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    Disease Modeling

    Disease modeling is the use of a disease model, which is an animal or cells containing all or some of the pathological characteristics and mechanisms of a disease, to study that particular disease.

    Webinars

    • JAN 01, 2020 | 6:00 AM
      3D-Micro Tissues in Translational Toxicology and Disease Modelling
      3D-Micro Tissues in Translational Toxicology and Disease Modelling
      The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
      Speaker: Armin Wolf, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2020
      1
      DEC 17, 2019 | 9:00 AM
      The role of SIRT1/LXR signaling in diabetic retinopathy
      The role of SIRT1/LXR signaling in diabetic retinopathy
      DATE: December 17, 2019TIME: 9:00am PST, 12:00pm EST Purpose: Liver x receptors (LXRs) are hypothesized to serve as a link between lipid metabolism and inflammation by prom...
      Speaker: Sandra Hammer, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      6
      DEC 04, 2019 | 7:00 AM
      Improve your reproducibility - Liquid Handling is a crucial factor Exemplarily shown for NGS, ELISA and qPCR
      Improve your reproducibility - Liquid Handling is a crucial factor...
      DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
      Speaker: Katja Baesler, PhD , Ulrike Gast, PhD , Alisa Gruschka
      Sponsored By: Eppendorf
      12
      NOV 19, 2019 | 10:00 AM
      LC3-associated endocytosis: guarding against neuroinflammation & neurodegeneration
      LC3-associated endocytosis: guarding against neuroinflammation...
      DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
      Speaker: Bradlee L. Heckmann, Ph.D.
      Sponsored By: Miltenyi Biotec
      6
      NOV 18, 2019 | 7:00 AM
      Protect your cells with proper pipetting - How liquid handling influences your cell culture work
      Protect your cells with proper pipetting - How liquid handling...
      DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
      Speaker: Nadine Mellies, PhD , Katja Baesler, PhD
      Sponsored By: Eppendorf
      22 2
      NOV 14, 2019 | 9:00 AM
      Discovering latent knowledge by applying machine learning techniques to QIAGEN resources
      Discovering latent knowledge by applying machine learning techniques...
      Applying machine learning methods to structured, expert-curated content from scientific literature is a powerful way to discover latent knowledge. Building on the QIAGEN Knowledge Base, we us...
      Speaker: Jeff Green
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2019
      Sponsored By: QIAGEN
      1
      NOV 12, 2019 | 10:00 AM
      Leveraging single cell copy number to resolve tumor clonality
      Leveraging single cell copy number to resolve tumor clonality
      DATE: November 12, 2019TIME: 10:00am PSTDirect measurement of copy number by droplet-based shallow sequencing of genomic DNA has the potential to provide new insights into tumor heterog...
      Speaker: Dr. David Craig
      Sponsored By: 10x Genomics
      9 1
      NOV 06, 2019 | 1:30 PM
      Challenges towards a Universal Influenza Virus Vaccine
      Challenges towards a Universal Influenza Virus Vaccine
      Despite FDA-approved vaccines and antivirals, seasonal and pandemic influenza remains a serious threat associated with substantial morbidity and mortality. The present modalities and vaccine...
      Speaker: Peter Palese, PhD
      Presented at: Influenza Virtual Event Series 2019
      4 1
      OCT 29, 2019 | 7:00 AM
      Optimizing high-content screening tools for physiologically-relevant 3D in vitro models
      Optimizing high-content screening tools for physiologically-relevant...
      DATE: October 29, 2019TIME: 7:00am PDT3D cell culture systems have recently emerged as tools for reproducing the cellular environment and the organization of tissues/organs, where cel...
      Speaker: Elodie Vandenhaute , Zied Souguir , Daniel O'Connor
      Sponsored By: Molecular Devices
      8
      OCT 10, 2019 | 12:00 PM
      Tumor Mutation Burden: Challenges and opportunities of measuring and interpreting tumor mutational burden for patient care
      Tumor Mutation Burden: Challenges and opportunities of measuring...
      Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
      Speaker: Ravindra Kolhe, MD, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: QIAGEN
      1
      OCT 10, 2019 | 10:30 AM
      Transcriptional Profiling of the Pediatric Tumor Microenvironment
      Transcriptional Profiling of the Pediatric Tumor Microenvironment
      Osteosarcoma (OS) is the most common bone tumor in pediatric and adolescent/young adult patients. Over the past three decades, significant improvements in the survival rates or therapeutic ap...
      Speaker: Troy McEachron, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: NanoString Technologies
      1
      OCT 10, 2019 | 9:00 AM
      Next Generation Targets for Immuno-Oncology
      Next Generation Targets for Immuno-Oncology
      Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
      Speaker: Anthony Persen, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
      Sponsored By: ACD - A Bio-Techne Brand
      1
      OCT 03, 2019 | 3:00 PM
      'Any Idiot can do it'.  How easy a knockout or knockin mouse could be generated using CRISPR/Cas9 gene editing technology?
      'Any Idiot can do it'. How easy a knockout or knockin mouse could...
      Novel precision genetic technologies such as CRISPR/Cas9 genome editing technology offer novel avenues to a better understanding the mechanisms of diseases. Using CRISPR/Cas9 we are able to p...
      Speaker: Gaetan Burgio, Msc, MBBS, MD, PhD
      Presented at: CRISPR Virtual Event Series 2019
      3
      OCT 03, 2019 | 6:00 AM
      CRISPR/Cas9 technology and insect population control
      CRISPR/Cas9 technology and insect population control
      Insects are the largest and most diverse arthropod group. Many insect species are agricultural pests or vectors of numerous diseases. In fact, the mosquito is the deadliest animal on the eart...
      Speaker: Nikolay Kandul, PhD
      Presented at: CRISPR Virtual Event Series 2019
      4
      OCT 01, 2019 | 10:00 AM
      High-throughput genotoxicity assays for DNA damage and mode of action analyses
      High-throughput genotoxicity assays for DNA damage and mode of...
      DATE: October 1, 2019TIME: 10:00am PDTThe toxicological testing market is no stranger to the principle of the three Rs of research: replacement, reduction, and refinement. With that to...
      Speaker: Jeffrey Bemis, PhD , Jakob Bonse, PhD
      Sponsored By: Miltenyi Biotec
      4 2
      SEP 30, 2019 | 8:00 AM
      Discovery and Verification of eQTLs Associated with Lung Adenocarcinoma
      Discovery and Verification of eQTLs Associated with Lung Adenocarcinoma
      DATE: September 30, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Expression quantitative trait loci (eQTLs) are SNPs that have an influence on expression levels of genes, and the ident...
      Speaker: Tommaso Dragani , Harita Veereshlingam, PhD
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      9
      SEP 27, 2019 | 9:00 AM
      Investigating how Tpz-1 may be used as a novel therapeutic agent in the treatment of human hematologic cancers
      Investigating how Tpz-1 may be used as a novel therapeutic agent...
      DATE: September 27, 2019TIME: 9:00am PT, 12:00pm ET Thienopyrazole derivatives have recently emerged as effective antitumoral agents with kinase inhibitory activity. In this s...
      Speaker: Jessica Hess
      Sponsored By: Thermo Fisher Scientific/Gibco
      5
      SEP 12, 2019 | 1:30 PM
      Gender Parity in Virology Conference Speaker Selections
      Gender Parity in Virology Conference Speaker Selections
      Scientific conferences are most beneficial to participants when they showcase significant new experimental developments, accurately summarize the current state of the field, and provide stron...
      Speaker: Ann Palmenberg, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      1
      SEP 12, 2019 | 8:00 AM
      Clinical uses of Mass Spectrometry
      Clinical uses of Mass Spectrometry
      DATE: September 12, 2019TIME: 8:00am PDTIn the upcoming era of personalized medicine, there is a growing need for the development of rapid, sensitive, precise and accurate analysis of t...
      Speaker: Nina Ogrinc , Philippe Saudemont
      Sponsored By: Agilent
      10
      SEP 12, 2019 | 6:00 AM
      Using the NASA GeneLab Data System to Study the Metagenomes of Spaceships and Their Occupants
      Using the NASA GeneLab Data System to Study the Metagenomes of...
      With humans pushing to live further off Earth for longer periods of time, it is increasingly important to understand the changes that occur in biological systems during spaceflight whether th...
      Speaker: Jonathan Galazka, PhD , Daniela Bezdan, PhD , Peng Jiang, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      1
      SEP 11, 2019 | 1:30 PM
      Development of Machine Learning Algorithms to Data Mine Meta-Omic Characterizations of Complex Microbiota
      Development of Machine Learning Algorithms to Data Mine Meta-Omic...
      Background: The vast majority of all genes are contained within the genomes of the prokaryotes, including the eubacteria and the archaea. These largely single-cellular domains of life thus...
      Speaker: Garth Ehrlich, PhD, FAAAS
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      Sponsored By: PacBio
      4
      SEP 11, 2019 | 12:00 PM
      Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
      Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
      immunocompromised populations where the virus can cause systemic and even fatal infections. Indeed, we have shown that astrovirus infections are more prevalent than norovirus in our pediatric...
      Speaker: Stacey Schultz-Cherry, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      5
      SEP 11, 2019 | 10:30 AM
      Structural analysis to understand the molecular mechanism for CPV species-jump
      Structural analysis to understand the molecular mechanism for...
      Canine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis and cerebellar disease. Cross-species transmission of CPV...
      Speaker: Susan Hafenstein, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2019
      1
      SEP 05, 2019 | 7:00 AM
      The bread and butter method of genomics: How to improve your (q)PCR
      The bread and butter method of genomics: How to improve your (q)PCR
      DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
      Speaker: Tim Schommartz, PhD
      Sponsored By: Eppendorf
      17 1
    JAN 01, 2020 | 6:00 AM
    3D-Micro Tissues in Translational Toxicology and Disease Modelling
    3D-Micro Tissues in Translational Toxicology and Disease Modelling
    The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
    Speaker: Armin Wolf, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2020
    1
    DEC 17, 2019 | 9:00 AM
    The role of SIRT1/LXR signaling in diabetic retinopathy
    The role of SIRT1/LXR signaling in diabetic retinopathy
    DATE: December 17, 2019TIME: 9:00am PST, 12:00pm EST Purpose: Liver x receptors (LXRs) are hypothesized to serve as a link between lipid metabolism and inflammation by prom...
    Speaker: Sandra Hammer, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    6
    DEC 04, 2019 | 7:00 AM
    Improve your reproducibility - Liquid Handling is a crucial factor Exemplarily shown for NGS, ELISA and qPCR
    Improve your reproducibility - Liquid Handling is a crucial factor...
    DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
    Speaker: Katja Baesler, PhD , Ulrike Gast, PhD , Alisa Gruschka
    Sponsored By: Eppendorf
    12
    NOV 19, 2019 | 10:00 AM
    LC3-associated endocytosis: guarding against neuroinflammation & neurodegeneration
    LC3-associated endocytosis: guarding against neuroinflammation...
    DATE: November 19, 2019TIME: 10:00am PSTMicroglial cells are the resident innate immune cells of the central nervous system (CNS) and are responsible for regulating inflammatory activati...
    Speaker: Bradlee L. Heckmann, Ph.D.
    Sponsored By: Miltenyi Biotec
    6
    NOV 18, 2019 | 7:00 AM
    Protect your cells with proper pipetting - How liquid handling influences your cell culture work
    Protect your cells with proper pipetting - How liquid handling...
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    Speaker: Nadine Mellies, PhD , Katja Baesler, PhD
    Sponsored By: Eppendorf
    22 2
     
     
  • NOV 14, 2019 | 9:00 AM
    Discovering latent knowledge by applying machine learning techniques to QIAGEN resources
    Discovering latent knowledge by applying machine learning techniques...
    Applying machine learning methods to structured, expert-curated content from scientific literature is a powerful way to discover latent knowledge. Building on the QIAGEN Knowledge Base, we us...
    Speaker: Jeff Green
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2019
    Sponsored By: QIAGEN
    1
    NOV 12, 2019 | 10:00 AM
    Leveraging single cell copy number to resolve tumor clonality
    Leveraging single cell copy number to resolve tumor clonality
    DATE: November 12, 2019TIME: 10:00am PSTDirect measurement of copy number by droplet-based shallow sequencing of genomic DNA has the potential to provide new insights into tumor heterog...
    Speaker: Dr. David Craig
    Sponsored By: 10x Genomics
    9 1
    NOV 06, 2019 | 1:30 PM
    Challenges towards a Universal Influenza Virus Vaccine
    Challenges towards a Universal Influenza Virus Vaccine
    Despite FDA-approved vaccines and antivirals, seasonal and pandemic influenza remains a serious threat associated with substantial morbidity and mortality. The present modalities and vaccine...
    Speaker: Peter Palese, PhD
    Presented at: Influenza Virtual Event Series 2019
    4 1
    OCT 29, 2019 | 7:00 AM
    Optimizing high-content screening tools for physiologically-relevant 3D in vitro models
    Optimizing high-content screening tools for physiologically-relevant...
    DATE: October 29, 2019TIME: 7:00am PDT3D cell culture systems have recently emerged as tools for reproducing the cellular environment and the organization of tissues/organs, where cel...
    Speaker: Elodie Vandenhaute , Zied Souguir , Daniel O'Connor
    Sponsored By: Molecular Devices
    8
    OCT 10, 2019 | 12:00 PM
    Tumor Mutation Burden: Challenges and opportunities of measuring and interpreting tumor mutational burden for patient care
    Tumor Mutation Burden: Challenges and opportunities of measuring...
    Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
    Speaker: Ravindra Kolhe, MD, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: QIAGEN
    1
     
     
  • OCT 10, 2019 | 10:30 AM
    Transcriptional Profiling of the Pediatric Tumor Microenvironment
    Transcriptional Profiling of the Pediatric Tumor Microenvironment
    Osteosarcoma (OS) is the most common bone tumor in pediatric and adolescent/young adult patients. Over the past three decades, significant improvements in the survival rates or therapeutic ap...
    Speaker: Troy McEachron, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: NanoString Technologies
    1
    OCT 10, 2019 | 9:00 AM
    Next Generation Targets for Immuno-Oncology
    Next Generation Targets for Immuno-Oncology
    Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
    Speaker: Anthony Persen, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2019
    Sponsored By: ACD - A Bio-Techne Brand
    1
    OCT 03, 2019 | 3:00 PM
    'Any Idiot can do it'.  How easy a knockout or knockin mouse could be generated using CRISPR/Cas9 gene editing technology?
    'Any Idiot can do it'. How easy a knockout or knockin mouse could...
    Novel precision genetic technologies such as CRISPR/Cas9 genome editing technology offer novel avenues to a better understanding the mechanisms of diseases. Using CRISPR/Cas9 we are able to p...
    Speaker: Gaetan Burgio, Msc, MBBS, MD, PhD
    Presented at: CRISPR Virtual Event Series 2019
    3
    OCT 03, 2019 | 6:00 AM
    CRISPR/Cas9 technology and insect population control
    CRISPR/Cas9 technology and insect population control
    Insects are the largest and most diverse arthropod group. Many insect species are agricultural pests or vectors of numerous diseases. In fact, the mosquito is the deadliest animal on the eart...
    Speaker: Nikolay Kandul, PhD
    Presented at: CRISPR Virtual Event Series 2019
    4
    OCT 01, 2019 | 10:00 AM
    High-throughput genotoxicity assays for DNA damage and mode of action analyses
    High-throughput genotoxicity assays for DNA damage and mode of...
    DATE: October 1, 2019TIME: 10:00am PDTThe toxicological testing market is no stranger to the principle of the three Rs of research: replacement, reduction, and refinement. With that to...
    Speaker: Jeffrey Bemis, PhD , Jakob Bonse, PhD
    Sponsored By: Miltenyi Biotec
    4 2
     
     
  • SEP 30, 2019 | 8:00 AM
    Discovery and Verification of eQTLs Associated with Lung Adenocarcinoma
    Discovery and Verification of eQTLs Associated with Lung Adenocarcinoma
    DATE: September 30, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Expression quantitative trait loci (eQTLs) are SNPs that have an influence on expression levels of genes, and the ident...
    Speaker: Tommaso Dragani , Harita Veereshlingam, PhD
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    9
    SEP 27, 2019 | 9:00 AM
    Investigating how Tpz-1 may be used as a novel therapeutic agent in the treatment of human hematologic cancers
    Investigating how Tpz-1 may be used as a novel therapeutic agent...
    DATE: September 27, 2019TIME: 9:00am PT, 12:00pm ET Thienopyrazole derivatives have recently emerged as effective antitumoral agents with kinase inhibitory activity. In this s...
    Speaker: Jessica Hess
    Sponsored By: Thermo Fisher Scientific/Gibco
    5
    SEP 12, 2019 | 1:30 PM
    Gender Parity in Virology Conference Speaker Selections
    Gender Parity in Virology Conference Speaker Selections
    Scientific conferences are most beneficial to participants when they showcase significant new experimental developments, accurately summarize the current state of the field, and provide stron...
    Speaker: Ann Palmenberg, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    1
    SEP 12, 2019 | 8:00 AM
    Clinical uses of Mass Spectrometry
    Clinical uses of Mass Spectrometry
    DATE: September 12, 2019TIME: 8:00am PDTIn the upcoming era of personalized medicine, there is a growing need for the development of rapid, sensitive, precise and accurate analysis of t...
    Speaker: Nina Ogrinc , Philippe Saudemont
    Sponsored By: Agilent
    10
    SEP 12, 2019 | 6:00 AM
    Using the NASA GeneLab Data System to Study the Metagenomes of Spaceships and Their Occupants
    Using the NASA GeneLab Data System to Study the Metagenomes of...
    With humans pushing to live further off Earth for longer periods of time, it is increasingly important to understand the changes that occur in biological systems during spaceflight whether th...
    Speaker: Jonathan Galazka, PhD , Daniela Bezdan, PhD , Peng Jiang, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    1
     
     
  • SEP 11, 2019 | 1:30 PM
    Development of Machine Learning Algorithms to Data Mine Meta-Omic Characterizations of Complex Microbiota
    Development of Machine Learning Algorithms to Data Mine Meta-Omic...
    Background: The vast majority of all genes are contained within the genomes of the prokaryotes, including the eubacteria and the archaea. These largely single-cellular domains of life thus...
    Speaker: Garth Ehrlich, PhD, FAAAS
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    Sponsored By: PacBio
    4
    SEP 11, 2019 | 12:00 PM
    Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
    Understanding Astrovirus Pathogenesis: Who Knew Viruses Had Toxins?
    immunocompromised populations where the virus can cause systemic and even fatal infections. Indeed, we have shown that astrovirus infections are more prevalent than norovirus in our pediatric...
    Speaker: Stacey Schultz-Cherry, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    5
    SEP 11, 2019 | 10:30 AM
    Structural analysis to understand the molecular mechanism for CPV species-jump
    Structural analysis to understand the molecular mechanism for...
    Canine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis and cerebellar disease. Cross-species transmission of CPV...
    Speaker: Susan Hafenstein, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2019
    1
    SEP 05, 2019 | 7:00 AM
    The bread and butter method of genomics: How to improve your (q)PCR
    The bread and butter method of genomics: How to improve your (q)PCR
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    Speaker: Tim Schommartz, PhD
    Sponsored By: Eppendorf
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