarker identification is drivi...
DATE: June 29, 2018TIME: 8:00AM PDTMeasurement of these metabolites represents the digital readout of health. A key aspect of metabolomics is the utilization of high resolu...
DATE: June 28, 2018TIME: 9:00AM PDTStep up your biologics stability screening with HunkyMany methods for studying protein stability and aggregation are qualitative, which can c...
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
Many research laboratories use the ExpiCHO Expression System to transiently produce candidate biomolecules for biologics development. However, after the lead candidate is found, a stable cell...
Complex disease phenotypes - obesity, type II diabetes, and cancer challenge simple models in both evolution and biology. Examination of molecular networks and their dynamic behavior o...
DATE: April 17, 2018TIME: 8:00AM PST, 11:00AM ESTRecently, much research has focused on obtaining 3D brain organoids in an attempt to better recapitulate brain development and function...
98% of small molecules and 100% of large molecules do not cross the blood-brain barrier (BBB). Biologics, including therapeutic antibodies (e.g. anti-amyloid antibodies), have been at the for...
GPCRs constitute the largest receptor family in the human genome. Over the years they have proven themselves to be druggable targets accounting for about 1/3 of all drugs on the market today....
This lecture introduces the evolving paradigm of Molecular Pathological Epidemiology (MPE) as simply as possible. Any given human disease represents fundamentally heterogeneous process,...
QuantiFERON TB (QFT) was the first interferon gamma release assay (IGRA) utilizing whole blood stimulation as a test for TB infection, gaining FDA approval in 2001. Subsequently there have be...
In 2012, Consumers Reports and the American Board of Internal Medicine Foundation launched the Choosing Wisely campaign. This initiative, which attracts media attention, assists physicians, n...
DATE: October 24, 2017TIME: 09:00am PDT, 12:00pm EDTDoes your work involve disease models? Do you have a need to introduce specific genomic changes in the cells of your choice? Do you w...
The “R2G2” (B6;129-Rag2tm1FwaIL2rgtm1Rsky/DwlHsd) knockout mouse is the latest advancement to provide an alternative option in the highly immunodeficient mouse model category for...
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