Complex Systems is a journal devoted to the science, mathematics and engineering of systems with simple components but complex overall behavior. It is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems.
Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms. At NCATS the approach taken has been to optimize our existing lega...
Growing living human cells in vitro for basic research, drug discovery and reparative/regenerative medicine is challenged by the difficulty in developing methods for reproducibly and cost eff...
Studying the molecular machinery of cells from atomic detail to the cellular context and beyond is a great challenge for cell biology. It is hugely important to zoom into the atom-by-atom arr...
G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets. However, a detailed mechanistic understanding of their...
Short-read sequencing has found wide-spread use in metagenomics but the short read lengths and bias with regard to sequence composition have translated to limitations of the study of complex...
Complex disease phenotypes - obesity, type II diabetes, and cancer challenge simple models in both evolution and biology. Examination of molecular networks and their dynamic behavior o...
I will update the current state of our candidate RM 8376 for mixed microbial DNA detection via NGS-based sequencing and metagenomics. After community engagement to understand the metrological...
DATE: April 4, 2018TIME: 09:00am PDT, 12:00pm CEST Multiplex is the ability to characterize three or more biomarkers on a single tissue section. The technique enables the combi...
The cannabis industry as a whole is under considerable scrutiny. Finger-pointing and blame regarding inaccurate product labels run rampant. Media outlets have often faulted the sk...
Analysis of pesticides in cannabis is essential to protect the public health, especially medical cannabis patients. Sensitive and selective measurement is required in order to provide confide...
DATE: March 28, 2018TIME: 10:30AM PDTAs consumers in modern society, we have become accustomed to the purchase of foods and drugs that are safe and accurately labeled. This is a result...
DATE: March 28, 2018TIME: 10:00am PDT, 01:00pm EDTPrimary cells are derived from various tissues typically via dissection, enzymatic dissociation, and subsequent culture in media specif...
Cannabis and its products are referred to in the USA as Medical Marijuana. The traditional approach tomedical research of a single compound for a single target does not work for cannabis, a...
DATE: March 22, 2018TIME: 09:00am PST, 12:00pm ESTGlioblastoma (GBM) is the most aggressive primary brain cancer, with nearly universal recurrence after treatment. GBMs are highly heter...
Some of the most significant hurdles faced by neuroscientists in the field of neurodegenerative disease research when seeking to acquire genetic information include sample accessibility, repr...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Most neuropsychiatric diseases involve multifactorial systems characterized by complex interactions among genetic predisposition/resiliency, environmental/social determinants, molecular seque...
Psychiatric diagnosis is inherently difficult, due to the lack of clear biomarkers or any other objective assessment. Although quantitative, the psychometric scales employed during the psychi...
Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
The aerodigestive tract is a combination of the respiratory tract and the upper portion of the digestive tract. As these two organ systems share many of the necessary structures used for swal...
DATE: December 12, 2017TIME: 10:00AM PTSince their discovery, dendritic cells (DCs) have demonstrated a central role in the development of effective immune responses. Their unique abili...
Over the years high throughput screening has evolved from monolithic static systems to modular more dynamic platforms. At NCATS the approach taken has been to optimize our existing lega...
Growing living human cells in vitro for basic research, drug discovery and reparative/regenerative medicine is challenged by the difficulty in developing methods for reproducibly and cost eff...
Studying the molecular machinery of cells from atomic detail to the cellular context and beyond is a great challenge for cell biology. It is hugely important to zoom into the atom-by-atom arr...
G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets. However, a detailed mechanistic understanding of their...
Short-read sequencing has found wide-spread use in metagenomics but the short read lengths and bias with regard to sequence composition have translated to limitations of the study of complex...
Complex disease phenotypes - obesity, type II diabetes, and cancer challenge simple models in both evolution and biology. Examination of molecular networks and their dynamic behavior o...
I will update the current state of our candidate RM 8376 for mixed microbial DNA detection via NGS-based sequencing and metagenomics. After community engagement to understand the metrological...
DATE: April 4, 2018TIME: 09:00am PDT, 12:00pm CEST Multiplex is the ability to characterize three or more biomarkers on a single tissue section. The technique enables the combi...
The cannabis industry as a whole is under considerable scrutiny. Finger-pointing and blame regarding inaccurate product labels run rampant. Media outlets have often faulted the sk...
Analysis of pesticides in cannabis is essential to protect the public health, especially medical cannabis patients. Sensitive and selective measurement is required in order to provide confide...
DATE: March 28, 2018TIME: 10:30AM PDTAs consumers in modern society, we have become accustomed to the purchase of foods and drugs that are safe and accurately labeled. This is a result...
DATE: March 28, 2018TIME: 10:00am PDT, 01:00pm EDTPrimary cells are derived from various tissues typically via dissection, enzymatic dissociation, and subsequent culture in media specif...
Cannabis and its products are referred to in the USA as Medical Marijuana. The traditional approach tomedical research of a single compound for a single target does not work for cannabis, a...
DATE: March 22, 2018TIME: 09:00am PST, 12:00pm ESTGlioblastoma (GBM) is the most aggressive primary brain cancer, with nearly universal recurrence after treatment. GBMs are highly heter...
Some of the most significant hurdles faced by neuroscientists in the field of neurodegenerative disease research when seeking to acquire genetic information include sample accessibility, repr...
Clathrin mediated endocytosis (CME) at pre-synaptic terminals is functionally coupled to neuro-transmitter release. Like other cytosolic proteins, clathrin is synthesized in cell-bodies and c...
Most neuropsychiatric diseases involve multifactorial systems characterized by complex interactions among genetic predisposition/resiliency, environmental/social determinants, molecular seque...
Psychiatric diagnosis is inherently difficult, due to the lack of clear biomarkers or any other objective assessment. Although quantitative, the psychometric scales employed during the psychi...
Complex animal behavior is produced by dynamic interactions between discrete regions of the brain. As such, defining functional connections between brain regions is critical in gaining a full...
The aerodigestive tract is a combination of the respiratory tract and the upper portion of the digestive tract. As these two organ systems share many of the necessary structures used for swal...
DATE: December 12, 2017TIME: 10:00AM PTSince their discovery, dendritic cells (DCs) have demonstrated a central role in the development of effective immune responses. Their unique abili...
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