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    Disease Modeling

    Disease modeling is the use of a disease model, which is an animal or cells containing all or some of the pathological characteristics and mechanisms of a disease, to study that particular disease.

    Webinars

    • FEB 13, 2019 | 10:30 AM
      Qualitative, Biased, Personal and Speculative Remarks on Digitization, Digitalization & Digital Transformation
      Qualitative, Biased, Personal and Speculative Remarks on Digitization,...
      A collection of opinions, questions and other assorted thoughts about the intersection of these developing technologies and preclinical studies primarily focused on the early discovery (as op...
      Speaker: Sean Maguire, VMD, MS, DACLAM
      Presented at: Laboratory Animal Sciences Virtual Event Series 2019
      4
      FEB 13, 2019 | 9:00 AM
      Making Data Fly in Formation
      Making Data Fly in Formation
      In biomedical research, data should be treated as first-class corporate assets--they were expensive to create, they are expensive to maintain, and they have future business value. The petabyt...
      Speaker: Chuck Donnelly , Julie Morrison
      Presented at: Laboratory Animal Sciences Virtual Event Series 2019
      1
      FEB 07, 2019 | 8:00 AM
      Acceleration of Neuroscience Research Discovery by Incorporation of Large Area/Volume Microscopic Data
      Acceleration of Neuroscience Research Discovery by Incorporation...
      Date:  February 7, 2019Time:  8:00am PST, 11:00am EST Modern microscopes are becoming increasingly complex instruments enabling registration of image sets far beyon...
      Speaker: Anastas Popratiloff, MD, PhD
      Sponsored By: Leica Microsystems
      8
      JAN 31, 2019 | 1:30 PM
      Standardization of Cell Viability Assays in Primary Cells as a Prerequisite for Novel Bioprocessing Applications
      Standardization of Cell Viability Assays in Primary Cells as a...
      Development of novel types of therapeutics require adaptation of traditional bioprocessing applications to include the use of primary cells, such as stem cells, fibroblasts, astrocytes and ne...
      Speaker: Simon Kaja, PhD
      Presented at: BioProcessing Virtual Event Series 2019
      2
      DEC 13, 2018 | 9:00 AM
      Optimizing Treatment Options for HER2+/ ER+ Breast Cancer using Models of Endocrine Resistance
      Optimizing Treatment Options for HER2+/ ER+ Breast Cancer using...
      DATE: December 13 15,2018TIME: 09:00am PST, 12:00pm EST Breast cancers are classified into three main subtypes according to their receptor status: estrogen receptor-positive...
      Speaker: Hillary Stires, PhD
      Sponsored By: Thermo Fisher Scientific/Gibco
      3
      DEC 10, 2018 | 10:00 PM
      Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into your Lung Research
      Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into...
      DATE: December 11, 2018TIME: 06:00 PSTIt’s understood and accepted that animal disease models generally offer great value for pre-clinical research and efficient drug screeni...
      Speaker: Dr. Christian Dullin , Dr. Sasha (Alexandre) Belenkov , Dr. Francesca Ruscitti
      Sponsored By: Revvity
      4 1
      DEC 06, 2018 | 8:00 AM
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
      DATE:  December 6, 2018TIME:   11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...
      Speaker: Rob van 't Hof, BSc, MSc, PhD
      Sponsored By: Bruker Microbiology & Diagnostics
      2
      DEC 05, 2018 | 8:00 PM
      The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary Tumors and in Circulation
      The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary...
      DATE: December 05, 2018TIME:  08:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
      Speaker: Bruno Sainz, PhD
      Sponsored By: Thermo Fisher Scientific
      5 3
      DEC 06, 2018 | 1:00 AM
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
      Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
      DATE:    December 6, 2018TIME:    10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...
      Speaker: Rob van 't Hof, BSc, MSc, PhD
      Sponsored By: Bruker Microbiology & Diagnostics
      8
      DEC 05, 2018 | 7:00 AM
      The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary Tumors and in Circulation
      The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary...
      DATE: December 05, 2018TIME:  07:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
      Speaker: Bruno Sainz, PhD
      Sponsored By: Thermo Fisher Scientific
      7
      DEC 04, 2018 | 7:00 AM
      Pluripotent stem cells:  How to raise the quality of your PSC culture
      Pluripotent stem cells: How to raise the quality of your PSC...
      DATE:    December 4, 2018TIME:    4:00pm CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
      Speaker: Jessica Wagener, PhD , Nadine Mellies, PhD
      Sponsored By: Eppendorf
      5
      DEC 03, 2018 | 11:00 PM
      Pluripotent stem cells: How to raise the quality of your PSC culture
      Pluripotent stem cells: How to raise the quality of your PSC culture
      DATE:    December 4, 2018TIME:    8:00am CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
      Speaker: Jessica Wagener, PhD , Nadine Mellies, PhD
      Sponsored By: Eppendorf
      5
      NOV 29, 2018 | 9:00 AM
      An overview of primary immune deficiency disorders (PID) and laboratory testing for PID
      An overview of primary immune deficiency disorders (PID) and laboratory...
      DATE: November 29, 2018TIME:  9:00AM PDTAn overview of primary immune deficiency disorders (PID) and laboratory testing for PIDPrimary immune deficiencies (PIDs), oth...
      Speaker: Vijaya Knight, MD, PhD, (D)ABMLI
      Sponsored By: Binding Site
      10
      NOV 15, 2018 | 12:00 PM
      Using human stem cells to model neocortical gyration phenotypes
      Using human stem cells to model neocortical gyration phenotypes
      Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
      Speaker: Ashleigh Schaffer
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      6 1
      NOV 15, 2018 | 11:00 AM
      LIVE TRAINING: Differentiating neurons
      LIVE TRAINING: Differentiating neurons
      Generation of robust iPSC-derived neural stem cell cultures and neurons with shorter maturation times provide opportunities for quick and reliable generation of neuronal in vitro models. This...
      Speaker: Jordan Dizon
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      7
      NOV 15, 2018 | 10:00 AM
      Applications of Brain-Model Technology
      Applications of Brain-Model Technology
      The complexity of the human brain, with thousands of neuronal types, permits the development of sophisticated behavioral repertoires, such as language, tool use, self-awareness, symbolic thou...
      Speaker: Alysson Muotri
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      4
      NOV 15, 2018 | 9:00 AM
      Best Practice Strategies and Tools for Scaling Clinical Bioinformatics
      Best Practice Strategies and Tools for Scaling Clinical Bioinformatics
      Clinical testing with next generation sequencing requires a complex bioinformatics pipeline to process raw DNA sequence into  interpretable variants for medical reporting. With sequencin...
      Speaker: Elaine Gee, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      1
      NOV 15, 2018 | 8:00 AM
      Precise Gene Editing of Human Pluripotent Stem Cells
      Precise Gene Editing of Human Pluripotent Stem Cells
      CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
      Speaker: Kris Saha
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      11
      NOV 15, 2018 | 7:00 AM
      Use of stem-cell derived endothelial cells for disease relevant cell modeling and drug discovery
      Use of stem-cell derived endothelial cells for disease relevant...
      The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
      Speaker: Filip Roudnicky
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      8
      NOV 15, 2018 | 4:00 AM
      Generation and application of 3D-organoid cell culture models using human induced pluripotent stem cells (iPSCs) for drug discovery
      Generation and application of 3D-organoid cell culture models...
      Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...
      Speaker: Ryan Hicks
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      10 2
      NOV 14, 2018 | 3:00 PM
      Modeling Inflammation and Fibrosis in Humans with PSC-derived Steatohepatitis Liver Organoids
      Modeling Inflammation and Fibrosis in Humans with PSC-derived...
      Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
      Speaker: Takanori Takebe
      Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
      8
      NOV 14, 2018 | 9:00 AM
      Accelerating Cancer Research and Clinical Innovations Using OncoLand
      Accelerating Cancer Research and Clinical Innovations Using OncoLand
      With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multipl...
      Speaker: Bing Zhou, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
      Sponsored By: QIAGEN
      1
      NOV 02, 2018 | 12:00 AM
      A Neuroscientist's Guide to Live-Cell Analysis: Techniques & Benefits
      A Neuroscientist's Guide to Live-Cell Analysis: Techniques & Benefits
      Despite exciting recent developments in neuroscience, identifying novel, truly effective treatments for patients with neurological and psychiatric conditions remains highly challenging. There...
      Speaker: Susana Alcantara
      Presented at: Dimension of Time: From Culture to Assay
      3
      OCT 25, 2018 | 12:00 PM
      Through the Looking Glass, and What Amino Acids Found There
      Through the Looking Glass, and What Amino Acids Found There
      Analytical chemistry can take you to strange places - for me it has been to the bottom of a quarry, being covered in dirt, excavating sesame-seed sized fossils that allow us to work out when...
      Speaker: Kirsty Penkman, PhD
      Presented at: Analytical Chemistry Virtual Event Series 2018
      1
    FEB 13, 2019 | 10:30 AM
    Qualitative, Biased, Personal and Speculative Remarks on Digitization, Digitalization & Digital Transformation
    Qualitative, Biased, Personal and Speculative Remarks on Digitization,...
    A collection of opinions, questions and other assorted thoughts about the intersection of these developing technologies and preclinical studies primarily focused on the early discovery (as op...
    Speaker: Sean Maguire, VMD, MS, DACLAM
    Presented at: Laboratory Animal Sciences Virtual Event Series 2019
    4
    FEB 13, 2019 | 9:00 AM
    Making Data Fly in Formation
    Making Data Fly in Formation
    In biomedical research, data should be treated as first-class corporate assets--they were expensive to create, they are expensive to maintain, and they have future business value. The petabyt...
    Speaker: Chuck Donnelly , Julie Morrison
    Presented at: Laboratory Animal Sciences Virtual Event Series 2019
    1
    FEB 07, 2019 | 8:00 AM
    Acceleration of Neuroscience Research Discovery by Incorporation of Large Area/Volume Microscopic Data
    Acceleration of Neuroscience Research Discovery by Incorporation...
    Date:  February 7, 2019Time:  8:00am PST, 11:00am EST Modern microscopes are becoming increasingly complex instruments enabling registration of image sets far beyon...
    Speaker: Anastas Popratiloff, MD, PhD
    Sponsored By: Leica Microsystems
    8
    JAN 31, 2019 | 1:30 PM
    Standardization of Cell Viability Assays in Primary Cells as a Prerequisite for Novel Bioprocessing Applications
    Standardization of Cell Viability Assays in Primary Cells as a...
    Development of novel types of therapeutics require adaptation of traditional bioprocessing applications to include the use of primary cells, such as stem cells, fibroblasts, astrocytes and ne...
    Speaker: Simon Kaja, PhD
    Presented at: BioProcessing Virtual Event Series 2019
    2
    DEC 13, 2018 | 9:00 AM
    Optimizing Treatment Options for HER2+/ ER+ Breast Cancer using Models of Endocrine Resistance
    Optimizing Treatment Options for HER2+/ ER+ Breast Cancer using...
    DATE: December 13 15,2018TIME: 09:00am PST, 12:00pm EST Breast cancers are classified into three main subtypes according to their receptor status: estrogen receptor-positive...
    Speaker: Hillary Stires, PhD
    Sponsored By: Thermo Fisher Scientific/Gibco
    3
     
     
  • DEC 10, 2018 | 10:00 PM
    Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into your Lung Research
    Better Data, Fewer Mice: micro-CT Imaging Breathes New Life into...
    DATE: December 11, 2018TIME: 06:00 PSTIt’s understood and accepted that animal disease models generally offer great value for pre-clinical research and efficient drug screeni...
    Speaker: Dr. Christian Dullin , Dr. Sasha (Alexandre) Belenkov , Dr. Francesca Ruscitti
    Sponsored By: Revvity
    4 1
    DEC 06, 2018 | 8:00 AM
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
    DATE:  December 6, 2018TIME:   11:00am EST, 5:00pm CET Introduction Micro-computed tomography (micro-CT) offers significant advantages o...
    Speaker: Rob van 't Hof, BSc, MSc, PhD
    Sponsored By: Bruker Microbiology & Diagnostics
    2
    DEC 05, 2018 | 8:00 PM
    The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary Tumors and in Circulation
    The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary...
    DATE: December 05, 2018TIME:  08:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
    Speaker: Bruno Sainz, PhD
    Sponsored By: Thermo Fisher Scientific
    5 3
    DEC 06, 2018 | 1:00 AM
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone Architecture
    Using Micro-CT Imaging for the Phenotyping and Analysis of Bone...
    DATE:    December 6, 2018TIME:    10:00am CET, 5:00pm CST Intro Micro-computed tomography (micro-CT) offers significant advantage...
    Speaker: Rob van 't Hof, BSc, MSc, PhD
    Sponsored By: Bruker Microbiology & Diagnostics
    8
    DEC 05, 2018 | 7:00 AM
    The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary Tumors and in Circulation
    The Use of Flow Cytometry to Identify Cancer Stem Cells in Primary...
    DATE: December 05, 2018TIME:  07:00 PSTWhat is desperately needed are methods to detect cells that cause metastasis–known as cancer stem cells (CSC), a subpopulation of...
    Speaker: Bruno Sainz, PhD
    Sponsored By: Thermo Fisher Scientific
    7
     
     
  • DEC 04, 2018 | 7:00 AM
    Pluripotent stem cells:  How to raise the quality of your PSC culture
    Pluripotent stem cells: How to raise the quality of your PSC...
    DATE:    December 4, 2018TIME:    4:00pm CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
    Speaker: Jessica Wagener, PhD , Nadine Mellies, PhD
    Sponsored By: Eppendorf
    5
    DEC 03, 2018 | 11:00 PM
    Pluripotent stem cells: How to raise the quality of your PSC culture
    Pluripotent stem cells: How to raise the quality of your PSC culture
    DATE:    December 4, 2018TIME:    8:00am CET PSCs represent an important tool in a wide range of applications, including basic research, disease...
    Speaker: Jessica Wagener, PhD , Nadine Mellies, PhD
    Sponsored By: Eppendorf
    5
    NOV 29, 2018 | 9:00 AM
    An overview of primary immune deficiency disorders (PID) and laboratory testing for PID
    An overview of primary immune deficiency disorders (PID) and laboratory...
    DATE: November 29, 2018TIME:  9:00AM PDTAn overview of primary immune deficiency disorders (PID) and laboratory testing for PIDPrimary immune deficiencies (PIDs), oth...
    Speaker: Vijaya Knight, MD, PhD, (D)ABMLI
    Sponsored By: Binding Site
    10
    NOV 15, 2018 | 12:00 PM
    Using human stem cells to model neocortical gyration phenotypes
    Using human stem cells to model neocortical gyration phenotypes
    Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
    Speaker: Ashleigh Schaffer
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    6 1
    NOV 15, 2018 | 11:00 AM
    LIVE TRAINING: Differentiating neurons
    LIVE TRAINING: Differentiating neurons
    Generation of robust iPSC-derived neural stem cell cultures and neurons with shorter maturation times provide opportunities for quick and reliable generation of neuronal in vitro models. This...
    Speaker: Jordan Dizon
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    7
     
     
  • NOV 15, 2018 | 10:00 AM
    Applications of Brain-Model Technology
    Applications of Brain-Model Technology
    The complexity of the human brain, with thousands of neuronal types, permits the development of sophisticated behavioral repertoires, such as language, tool use, self-awareness, symbolic thou...
    Speaker: Alysson Muotri
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    4
    NOV 15, 2018 | 9:00 AM
    Best Practice Strategies and Tools for Scaling Clinical Bioinformatics
    Best Practice Strategies and Tools for Scaling Clinical Bioinformatics
    Clinical testing with next generation sequencing requires a complex bioinformatics pipeline to process raw DNA sequence into  interpretable variants for medical reporting. With sequencin...
    Speaker: Elaine Gee, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    1
    NOV 15, 2018 | 8:00 AM
    Precise Gene Editing of Human Pluripotent Stem Cells
    Precise Gene Editing of Human Pluripotent Stem Cells
    CRISPR ribonucleoproteins (RNPs) can generate programmable gene edits, however imprecise editing and efficient delivery to human stem cells are key challenges. Here we describe novel biochemi...
    Speaker: Kris Saha
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    11
    NOV 15, 2018 | 7:00 AM
    Use of stem-cell derived endothelial cells for disease relevant cell modeling and drug discovery
    Use of stem-cell derived endothelial cells for disease relevant...
    The use of human pluripotent stem cells (hPSCs) for in vitro disease-modeling is limited by the lack of robust and efficient protocols for the differentiation of relevant adult cell types. Pr...
    Speaker: Filip Roudnicky
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    8
    NOV 15, 2018 | 4:00 AM
    Generation and application of 3D-organoid cell culture models using human induced pluripotent stem cells (iPSCs) for drug discovery
    Generation and application of 3D-organoid cell culture models...
    Development of physiologically relevant cellular models, with strong translatability to human pathophysiology, is critical for identification and validation of novel therapeutic targets. Cell...
    Speaker: Ryan Hicks
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    10 2
     
     
  • NOV 14, 2018 | 3:00 PM
    Modeling Inflammation and Fibrosis in Humans with PSC-derived Steatohepatitis Liver Organoids
    Modeling Inflammation and Fibrosis in Humans with PSC-derived...
    Neuronal migration defects, including pachygyria, are among the most severe developmental brain defects in humans. Using human genetics approaches, we recently identified bi-allelic truncatin...
    Speaker: Takanori Takebe
    Presented at: 6th annual 24 Hours of Stem Cellsâ„¢ virtual event
    8
    NOV 14, 2018 | 9:00 AM
    Accelerating Cancer Research and Clinical Innovations Using OncoLand
    Accelerating Cancer Research and Clinical Innovations Using OncoLand
    With significant decrease in the cost of sequencing in numerous commercial as well as cancer center–driven initiatives, genomic profiling is increasingly becoming routine across multipl...
    Speaker: Bing Zhou, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2018
    Sponsored By: QIAGEN
    1
    NOV 02, 2018 | 12:00 AM
    A Neuroscientist's Guide to Live-Cell Analysis: Techniques & Benefits
    A Neuroscientist's Guide to Live-Cell Analysis: Techniques & Benefits
    Despite exciting recent developments in neuroscience, identifying novel, truly effective treatments for patients with neurological and psychiatric conditions remains highly challenging. There...
    Speaker: Susana Alcantara
    Presented at: Dimension of Time: From Culture to Assay
    3
    OCT 25, 2018 | 12:00 PM
    Through the Looking Glass, and What Amino Acids Found There
    Through the Looking Glass, and What Amino Acids Found There
    Analytical chemistry can take you to strange places - for me it has been to the bottom of a quarry, being covered in dirt, excavating sesame-seed sized fossils that allow us to work out when...
    Speaker: Kirsty Penkman, PhD
    Presented at: Analytical Chemistry Virtual Event Series 2018
    1
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