Biological Organisms: Living things that are capable of reacting to stimuli, reproduction, growth, and homeostasis. Organisms are classified by taxonomy into specified groups such as the multicellular animals, plants, and fungi; or unicellular microorganisms such as a protists, bacteria, and archaea. All types of organisms are capable of reproduction, growth and development, maintenance, and some degree of response to stimuli. An organism may be either a prokaryote or a eukaryote. Prokaryotes are represented by two separate domains-bacteria and archaea. Eukaryotic organisms are characterized by the presence of a membrane-bound cell nucleus and contain additional membrane-bound compartments called organelles.
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
In the past two decades a small number of infrequently dividing cells have been proposed as the source of multi-drug resistance during cancer treatment. These cells identified by their expres...
PacBio Sequencing simultaneously provides long sequence reads, high consensus accuracy, minimal sequence bias, and methylation detection. I will highlight new advances and updates on applying...
To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
RNA sequencing unlocks the mysteries hidden in the transcriptome. Whether your goal is gene expression analysis, gene fusion analysis, SNP analysis or miRNA expression analysis, achieving hig...
High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance. Millipor...
In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. P...
Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
Dr. Sigrid Reinsch will discuss NASA’s GeneLab Project whose goal is to develop a unique publicly accessible repository and collaborative workspace that hosts multi-omics datasets gener...
Tuberculosis (TB) is the No.1 cause of death due to a single infectious agent in the world today. According to the global report from World Health Organization, one third of world population...
DATE: November 16, 2017TIME: 9:00AM PT, 12:00PM ETThe wide use of 2D monolayer cultures for cancer drug discovery reflects the technical ease of implementation for drug screening, and t...
The Resource Identification Initiative supports NIH's new guidelines for Rigor and Transparency as these apply in biomedical publications. Authors are instructed to authenticate key biolo...
Although the cell is commonly referred to as “the most basic unit of life”, it is actually so complex that despite over 350 years of research we are still far from fully understan...
DATE: June 14, 2017TIME: 6:00am PT, 9:00am ET, 3:00pm CETComprehensive metabolite profiling (i.e., metabolomics) offers a holistic approach for understanding the phenotype of an organis...
A hardware architecture was developed specifically to facilitate collaborative development and dissemination of microfluidic experiments. Modular pressure regulators, incubators, and chip-to-...
DATE: May 22, 2017TIME: 8:00AM PDT, 11:00AM ETCrohn's disease (CD) results from a complex interplay between host genetic factors and endogenous microbial communities. In the current...
In this seminar, I will discuss issues in transcriptome analysis. I will first talk about core aspects - how we analyze the activity patterns of genes in model organisms and humans. I will fo...
DATE: December 1, 2016TIME: 8:00 AM PT, 11:00 AM ETPreclinical imaging enables the measurement and assessment of biological processes in vivo utilizing technologies such as biolum...
Stem cells play critical roles in the development of organisms, as well as in the maintenance and repair of organs and tissues throughout adulthood. Advancing our understanding of mecha...
It is well accepted that microorganisms can exist as self-organized communities attached to surfaces and one another (i.e., biofilm), often surrounded by extracellular polymeric substances (E...
DATE: June 9, 2016
TIME: 9AM Pacific time, 12pm Eastern time
The rapid growth of Microbiomics has increased the demand for standard methods to improve the reproducibility and...
Cell death is involved in diseases such as cancer and neurodegeneration, and also has a natural role in the development of multicellular organisms. Although apoptosis has been well defined, a...
One of the primary goals of precision medicine is the aggregation and interpretation of deep, longitudinal patient-specific data in the context of the digital universe of information, using a...
The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease,...
In the past two decades a small number of infrequently dividing cells have been proposed as the source of multi-drug resistance during cancer treatment. These cells identified by their expres...
PacBio Sequencing simultaneously provides long sequence reads, high consensus accuracy, minimal sequence bias, and methylation detection. I will highlight new advances and updates on applying...
To date the anatomic extent of tumor (TNM-classification) has been by far the most important factors to predict the prognosis of cancer patients. However, this classification provides limited...
RNA sequencing unlocks the mysteries hidden in the transcriptome. Whether your goal is gene expression analysis, gene fusion analysis, SNP analysis or miRNA expression analysis, achieving hig...
High-throughput screening is widely useful in identifying genes and pathways that drive changes in cell behavior such as cell cycle regulation, metastasis, and drug resistance. Millipor...
In prior work, we have pursued how tumor reactive monoclonal antibody (mAb), together with activators of innate immune cells, like NK cells, can augment antibody dependent cell-mediated cytot...
Molecular analyses of cancer biology have tended to segregate between a focus on nucleic acids – DNA, RNA and their modifications – and a focus on proteins and protein function. P...
Understanding the immune repertoire is an important aspect of immuno-oncology research, which can be used to gather insights into the function and overall status of the immune system. We have...
Dr. Sigrid Reinsch will discuss NASA’s GeneLab Project whose goal is to develop a unique publicly accessible repository and collaborative workspace that hosts multi-omics datasets gener...
Tuberculosis (TB) is the No.1 cause of death due to a single infectious agent in the world today. According to the global report from World Health Organization, one third of world population...
DATE: November 16, 2017TIME: 9:00AM PT, 12:00PM ETThe wide use of 2D monolayer cultures for cancer drug discovery reflects the technical ease of implementation for drug screening, and t...
The Resource Identification Initiative supports NIH's new guidelines for Rigor and Transparency as these apply in biomedical publications. Authors are instructed to authenticate key biolo...
Although the cell is commonly referred to as “the most basic unit of life”, it is actually so complex that despite over 350 years of research we are still far from fully understan...
DATE: June 14, 2017TIME: 6:00am PT, 9:00am ET, 3:00pm CETComprehensive metabolite profiling (i.e., metabolomics) offers a holistic approach for understanding the phenotype of an organis...
A hardware architecture was developed specifically to facilitate collaborative development and dissemination of microfluidic experiments. Modular pressure regulators, incubators, and chip-to-...
DATE: May 22, 2017TIME: 8:00AM PDT, 11:00AM ETCrohn's disease (CD) results from a complex interplay between host genetic factors and endogenous microbial communities. In the current...
In this seminar, I will discuss issues in transcriptome analysis. I will first talk about core aspects - how we analyze the activity patterns of genes in model organisms and humans. I will fo...
DATE: December 1, 2016TIME: 8:00 AM PT, 11:00 AM ETPreclinical imaging enables the measurement and assessment of biological processes in vivo utilizing technologies such as biolum...
Stem cells play critical roles in the development of organisms, as well as in the maintenance and repair of organs and tissues throughout adulthood. Advancing our understanding of mecha...
It is well accepted that microorganisms can exist as self-organized communities attached to surfaces and one another (i.e., biofilm), often surrounded by extracellular polymeric substances (E...
DATE: June 9, 2016
TIME: 9AM Pacific time, 12pm Eastern time
The rapid growth of Microbiomics has increased the demand for standard methods to improve the reproducibility and...
Cell death is involved in diseases such as cancer and neurodegeneration, and also has a natural role in the development of multicellular organisms. Although apoptosis has been well defined, a...
One of the primary goals of precision medicine is the aggregation and interpretation of deep, longitudinal patient-specific data in the context of the digital universe of information, using a...
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