Neurons: A nerve cell that receives and sends electrical signals over long distances within the body. A neuron receives electrical input signals from sensory cells (called sensory neurons) and from other neurons. The neuron sends electrical output signals to muscle neurons (called motoneurons or motor neurons) and to other neurons. A neuron that simply signals another neuron is called an interneuron.
Working memory ability matures late in life, in adolescence or early adulthood, and may be enhanced even in adulthood through cognitive training. The mechanisms through which working memory i...
Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (adjunct) in the Dept. of Neurobiology, University of Chicago. He has an MD from Washington...
Our decisions are governed by a balance between prospective instrumental goal-oriented and retrospective habitual learning strategies. This arbitration is relevant dimensionally across psychi...
Recent advances in single-cell RNA sequencing are producing exciting new insights into cell diversity within different tissues and cancers. Listen in to hear Dr Gonçalo Castelo-B...
DATE: December 14, 2016
TIME: 7:30am PT, 10:30am ET
A major hurdle in developing relevant disease models for drug discovery is access to the healthy and diseased tissue of interest; induc...
Stem cells play critical roles in the development of organisms, as well as in the maintenance and repair of organs and tissues throughout adulthood. Advancing our understanding of mecha...
DATE: November 17, 2016
TIME: 7:00am PT, 10:00am ET
Induced pluripotent stem (iPS) cell reprogramming allows turning an adult somatic cell into a pluripotent stem cell. Four Fac...
Inherited retinal degenerative disorders such as retinitis pigmentosa are characterized by death of the light sensing photoreceptive neurons of the outer retina. Like the rest of the CNS, the...
The central nervous system (CNS) is a conglomerate of diverse, interconnected tissues that each contain cell phenotypes specific to their distinct anatomical region. Recent studies have demon...
A major challenge for the clinical application of pluripotent stem cell therapy for neurodegenerative diseases is large-scale manufacturing and cryopreservation of neurons and glia that can b...
PrPC is a conserved lipid-raft associated, GPI-anchored cell membrane glycoprotein. Misfolding of cellular PrPC into the pathogenic PrPSc results in Prion disease, an untreatable and fatal ne...
The isolation of human embryonic stem cells (hESCs) and the discovery of human induced pluripotent stem cell (hiPSC) reprogramming have sparked a renaissance in stem cell biology, in vitro di...
The human umbilical cord is a promising abundant source of mesenchymal stem cells (MSCs). Compare to other MSCs, the advantages of human umbilical cord MSCs (hUC-MSCs) are easily accessible a...
Neuropathic pain and bladder dysfunction represent significant quality of life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to...
Neurons derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are excellent resources for disease modeling and d...
The human enteric nervous system (ENS) is derived from the neural crest and represents a complex network of ~500 million neurons with dozens of distinct neurotransmitter and hormone subtypes ...
Most discussions about pluripotent stem cells center around their promise for regenerative medicine. The most remarkable quality of these cells is their ability to turn into all of the ...
Maturing neural circuits are dramatically shaped by the environment, but this timing varies across brain regions and plasticity declines with age. Focusing on cellular/molecular mechanisms un...
Given the challenges of replicating Parkinson’s disease in animal models, returning to models that are human-based and highly clinically characterized may provide the most successful pa...
There is a growing appreciation of the relationship between gut microbiota, and the host in maintaining homeostasis in health and predisposing to disease. Bacterial colonisation of the gut pl...
Impulse control disorders (ICDs), also known as behavioural addictions, are common in the general population and can have marked consequences. ICDs can also commonly occur with exposure...
Traditional models of basal ganglia disorders are grounded in the assumption that network dysfunction is driven by alterations in intrinsic excitability of striatal neurons. Recent work has c...
In the adult central nervous system (CNS) small populations of neurons are formed in the adult olfactory bulb and dentate gyrus of the hippocampus. In the adult hippocampus, newly born neuron...
Working memory ability matures late in life, in adolescence or early adulthood, and may be enhanced even in adulthood through cognitive training. The mechanisms through which working memory i...
Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are b...
Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (adjunct) in the Dept. of Neurobiology, University of Chicago. He has an MD from Washington...
Our decisions are governed by a balance between prospective instrumental goal-oriented and retrospective habitual learning strategies. This arbitration is relevant dimensionally across psychi...
Recent advances in single-cell RNA sequencing are producing exciting new insights into cell diversity within different tissues and cancers. Listen in to hear Dr Gonçalo Castelo-B...
DATE: December 14, 2016
TIME: 7:30am PT, 10:30am ET
A major hurdle in developing relevant disease models for drug discovery is access to the healthy and diseased tissue of interest; induc...
Stem cells play critical roles in the development of organisms, as well as in the maintenance and repair of organs and tissues throughout adulthood. Advancing our understanding of mecha...
DATE: November 17, 2016
TIME: 7:00am PT, 10:00am ET
Induced pluripotent stem (iPS) cell reprogramming allows turning an adult somatic cell into a pluripotent stem cell. Four Fac...
Inherited retinal degenerative disorders such as retinitis pigmentosa are characterized by death of the light sensing photoreceptive neurons of the outer retina. Like the rest of the CNS, the...
The central nervous system (CNS) is a conglomerate of diverse, interconnected tissues that each contain cell phenotypes specific to their distinct anatomical region. Recent studies have demon...
A major challenge for the clinical application of pluripotent stem cell therapy for neurodegenerative diseases is large-scale manufacturing and cryopreservation of neurons and glia that can b...
PrPC is a conserved lipid-raft associated, GPI-anchored cell membrane glycoprotein. Misfolding of cellular PrPC into the pathogenic PrPSc results in Prion disease, an untreatable and fatal ne...
The isolation of human embryonic stem cells (hESCs) and the discovery of human induced pluripotent stem cell (hiPSC) reprogramming have sparked a renaissance in stem cell biology, in vitro di...
The human umbilical cord is a promising abundant source of mesenchymal stem cells (MSCs). Compare to other MSCs, the advantages of human umbilical cord MSCs (hUC-MSCs) are easily accessible a...
Neuropathic pain and bladder dysfunction represent significant quality of life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to...
Neurons derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are excellent resources for disease modeling and d...
The human enteric nervous system (ENS) is derived from the neural crest and represents a complex network of ~500 million neurons with dozens of distinct neurotransmitter and hormone subtypes ...
Most discussions about pluripotent stem cells center around their promise for regenerative medicine. The most remarkable quality of these cells is their ability to turn into all of the ...
Maturing neural circuits are dramatically shaped by the environment, but this timing varies across brain regions and plasticity declines with age. Focusing on cellular/molecular mechanisms un...
Given the challenges of replicating Parkinson’s disease in animal models, returning to models that are human-based and highly clinically characterized may provide the most successful pa...
There is a growing appreciation of the relationship between gut microbiota, and the host in maintaining homeostasis in health and predisposing to disease. Bacterial colonisation of the gut pl...
Impulse control disorders (ICDs), also known as behavioural addictions, are common in the general population and can have marked consequences. ICDs can also commonly occur with exposure...
Traditional models of basal ganglia disorders are grounded in the assumption that network dysfunction is driven by alterations in intrinsic excitability of striatal neurons. Recent work has c...
In the adult central nervous system (CNS) small populations of neurons are formed in the adult olfactory bulb and dentate gyrus of the hippocampus. In the adult hippocampus, newly born neuron...
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